Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3660
Gene name Gene Name - the full gene name approved by the HGNC.
Interferon regulatory factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IRF2
Synonyms (NCBI Gene) Gene synonyms aliases
IRF-2
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q35.1
Summary Summary of gene provided in NCBI Entrez Gene.
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that e
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006178 hsa-miR-20a-5p Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot 21880628
MIRT006178 hsa-miR-20a-5p Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot 21880628
MIRT006178 hsa-miR-20a-5p Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot 21880628
MIRT006178 hsa-miR-20a-5p Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot 21880628
MIRT006178 hsa-miR-20a-5p Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot 21880628
Transcription factors
Transcription factor Regulation Reference
CIITA Unknown 15950283
IRF1 Activation 9054665
PITX1 Repression 12242290
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 7507207
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP 9540062
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147576 6117 ENSG00000168310
Protein
UniProt ID P14316
Protein name Interferon regulatory factor 2 (IRF-2)
Protein function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constit
PDB 8YTG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00605 IRF 7 112 Interferon regulatory factor transcription factor Domain
Tissue specificity TISSUE SPECIFICITY: Expressed throughout the epithelium of the colon. Also expressed in lamina propria. {ECO:0000269|PubMed:15226432}.
Sequence
MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAI
HTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRML
PLSERPSK
KGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQ
SHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVP
SDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVP
YNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC
Sequence length 349
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Interferon gamma signaling
Interferon alpha/beta signaling
Factors involved in megakaryocyte development and platelet production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
29274321
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 27576016
Breast Neoplasms Associate 11323500, 14651776, 16241857, 35441810, 37584152
Burkitt Lymphoma Associate 9261415
Carcinogenesis Associate 22119988
Carcinoid Tumor Associate 10942060
Carcinoma Ductal Stimulate 11323500
Carcinoma Hepatocellular Associate 22561517, 25021421, 32671843
Carcinoma Intraductal Noninfiltrating Associate 11323500
Carcinoma Non Small Cell Lung Associate 34022918
Cell Transformation Viral Associate 11559933