IRF2 (interferon regulatory factor 2)

Gene

• Entrez ID: 3660
• Gene name: Interferon regulatory factor 2
• Gene symbol: IRF2
• Synonyms (NCBI Gene): IRF-2
• Chromosome: 4
• Chromosome location: 4q35.1
• Summary: IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that e

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006178	hsa-miR-20a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT017202	hsa-miR-335-5p	Microarray	18185580
MIRT047780	hsa-miR-30d-5p	CLASH	23622248
MIRT536623	hsa-miR-18b-5p	PAR-CLIP	22012620
MIRT536622	hsa-miR-4735-3p	PAR-CLIP	22012620
MIRT536621	hsa-miR-18a-5p	PAR-CLIP	22012620
MIRT536610	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536620	hsa-miR-520f-3p	PAR-CLIP	22012620
MIRT536619	hsa-miR-520b	PAR-CLIP	22012620
MIRT536618	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536617	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536616	hsa-miR-520e	PAR-CLIP	22012620
MIRT536615	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536614	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536613	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536612	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536611	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536610	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536609	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536608	hsa-miR-302e	PAR-CLIP	22012620
MIRT536607	hsa-miR-4662a-3p	PAR-CLIP	22012620
MIRT536606	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT536605	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT536604	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT536603	hsa-miR-3607-3p	PAR-CLIP	22012620
MIRT536602	hsa-miR-298	PAR-CLIP	22012620
MIRT536600	hsa-miR-3686	PAR-CLIP	22012620
MIRT536601	hsa-miR-3658	PAR-CLIP	22012620
MIRT503946	hsa-miR-1276	PAR-CLIP	22012620
MIRT503943	hsa-miR-5187-5p	PAR-CLIP	22012620
MIRT503944	hsa-miR-6728-5p	PAR-CLIP	22012620
MIRT503946	hsa-miR-1276	PAR-CLIP	23446348
MIRT503945	hsa-miR-5191	PAR-CLIP	23446348
MIRT503943	hsa-miR-5187-5p	PAR-CLIP	23446348
MIRT503944	hsa-miR-6728-5p	PAR-CLIP	23446348
MIRT503946	hsa-miR-1276	PAR-CLIP	23446348
MIRT503945	hsa-miR-5191	PAR-CLIP	23446348
MIRT503943	hsa-miR-5187-5p	PAR-CLIP	23446348
MIRT503944	hsa-miR-6728-5p	PAR-CLIP	23446348
MIRT536621	hsa-miR-18a-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	26173586
MIRT536621	hsa-miR-18a-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	26173586
MIRT536618	hsa-miR-520c-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	28203525
MIRT536618	hsa-miR-520c-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	28203525
MIRT733498	hsa-miR-204-5p	Luciferase reporter assay, qRT-PCR, Western blotting	31934069
MIRT733498	hsa-miR-204-5p	Luciferase reporter assay, qRT-PCR, Western blotting	31934069
MIRT737538	hsa-miR-204-3p	Luciferase reporter assay, Western blotting, ELISA	31934069
MIRT536623	hsa-miR-18b-5p	PAR-CLIP	22012620
MIRT536622	hsa-miR-4735-3p	PAR-CLIP	22012620
MIRT536621	hsa-miR-18a-5p	PAR-CLIP	22012620
MIRT536610	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536620	hsa-miR-520f-3p	PAR-CLIP	22012620
MIRT536619	hsa-miR-520b	PAR-CLIP	22012620
MIRT536618	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536617	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536616	hsa-miR-520e	PAR-CLIP	22012620
MIRT536615	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536614	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536613	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536612	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536611	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536610	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536609	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536608	hsa-miR-302e	PAR-CLIP	22012620
MIRT536607	hsa-miR-4662a-3p	PAR-CLIP	22012620
MIRT536606	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT536605	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT536604	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT536603	hsa-miR-3607-3p	PAR-CLIP	22012620
MIRT536602	hsa-miR-298	PAR-CLIP	22012620
MIRT536600	hsa-miR-3686	PAR-CLIP	22012620
MIRT536601	hsa-miR-3658	PAR-CLIP	22012620
MIRT503946	hsa-miR-1276	PAR-CLIP	22012620
MIRT503943	hsa-miR-5187-5p	PAR-CLIP	22012620
MIRT503944	hsa-miR-6728-5p	PAR-CLIP	22012620
MIRT503946	hsa-miR-1276	PAR-CLIP	23446348
MIRT503945	hsa-miR-5191	PAR-CLIP	23446348
MIRT503943	hsa-miR-5187-5p	PAR-CLIP	23446348
MIRT503944	hsa-miR-6728-5p	PAR-CLIP	23446348
MIRT503946	hsa-miR-1276	PAR-CLIP	23446348
MIRT503945	hsa-miR-5191	PAR-CLIP	23446348
MIRT503943	hsa-miR-5187-5p	PAR-CLIP	23446348
MIRT503944	hsa-miR-6728-5p	PAR-CLIP	23446348
MIRT755962	gga-miR-455-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35806321
MIRT756288	hsa-miR-222-3p	Luciferase reporter assay, Western blotting, qRT-PCR	37621743
MIRT1070875	hsa-miR-1	CLIP-seq
MIRT1070876	hsa-miR-1200	CLIP-seq
MIRT1070877	hsa-miR-1227	CLIP-seq
MIRT1070878	hsa-miR-1237	CLIP-seq
MIRT1070879	hsa-miR-1248	CLIP-seq
MIRT1070880	hsa-miR-1256	CLIP-seq
MIRT1070881	hsa-miR-1265	CLIP-seq
MIRT1070882	hsa-miR-1289	CLIP-seq
MIRT1070883	hsa-miR-1290	CLIP-seq
MIRT1070884	hsa-miR-1302	CLIP-seq
MIRT1070885	hsa-miR-2054	CLIP-seq
MIRT1070886	hsa-miR-206	CLIP-seq
MIRT1070887	hsa-miR-2110	CLIP-seq
MIRT1070888	hsa-miR-2278	CLIP-seq
MIRT1070889	hsa-miR-3064-3p	CLIP-seq
MIRT1070890	hsa-miR-3065-5p	CLIP-seq
MIRT1070891	hsa-miR-3120-3p	CLIP-seq
MIRT1070892	hsa-miR-3121-5p	CLIP-seq
MIRT1070893	hsa-miR-3123	CLIP-seq
MIRT1070894	hsa-miR-3137	CLIP-seq
MIRT1070895	hsa-miR-3154	CLIP-seq
MIRT1070896	hsa-miR-3179	CLIP-seq
MIRT1070897	hsa-miR-3190	CLIP-seq
MIRT1070898	hsa-miR-3198	CLIP-seq
MIRT1070899	hsa-miR-342-5p	CLIP-seq
MIRT1070900	hsa-miR-3647-3p	CLIP-seq
MIRT1070901	hsa-miR-3659	CLIP-seq
MIRT1070902	hsa-miR-3673	CLIP-seq
MIRT1070903	hsa-miR-380	CLIP-seq
MIRT1070904	hsa-miR-3919	CLIP-seq
MIRT1070905	hsa-miR-3925-5p	CLIP-seq
MIRT1070906	hsa-miR-4271	CLIP-seq
MIRT1070907	hsa-miR-4274	CLIP-seq
MIRT1070908	hsa-miR-4279	CLIP-seq
MIRT1070909	hsa-miR-4294	CLIP-seq
MIRT1070910	hsa-miR-4298	CLIP-seq
MIRT1070911	hsa-miR-4309	CLIP-seq
MIRT1070912	hsa-miR-4311	CLIP-seq
MIRT1070913	hsa-miR-4324	CLIP-seq
MIRT1070914	hsa-miR-4422	CLIP-seq
MIRT1070915	hsa-miR-4424	CLIP-seq
MIRT1070916	hsa-miR-4457	CLIP-seq
MIRT1070917	hsa-miR-4473	CLIP-seq
MIRT1070918	hsa-miR-4476	CLIP-seq
MIRT1070919	hsa-miR-4491	CLIP-seq
MIRT1070920	hsa-miR-4505	CLIP-seq
MIRT1070921	hsa-miR-451b	CLIP-seq
MIRT1070922	hsa-miR-4520a-3p	CLIP-seq
MIRT1070923	hsa-miR-4520b-3p	CLIP-seq
MIRT1070924	hsa-miR-455-5p	CLIP-seq
MIRT1070925	hsa-miR-4657	CLIP-seq
MIRT1070926	hsa-miR-4658	CLIP-seq
MIRT1070927	hsa-miR-4659a-3p	CLIP-seq
MIRT1070928	hsa-miR-4659b-3p	CLIP-seq
MIRT1070929	hsa-miR-4663	CLIP-seq
MIRT1070930	hsa-miR-4664-5p	CLIP-seq
MIRT1070931	hsa-miR-4667-5p	CLIP-seq
MIRT1070932	hsa-miR-4677-3p	CLIP-seq
MIRT1070933	hsa-miR-4682	CLIP-seq
MIRT1070934	hsa-miR-4700-5p	CLIP-seq
MIRT1070935	hsa-miR-4725-3p	CLIP-seq
MIRT1070936	hsa-miR-4731-5p	CLIP-seq
MIRT1070937	hsa-miR-4732-5p	CLIP-seq
MIRT1070938	hsa-miR-4760-3p	CLIP-seq
MIRT1070939	hsa-miR-4764-5p	CLIP-seq
MIRT1070940	hsa-miR-4766-5p	CLIP-seq
MIRT1070941	hsa-miR-4778-3p	CLIP-seq
MIRT1070942	hsa-miR-485-5p	CLIP-seq
MIRT1070943	hsa-miR-498	CLIP-seq
MIRT1070944	hsa-miR-512-3p	CLIP-seq
MIRT1070945	hsa-miR-513b	CLIP-seq
MIRT1070946	hsa-miR-520f	CLIP-seq
MIRT1070947	hsa-miR-539	CLIP-seq
MIRT1070948	hsa-miR-544b	CLIP-seq
MIRT1070949	hsa-miR-574-5p	CLIP-seq
MIRT1070950	hsa-miR-579	CLIP-seq
MIRT1070951	hsa-miR-583	CLIP-seq
MIRT1070952	hsa-miR-613	CLIP-seq
MIRT1070953	hsa-miR-622	CLIP-seq
MIRT1070954	hsa-miR-648	CLIP-seq
MIRT1070955	hsa-miR-664	CLIP-seq
MIRT1070956	hsa-miR-671-5p	CLIP-seq
MIRT1070957	hsa-miR-942	CLIP-seq
MIRT1070891	hsa-miR-3120-3p	CLIP-seq
MIRT1070922	hsa-miR-4520a-3p	CLIP-seq
MIRT1070923	hsa-miR-4520b-3p	CLIP-seq
MIRT1070891	hsa-miR-3120-3p	CLIP-seq
MIRT1070916	hsa-miR-4457	CLIP-seq
MIRT1070922	hsa-miR-4520a-3p	CLIP-seq
MIRT1070923	hsa-miR-4520b-3p	CLIP-seq
MIRT1070880	hsa-miR-1256	CLIP-seq
MIRT1070883	hsa-miR-1290	CLIP-seq
MIRT2249351	hsa-miR-129-3p	CLIP-seq
MIRT2249352	hsa-miR-214	CLIP-seq
MIRT1070891	hsa-miR-3120-3p	CLIP-seq
MIRT1070892	hsa-miR-3121-5p	CLIP-seq
MIRT1070895	hsa-miR-3154	CLIP-seq
MIRT2249353	hsa-miR-3155	CLIP-seq
MIRT2249354	hsa-miR-3155b	CLIP-seq
MIRT2249355	hsa-miR-3192	CLIP-seq
MIRT2249356	hsa-miR-338-3p	CLIP-seq
MIRT2249357	hsa-miR-3619-5p	CLIP-seq
MIRT1070900	hsa-miR-3647-3p	CLIP-seq
MIRT1070907	hsa-miR-4274	CLIP-seq
MIRT2249358	hsa-miR-4292	CLIP-seq
MIRT1070914	hsa-miR-4422	CLIP-seq
MIRT1070922	hsa-miR-4520a-3p	CLIP-seq
MIRT1070923	hsa-miR-4520b-3p	CLIP-seq
MIRT2249359	hsa-miR-4530	CLIP-seq
MIRT2249360	hsa-miR-4683	CLIP-seq
MIRT2249361	hsa-miR-4687-5p	CLIP-seq
MIRT2249362	hsa-miR-4690-5p	CLIP-seq
MIRT1070940	hsa-miR-4766-5p	CLIP-seq
MIRT2249363	hsa-miR-484	CLIP-seq
MIRT1070943	hsa-miR-498	CLIP-seq
MIRT1070946	hsa-miR-520f	CLIP-seq
MIRT1070953	hsa-miR-622	CLIP-seq
MIRT2249364	hsa-miR-761	CLIP-seq
MIRT1070883	hsa-miR-1290	CLIP-seq
MIRT2430078	hsa-miR-1827	CLIP-seq
MIRT2430079	hsa-miR-23a	CLIP-seq
MIRT2430080	hsa-miR-23b	CLIP-seq
MIRT2430081	hsa-miR-23c	CLIP-seq
MIRT2430082	hsa-miR-3176	CLIP-seq
MIRT2430083	hsa-miR-3200-3p	CLIP-seq
MIRT2430084	hsa-miR-3922-3p	CLIP-seq
MIRT2430085	hsa-miR-4267	CLIP-seq
MIRT2430086	hsa-miR-4303	CLIP-seq
MIRT2430087	hsa-miR-4649-3p	CLIP-seq
MIRT1070881	hsa-miR-1265	CLIP-seq
MIRT1070885	hsa-miR-2054	CLIP-seq
MIRT1070889	hsa-miR-3064-3p	CLIP-seq
MIRT2552935	hsa-miR-340	CLIP-seq
MIRT1070903	hsa-miR-380	CLIP-seq
MIRT2552936	hsa-miR-4282	CLIP-seq
MIRT1070916	hsa-miR-4457	CLIP-seq
MIRT2552937	hsa-miR-4718	CLIP-seq
MIRT2552938	hsa-miR-513a-3p	CLIP-seq
MIRT2552939	hsa-miR-577	CLIP-seq
MIRT2682911	hsa-miR-4323	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CIITA	Unknown	15950283
IRF1	Activation	9054665
PITX1	Repression	12242290

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	TAS	7507207
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	9540062
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	9540062
GO:0002376	Process	Immune system process	IBA
GO:0003677	Function	DNA binding	IDA	9540062
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IMP	9540062
GO:0005515	Function	Protein binding	IPI	9540062, 21903422, 25609649, 28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IMP	9540062
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008283	Process	Cell population proliferation	TAS	8438157
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	9540062
GO:0051607	Process	Defense response to virus	IDA	21478870
GO:0051607	Process	Defense response to virus	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 147576
• HGNC: 6117
• e!Ensembl: ENSG00000168310

Protein

• UniProt ID: P14316
• Protein name: Interferon regulatory factor 2 (IRF-2)
• Protein function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constit
• PDB: 8YTG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00605	IRF	7 → 112	Interferon regulatory factor transcription factor	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed throughout the epithelium of the colon. Also expressed in lamina propria. {ECO:0000269|PubMed:15226432}.
• Sequence:

  MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAI
  HTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSK
  KGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQ
  SHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVP
  SDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVP
  YNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC

• Sequence length: 349

Pathways

Reactome:

Interferon gamma signaling
Interferon alpha/beta signaling
Factors involved in megakaryocyte development and platelet production