IREB2 (iron responsive element binding protein 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 3658 |
| Gene name | Iron responsive element binding protein 2 |
| Gene symbol | IREB2 |
| Synonyms (NCBI Gene) |
ACO3IRE-BP 2IRE-BP2IRP2IRP2ADNDCAMA
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| Chromosome | 15 |
| Chromosome location | 15q25.1 |
| Summary | The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, t |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
947
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P48200 | ||||||||||||||||||||
| Protein name | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | ||||||||||||||||||||
| Protein function | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE e | ||||||||||||||||||||
| PDB | 6VCD | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 963 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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