Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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3658
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Iron responsive element binding protein 2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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IREB2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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ACO3, IRE-BP 2, IRE-BP2, IRP2, IRP2AD, NDCAMA |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
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NDCAMA |
Chromosome
Chromosome number
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15 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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15q25.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, t |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Anemia |
Iron-Refractory Iron Deficiency Anemia |
rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505 View all (89 more) |
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Developmental delay |
Global developmental delay |
rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074 View all (32 more) |
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Lung adenocarcinoma |
Adenocarcinoma of lung (disorder) |
rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382 View all (5 more) |
19836008 |
Lung cancer |
Malignant neoplasm of lung |
rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 |
18978790, 19654303, 22899653 |
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Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Chronic obstructive pulmonary disease |
Chronic Obstructive Airway Disease |
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21921092, 25241909, 25101718, 22080838, 29767774, 26634245, 20173748 |
ClinVar |
Ptosis |
Blepharoptosis, Ptosis |
|
|
ClinVar |
Insomnia |
Insomnia |
|
|
GWAS |
Schizophrenia |
Schizophrenia |
|
|
GWAS |
Colorectal Cancer |
Colorectal Cancer |
In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. |
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GWAS, CBGDA |
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Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma of Lung |
Associate
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28181565 |
alpha 1 Antitrypsin Deficiency |
Associate
|
22356581 |
Alzheimer Disease |
Associate
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16914832, 17408857 |
Anemia |
Associate
|
17485548, 30915432 |
Carcinogenesis |
Associate
|
28281325 |
Carcinoma Non Small Cell Lung |
Associate
|
28404645 |
Cholangiocarcinoma |
Associate
|
36111744 |
Chorea |
Associate
|
30915432 |
Colorectal Neoplasms |
Associate
|
24078156 |
Colorectal Neoplasms |
Stimulate
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28281325 |
Dementia |
Associate
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17408857 |
Emphysema |
Associate
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22356581, 33295723 |
Escherichia coli Infections |
Associate
|
17093030 |
Friedreich Ataxia |
Associate
|
18424449 |
Glycogen Storage Disease Type II |
Associate
|
22331484 |
Heredodegenerative Disorders Nervous System |
Associate
|
30915432, 39587636 |
Hypothyroidism Congenital Nongoitrous 2 |
Associate
|
22633261 |
Hypoxia Brain |
Associate
|
33295723 |
Iron Deficiencies |
Associate
|
20364084 |
Iron Deficiencies |
Inhibit
|
30915432 |
Iron Overload |
Associate
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35644542 |
Lung Diseases |
Associate
|
26310313 |
Lung Injury |
Associate
|
25928290 |
Lung Neoplasms |
Associate
|
20587604, 25117307, 26310313, 28404645, 28453699, 31696517 |
Lung Neoplasms |
Inhibit
|
28453699 |
Macular Degeneration |
Associate
|
22331484 |
Mesothelioma Malignant |
Associate
|
31442913 |
Mitochondrial Diseases |
Associate
|
30915432 |
Neoplasms |
Associate
|
28181565, 28404645, 33351833 |
Neurodegenerative Diseases |
Associate
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30915432, 39587636 |
Parkinson Disease |
Associate
|
28638917 |
Protoporphyria Erythropoietic |
Associate
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30915432, 31076252 |
Pulmonary Disease Chronic Obstructive |
Associate
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19800047, 21320324, 21949713, 22356581, 22461431, 24587150, 25006744, 25565795, 25928290, 26310313, 28474623, 29422661, 29872291, 33295723 |
Stomach Neoplasms |
Associate
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26330360 |
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