IREB2 (iron responsive element binding protein 2)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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3658 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Iron responsive element binding protein 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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IREB2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ACO3, IRE-BP 2, IRE-BP2, IRP2, IRP2AD, NDCAMA |
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Chromosome
Chromosome number
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15 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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15q25.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, t |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | P48200 | ||||||||||||||||||||
| Protein name | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | ||||||||||||||||||||
| Protein function | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE e | ||||||||||||||||||||
| PDB | 6VCD | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 963 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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