Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3652
Gene name Gene Name - the full gene name approved by the HGNC.
Intracisternal A particle-promoted polypeptide
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IPP
Synonyms (NCBI Gene) Gene synonyms aliases
KLHL27
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provi
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030826 hsa-miR-21-5p Microarray 18591254
MIRT046572 hsa-miR-222-3p CLASH 23622248
MIRT691633 hsa-miR-106a-5p HITS-CLIP 23313552
MIRT691632 hsa-miR-106b-5p HITS-CLIP 23313552
MIRT691631 hsa-miR-17-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0003779 Function Actin binding TAS 10072760
GO:0005515 Function Protein binding IPI 32296183
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147485 6108 ENSG00000197429
Protein
UniProt ID Q9Y573
Protein name Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27)
Protein function May play a role in organizing the actin cytoskeleton.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 27 134 BTB/POZ domain Domain
PF07707 BACK 139 241 BTB And C-terminal Kelch Domain
PF01344 Kelch_1 287 330 Kelch motif Repeat
PF01344 Kelch_1 332 377 Kelch motif Repeat
PF01344 Kelch_1 379 424 Kelch motif Repeat
PF01344 Kelch_1 426 472 Kelch motif Repeat
PF01344 Kelch_1 474 520 Kelch motif Repeat
PF01344 Kelch_1 522 573 Kelch motif Repeat
Sequence
Sequence length 584
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 32751711