Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3633
Gene name Gene Name - the full gene name approved by the HGNC.
Inositol polyphosphate-5-phosphatase B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
INPP5B
Synonyms (NCBI Gene) Gene synonyms aliases
5PTase
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and assoc
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030250 hsa-miR-26b-5p Microarray 19088304
MIRT692726 hsa-miR-1537-3p HITS-CLIP 23313552
MIRT692725 hsa-miR-187-3p HITS-CLIP 23313552
MIRT692724 hsa-miR-1284 HITS-CLIP 23313552
MIRT692723 hsa-miR-4796-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0004439 Function Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA 21873635
GO:0004439 Function Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA 7721860
GO:0005515 Function Protein binding IPI 21233288, 25869668
GO:0005793 Component Endoplasmic reticulum-Golgi intermediate compartment IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147264 6077 ENSG00000204084
Protein
UniProt ID P32019
Protein name Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
Protein function Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
PDB 3MTC , 3N9V , 4CML , 5A7I , 5A7J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16776 INPP5B_PH 1 149 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain Domain
PF03372 Exo_endo_phos 350 629 Endonuclease/Exonuclease/phosphatase family Domain
PF00620 RhoGAP 830 972 RhoGAP domain Domain
Tissue specificity TISSUE SPECIFICITY: Platelets.
Sequence
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRM
AITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM
FLHEVARACPGFDSATRDPEFLWLSRYRC
AELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEE
AGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITD
MVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVK
LIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSH
LAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKV
KKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAP
AWCDRILWKGKNITQLSYQSHMALKTSDH
KPVSSVFDIGVRVVNDELYRKTLEEIVRSLD
KMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLN
ANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYL
PSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYL
YRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICY
STYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFG
SLLLRNPAGHQK
LDMTEKKKAQEFIHQFLCNPL
Sequence length 993
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Rho GTPase cycle
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Dent`s disease Dent Disease 2 rs137853262, rs137853263, rs151340620, rs151340621, rs151340622, rs151340623, rs151340625, rs151340626, rs151340630, rs1569540382, rs2124412922, rs2124388022, rs273585644, rs137853846, rs797044808
View all (16 more)
28018608
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)
30595370
Unknown
Disease term Disease name Evidence References Source
Myocardial Infarction Myocardial Infarction GWAS
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Alzheimer disease Alzheimer disease GWAS
Carcinoma Carcinoma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Neoplasms Associate 27057633