INPP5A (inositol polyphosphate-5-phosphatase A)

Gene

• Entrez ID: 3632
• Gene name: Inositol polyphosphate-5-phosphatase A
• Gene symbol: INPP5A
• Synonyms (NCBI Gene): 5PTASE
• Chromosome: 10
• Chromosome location: 10q26.3
• Summary: The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029103	hsa-miR-26b-5p	Microarray	19088304
MIRT042796	hsa-miR-339-5p	CLASH	23622248
MIRT054208	hsa-miR-210-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23028679
MIRT177101	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440454	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT177101	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440454	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT1067202	hsa-let-7a	CLIP-seq
MIRT1067203	hsa-let-7b	CLIP-seq
MIRT1067204	hsa-let-7c	CLIP-seq
MIRT1067205	hsa-let-7d	CLIP-seq
MIRT1067206	hsa-let-7e	CLIP-seq
MIRT1067207	hsa-let-7f	CLIP-seq
MIRT1067208	hsa-let-7g	CLIP-seq
MIRT1067209	hsa-let-7i	CLIP-seq
MIRT1067210	hsa-miR-1203	CLIP-seq
MIRT1067211	hsa-miR-1224-3p	CLIP-seq
MIRT1067212	hsa-miR-1231	CLIP-seq
MIRT1067213	hsa-miR-1236	CLIP-seq
MIRT1067214	hsa-miR-1260	CLIP-seq
MIRT1067215	hsa-miR-1260b	CLIP-seq
MIRT1067216	hsa-miR-1266	CLIP-seq
MIRT1067217	hsa-miR-1271	CLIP-seq
MIRT1067218	hsa-miR-1280	CLIP-seq
MIRT1067219	hsa-miR-1294	CLIP-seq
MIRT1067220	hsa-miR-148a	CLIP-seq
MIRT1067221	hsa-miR-148b	CLIP-seq
MIRT1067222	hsa-miR-150	CLIP-seq
MIRT1067223	hsa-miR-152	CLIP-seq
MIRT1067224	hsa-miR-154	CLIP-seq
MIRT1067225	hsa-miR-188-3p	CLIP-seq
MIRT1067226	hsa-miR-202	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT1067228	hsa-miR-3127-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT1067230	hsa-miR-3145-3p	CLIP-seq
MIRT1067231	hsa-miR-3151	CLIP-seq
MIRT1067232	hsa-miR-3156-3p	CLIP-seq
MIRT1067233	hsa-miR-3188	CLIP-seq
MIRT1067234	hsa-miR-323b-5p	CLIP-seq
MIRT1067235	hsa-miR-3607-5p	CLIP-seq
MIRT1067236	hsa-miR-3613-5p	CLIP-seq
MIRT1067237	hsa-miR-3648	CLIP-seq
MIRT1067238	hsa-miR-3665	CLIP-seq
MIRT1067239	hsa-miR-371-3p	CLIP-seq
MIRT1067240	hsa-miR-376c	CLIP-seq
MIRT1067241	hsa-miR-3908	CLIP-seq
MIRT1067242	hsa-miR-3915	CLIP-seq
MIRT1067243	hsa-miR-3918	CLIP-seq
MIRT1067244	hsa-miR-3928	CLIP-seq
MIRT1067245	hsa-miR-3929	CLIP-seq
MIRT1067246	hsa-miR-3940-5p	CLIP-seq
MIRT1067247	hsa-miR-3975	CLIP-seq
MIRT1067248	hsa-miR-425	CLIP-seq
MIRT1067249	hsa-miR-4283	CLIP-seq
MIRT1067250	hsa-miR-4288	CLIP-seq
MIRT1067251	hsa-miR-4316	CLIP-seq
MIRT1067252	hsa-miR-4328	CLIP-seq
MIRT1067253	hsa-miR-4419b	CLIP-seq
MIRT1067254	hsa-miR-4447	CLIP-seq
MIRT1067255	hsa-miR-4458	CLIP-seq
MIRT1067256	hsa-miR-4462	CLIP-seq
MIRT1067257	hsa-miR-4472	CLIP-seq
MIRT1067258	hsa-miR-4478	CLIP-seq
MIRT1067259	hsa-miR-4489	CLIP-seq
MIRT1067260	hsa-miR-4492	CLIP-seq
MIRT1067261	hsa-miR-4498	CLIP-seq
MIRT1067262	hsa-miR-4500	CLIP-seq
MIRT1067263	hsa-miR-4501	CLIP-seq
MIRT1067264	hsa-miR-4504	CLIP-seq
MIRT1067265	hsa-miR-4507	CLIP-seq
MIRT1067266	hsa-miR-4518	CLIP-seq
MIRT1067267	hsa-miR-4533	CLIP-seq
MIRT1067268	hsa-miR-4640-3p	CLIP-seq
MIRT1067269	hsa-miR-4642	CLIP-seq
MIRT1067270	hsa-miR-4659a-5p	CLIP-seq
MIRT1067271	hsa-miR-4659b-5p	CLIP-seq
MIRT1067272	hsa-miR-4690-5p	CLIP-seq
MIRT1067273	hsa-miR-4697-3p	CLIP-seq
MIRT1067274	hsa-miR-4713-5p	CLIP-seq
MIRT1067275	hsa-miR-4720-5p	CLIP-seq
MIRT1067276	hsa-miR-4776-3p	CLIP-seq
MIRT1067277	hsa-miR-4790-3p	CLIP-seq
MIRT1067278	hsa-miR-4795-3p	CLIP-seq
MIRT1067279	hsa-miR-4799-3p	CLIP-seq
MIRT1067280	hsa-miR-485-5p	CLIP-seq
MIRT1067281	hsa-miR-491-5p	CLIP-seq
MIRT1067282	hsa-miR-516a-5p	CLIP-seq
MIRT1067283	hsa-miR-532-3p	CLIP-seq
MIRT1067284	hsa-miR-542-3p	CLIP-seq
MIRT1067285	hsa-miR-548aa	CLIP-seq
MIRT1067286	hsa-miR-582-5p	CLIP-seq
MIRT1067287	hsa-miR-595	CLIP-seq
MIRT1067288	hsa-miR-632	CLIP-seq
MIRT1067289	hsa-miR-635	CLIP-seq
MIRT1067290	hsa-miR-645	CLIP-seq
MIRT1067291	hsa-miR-656	CLIP-seq
MIRT1067292	hsa-miR-762	CLIP-seq
MIRT1067293	hsa-miR-767-5p	CLIP-seq
MIRT1067294	hsa-miR-890	CLIP-seq
MIRT1067295	hsa-miR-96	CLIP-seq
MIRT1067296	hsa-miR-98	CLIP-seq
MIRT1067202	hsa-let-7a	CLIP-seq
MIRT1067203	hsa-let-7b	CLIP-seq
MIRT1067204	hsa-let-7c	CLIP-seq
MIRT1067205	hsa-let-7d	CLIP-seq
MIRT1067206	hsa-let-7e	CLIP-seq
MIRT1067207	hsa-let-7f	CLIP-seq
MIRT1067208	hsa-let-7g	CLIP-seq
MIRT1067209	hsa-let-7i	CLIP-seq
MIRT1067219	hsa-miR-1294	CLIP-seq
MIRT1067220	hsa-miR-148a	CLIP-seq
MIRT1067221	hsa-miR-148b	CLIP-seq
MIRT1067223	hsa-miR-152	CLIP-seq
MIRT1067226	hsa-miR-202	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT2016287	hsa-miR-3614-5p	CLIP-seq
MIRT1067237	hsa-miR-3648	CLIP-seq
MIRT2016288	hsa-miR-3664-5p	CLIP-seq
MIRT1067239	hsa-miR-371-3p	CLIP-seq
MIRT1067240	hsa-miR-376c	CLIP-seq
MIRT2016289	hsa-miR-3978	CLIP-seq
MIRT1067255	hsa-miR-4458	CLIP-seq
MIRT1067256	hsa-miR-4462	CLIP-seq
MIRT1067262	hsa-miR-4500	CLIP-seq
MIRT2016290	hsa-miR-450b-5p	CLIP-seq
MIRT1067267	hsa-miR-4533	CLIP-seq
MIRT2016291	hsa-miR-4536	CLIP-seq
MIRT1067273	hsa-miR-4697-3p	CLIP-seq
MIRT2016292	hsa-miR-4704-3p	CLIP-seq
MIRT2016293	hsa-miR-495	CLIP-seq
MIRT2016294	hsa-miR-548l	CLIP-seq
MIRT2016295	hsa-miR-553	CLIP-seq
MIRT1067293	hsa-miR-767-5p	CLIP-seq
MIRT2016296	hsa-miR-802	CLIP-seq
MIRT1067296	hsa-miR-98	CLIP-seq
MIRT1067202	hsa-let-7a	CLIP-seq
MIRT1067203	hsa-let-7b	CLIP-seq
MIRT1067204	hsa-let-7c	CLIP-seq
MIRT1067205	hsa-let-7d	CLIP-seq
MIRT1067206	hsa-let-7e	CLIP-seq
MIRT1067207	hsa-let-7f	CLIP-seq
MIRT1067208	hsa-let-7g	CLIP-seq
MIRT1067209	hsa-let-7i	CLIP-seq
MIRT1067217	hsa-miR-1271	CLIP-seq
MIRT1067219	hsa-miR-1294	CLIP-seq
MIRT2248586	hsa-miR-140-3p	CLIP-seq
MIRT1067222	hsa-miR-150	CLIP-seq
MIRT2248587	hsa-miR-181a	CLIP-seq
MIRT2248588	hsa-miR-181b	CLIP-seq
MIRT2248589	hsa-miR-181c	CLIP-seq
MIRT2248590	hsa-miR-181d	CLIP-seq
MIRT1067225	hsa-miR-188-3p	CLIP-seq
MIRT1067226	hsa-miR-202	CLIP-seq
MIRT2248591	hsa-miR-2052	CLIP-seq
MIRT2248592	hsa-miR-2116	CLIP-seq
MIRT2248593	hsa-miR-2277-3p	CLIP-seq
MIRT2248594	hsa-miR-23a	CLIP-seq
MIRT2248595	hsa-miR-23b	CLIP-seq
MIRT2248596	hsa-miR-23c	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT1067230	hsa-miR-3145-3p	CLIP-seq
MIRT1067231	hsa-miR-3151	CLIP-seq
MIRT1067233	hsa-miR-3188	CLIP-seq
MIRT1067236	hsa-miR-3613-5p	CLIP-seq
MIRT2016287	hsa-miR-3614-5p	CLIP-seq
MIRT1067238	hsa-miR-3665	CLIP-seq
MIRT1067240	hsa-miR-376c	CLIP-seq
MIRT1067245	hsa-miR-3929	CLIP-seq
MIRT2248597	hsa-miR-3941	CLIP-seq
MIRT1067247	hsa-miR-3975	CLIP-seq
MIRT2248598	hsa-miR-4262	CLIP-seq
MIRT2248599	hsa-miR-4274	CLIP-seq
MIRT2248600	hsa-miR-4277	CLIP-seq
MIRT1067249	hsa-miR-4283	CLIP-seq
MIRT1067251	hsa-miR-4316	CLIP-seq
MIRT1067253	hsa-miR-4419b	CLIP-seq
MIRT1067254	hsa-miR-4447	CLIP-seq
MIRT1067255	hsa-miR-4458	CLIP-seq
MIRT1067256	hsa-miR-4462	CLIP-seq
MIRT1067257	hsa-miR-4472	CLIP-seq
MIRT1067258	hsa-miR-4478	CLIP-seq
MIRT1067259	hsa-miR-4489	CLIP-seq
MIRT1067260	hsa-miR-4492	CLIP-seq
MIRT1067261	hsa-miR-4498	CLIP-seq
MIRT1067262	hsa-miR-4500	CLIP-seq
MIRT1067263	hsa-miR-4501	CLIP-seq
MIRT2016290	hsa-miR-450b-5p	CLIP-seq
MIRT2016291	hsa-miR-4536	CLIP-seq
MIRT2248601	hsa-miR-466	CLIP-seq
MIRT2248602	hsa-miR-4672	CLIP-seq
MIRT1067272	hsa-miR-4690-5p	CLIP-seq
MIRT2016292	hsa-miR-4704-3p	CLIP-seq
MIRT1067274	hsa-miR-4713-5p	CLIP-seq
MIRT2248603	hsa-miR-4733-5p	CLIP-seq
MIRT1067277	hsa-miR-4790-3p	CLIP-seq
MIRT1067278	hsa-miR-4795-3p	CLIP-seq
MIRT1067280	hsa-miR-485-5p	CLIP-seq
MIRT1067281	hsa-miR-491-5p	CLIP-seq
MIRT2248604	hsa-miR-492	CLIP-seq
MIRT2016293	hsa-miR-495	CLIP-seq
MIRT2248605	hsa-miR-503	CLIP-seq
MIRT2248606	hsa-miR-514	CLIP-seq
MIRT2248607	hsa-miR-514b-3p	CLIP-seq
MIRT1067283	hsa-miR-532-3p	CLIP-seq
MIRT2248608	hsa-miR-549	CLIP-seq
MIRT1067287	hsa-miR-595	CLIP-seq
MIRT2248609	hsa-miR-624	CLIP-seq
MIRT1067289	hsa-miR-635	CLIP-seq
MIRT1067290	hsa-miR-645	CLIP-seq
MIRT2248610	hsa-miR-653	CLIP-seq
MIRT1067291	hsa-miR-656	CLIP-seq
MIRT1067292	hsa-miR-762	CLIP-seq
MIRT1067293	hsa-miR-767-5p	CLIP-seq
MIRT2016296	hsa-miR-802	CLIP-seq
MIRT2248611	hsa-miR-889	CLIP-seq
MIRT1067294	hsa-miR-890	CLIP-seq
MIRT1067295	hsa-miR-96	CLIP-seq
MIRT1067296	hsa-miR-98	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT1067241	hsa-miR-3908	CLIP-seq
MIRT1067242	hsa-miR-3915	CLIP-seq
MIRT1067244	hsa-miR-3928	CLIP-seq
MIRT1067252	hsa-miR-4328	CLIP-seq
MIRT1067286	hsa-miR-582-5p	CLIP-seq
MIRT1067202	hsa-let-7a	CLIP-seq
MIRT1067203	hsa-let-7b	CLIP-seq
MIRT1067204	hsa-let-7c	CLIP-seq
MIRT1067205	hsa-let-7d	CLIP-seq
MIRT1067206	hsa-let-7e	CLIP-seq
MIRT1067207	hsa-let-7f	CLIP-seq
MIRT1067208	hsa-let-7g	CLIP-seq
MIRT1067209	hsa-let-7i	CLIP-seq
MIRT1067219	hsa-miR-1294	CLIP-seq
MIRT1067226	hsa-miR-202	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT2430068	hsa-miR-299-5p	CLIP-seq
MIRT1067233	hsa-miR-3188	CLIP-seq
MIRT1067240	hsa-miR-376c	CLIP-seq
MIRT1067247	hsa-miR-3975	CLIP-seq
MIRT1067251	hsa-miR-4316	CLIP-seq
MIRT1067255	hsa-miR-4458	CLIP-seq
MIRT1067262	hsa-miR-4500	CLIP-seq
MIRT1067263	hsa-miR-4501	CLIP-seq
MIRT1067277	hsa-miR-4790-3p	CLIP-seq
MIRT1067280	hsa-miR-485-5p	CLIP-seq
MIRT2430069	hsa-miR-520d-5p	CLIP-seq
MIRT2430070	hsa-miR-524-5p	CLIP-seq
MIRT2016295	hsa-miR-553	CLIP-seq
MIRT1067296	hsa-miR-98	CLIP-seq
MIRT1067212	hsa-miR-1231	CLIP-seq
MIRT2552073	hsa-miR-1243	CLIP-seq
MIRT2552074	hsa-miR-138	CLIP-seq
MIRT2248587	hsa-miR-181a	CLIP-seq
MIRT2248588	hsa-miR-181b	CLIP-seq
MIRT2248589	hsa-miR-181c	CLIP-seq
MIRT2248590	hsa-miR-181d	CLIP-seq
MIRT2552075	hsa-miR-1914	CLIP-seq
MIRT2552076	hsa-miR-1976	CLIP-seq
MIRT2552077	hsa-miR-210	CLIP-seq
MIRT2248592	hsa-miR-2116	CLIP-seq
MIRT2248594	hsa-miR-23a	CLIP-seq
MIRT2248595	hsa-miR-23b	CLIP-seq
MIRT2248596	hsa-miR-23c	CLIP-seq
MIRT2430068	hsa-miR-299-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT2552078	hsa-miR-3145-5p	CLIP-seq
MIRT2552079	hsa-miR-3166	CLIP-seq
MIRT2552080	hsa-miR-3199	CLIP-seq
MIRT1067234	hsa-miR-323b-5p	CLIP-seq
MIRT2552081	hsa-miR-337-5p	CLIP-seq
MIRT2552082	hsa-miR-340	CLIP-seq
MIRT2552083	hsa-miR-3622b-5p	CLIP-seq
MIRT2552084	hsa-miR-3654	CLIP-seq
MIRT2552085	hsa-miR-3670	CLIP-seq
MIRT2552086	hsa-miR-370	CLIP-seq
MIRT1067241	hsa-miR-3908	CLIP-seq
MIRT1067242	hsa-miR-3915	CLIP-seq
MIRT1067244	hsa-miR-3928	CLIP-seq
MIRT1067246	hsa-miR-3940-5p	CLIP-seq
MIRT2248597	hsa-miR-3941	CLIP-seq
MIRT2016289	hsa-miR-3978	CLIP-seq
MIRT2248598	hsa-miR-4262	CLIP-seq
MIRT2248600	hsa-miR-4277	CLIP-seq
MIRT1067250	hsa-miR-4288	CLIP-seq
MIRT2552087	hsa-miR-4304	CLIP-seq
MIRT1067252	hsa-miR-4328	CLIP-seq
MIRT2552088	hsa-miR-4485	CLIP-seq
MIRT1067265	hsa-miR-4507	CLIP-seq
MIRT2552089	hsa-miR-4632	CLIP-seq
MIRT2552090	hsa-miR-4641	CLIP-seq
MIRT2248601	hsa-miR-466	CLIP-seq
MIRT2552091	hsa-miR-4663	CLIP-seq
MIRT2248602	hsa-miR-4672	CLIP-seq
MIRT2552092	hsa-miR-4690-3p	CLIP-seq
MIRT2552093	hsa-miR-4716-5p	CLIP-seq
MIRT2552094	hsa-miR-4753-3p	CLIP-seq
MIRT2552095	hsa-miR-4768-5p	CLIP-seq
MIRT2552096	hsa-miR-4771	CLIP-seq
MIRT2552097	hsa-miR-485-3p	CLIP-seq
MIRT2430069	hsa-miR-520d-5p	CLIP-seq
MIRT2430070	hsa-miR-524-5p	CLIP-seq
MIRT2016294	hsa-miR-548l	CLIP-seq
MIRT2552098	hsa-miR-548m	CLIP-seq
MIRT2552099	hsa-miR-548q	CLIP-seq
MIRT2016295	hsa-miR-553	CLIP-seq
MIRT1067286	hsa-miR-582-5p	CLIP-seq
MIRT1067288	hsa-miR-632	CLIP-seq
MIRT2552100	hsa-miR-671-5p	CLIP-seq
MIRT2552101	hsa-miR-875-3p	CLIP-seq
MIRT2248611	hsa-miR-889	CLIP-seq
MIRT2552102	hsa-miR-944	CLIP-seq
MIRT1067212	hsa-miR-1231	CLIP-seq
MIRT2552073	hsa-miR-1243	CLIP-seq
MIRT2248587	hsa-miR-181a	CLIP-seq
MIRT2248588	hsa-miR-181b	CLIP-seq
MIRT2248589	hsa-miR-181c	CLIP-seq
MIRT2248590	hsa-miR-181d	CLIP-seq
MIRT2552075	hsa-miR-1914	CLIP-seq
MIRT2552076	hsa-miR-1976	CLIP-seq
MIRT2552077	hsa-miR-210	CLIP-seq
MIRT2248592	hsa-miR-2116	CLIP-seq
MIRT2248594	hsa-miR-23a	CLIP-seq
MIRT2248595	hsa-miR-23b	CLIP-seq
MIRT2248596	hsa-miR-23c	CLIP-seq
MIRT2430068	hsa-miR-299-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT2552078	hsa-miR-3145-5p	CLIP-seq
MIRT2552080	hsa-miR-3199	CLIP-seq
MIRT1067234	hsa-miR-323b-5p	CLIP-seq
MIRT2552083	hsa-miR-3622b-5p	CLIP-seq
MIRT2552084	hsa-miR-3654	CLIP-seq
MIRT2552085	hsa-miR-3670	CLIP-seq
MIRT2552086	hsa-miR-370	CLIP-seq
MIRT1067241	hsa-miR-3908	CLIP-seq
MIRT1067242	hsa-miR-3915	CLIP-seq
MIRT1067244	hsa-miR-3928	CLIP-seq
MIRT1067246	hsa-miR-3940-5p	CLIP-seq
MIRT2248597	hsa-miR-3941	CLIP-seq
MIRT2016289	hsa-miR-3978	CLIP-seq
MIRT2248598	hsa-miR-4262	CLIP-seq
MIRT2248600	hsa-miR-4277	CLIP-seq
MIRT1067250	hsa-miR-4288	CLIP-seq
MIRT2552087	hsa-miR-4304	CLIP-seq
MIRT1067252	hsa-miR-4328	CLIP-seq
MIRT1067265	hsa-miR-4507	CLIP-seq
MIRT2552089	hsa-miR-4632	CLIP-seq
MIRT2248601	hsa-miR-466	CLIP-seq
MIRT2552091	hsa-miR-4663	CLIP-seq
MIRT2248602	hsa-miR-4672	CLIP-seq
MIRT2552094	hsa-miR-4753-3p	CLIP-seq
MIRT2552095	hsa-miR-4768-5p	CLIP-seq
MIRT2552097	hsa-miR-485-3p	CLIP-seq
MIRT2430069	hsa-miR-520d-5p	CLIP-seq
MIRT2430070	hsa-miR-524-5p	CLIP-seq
MIRT2016294	hsa-miR-548l	CLIP-seq
MIRT2552098	hsa-miR-548m	CLIP-seq
MIRT2016295	hsa-miR-553	CLIP-seq
MIRT1067286	hsa-miR-582-5p	CLIP-seq
MIRT1067288	hsa-miR-632	CLIP-seq
MIRT2552101	hsa-miR-875-3p	CLIP-seq
MIRT2248611	hsa-miR-889	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004445	Function	Inositol-polyphosphate 5-phosphatase activity	IBA
GO:0004445	Function	Inositol-polyphosphate 5-phosphatase activity	IDA	8006039, 8013665, 8626616
GO:0004445	Function	Inositol-polyphosphate 5-phosphatase activity	IEA
GO:0004445	Function	Inositol-polyphosphate 5-phosphatase activity	NAS	8006039
GO:0005515	Function	Protein binding	IPI	8999861, 32296183, 33961781
GO:0005886	Component	Plasma membrane	IDA	8626616
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006796	Process	Phosphate-containing compound metabolic process	IEA
GO:0016020	Component	Membrane	IDA	8006039
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	8006039
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0019637	Process	Organophosphate metabolic process	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0042731	Function	PH domain binding	IPI	8999861
GO:0042995	Component	Cell projection	IEA
GO:0043647	Process	Inositol phosphate metabolic process	IDA	8999861
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IEA
GO:0050849	Process	Negative regulation of calcium-mediated signaling	IDA	8999861
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	IDA	8999861
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	IEA
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	TAS
GO:0052659	Function	Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IDA	8999861
GO:0052659	Function	Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA
GO:1900737	Process	Negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:1900737	Process	Negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	ISS

Other IDs

• MIM: 600106
• HGNC: 6076
• e!Ensembl: ENSG00000068383

Protein

• UniProt ID: Q14642
• Protein name: Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (43 kDa inositol polyphosphate 5-phosphatase) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase)
• Protein function: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8626616, PubMed:8769125). Plays a
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03372	Exo_endo_phos	15 → 385	Endonuclease/Exonuclease/phosphatase family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in heart, brain, and skeletal muscle (PubMed:8006039). In brain; high level in Purkinje cells (PubMed:8013665). {ECO:0000269|PubMed:8006039, ECO:0000269|PubMed:8013665}.
• Sequence:

  MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN
  YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF
  DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL
  VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK
  SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT
  ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL
  VLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ

• Sequence length: 412

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Insulin signaling pathway

Reactome:

Synthesis of IP2, IP, and Ins in the cytosol