CXCL10 (C-X-C motif chemokine ligand 10)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3627
Gene name Gene Name - the full gene name approved by the HGNC.
C-X-C motif chemokine ligand 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CXCL10
Synonyms (NCBI Gene) Gene synonyms aliases
C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(121)
miRTarBase ID miRNA Experiments Reference
MIRT438112 hsa-miR-21-5p qRT-PCR 24889251
MIRT438109 hsa-miR-21-5p qRT-PCR 24889251
MIRT438110 hsa-miR-21-5p qRT-PCR 24889251
MIRT438108 hsa-miR-21-5p qRT-PCR 24889251
MIRT438112 hsa-miR-21-5p qRT-PCR 24889251
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
Transcription factor Regulation Reference
IRF1 Activation 19342664
IRF3 Activation 18691624;24257594
IRF7 Activation 24701034
NFKB1 Activation 16982926;20164184;24701034
NFKB1 Unknown 16818736;19479051;24257594
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(52)
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding TAS 10201891
GO:0005515 Function Protein binding IPI 18275857, 21314817, 28381538
GO:0005576 Component Extracellular region IDA 20041150
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147310 10637 ENSG00000169245
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P02778
Protein name C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
Protein function Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:11157474
PDB 1LV9 , 1O7Y , 1O7Z , 1O80 , 8K2X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 28 → 89 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757). {ECO:0000269|PubMed:
Sequence
Sequence length 98
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
IL-17 signaling pathway
TNF signaling pathway
Hepatitis C
Influenza A
Epstein-Barr virus infection
Coronavirus disease - COVID-19 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 15059925
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 18249437
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac Disease 30097691 ClinVar
Mental depression Unipolar Depression, Major Depressive Disorder 18504423 ClinVar
Show/Hide Text Mining Associations (521)
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Stimulate 26475133
Acrodermatitis Associate 17606602
Acute Disease Associate 19551822, 22674409, 23012327
Acute Febrile Encephalopathy Stimulate 15608388
Acute Kidney Injury Stimulate 32165324, 33348065
Acute On Chronic Liver Failure Stimulate 33717119
Addison Disease Associate 25978633
Adenocarcinoma Associate 31960110
Adenocarcinoma of Lung Associate 31221150, 36991099
Aicardi Goutieres syndrome Associate 23408864, 35320431