Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3625
Gene name Gene Name - the full gene name approved by the HGNC.
Inhibin subunit beta B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
INHBB
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q14.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activa
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018821 hsa-miR-335-5p Microarray 18185580
MIRT054468 hsa-miR-34a-5p Luciferase reporter assay, qRT-PCR, Western blot 24446339
MIRT1066474 hsa-miR-105 CLIP-seq
MIRT1066475 hsa-miR-1207-3p CLIP-seq
MIRT1066476 hsa-miR-1207-5p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001541 Process Ovarian follicle development NAS 12790766
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity TAS 3122219
GO:0005179 Function Hormone activity IEA
GO:0005179 Function Hormone activity TAS 3122219
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147390 6067 ENSG00000163083
Protein
UniProt ID P09529
Protein name Inhibin beta B chain (Activin beta-B chain)
Protein function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonad
PDB 7U5O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00688 TGFb_propeptide 61 278 TGF-beta propeptide Family
PF00019 TGF_beta 302 406 Transforming growth factor beta like domain Domain
Sequence
Sequence length 407
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells
  Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Postmenopausal breast cancer N/A N/A GWAS
Breast cancer Breast cancer (estrogen-receptor negative), Breast cancer N/A N/A GWAS
Dementia Dementia N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Mucinous Associate 25528498
Breast Neoplasms Associate 22747683, 23593120, 29665850
Carcinoma Ovarian Epithelial Associate 39248018
Carcinoma Renal Cell Associate 28004769
Colonic Neoplasms Associate 38143338
Colorectal Neoplasms Associate 18403637, 28424419, 33083477, 40135319
Ectrodactyly Associate 19223936
Hydatidiform Mole Associate 17649811
Lymphatic Metastasis Associate 30151927
Nasopharyngeal Carcinoma Inhibit 30151927