Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3624
Gene name Gene Name - the full gene name approved by the HGNC.
Inhibin subunit beta A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
INHBA
Synonyms (NCBI Gene) Gene synonyms aliases
EDF, FRP
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p14.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activa
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019457 hsa-miR-148b-3p Microarray 17612493
MIRT047412 hsa-miR-10b-5p CLASH 23622248
MIRT038928 hsa-miR-31-3p CLASH 23622248
MIRT484725 hsa-miR-548ac HITS-CLIP 21572407
MIRT484724 hsa-miR-548bb-3p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001541 Process Ovarian follicle development IGI 10932194
GO:0001541 Process Ovarian follicle development NAS 9166111
GO:0001707 Process Mesoderm formation IEA
GO:0001942 Process Hair follicle development IGI 10932194
GO:0002244 Process Hematopoietic progenitor cell differentiation IDA 15451575
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147290 6066 ENSG00000122641
Protein
UniProt ID P08476
Protein name Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)
Protein function Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve
PDB 1NYS , 1NYU , 1S4Y , 2ARP , 2ARV , 2B0U , 2P6A , 3B4V , 4MID , 5HLY , 5HLZ , 6Y6N , 6Y6O , 7OLY , 7U5P , 9I5W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00688 TGFb_propeptide 46 295 TGF-beta propeptide Family
PF00019 TGF_beta 320 425 Transforming growth factor beta like domain Domain
Sequence
Sequence length 426
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells
  Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Ischemic Stroke Ischemic stroke N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 19308293
Adenocarcinoma of Lung Associate 19308293
Adrenocortical Carcinoma Associate 36039643
Bone Diseases Associate 17900349
Brain Neoplasms Associate 7670558
Breast Neoplasms Associate 33378021, 33819300, 34889158, 35248133, 35999846
Breast Neoplasms Stimulate 35689549
Cachexia Associate 32970737
Carcinogenesis Associate 18827816, 31586103, 35216189
Carcinoma Non Small Cell Lung Associate 25432175