IDO1 (indoleamine 2,3-dioxygenase 1)

Gene

• Entrez ID: 3620
• Gene name: Indoleamine 2,3-dioxygenase 1
• Gene symbol: IDO1
• Synonyms (NCBI Gene): IDO, IDO-1, INDO
• Chromosome: 8
• Chromosome location: 8p11.21
• Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1059501	hsa-miR-106a	CLIP-seq
MIRT1059502	hsa-miR-106b	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1059504	hsa-miR-150	CLIP-seq
MIRT1059505	hsa-miR-17	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1059507	hsa-miR-20a	CLIP-seq
MIRT1059508	hsa-miR-20b	CLIP-seq
MIRT1059509	hsa-miR-302a	CLIP-seq
MIRT1059510	hsa-miR-302b	CLIP-seq
MIRT1059511	hsa-miR-302c	CLIP-seq
MIRT1059512	hsa-miR-302d	CLIP-seq
MIRT1059513	hsa-miR-302e	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1059515	hsa-miR-372	CLIP-seq
MIRT1059516	hsa-miR-373	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT1059518	hsa-miR-4438	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT1059521	hsa-miR-4731-5p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1059525	hsa-miR-5095	CLIP-seq
MIRT1059526	hsa-miR-512-3p	CLIP-seq
MIRT1059527	hsa-miR-519d	CLIP-seq
MIRT1059528	hsa-miR-520a-3p	CLIP-seq
MIRT1059529	hsa-miR-520b	CLIP-seq
MIRT1059530	hsa-miR-520c-3p	CLIP-seq
MIRT1059531	hsa-miR-520d-3p	CLIP-seq
MIRT1059532	hsa-miR-520e	CLIP-seq
MIRT1059533	hsa-miR-520g	CLIP-seq
MIRT1059534	hsa-miR-520h	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq
MIRT1059538	hsa-miR-93	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922117	hsa-miR-3152-3p	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1922119	hsa-miR-4426	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1922120	hsa-miR-4647	CLIP-seq
MIRT1922121	hsa-miR-4662a-5p	CLIP-seq
MIRT1922122	hsa-miR-4662b	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922117	hsa-miR-3152-3p	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1922119	hsa-miR-4426	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1922120	hsa-miR-4647	CLIP-seq
MIRT1922121	hsa-miR-4662a-5p	CLIP-seq
MIRT1922122	hsa-miR-4662b	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1059501	hsa-miR-106a	CLIP-seq
MIRT1059502	hsa-miR-106b	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1059504	hsa-miR-150	CLIP-seq
MIRT1059505	hsa-miR-17	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1059507	hsa-miR-20a	CLIP-seq
MIRT1059508	hsa-miR-20b	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT2013857	hsa-miR-24	CLIP-seq
MIRT1059509	hsa-miR-302a	CLIP-seq
MIRT1059510	hsa-miR-302b	CLIP-seq
MIRT1059511	hsa-miR-302c	CLIP-seq
MIRT1059512	hsa-miR-302d	CLIP-seq
MIRT1059513	hsa-miR-302e	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1059515	hsa-miR-372	CLIP-seq
MIRT1059516	hsa-miR-373	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT2013859	hsa-miR-4284	CLIP-seq
MIRT1922119	hsa-miR-4426	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1922120	hsa-miR-4647	CLIP-seq
MIRT1922122	hsa-miR-4662b	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1059526	hsa-miR-512-3p	CLIP-seq
MIRT1059527	hsa-miR-519d	CLIP-seq
MIRT1059528	hsa-miR-520a-3p	CLIP-seq
MIRT1059529	hsa-miR-520b	CLIP-seq
MIRT1059530	hsa-miR-520c-3p	CLIP-seq
MIRT1059531	hsa-miR-520d-3p	CLIP-seq
MIRT1059532	hsa-miR-520e	CLIP-seq
MIRT1059533	hsa-miR-520g	CLIP-seq
MIRT1059534	hsa-miR-520h	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq
MIRT1059538	hsa-miR-93	CLIP-seq
MIRT1059501	hsa-miR-106a	CLIP-seq
MIRT1059502	hsa-miR-106b	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1059504	hsa-miR-150	CLIP-seq
MIRT1059505	hsa-miR-17	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1059507	hsa-miR-20a	CLIP-seq
MIRT1059508	hsa-miR-20b	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT2013857	hsa-miR-24	CLIP-seq
MIRT1059509	hsa-miR-302a	CLIP-seq
MIRT1059510	hsa-miR-302b	CLIP-seq
MIRT1059511	hsa-miR-302c	CLIP-seq
MIRT1059512	hsa-miR-302d	CLIP-seq
MIRT1059513	hsa-miR-302e	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1059515	hsa-miR-372	CLIP-seq
MIRT1059516	hsa-miR-373	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT2013859	hsa-miR-4284	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1059527	hsa-miR-519d	CLIP-seq
MIRT1059528	hsa-miR-520a-3p	CLIP-seq
MIRT1059529	hsa-miR-520b	CLIP-seq
MIRT1059530	hsa-miR-520c-3p	CLIP-seq
MIRT1059531	hsa-miR-520d-3p	CLIP-seq
MIRT1059532	hsa-miR-520e	CLIP-seq
MIRT1059533	hsa-miR-520g	CLIP-seq
MIRT1059534	hsa-miR-520h	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq
MIRT1059538	hsa-miR-93	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT2451588	hsa-miR-1289	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT2451589	hsa-miR-139-3p	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059501	hsa-miR-106a	CLIP-seq
MIRT1059502	hsa-miR-106b	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1059504	hsa-miR-150	CLIP-seq
MIRT1059505	hsa-miR-17	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1059507	hsa-miR-20a	CLIP-seq
MIRT1059508	hsa-miR-20b	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT2013857	hsa-miR-24	CLIP-seq
MIRT1059509	hsa-miR-302a	CLIP-seq
MIRT1059510	hsa-miR-302b	CLIP-seq
MIRT1059511	hsa-miR-302c	CLIP-seq
MIRT1059512	hsa-miR-302d	CLIP-seq
MIRT1059513	hsa-miR-302e	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922117	hsa-miR-3152-3p	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1059515	hsa-miR-372	CLIP-seq
MIRT1059516	hsa-miR-373	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT2013859	hsa-miR-4284	CLIP-seq
MIRT1922121	hsa-miR-4662a-5p	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059521	hsa-miR-4731-5p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1059526	hsa-miR-512-3p	CLIP-seq
MIRT1059527	hsa-miR-519d	CLIP-seq
MIRT1059528	hsa-miR-520a-3p	CLIP-seq
MIRT1059529	hsa-miR-520b	CLIP-seq
MIRT1059530	hsa-miR-520c-3p	CLIP-seq
MIRT1059531	hsa-miR-520d-3p	CLIP-seq
MIRT1059532	hsa-miR-520e	CLIP-seq
MIRT1059533	hsa-miR-520g	CLIP-seq
MIRT1059534	hsa-miR-520h	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq
MIRT1059538	hsa-miR-93	CLIP-seq
MIRT1059503	hsa-miR-1234	CLIP-seq
MIRT1549732	hsa-miR-1281	CLIP-seq
MIRT1922115	hsa-miR-129-5p	CLIP-seq
MIRT1549733	hsa-miR-1915	CLIP-seq
MIRT1059506	hsa-miR-1976	CLIP-seq
MIRT1549734	hsa-miR-2276	CLIP-seq
MIRT2013857	hsa-miR-24	CLIP-seq
MIRT1922116	hsa-miR-3149	CLIP-seq
MIRT1922117	hsa-miR-3152-3p	CLIP-seq
MIRT1059514	hsa-miR-3199	CLIP-seq
MIRT1922118	hsa-miR-411	CLIP-seq
MIRT1059517	hsa-miR-4258	CLIP-seq
MIRT2013858	hsa-miR-4279	CLIP-seq
MIRT2013859	hsa-miR-4284	CLIP-seq
MIRT1059519	hsa-miR-4454	CLIP-seq
MIRT1922121	hsa-miR-4662a-5p	CLIP-seq
MIRT1059520	hsa-miR-4707-3p	CLIP-seq
MIRT2013860	hsa-miR-4722-3p	CLIP-seq
MIRT1549735	hsa-miR-4726-3p	CLIP-seq
MIRT1059522	hsa-miR-4735-5p	CLIP-seq
MIRT1059523	hsa-miR-4740-3p	CLIP-seq
MIRT1059524	hsa-miR-4775	CLIP-seq
MIRT1922123	hsa-miR-483-5p	CLIP-seq
MIRT1922124	hsa-miR-5096	CLIP-seq
MIRT1059535	hsa-miR-552	CLIP-seq
MIRT1059536	hsa-miR-590-3p	CLIP-seq
MIRT1059537	hsa-miR-764	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
EGR2	Unknown	24007274
PTMA	Activation	21176371;21575365

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0002666	Process	Positive regulation of T cell tolerance induction	IEA
GO:0002678	Process	Positive regulation of chronic inflammatory response	IEA
GO:0002830	Process	Positive regulation of type 2 immune response	IEA
GO:0004833	Function	Tryptophan 2,3-dioxygenase activity	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006569	Process	Tryptophan catabolic process	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0007565	Process	Female pregnancy	TAS	9712583
GO:0009055	Function	Electron transfer activity	TAS	2109605
GO:0019441	Process	Tryptophan catabolic process to kynurenine	IBA	21873635
GO:0019441	Process	Tryptophan catabolic process to kynurenine	IEA
GO:0020037	Function	Heme binding	IEA
GO:0022900	Process	Electron transport chain	IEA
GO:0030485	Component	Smooth muscle contractile fiber	IEA
GO:0032421	Component	Stereocilium bundle	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032693	Process	Negative regulation of interleukin-10 production	IEA
GO:0032735	Process	Positive regulation of interleukin-12 production	IEA
GO:0033555	Process	Multicellular organismal response to stress	IEA
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	IBA	21873635
GO:0033754	Function	Indoleamine 2,3-dioxygenase activity	IMP	25310899
GO:0034276	Process	Kynurenic acid biosynthetic process	IEA
GO:0034354	Process	'de novo' NAD biosynthetic process from tryptophan	IBA	21873635
GO:0036269	Process	Swimming behavior	IEA
GO:0042130	Process	Negative regulation of T cell proliferation	IEA
GO:0046006	Process	Regulation of activated T cell proliferation	IMP	25310899
GO:0046872	Function	Metal ion binding	IEA
GO:0070233	Process	Negative regulation of T cell apoptotic process	IEA
GO:0070234	Process	Positive regulation of T cell apoptotic process	IMP	25310899

Other IDs

• MIM: 147435
• HGNC: 6059
• e!Ensembl: ENSG00000131203

Protein

• UniProt ID: P14902
• Protein name: Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)
• Protein function: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing a
• PDB: 2D0T, 2D0U, 4PK5, 4PK6, 4U72, 4U74, 5EK2, 5EK3, 5EK4, 5ETW, 5WHR, 5WMU, 5WMV, 5WMW, 5WMX, 5WN8, 5XE1, 6AZU, 6AZV, 6AZW, 6CXU, 6CXV, 6DPQ, 6DPR, 6E35, 6E40, 6E41, 6E42, 6E43, 6E44, 6E45, 6E46, 6F0A, 6KOF, 6KPS, 6KW7, 6MQ6, 6O3I, 6PU7, 6PZ1, 6R63, 6UBP, 6V52, 6WJY, 6WPE, 6X5Y, 7A62, 7AH4, 7AH5, 7AH6, 7B1O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01231	IDO	11 → 398	Indoleamine 2,3-dioxygenase	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as
• Sequence:

  MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
  KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
  PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
  IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
  PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
  PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
  QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG

• Sequence length: 403

Pathways

KEGG:

Tryptophan metabolism
Metabolic pathways
Biosynthesis of cofactors
African trypanosomiasis

Reactome:

Tryptophan catabolism

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	18925433
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	18925433
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	18925433
Obesity	Obesity	rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs193922650, rs193922685, rs193922687, rs751160202, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829	27020609

Unknown
Disease term	Disease name	Evidence	References	Source
Endometriosis	Endometriosis		21063030	ClinVar
Mental depression	Mental Depression, Depressive disorder, Chronic depression		23866724, 22683764, 22751107, 21693183, 19234218	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
AA amyloidosis	Associate	31377728
Ablepharon macrostomia syndrome	Stimulate	26110930
Acquired Immunodeficiency Syndrome	Associate	24073214
Acute Coronary Syndrome	Associate	29278387
Acute Retroviral Syndrome	Inhibit	35883685
Adenocarcinoma	Associate	31163080, 33029538, 37527282
Adenocarcinoma Mucinous	Associate	32840168
Adenocarcinoma of Lung	Associate	30014971, 30367104, 31163080, 35187162, 35791738, 37061716, 37131252, 37985999, 38149244, 39989741
Anal Gland Neoplasms	Associate	25541686
Angina Stable	Inhibit	29278387
Anus Neoplasms	Associate	30755500
Arthritis	Associate	37958918
Arthritis Rheumatoid	Associate	21654189
Asthma	Associate	21654189, 27695127
Astrocytoma	Associate	14963171
Autoimmune Diseases	Associate	21654189, 23200754, 24533148, 26110930, 33837229, 36830609
Autoimmune Diseases	Inhibit	39692554
Brain Diseases	Inhibit	40621453
Brain Injuries Diffuse	Associate	36894313
Brain Neoplasms	Associate	19434461, 32017467, 32117271
Breast Neoplasms	Associate	19604349, 19933867, 23344392, 24687552, 25063873, 25081660, 28264810, 29037255, 29621426, 29719533, 29802358, 30808421, 31186442, 31665365, 31759380, 32227579, 33029538, 33109232, 33679700, 35157906, 37178414
Breast Neoplasms	Stimulate	23440412
Bronchiolitis	Associate	18256061
Bronchiolitis Obliterans Syndrome	Stimulate	33078555
Bronchiolitis Obliterans Syndrome	Associate	34755129
Calcinosis Cutis	Associate	32388585, 34697217
Carcinogenesis	Associate	31412167
Carcinoma	Associate	33155664
Carcinoma Hepatocellular	Associate	30264546, 30843276, 34769098, 37247278
Carcinoma Medullary	Associate	26965581
Carcinoma Merkel Cell	Associate	33547200
Carcinoma Non Small Cell Lung	Associate	15967116, 22107611, 25292102, 32555523, 32764075, 33671892, 36419183, 37139184, 37756581
Carcinoma Ovarian Epithelial	Associate	25376937, 26657115, 27118139, 36233312
Carcinoma Pancreatic Ductal	Stimulate	22190968
Carcinoma Pancreatic Ductal	Associate	32384638, 33390837, 36281157
Carcinoma Renal Cell	Associate	18418598, 29498788, 33410234, 33735492, 35739510
Carcinoma Squamous Cell	Associate	30755500, 32125093, 32227579, 35799269, 35986392
Carcinoma Squamous Cell	Stimulate	31412167
Cardiovascular Diseases	Associate	37880104
Cataract	Associate	21617756
Cataract Age Related Nuclear	Associate	21617756
Cerebral Infarction	Associate	31186442
Chlamydial Pneumonia	Associate	19643200
Cholangitis Sclerosing	Associate	21617756
Chordoma	Associate	35145510
Chronic Urticaria	Associate	21985375
Clear cell metastatic renal cell carcinoma	Associate	33410234
Colorectal Neoplasms	Associate	19695096, 22108515, 25583798, 27578919, 29853736, 30068874, 30891459, 31061070, 32265897, 33045001, 34249475, 34364366, 34797860, 34975867, 35213358, 36248886, 38369188
Colorectal Neoplasms	Stimulate	32468013
Coronary Artery Disease	Associate	34311709
COVID 19	Associate	33692788, 33725700, 34859884, 35301248
Crohn Disease	Associate	21823214, 25541686, 25899824, 26206376
Cytomegalovirus Infections	Associate	22539948
Death	Stimulate	27003769
Death	Associate	29505109, 32764075
Depressive Disorder	Associate	21693183, 25540092, 36911716
Dermatitis Atopic	Associate	26198597
Diabetes Mellitus	Associate	29746559, 31186442
Diabetes Mellitus	Stimulate	34566972
Diabetes Mellitus Type 1	Associate	25714914
Diabetes Mellitus Type 1	Inhibit	29945890, 32483133
Disease	Associate	17362267, 22013481, 31665365
DNA Repair Deficiency Disorders	Associate	27003769
Drug Hypersensitivity	Associate	25559824
Drug Related Side Effects and Adverse Reactions	Associate	32384638
Encephalitis	Associate	17626075
Endometrial Neoplasms	Associate	17117179, 24658839, 29559741, 33922995, 34158412, 36199963
Endometriosis	Associate	23411497, 25031694, 38062922
Endophthalmitis	Associate	31267172
Ependymoma	Associate	30483834
Epstein Barr Virus Infections	Stimulate	24696473, 31033497
Epstein Barr Virus Infections	Associate	31481499
Erythema Chronicum Migrans	Associate	29099929
Esophageal Neoplasms	Associate	28470572, 31012515
Esophageal Squamous Cell Carcinoma	Associate	22013481, 32004580, 36288460, 37839637
Eye Infections	Associate	22509103
Familial Mediterranean Fever	Associate	31377728
Fetal Growth Retardation	Inhibit	29615752
Fibrolamellar hepatocellular carcinoma	Associate	30902819
Gastritis	Associate	33127161
Giant Cell Tumor of Bone	Associate	34285260
Glioblastoma	Associate	20493562, 26279502, 28245795, 30415456, 30723577, 32035622, 32310827, 34440798
Glioma	Associate	25415278, 32035622, 37782060
Graft vs Host Disease	Associate	12588666, 21835147, 23089565, 24732701
Graft vs Host Disease	Inhibit	31393854
Granuloma	Associate	17111046, 38460493
Granulomatous Disease Chronic	Associate	17111046
Head and Neck Neoplasms	Associate	35140722
Heart Diseases	Associate	31186442
HIV Infections	Associate	17158233, 20484731, 24073214, 24924152, 27088321
HIV Infections	Stimulate	24585899
Hodgkin Disease	Associate	24886161, 34941990
Hypertension	Associate	22592557
Hypocalciuric hypercalcemia familial type 1	Associate	27861788
Hypoxia	Inhibit	23675474, 25376937
Hypoxia Brain	Inhibit	23675474
Hypoxia Brain	Associate	25376937
Ichthyosis prematurity syndrome	Associate	24886161
Immune System Diseases	Inhibit	22107611
Immune System Diseases	Associate	23232072, 23973990
Infections	Associate	17111046, 30832593, 31461509, 34819931
Infections	Stimulate	19643200, 25540092
Inflammation	Associate	10939283, 20484731, 22539948, 22592557, 24147117, 24533148, 27174915, 29054599, 29615752, 29796641, 29896191, 30264546, 32227579, 33692788, 34311709, 34917094, 36499104, 36830609, 36999025, 37147986, 37703626, 40471422
Inflammation	Inhibit	18055547, 25541686, 34127731, 39692554
Inflammation	Stimulate	31001285, 31316519, 33339125, 36291123, 36945068, 37644468
Inflammatory Bowel Diseases	Associate	34948292
Kaposi Varicelliform Eruption	Stimulate	26198597
Latent Tuberculosis	Stimulate	32369456
Leiomyoma	Associate	34116832, 35715314
Leprosy	Associate	33040382, 34695167
Leprosy Lepromatous	Associate	21592112, 22851198
Leukemia	Associate	24903009, 25815345, 25886742, 35371054
Leukemia Lymphocytic Chronic B Cell	Associate	24850760, 35371054
Leukemia Myeloid Acute	Stimulate	24903009
Leukemia Myeloid Acute	Associate	25886742, 27077762, 28084439, 29038460, 34535017
Lichen Planus	Associate	18055547
Liver Failure	Associate	35731891
Liver Failure Acute	Associate	35905417
Lung Diseases	Associate	15528322, 27695127
Lung Neoplasms	Associate	17700060, 24657910, 27440266, 30367104, 32017467, 32067413, 35872931
Lupus Erythematosus Systemic	Associate	24756936, 25897671, 31536674, 35197962
Lymphatic Diseases	Associate	36830609
Lymphatic Metastasis	Associate	19604349, 23440412, 24870595, 32506804, 39989741
Lymphatic Metastasis	Inhibit	19695096
Lymphatic Metastasis	Stimulate	28303855, 35963900
Lymphoma	Associate	29998979
Lymphoma Follicular	Associate	24886161, 37108483
Lymphoma Large B Cell Diffuse	Associate	23489474, 30696890, 32481253, 33579170, 35760783
Lymphoma Non Hodgkin	Stimulate	37782060
Lymphoma T Cell	Associate	37577144
Malignant mesenchymal tumor	Associate	28245795
Medulloblastoma	Associate	27174915
Melanoma	Associate	17565341, 21327637, 22258454, 23879623, 27003769, 29054599, 29505109, 30021908, 31509303, 31630873, 32380691, 32535222, 32776284, 34051744, 34557196, 35408802, 37123046, 37305390, 37770497
Melanoma	Inhibit	40621453
Melanoma Cutaneous Malignant	Associate	34051744
Meningioma	Associate	23358471
Meningitis Bacterial	Stimulate	25274277
Microsatellite Instability	Stimulate	25358689
Microsatellite Instability	Associate	25583798
Mohr Tranebjaerg syndrome	Associate	36233312
Mouth Diseases	Associate	25928531
Multiple Myeloma	Associate	22722711, 23232072, 27418644, 37812476
Multiple Sclerosis	Associate	21075457, 26110930, 37175706
Multiple Sclerosis Relapsing Remitting	Associate	26110930
Myocardial Infarction	Associate	37798364
Myocardial Ischemia	Associate	31186442
Myocarditis	Associate	37021424
Myopathy with Lactic Acidosis Hereditary	Stimulate	33558879
Nasopharyngeal Carcinoma	Associate	19948041, 24696473, 31722750, 32564263, 36039641
Neoplasm Invasiveness	Associate	30014971
Neoplasm Metastasis	Associate	17433037, 22108515, 25752522, 27578919, 29719533, 30755500, 31703602, 33208630, 34158230, 34769098, 35157906, 37839637, 38062922
Neoplasm Metastasis	Inhibit	40621453
Neoplasms	Associate	11985668, 15967116, 16385630, 16522817, 17117179, 17433037, 17565341, 17700060, 18418598, 18619832, 19434461, 19604349, 19695096, 19933867, 19948041, 20644162, 21079151, 21625531, 22013481, 22108515, 22444239, 22539948, 22722711, 23200064, 23344392, 23675474, 23879623, 24533148, 24657910, 24687552, 24696473, 24870595, 24911872, 25274283, 25358689, 25881064, 25973066, 26561720, 26657115, 27192116, 27211104, 27499237, 27578919, 27651314, 27868139, 28027300, 28460011, 29037255, 29038460, 29054599, 29133053, 29485423, 29498788, 29621426, 29667084, 29719533, 29802358, 30014971, 30089500, 30193111, 30194138, 30264546, 30314496, 30367104, 30415456, 30483834, 30671614, 30682105, 30755500, 30843276, 30902819, 31033497, 31163080, 31434983, 31481499, 31509303, 31628024, 31631566, 31665365, 31722750, 31759380, 31802183, 32125093, 32227579, 32270230, 32388585, 32390008, 32414944, 32481253, 32506804, 32535222, 32536910, 32764075, 32776284, 32987253, 33010009, 33029538, 33045001, 33063451, 33125511, 33155664, 33390854, 33414262, 33579170, 33922388, 33922995, 33968070, 34051744, 34285260, 34331874, 34364366, 34557196, 34593617, 34769098, 34962030, 35145510, 35150740, 35187162, 35371054, 35760783, 35791738, 35962343, 35963900, 36233312, 36288460, 36380437, 36430322, 36680216, 37122718, 37139184, 37147986, 37148546, 37527282, 37577144, 37619986, 37703626, 37756581, 37839637, 38062922, 38369188, 39312339, 39428479, 39989741
Neoplasms	Stimulate	19079205, 27197067, 35157906, 37247278
Neoplasms	Inhibit	25415278, 33151286, 33737337, 35127252, 37782060
Neoplasms Neuroepithelial	Associate	22048879
Neoplasms Squamous Cell	Associate	33029538
Neuroblastoma	Associate	33252831, 33737337, 37130627
Neuroendocrine Tumors	Associate	32506804
Neurotoxicity Syndromes	Associate	17626075
Non alcoholic Fatty Liver Disease	Associate	35731891
Obesity	Associate	22592557, 26347385
Osteosarcoma	Associate	32388585, 36519392
Ovarian Neoplasms	Associate	25376937, 26561720, 29093164, 32912307, 32977853, 33887301, 34260536, 36233312, 37703626, 38062922
Pancreatic Neoplasms	Associate	23029049, 28303855, 31043417, 31609478
Pancreatic Neoplasms	Stimulate	25274283, 33062039
Papillomavirus Infections	Associate	31412167
Parkinson Disease	Associate	29621426, 36224022
Peptic Ulcer	Stimulate	33127161
Persistent Infection	Associate	21592112
Pneumonia	Stimulate	19643200
Pre Eclampsia	Inhibit	29615752
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	23973990
Prostatic Neoplasms	Associate	18619832, 28027300, 29896191, 31186442, 31606777, 31703602, 31842810, 32922383, 38087324
Prostatic Neoplasms Castration Resistant	Associate	35127252
Prostatic stromal proliferation of uncertain malignant potential	Associate	36380437
Pulmonary Disease Chronic Obstructive	Associate	27695127
Rectal Neoplasms	Associate	30671614, 36471264
Recurrence	Associate	30755500
Renal Insufficiency Chronic	Associate	34946851
Respiratory Syncytial Virus Infections	Associate	27695127
Respiratory Tract Infections	Associate	34962030
Retroviridae Infections	Inhibit	35883685
Rupture	Associate	38062922
Sarcoidosis	Associate	36830609
Sarcoma	Associate	24658839, 32313727, 37661910
Scleroderma Systemic	Associate	23200754
Serotonin Syndrome	Associate	32270230
Sexual Dysfunction Physiological	Associate	29621426
Sick Sinus Syndrome	Associate	19604349, 23344392
Sjogren's Syndrome	Associate	36999025
Skin Diseases	Associate	18055547
Skin Neoplasms	Associate	33968070
Small Cell Lung Carcinoma	Stimulate	36879122
Smith Magenis Syndrome	Associate	26110930
Soft Tissue Injuries	Associate	31267172
Spondylitis Ankylosing	Stimulate	39692554
Squamous Cell Carcinoma of Head and Neck	Associate	28460011, 31628024, 32117235, 32414944, 33125511, 35963900, 40332319
Squamous Intraepithelial Lesions	Associate	31412167
ST Elevation Myocardial Infarction	Inhibit	29278387
Stomach Neoplasms	Associate	24870595, 26887337, 27241062, 31033497, 31631566, 33575321, 36680216
Stroke	Associate	31186442, 36911716
Tachycardia Atrioventricular Nodal Reentry	Associate	27003769
Thyroid Neoplasms	Associate	29372535
Tics	Associate	31630873
Triple Negative Breast Neoplasms	Associate	29802358, 31921107, 32987253, 35748713, 37147986, 37981615, 39428479, 40217479
Tuberculosis	Stimulate	32369456
Tuberculosis	Associate	38460493
Turcot syndrome	Associate	29559741
Urinary Bladder Neoplasms	Associate	25973066, 27189278, 31174611, 32907554, 37670034, 37954600, 38518167
Uterine Cervical Diseases	Stimulate	19079205
Uterine Cervical Dysplasia	Stimulate	17433037
Uterine Cervical Dysplasia	Associate	19079205
Uterine Cervical Neoplasms	Associate	17433037, 30314496, 31412167, 33390854, 39312339
Uveal melanoma	Associate	30993893, 31960425
Vascular Diseases	Associate	37880104
Vasoplegia	Associate	33725700