ILF3 (interleukin enhancer binding factor 3)

Gene

• Entrez ID: 3609
• Gene name: Interleukin enhancer binding factor 3
• Gene symbol: ILF3
• Synonyms (NCBI Gene): CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, MPP4110, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NF90c, NF90ctv, NFAR, NFAR-1, NFAR-2, NFAR110, NFAR2, NFAR90, TCP110, TCP80
• Chromosome: 19
• Chromosome location: 19p13.2
• Summary: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025730	hsa-miR-7-5p	Microarray	19073608
MIRT050983	hsa-miR-17-5p	CLASH	23622248
MIRT045490	hsa-miR-149-5p	CLASH	23622248
MIRT045018	hsa-miR-186-5p	CLASH	23622248
MIRT045018	hsa-miR-186-5p	CLASH	23622248
MIRT044800	hsa-miR-320a	CLASH	23622248
MIRT044381	hsa-miR-200c-3p	CLASH	23622248
MIRT041999	hsa-miR-484	CLASH	23622248
MIRT040678	hsa-miR-92b-3p	CLASH	23622248
MIRT040110	hsa-miR-615-3p	CLASH	23622248
MIRT039142	hsa-miR-769-5p	CLASH	23622248
MIRT039142	hsa-miR-769-5p	CLASH	23622248
MIRT037927	hsa-miR-532-3p	CLASH	23622248
MIRT036091	hsa-miR-1296-5p	CLASH	23622248
MIRT025730	hsa-miR-7-5p	Microarray, Northern blot, qRT-PCR, Western blot	27519414
MIRT1065468	hsa-miR-1305	CLIP-seq
MIRT1065469	hsa-miR-3940-5p	CLIP-seq
MIRT1065470	hsa-miR-4507	CLIP-seq
MIRT1065471	hsa-miR-4716-3p	CLIP-seq
MIRT1065472	hsa-miR-4723-5p	CLIP-seq
MIRT1065473	hsa-miR-4728-5p	CLIP-seq
MIRT1065474	hsa-miR-548an	CLIP-seq
MIRT1065475	hsa-miR-598	CLIP-seq
MIRT1065476	hsa-miR-629	CLIP-seq
MIRT1065477	hsa-miR-95	CLIP-seq
MIRT1065478	hsa-miR-101	CLIP-seq
MIRT1065479	hsa-miR-1237	CLIP-seq
MIRT1065480	hsa-miR-1245b-3p	CLIP-seq
MIRT1065481	hsa-miR-1254	CLIP-seq
MIRT1065482	hsa-miR-1273e	CLIP-seq
MIRT1065483	hsa-miR-1291	CLIP-seq
MIRT1065484	hsa-miR-136	CLIP-seq
MIRT1065485	hsa-miR-144	CLIP-seq
MIRT1065486	hsa-miR-1470	CLIP-seq
MIRT1065487	hsa-miR-150	CLIP-seq
MIRT1065488	hsa-miR-188-5p	CLIP-seq
MIRT1065489	hsa-miR-1908	CLIP-seq
MIRT1065490	hsa-miR-1912	CLIP-seq
MIRT1065491	hsa-miR-1913	CLIP-seq
MIRT1065492	hsa-miR-1915	CLIP-seq
MIRT1065493	hsa-miR-202	CLIP-seq
MIRT1065494	hsa-miR-2116	CLIP-seq
MIRT1065495	hsa-miR-2276	CLIP-seq
MIRT1065496	hsa-miR-2277-3p	CLIP-seq
MIRT1065497	hsa-miR-2861	CLIP-seq
MIRT1065498	hsa-miR-3116	CLIP-seq
MIRT1065499	hsa-miR-3135	CLIP-seq
MIRT1065500	hsa-miR-3140-3p	CLIP-seq
MIRT1065501	hsa-miR-3140-5p	CLIP-seq
MIRT1065502	hsa-miR-3144-5p	CLIP-seq
MIRT1065503	hsa-miR-3151	CLIP-seq
MIRT1065504	hsa-miR-3163	CLIP-seq
MIRT1065505	hsa-miR-3173-5p	CLIP-seq
MIRT1065506	hsa-miR-3174	CLIP-seq
MIRT1065507	hsa-miR-3180	CLIP-seq
MIRT1065508	hsa-miR-3180-3p	CLIP-seq
MIRT1065509	hsa-miR-3182	CLIP-seq
MIRT1065510	hsa-miR-3192	CLIP-seq
MIRT1065511	hsa-miR-3196	CLIP-seq
MIRT1065512	hsa-miR-323-5p	CLIP-seq
MIRT1065513	hsa-miR-324-3p	CLIP-seq
MIRT1065514	hsa-miR-324-5p	CLIP-seq
MIRT1065515	hsa-miR-340	CLIP-seq
MIRT1065516	hsa-miR-3607-3p	CLIP-seq
MIRT1065517	hsa-miR-3618	CLIP-seq
MIRT1065518	hsa-miR-3657	CLIP-seq
MIRT1065519	hsa-miR-3665	CLIP-seq
MIRT1065520	hsa-miR-3680	CLIP-seq
MIRT1065521	hsa-miR-3686	CLIP-seq
MIRT1065522	hsa-miR-3689d	CLIP-seq
MIRT1065523	hsa-miR-3918	CLIP-seq
MIRT1065524	hsa-miR-3922-5p	CLIP-seq
MIRT1065525	hsa-miR-3929	CLIP-seq
MIRT1065526	hsa-miR-3942-3p	CLIP-seq
MIRT1065527	hsa-miR-412	CLIP-seq
MIRT1065528	hsa-miR-4254	CLIP-seq
MIRT1065529	hsa-miR-4273	CLIP-seq
MIRT1065530	hsa-miR-4286	CLIP-seq
MIRT1065531	hsa-miR-4419b	CLIP-seq
MIRT1065532	hsa-miR-4420	CLIP-seq
MIRT1065533	hsa-miR-4422	CLIP-seq
MIRT1065534	hsa-miR-4443	CLIP-seq
MIRT1065535	hsa-miR-4446-5p	CLIP-seq
MIRT1065536	hsa-miR-4454	CLIP-seq
MIRT1065537	hsa-miR-4469	CLIP-seq
MIRT1065538	hsa-miR-4478	CLIP-seq
MIRT1065539	hsa-miR-4488	CLIP-seq
MIRT1065540	hsa-miR-4512	CLIP-seq
MIRT1065541	hsa-miR-4524	CLIP-seq
MIRT1065542	hsa-miR-4640-5p	CLIP-seq
MIRT1065543	hsa-miR-4643	CLIP-seq
MIRT1065544	hsa-miR-4650-5p	CLIP-seq
MIRT1065545	hsa-miR-4661-5p	CLIP-seq
MIRT1065546	hsa-miR-4667-3p	CLIP-seq
MIRT1065547	hsa-miR-4672	CLIP-seq
MIRT1065548	hsa-miR-4677-5p	CLIP-seq
MIRT1065549	hsa-miR-4678	CLIP-seq
MIRT1065550	hsa-miR-4685-5p	CLIP-seq
MIRT1065551	hsa-miR-4690-3p	CLIP-seq
MIRT1065552	hsa-miR-4690-5p	CLIP-seq
MIRT1065553	hsa-miR-4697-5p	CLIP-seq
MIRT1065554	hsa-miR-4708-3p	CLIP-seq
MIRT1065555	hsa-miR-4719	CLIP-seq
MIRT1065556	hsa-miR-4726-5p	CLIP-seq
MIRT1065557	hsa-miR-4728-3p	CLIP-seq
MIRT1065558	hsa-miR-4738-3p	CLIP-seq
MIRT1065559	hsa-miR-4749-3p	CLIP-seq
MIRT1065560	hsa-miR-4753-5p	CLIP-seq
MIRT1065561	hsa-miR-4755-3p	CLIP-seq
MIRT1065562	hsa-miR-4757-3p	CLIP-seq
MIRT1065563	hsa-miR-4760-3p	CLIP-seq
MIRT1065564	hsa-miR-4763-5p	CLIP-seq
MIRT1065565	hsa-miR-4764-3p	CLIP-seq
MIRT1065566	hsa-miR-494	CLIP-seq
MIRT1065567	hsa-miR-495	CLIP-seq
MIRT1065568	hsa-miR-502-5p	CLIP-seq
MIRT1065569	hsa-miR-5096	CLIP-seq
MIRT1065570	hsa-miR-513b	CLIP-seq
MIRT1065571	hsa-miR-515-5p	CLIP-seq
MIRT1065572	hsa-miR-518a-5p	CLIP-seq
MIRT1065573	hsa-miR-527	CLIP-seq
MIRT1065574	hsa-miR-548a-3p	CLIP-seq
MIRT1065575	hsa-miR-548e	CLIP-seq
MIRT1065576	hsa-miR-548f	CLIP-seq
MIRT1065577	hsa-miR-548g	CLIP-seq
MIRT1065578	hsa-miR-615-5p	CLIP-seq
MIRT1065579	hsa-miR-642a	CLIP-seq
MIRT1065580	hsa-miR-663	CLIP-seq
MIRT1065581	hsa-miR-759	CLIP-seq
MIRT1065582	hsa-miR-876-3p	CLIP-seq
MIRT1065475	hsa-miR-598	CLIP-seq
MIRT2247881	hsa-miR-1184	CLIP-seq
MIRT2247882	hsa-miR-1205	CLIP-seq
MIRT2247883	hsa-miR-1289	CLIP-seq
MIRT2247884	hsa-miR-1301	CLIP-seq
MIRT1065468	hsa-miR-1305	CLIP-seq
MIRT2247885	hsa-miR-1343	CLIP-seq
MIRT2247886	hsa-miR-147	CLIP-seq
MIRT2247887	hsa-miR-155	CLIP-seq
MIRT2247888	hsa-miR-15a	CLIP-seq
MIRT2247889	hsa-miR-15b	CLIP-seq
MIRT2247890	hsa-miR-16	CLIP-seq
MIRT2247891	hsa-miR-195	CLIP-seq
MIRT2247892	hsa-miR-19a	CLIP-seq
MIRT2247893	hsa-miR-19b	CLIP-seq
MIRT2247894	hsa-miR-208a	CLIP-seq
MIRT2247895	hsa-miR-208b	CLIP-seq
MIRT2247896	hsa-miR-2113	CLIP-seq
MIRT2247897	hsa-miR-3065-3p	CLIP-seq
MIRT2247898	hsa-miR-3074-5p	CLIP-seq
MIRT2247899	hsa-miR-3119	CLIP-seq
MIRT2247900	hsa-miR-3122	CLIP-seq
MIRT1065500	hsa-miR-3140-3p	CLIP-seq
MIRT2247901	hsa-miR-3152-5p	CLIP-seq
MIRT2247902	hsa-miR-3158-5p	CLIP-seq
MIRT2247903	hsa-miR-3160-5p	CLIP-seq
MIRT2247904	hsa-miR-3198	CLIP-seq
MIRT2247905	hsa-miR-3611	CLIP-seq
MIRT2247906	hsa-miR-3688-5p	CLIP-seq
MIRT2247907	hsa-miR-3689a-3p	CLIP-seq
MIRT2247908	hsa-miR-3689c	CLIP-seq
MIRT2247909	hsa-miR-3692	CLIP-seq
MIRT2247910	hsa-miR-3910	CLIP-seq
MIRT2247911	hsa-miR-3913-5p	CLIP-seq
MIRT2247912	hsa-miR-424	CLIP-seq
MIRT2247913	hsa-miR-4294	CLIP-seq
MIRT2247914	hsa-miR-4309	CLIP-seq
MIRT2247915	hsa-miR-4312	CLIP-seq
MIRT2247916	hsa-miR-4417	CLIP-seq
MIRT2247917	hsa-miR-4432	CLIP-seq
MIRT2247918	hsa-miR-4434	CLIP-seq
MIRT2247919	hsa-miR-4436b-5p	CLIP-seq
MIRT2247920	hsa-miR-4516	CLIP-seq
MIRT2247921	hsa-miR-4530	CLIP-seq
MIRT2247922	hsa-miR-4660	CLIP-seq
MIRT2247923	hsa-miR-4691-3p	CLIP-seq
MIRT2247924	hsa-miR-4774-3p	CLIP-seq
MIRT2247925	hsa-miR-4774-5p	CLIP-seq
MIRT2247926	hsa-miR-497	CLIP-seq
MIRT2247927	hsa-miR-499-3p	CLIP-seq
MIRT2247928	hsa-miR-499-5p	CLIP-seq
MIRT2247929	hsa-miR-499a-3p	CLIP-seq
MIRT2247930	hsa-miR-5047	CLIP-seq
MIRT2247931	hsa-miR-541	CLIP-seq
MIRT2247932	hsa-miR-548a-5p	CLIP-seq
MIRT2247933	hsa-miR-548ab	CLIP-seq
MIRT2247934	hsa-miR-548ak	CLIP-seq
MIRT1065474	hsa-miR-548an	CLIP-seq
MIRT2247935	hsa-miR-548b-3p	CLIP-seq
MIRT2247936	hsa-miR-548b-5p	CLIP-seq
MIRT2247937	hsa-miR-548c-5p	CLIP-seq
MIRT2247938	hsa-miR-548d-5p	CLIP-seq
MIRT2247939	hsa-miR-548h	CLIP-seq
MIRT2247940	hsa-miR-548i	CLIP-seq
MIRT2247941	hsa-miR-548j	CLIP-seq
MIRT2247942	hsa-miR-548w	CLIP-seq
MIRT2247943	hsa-miR-548y	CLIP-seq
MIRT2247944	hsa-miR-559	CLIP-seq
MIRT2247945	hsa-miR-587	CLIP-seq
MIRT1065475	hsa-miR-598	CLIP-seq
MIRT2247946	hsa-miR-599	CLIP-seq
MIRT2247947	hsa-miR-654-5p	CLIP-seq
MIRT2247948	hsa-miR-885-3p	CLIP-seq
MIRT1065477	hsa-miR-95	CLIP-seq
MIRT2682805	hsa-miR-1207-5p	CLIP-seq
MIRT1065481	hsa-miR-1254	CLIP-seq
MIRT2247885	hsa-miR-1343	CLIP-seq
MIRT1065486	hsa-miR-1470	CLIP-seq
MIRT2682806	hsa-miR-184	CLIP-seq
MIRT1065489	hsa-miR-1908	CLIP-seq
MIRT2682807	hsa-miR-2110	CLIP-seq
MIRT1065497	hsa-miR-2861	CLIP-seq
MIRT1065498	hsa-miR-3116	CLIP-seq
MIRT2682808	hsa-miR-3120-3p	CLIP-seq
MIRT2682809	hsa-miR-3153	CLIP-seq
MIRT1065507	hsa-miR-3180	CLIP-seq
MIRT1065508	hsa-miR-3180-3p	CLIP-seq
MIRT1065511	hsa-miR-3196	CLIP-seq
MIRT1065528	hsa-miR-4254	CLIP-seq
MIRT2682810	hsa-miR-4268	CLIP-seq
MIRT2682811	hsa-miR-4271	CLIP-seq
MIRT1065537	hsa-miR-4469	CLIP-seq
MIRT1065539	hsa-miR-4488	CLIP-seq
MIRT1065542	hsa-miR-4640-5p	CLIP-seq
MIRT1065546	hsa-miR-4667-3p	CLIP-seq
MIRT2682812	hsa-miR-4667-5p	CLIP-seq
MIRT1065553	hsa-miR-4697-5p	CLIP-seq
MIRT2682813	hsa-miR-4700-5p	CLIP-seq
MIRT2682814	hsa-miR-4707-5p	CLIP-seq
MIRT2682815	hsa-miR-4725-3p	CLIP-seq
MIRT1065556	hsa-miR-4726-5p	CLIP-seq
MIRT2682816	hsa-miR-4763-3p	CLIP-seq
MIRT2682817	hsa-miR-4804-5p	CLIP-seq
MIRT1065474	hsa-miR-548an	CLIP-seq
MIRT1065580	hsa-miR-663	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ILF2	Unknown	11739746

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IDA	21123651
GO:0003677	Function	DNA binding	IDA	7519613, 10574923
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	10400669
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003725	Function	Double-stranded RNA binding	IDA	10574923, 11777942
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IBA
GO:0005515	Function	Protein binding	IPI	9442054, 10574923, 10749851, 11739746, 11777942, 14731398, 17932509, 18337511, 21987769, 22810585, 23853584, 23976881, 24965446, 32296183, 32814053, 35271311, 39251607
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005634	Component	Nucleus	IDA	7519613, 8885239, 10749851, 11739746, 21123651
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	10400669
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	21123651
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	21123651
GO:0016020	Component	Membrane	HDA	19946888
GO:0017148	Process	Negative regulation of translation	IEA
GO:0017148	Process	Negative regulation of translation	ISS
GO:0035925	Function	MRNA 3'-UTR AU-rich region binding	IDA	14731398
GO:0045071	Process	Negative regulation of viral genome replication	IEA
GO:0045071	Process	Negative regulation of viral genome replication	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	11739746
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	11739746
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0160091	Process	Spliceosome-depend formation of circular RNA	IDA	28625552
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661

Other IDs

• MIM: 603182
• HGNC: 6038
• e!Ensembl: ENSG00000129351

Protein

• UniProt ID: Q12906
• Protein name: Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein
• Protein function: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory eleme
• PDB: 2L33, 3P1X, 7RJM, 7RJQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07528	DZF	94 → 342	DZF domain	Domain
  PF00035	dsrm	402 → 465	Double-stranded RNA binding motif	Domain
  PF00035	dsrm	526 → 588	Double-stranded RNA binding motif	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA
  ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP
  TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM
  EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV
  PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT
  DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP
  PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL
  VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE
  DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLK
  YELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANK
  KKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGA
  NHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGD
  NYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHG
  QGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGS
  GGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR

• Sequence length: 894