Gene Gene information from NCBI Gene database.
Entrez ID 3607
Gene name Forkhead box K2
Gene symbol FOXK2
Synonyms (NCBI Gene)
ILFILF-1ILF1nGTBP
Chromosome 17
Chromosome location 17q25.3
Summary The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved i
miRNA miRNA information provided by mirtarbase database.
736
miRTarBase ID miRNA Experiments Reference
MIRT023397 hsa-miR-122-5p Microarray 17612493
MIRT047114 hsa-miR-183-5p CLASH 23622248
MIRT040827 hsa-miR-18a-3p CLASH 23622248
MIRT039330 hsa-miR-425-5p CLASH 23622248
MIRT039207 hsa-miR-769-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
47
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000287 Function Magnesium ion binding IDA 16624804
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription cis-regulatory region binding IDA 22083952
GO:0000976 Function Transcription cis-regulatory region binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147685 6036 ENSG00000141568
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q01167
Protein name Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1)
Protein function Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription acti
PDB 1JXS , 2C6Y
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00498 FHA 54 145 FHA domain Family
PF00250 Forkhead 257 343 Forkhead domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in both lymphoid and non-lymphoid cells. {ECO:0000269|PubMed:1339390}.
Sequence
MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNS
SQGSVDVSMGHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG
VFVDGVFQRRGAPPLQLPRVCTFRF
PSTNIKITFTALSSEKREKQEASESPVKAVQPHIS
PLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQ
PENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADK
GWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLI
EQAFRKRRPRGVPCFRT
PLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEAR
FAQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAV
SVTSVAGLAPANTYTVSGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLG
TASRIIQTAQTTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVASVPTAVHGQVNNAAASP
LHMLATHASASASLPTKRHNGDQPEQPELKRIKTEDGEGIVIALSVDTPPAAVREKGVQN
Sequence length 660
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Polycomb repressive complex   UCH proteinases
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Malignant tumor of esophagus Likely benign rs7212607 RCV005907283
Ovarian serous cystadenocarcinoma Likely benign rs7212607 RCV005907284
Premature ovarian insufficiency Likely benign rs146516291, rs138822262 RCV000766179
RCV000766178
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Lung Injury Associate 34900201
Adenocarcinoma Inhibit 36790524
Blister Associate 31572359
Breast Neoplasms Inhibit 25740706
Candidiasis Associate 35319722
Candidiasis Chronic Mucocutaneous Associate 31784499
Carcinoma Hepatocellular Associate 36682222
Carcinoma Renal Cell Associate 32425115
Colonic Neoplasms Associate 29548809
Connective Tissue Diseases Associate 31784499