Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3607
Gene name Gene Name - the full gene name approved by the HGNC.
Forkhead box K2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FOXK2
Synonyms (NCBI Gene) Gene synonyms aliases
ILF, ILF-1, ILF1, nGTBP
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved i
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023397 hsa-miR-122-5p Microarray 17612493
MIRT047114 hsa-miR-183-5p CLASH 23622248
MIRT040827 hsa-miR-18a-3p CLASH 23622248
MIRT039330 hsa-miR-425-5p CLASH 23622248
MIRT039207 hsa-miR-769-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000287 Function Magnesium ion binding IDA 16624804
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 22083952
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147685 6036 ENSG00000141568
Protein
UniProt ID Q01167
Protein name Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1)
Protein function Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription acti
PDB 1JXS , 2C6Y
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00498 FHA 54 145 FHA domain Family
PF00250 Forkhead 257 343 Forkhead domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in both lymphoid and non-lymphoid cells. {ECO:0000269|PubMed:1339390}.
Sequence
MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNS
SQGSVDVSMGHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG
VFVDGVFQRRGAPPLQLPRVCTFRF
PSTNIKITFTALSSEKREKQEASESPVKAVQPHIS
PLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQ
PENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADK
GWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLI
EQAFRKRRPRGVPCFRT
PLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEAR
FAQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAV
SVTSVAGLAPANTYTVSGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLG
TASRIIQTAQTTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVASVPTAVHGQVNNAAASP
LHMLATHASASASLPTKRHNGDQPEQPELKRIKTEDGEGIVIALSVDTPPAAVREKGVQN
Sequence length 660
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Polycomb repressive complex   UCH proteinases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059683
Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures NEURODEVELOPMENTAL DISORDER WITH SPASTIC QUADRIPLEGIA AND BRAIN ABNORMALITIES WITH OR WITHOUT SEIZURES rs786205510, rs1555647262
Unknown
Disease term Disease name Evidence References Source
Gout Gout GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Acute Lung Injury Associate 34900201
Adenocarcinoma Inhibit 36790524
Blister Associate 31572359
Breast Neoplasms Inhibit 25740706
Candidiasis Associate 35319722
Candidiasis Chronic Mucocutaneous Associate 31784499
Carcinoma Hepatocellular Associate 36682222
Carcinoma Renal Cell Associate 32425115
Colonic Neoplasms Associate 29548809
Connective Tissue Diseases Associate 31784499