Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	3601
Gene name	Interleukin 15 receptor subunit alpha
Gene symbol	IL15RA
Synonyms (NCBI Gene)	CD215
Chromosome	10
Chromosome location	10p15.1
Summary	This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and

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miRTarBase ID	miRNA	Experiments	Reference
MIRT735808	hsa-miR-370-3p	Luciferase reporter assay	31513636
MIRT1063731	hsa-miR-1225-5p	CLIP-seq
MIRT1063732	hsa-miR-150	CLIP-seq
MIRT1063733	hsa-miR-2054	CLIP-seq
MIRT1063734	hsa-miR-4312	CLIP-seq
MIRT1063735	hsa-miR-4434	CLIP-seq
MIRT1063736	hsa-miR-4516	CLIP-seq
MIRT1063737	hsa-miR-4713-5p	CLIP-seq
MIRT1063738	hsa-miR-4768-3p	CLIP-seq
MIRT1063739	hsa-miR-4768-5p	CLIP-seq
MIRT1063740	hsa-miR-532-3p	CLIP-seq
MIRT1063741	hsa-miR-662	CLIP-seq
MIRT1063742	hsa-miR-665	CLIP-seq
MIRT1063743	hsa-miR-668	CLIP-seq
MIRT1063744	hsa-miR-1224-3p	CLIP-seq
MIRT1063745	hsa-miR-1260	CLIP-seq
MIRT1063746	hsa-miR-1260b	CLIP-seq
MIRT1063747	hsa-miR-1280	CLIP-seq
MIRT1063732	hsa-miR-150	CLIP-seq
MIRT1063748	hsa-miR-1915	CLIP-seq
MIRT1063737	hsa-miR-4713-5p	CLIP-seq
MIRT1063749	hsa-miR-4726-3p	CLIP-seq
MIRT1063740	hsa-miR-532-3p	CLIP-seq
MIRT1550101	hsa-miR-133a	CLIP-seq
MIRT1550102	hsa-miR-133b	CLIP-seq
MIRT1550103	hsa-miR-1343	CLIP-seq
MIRT1550104	hsa-miR-1976	CLIP-seq
MIRT1550101	hsa-miR-133a	CLIP-seq
MIRT1550102	hsa-miR-133b	CLIP-seq
MIRT1550103	hsa-miR-1343	CLIP-seq
MIRT1550104	hsa-miR-1976	CLIP-seq
MIRT2015102	hsa-miR-205	CLIP-seq
MIRT2015103	hsa-miR-296-5p	CLIP-seq
MIRT2015104	hsa-miR-320e	CLIP-seq
MIRT2015105	hsa-miR-4646-5p	CLIP-seq
MIRT2015106	hsa-miR-4747-5p	CLIP-seq
MIRT1550101	hsa-miR-133a	CLIP-seq
MIRT1550102	hsa-miR-133b	CLIP-seq
MIRT1550103	hsa-miR-1343	CLIP-seq
MIRT1550104	hsa-miR-1976	CLIP-seq
MIRT2015103	hsa-miR-296-5p	CLIP-seq
MIRT2015104	hsa-miR-320e	CLIP-seq
MIRT2015105	hsa-miR-4646-5p	CLIP-seq
MIRT2015106	hsa-miR-4747-5p	CLIP-seq
MIRT2550876	hsa-miR-1200	CLIP-seq
MIRT1550101	hsa-miR-133a	CLIP-seq
MIRT1550102	hsa-miR-133b	CLIP-seq
MIRT1550103	hsa-miR-1343	CLIP-seq
MIRT2550877	hsa-miR-185	CLIP-seq
MIRT1550104	hsa-miR-1976	CLIP-seq
MIRT2015102	hsa-miR-205	CLIP-seq
MIRT2550878	hsa-miR-219-1-3p	CLIP-seq
MIRT2015103	hsa-miR-296-5p	CLIP-seq
MIRT2550879	hsa-miR-3140-5p	CLIP-seq
MIRT2015104	hsa-miR-320e	CLIP-seq
MIRT2550880	hsa-miR-4306	CLIP-seq
MIRT2550881	hsa-miR-4644	CLIP-seq
MIRT2015105	hsa-miR-4646-5p	CLIP-seq
MIRT2550882	hsa-miR-4659a-3p	CLIP-seq
MIRT2550883	hsa-miR-4659b-3p	CLIP-seq
MIRT2550884	hsa-miR-4682	CLIP-seq
MIRT2015106	hsa-miR-4747-5p	CLIP-seq
MIRT2550885	hsa-miR-4778-3p	CLIP-seq
MIRT2550886	hsa-miR-500a	CLIP-seq
MIRT2550887	hsa-miR-571	CLIP-seq
MIRT2550888	hsa-miR-639	CLIP-seq
MIRT2550876	hsa-miR-1200	CLIP-seq
MIRT1063744	hsa-miR-1224-3p	CLIP-seq
MIRT1063745	hsa-miR-1260	CLIP-seq
MIRT1063746	hsa-miR-1260b	CLIP-seq
MIRT1063747	hsa-miR-1280	CLIP-seq
MIRT1550101	hsa-miR-133a	CLIP-seq
MIRT1550102	hsa-miR-133b	CLIP-seq
MIRT1550103	hsa-miR-1343	CLIP-seq
MIRT1063732	hsa-miR-150	CLIP-seq
MIRT2550877	hsa-miR-185	CLIP-seq
MIRT1063748	hsa-miR-1915	CLIP-seq
MIRT1550104	hsa-miR-1976	CLIP-seq
MIRT2015102	hsa-miR-205	CLIP-seq
MIRT2550878	hsa-miR-219-1-3p	CLIP-seq
MIRT2682755	hsa-miR-24	CLIP-seq
MIRT2015103	hsa-miR-296-5p	CLIP-seq
MIRT2550879	hsa-miR-3140-5p	CLIP-seq
MIRT2015104	hsa-miR-320e	CLIP-seq
MIRT2682756	hsa-miR-378g	CLIP-seq
MIRT2550880	hsa-miR-4306	CLIP-seq
MIRT2682757	hsa-miR-4310	CLIP-seq
MIRT2682758	hsa-miR-4437	CLIP-seq
MIRT2550881	hsa-miR-4644	CLIP-seq
MIRT2015105	hsa-miR-4646-5p	CLIP-seq
MIRT2550882	hsa-miR-4659a-3p	CLIP-seq
MIRT2550883	hsa-miR-4659b-3p	CLIP-seq
MIRT2682759	hsa-miR-4674	CLIP-seq
MIRT2550884	hsa-miR-4682	CLIP-seq
MIRT1063737	hsa-miR-4713-5p	CLIP-seq
MIRT1063749	hsa-miR-4726-3p	CLIP-seq
MIRT2015106	hsa-miR-4747-5p	CLIP-seq
MIRT2550885	hsa-miR-4778-3p	CLIP-seq
MIRT2550886	hsa-miR-500a	CLIP-seq
MIRT1063740	hsa-miR-532-3p	CLIP-seq
MIRT2550887	hsa-miR-571	CLIP-seq
MIRT2550888	hsa-miR-639	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0001779	Process	Natural killer cell differentiation	IEA
GO:0004896	Function	Cytokine receptor activity	TAS	7641685
GO:0005515	Function	Protein binding	IPI	16284400, 23104097
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005768	Component	Endosome	TAS
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IEA
GO:0009986	Component	Cell surface	IDA	15123770
GO:0009986	Component	Cell surface	IEA
GO:0010977	Process	Negative regulation of neuron projection development	IEA
GO:0016020	Component	Membrane	IEA
GO:0019901	Function	Protein kinase binding	IPI	15123770
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031667	Process	Response to nutrient levels	IEA
GO:0031965	Component	Nuclear membrane	IEA
GO:0032825	Process	Positive regulation of natural killer cell differentiation	IEA
GO:0035723	Process	Interleukin-15-mediated signaling pathway	IBA
GO:0035723	Process	Interleukin-15-mediated signaling pathway	IDA	7568001
GO:0035723	Process	Interleukin-15-mediated signaling pathway	IEA
GO:0035723	Process	Interleukin-15-mediated signaling pathway	IMP	15123770
GO:0042010	Function	Interleukin-15 receptor activity	IBA
GO:0042010	Function	Interleukin-15 receptor activity	IDA	15123770
GO:0042010	Function	Interleukin-15 receptor activity	IEA
GO:0050766	Process	Positive regulation of phagocytosis	IMP	15123770

MIM	HGNC	e!Ensembl
601070	5978	ENSG00000134470

Q13261

Protein name

Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]

Protein function

High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK

PDB

2ERS , 2Z3Q , 2Z3R , 4GS7

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in neutrophils (at protein level) (PubMed:15123770). Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus (PubMed:12114302). Higher levels of soluble sIL-15RA form in c

Sequence

MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICN
SGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPE
SLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTA
KNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVE
MEAMEALPVTWGTSSRDEDLENCSHHL

Sequence length

267

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Intestinal immune network for IgA production Human T-cell leukemia virus 1 infection Pathways in cancer		Interleukin-15 signaling

IL15RA (interleukin 15 receptor subunit alpha)