IL15 (interleukin 15)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3600
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL15
Synonyms (NCBI Gene) Gene synonyms aliases
IL-15
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q31.21
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT024918 hsa-miR-215-5p Microarray 19074876
MIRT026532 hsa-miR-192-5p Microarray 19074876
MIRT724031 hsa-miR-495-3p HITS-CLIP 19536157
MIRT724030 hsa-miR-5688 HITS-CLIP 19536157
MIRT724029 hsa-miR-7-1-3p HITS-CLIP 19536157
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
HOXA10 Activation 20478621
MYB Activation 11675351
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001819 Process Positive regulation of cytokine production IBA 21873635
GO:0001866 Process NK T cell proliferation IEA
GO:0005125 Function Cytokine activity IBA 21873635
GO:0005126 Function Cytokine receptor binding IEA
GO:0005515 Function Protein binding IPI 16284400, 23104097, 25416956
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600554 5977 ENSG00000164136
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P40933
Protein name Interleukin-15 (IL-15)
Protein function Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770). Stimulates the p
PDB 2XQB , 2Z3Q , 2Z3R , 4GS7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02372 IL15 33 → 160 Interleukin 15 Domain
Tissue specificity TISSUE SPECIFICITY: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Sequence
Sequence length 162
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
TNF signaling pathway
Intestinal immune network for IgA production
Human T-cell leukemia virus 1 infection
Pathways in cancer
Rheumatoid arthritis 		  Interleukin-15 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)		 18929414
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac Disease 23269601 ClinVar
Endometriosis Endometriosis 21063030 ClinVar
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Dermatitis Dermatitis GWAS
Show/Hide Text Mining Associations (226)
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Injuries Stimulate 24603895
Acute Coronary Syndrome Associate 32647892
Aicardi Goutieres syndrome Associate 23408864
Alzheimer Disease Associate 30193587
Anemia Associate 21442636
Anthropophobia Associate 37031355
Arthritis Juvenile Associate 12860732, 15939793
Arthritis Psoriatic Associate 10857783, 24086722
Arthritis Rheumatoid Associate 10403280, 10886401, 10976081, 11219394, 12571841, 12878725, 15879699, 16142748, 16507118, 18292234, 18482208, 20736143, 21204897, 22355377, 22792388
View all (5 more)
Arthritis Rheumatoid Stimulate 10688908, 15022319, 18311795, 32246007