IL13 (interleukin 13)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3596
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 13
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL13
Synonyms (NCBI Gene) Gene synonyms aliases
IL-13, P600
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype swit
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs20541 A>C,G,T Risk-factor Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(45)
miRTarBase ID miRNA Experiments Reference
MIRT006397 hsa-miR-98-5p Luciferase reporter assay 21616524
MIRT006398 hsa-let-7d-5p Luciferase reporter assay 21616524
MIRT006399 hsa-let-7g-5p Luciferase reporter assay 21616524
MIRT006400 hsa-let-7f-5p Luciferase reporter assay 21616524
MIRT006401 hsa-let-7i-5p Luciferase reporter assay 21616524
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
Transcription factor Regulation Reference
AHR Unknown 22981205
CEBPB Unknown 22981205
E2F6 Unknown 22981205
STAT6 Unknown 12776189
TBX21 Repression 18504404;19348920
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001774 Process Microglial cell activation IEA
GO:0002639 Process Positive regulation of immunoglobulin production IBA
GO:0002639 Process Positive regulation of immunoglobulin production IEA
GO:0002639 Process Positive regulation of immunoglobulin production IEA
GO:0005125 Function Cytokine activity IDA 8096327
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147683 5973 ENSG00000169194
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P35225
Protein name Interleukin-13 (IL-13)
Protein function Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferati
PDB 1GA3 , 1IJZ , 1IK0 , 3BPO , 3G6D , 3L5W , 3L5X , 3LB6 , 4I77 , 4PS4 , 5E4E , 5L6Y , 8BLQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03487 IL13 16 → 144 Interleukin-13 Domain
Sequence
Sequence length 146
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Fc epsilon RI signaling pathway
Pathways in cancer
Asthma
Inflammatory bowel disease 		  Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (7)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Allergic Sensitization Allergic sensitization N/A N/A GWAS
Alopecia Areata Alopecia areata N/A N/A GWAS
Asthma Asthma, Atopic asthma, Asthma (childhood onset), Pediatric asthma N/A N/A GWAS
Dermatitis Atopic dermatitis N/A N/A GWAS
Show/Hide Text Mining Associations (342)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 34131192
Adenocarcinoma Associate 16884377
Adenocarcinoma Stimulate 30105735
Adenomyosis Associate 32933042
Aggressive Periodontitis Associate 21198753
Agricultural Workers' Diseases Associate 21857939
Airway Obstruction Associate 26646664, 31596609, 34822557
Airway Remodeling Associate 15826950, 23671562, 23682108
Allergic Fungal Sinusitis Associate 23805875, 27717558, 29417576, 30316748, 32673430, 33629532, 36780897
Alopecia Areata Associate 27094591, 33099387, 33807704