IL13 (interleukin 13)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 3596
Gene name Interleukin 13
Gene symbol IL13
Synonyms (NCBI Gene)
IL-13P600
Chromosome 5
Chromosome location 5q31.1
Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype swit
SNPs SNP information provided by dbSNP.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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SNP ID Visualize variation Clinical significance Consequence
rs20541 A>C,G,T Risk-factor Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT006397 hsa-miR-98-5p Luciferase reporter assay 21616524
MIRT006398 hsa-let-7d-5p Luciferase reporter assay 21616524
MIRT006399 hsa-let-7g-5p Luciferase reporter assay 21616524
MIRT006400 hsa-let-7f-5p Luciferase reporter assay 21616524
MIRT006401 hsa-let-7i-5p Luciferase reporter assay 21616524
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
AHR Unknown 22981205
CEBPB Unknown 22981205
E2F6 Unknown 22981205
STAT6 Unknown 12776189
TBX21 Repression 18504404;19348920
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001774 Process Microglial cell activation IEA
GO:0002639 Process Positive regulation of immunoglobulin production IBA
GO:0002639 Process Positive regulation of immunoglobulin production IEA
GO:0002639 Process Positive regulation of immunoglobulin production IEA
GO:0005125 Function Cytokine activity IDA 8096327
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147683 5973 ENSG00000169194
Protein Protein information from UniProt database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35225
Protein name Interleukin-13 (IL-13)
Protein function Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferati
PDB 1GA3 , 1IJZ , 1IK0 , 3BPO , 3G6D , 3L5W , 3L5X , 3LB6 , 4I77 , 4PS4 , 5E4E , 5L6Y , 8BLQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03487 IL13 16 → 144 Interleukin-13 Domain
Sequence
Sequence length 146
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Fc epsilon RI signaling pathway
Pathways in cancer
Asthma
Inflammatory bowel disease 		  Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Allergic rhinitis, susceptibility to Benign; risk factor rs20541 RCV002509161
Clear cell carcinoma of kidney Benign rs34255686 RCV005913365
IL13-related disorder Benign; risk factor; Likely benign rs20541, rs961082728, rs140828306 RCV003974831
RCV003934185
RCV003942259
Inherited susceptibility to asthma risk factor; Benign rs1800925, rs20541 RCV000015784
RCV000015785
Show/Hide Text Mining Associations (342)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 34131192
Adenocarcinoma Associate 16884377
Adenocarcinoma Stimulate 30105735
Adenomyosis Associate 32933042
Aggressive Periodontitis Associate 21198753
Agricultural Workers' Diseases Associate 21857939
Airway Obstruction Associate 26646664, 31596609, 34822557
Airway Remodeling Associate 15826950, 23671562, 23682108
Allergic Fungal Sinusitis Associate 23805875, 27717558, 29417576, 30316748, 32673430, 33629532, 36780897
Alopecia Areata Associate 27094591, 33099387, 33807704