IL12A (interleukin 12A)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3592
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 12A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL12A
Synonyms (NCBI Gene) Gene synonyms aliases
CLMF, IL-12A, NFSK, NKSF1, P35
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q25.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
miRTarBase ID miRNA Experiments Reference
MIRT030009 hsa-miR-26b-5p Microarray 19088304
MIRT208864 hsa-miR-21-5p Microarray, qRT-PCR 22815788
MIRT208864 hsa-miR-21-5p Luciferase reporter assay, Western blot 25327529
MIRT208864 hsa-miR-21-5p Luciferase reporter assay, qRT-PCR, Western blot 27571873
MIRT1063591 hsa-miR-1237 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
Transcription factor Regulation Reference
IRF1 Unknown 16622221
IRF8 Unknown 16622221
JUN Unknown 22904313
NFKB1 Activation 18690006
RELA Activation 18690006
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(45)
GO ID Ontology Definition Evidence Reference
GO:0001916 Process Positive regulation of T cell mediated cytotoxicity IDA 1674604, 2204066
GO:0002860 Process Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA 7903063
GO:0005125 Function Cytokine activity IDA 1674604
GO:0005125 Function Cytokine activity TAS 1673147
GO:0005143 Function Interleukin-12 receptor binding NAS 1674604
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
161560 5969 ENSG00000168811
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P29459
Protein name Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1)
Protein function Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine (PubMed:8605935, PubMed:8943050). IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells
PDB 1F45 , 3HMX , 8XRP , 8YI7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03039 IL12 6 → 219 Interleukin-12 alpha subunit Domain
Sequence
Sequence length 219
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
C-type lectin receptor signaling pathway
JAK-STAT signaling pathway
Th1 and Th2 cell differentiation
Alcoholic liver disease
Type I diabetes mellitus
Pertussis
Legionellosis
Leishmaniasis
Chagas disease
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Inflammatory bowel disease
Allograft rejection
Lipid and atherosclerosis 		  Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (11)
Causal
Disease term Disease name dbSNP ID References
Arthritis Arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470
Behcet syndrome Behcet Syndrome, Behçet disease rs886040969, rs886039866, rs746055479, rs752615209, rs774164456, rs751454741 25799145
Cataract Cataract rs118203965, rs118203966, rs104893685, rs121908938, rs104894175, rs121909048, rs28937573, rs121909049, rs121909050, rs74315488, rs80358200, rs80358203, rs121434643, rs56141211, rs132630322
View all (150 more)
Developmental regression Developmental regression rs1224421127
Show/Hide Unknown Diseases (12)
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac Disease, Celiac disease ClinVar, GWAS
Cirrhosis Cirrhosis ClinVar
Myocardial infarction Myocardial Infarction ClinVar
Pancreatitis Pancreatitis ClinVar
Show/Hide Text Mining Associations (72)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32603557
Adenoma Stimulate 17160410
Anemia Associate 21107304
Anemia Hemolytic Associate 20350312
Arthritis Juvenile Associate 20647273
Asthma Associate 28600552
Behcet Syndrome Associate 25799145, 27548383, 32518111, 33393726
Breast Neoplasms Inhibit 31552680
Carcinoma Hepatocellular Associate 26631030
Carcinoma Non Small Cell Lung Associate 25597281