Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	3589
Gene name	Interleukin 11
Gene symbol	IL11
Synonyms (NCBI Gene)	AGIFIL-11
Chromosome	19
Chromosome location	19q13.42
Summary	The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cy

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005829	hsa-miR-204-5p	ELISAMicroarray	21282569
MIRT005829	hsa-miR-204-5p	Luciferase reporter assay	22629385
MIRT007023	hsa-miR-211-5p	Luciferase reporter assay	22629385
MIRT007025	hsa-miR-379-5p	Luciferase reporter assay	22629385
MIRT022448	hsa-miR-124-3p	Microarray	18668037
MIRT023653	hsa-miR-1-3p	Microarray	18668037
0	hsa-miR-30c-5p	ImmunofluorescenceLuciferase reporter assayWestern blotqRT-PCR	23340433
MIRT053027	hsa-miR-30c-5p	ImmunofluorescenceLuciferase reporter assayWestern blotqRT-PCR	23340433
MIRT007023	hsa-miR-211-5p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	24039954
MIRT023653	hsa-miR-1-3p	Western blot	28186993
MIRT005829	hsa-miR-204-5p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCR	31544245
MIRT1063545	hsa-miR-106a	CLIP-seq
MIRT1063546	hsa-miR-106b	CLIP-seq
MIRT1063547	hsa-miR-10a	CLIP-seq
MIRT1063548	hsa-miR-10b	CLIP-seq
MIRT1063549	hsa-miR-1273e	CLIP-seq
MIRT1063550	hsa-miR-150	CLIP-seq
MIRT1063551	hsa-miR-17	CLIP-seq
MIRT1063552	hsa-miR-1827	CLIP-seq
MIRT1063553	hsa-miR-192	CLIP-seq
MIRT1063554	hsa-miR-20a	CLIP-seq
MIRT1063555	hsa-miR-20b	CLIP-seq
MIRT1063556	hsa-miR-215	CLIP-seq
MIRT1063557	hsa-miR-2964a-3p	CLIP-seq
MIRT1063558	hsa-miR-302f	CLIP-seq
MIRT1063559	hsa-miR-3122	CLIP-seq
MIRT1063560	hsa-miR-3135	CLIP-seq
MIRT1063561	hsa-miR-3152-5p	CLIP-seq
MIRT1063562	hsa-miR-3200-3p	CLIP-seq
MIRT1063563	hsa-miR-339-5p	CLIP-seq
MIRT1063564	hsa-miR-3622a-3p	CLIP-seq
MIRT1063565	hsa-miR-3622b-3p	CLIP-seq
MIRT1063566	hsa-miR-3689a-3p	CLIP-seq
MIRT1063567	hsa-miR-3689c	CLIP-seq
MIRT1063568	hsa-miR-3689d	CLIP-seq
MIRT1063569	hsa-miR-3913-5p	CLIP-seq
MIRT1063570	hsa-miR-3926	CLIP-seq
MIRT1063571	hsa-miR-4330	CLIP-seq
MIRT1063572	hsa-miR-4421	CLIP-seq
MIRT1063573	hsa-miR-4433	CLIP-seq
MIRT1063574	hsa-miR-4459	CLIP-seq
MIRT1063575	hsa-miR-4684-5p	CLIP-seq
MIRT1063576	hsa-miR-4722-5p	CLIP-seq
MIRT1063577	hsa-miR-4728-5p	CLIP-seq
MIRT1063578	hsa-miR-4755-3p	CLIP-seq
MIRT1063579	hsa-miR-4768-3p	CLIP-seq
MIRT1063580	hsa-miR-4793-3p	CLIP-seq
MIRT1063581	hsa-miR-508-5p	CLIP-seq
MIRT1063582	hsa-miR-519d	CLIP-seq
MIRT1063583	hsa-miR-520g	CLIP-seq
MIRT1063584	hsa-miR-520h	CLIP-seq
MIRT1063585	hsa-miR-544b	CLIP-seq
MIRT1063586	hsa-miR-548s	CLIP-seq
MIRT1063587	hsa-miR-593	CLIP-seq
MIRT1063588	hsa-miR-766	CLIP-seq
MIRT1063589	hsa-miR-93	CLIP-seq
MIRT1063590	hsa-miR-940	CLIP-seq
MIRT1063550	hsa-miR-150	CLIP-seq
MIRT1063583	hsa-miR-520g	CLIP-seq
MIRT1063584	hsa-miR-520h	CLIP-seq
MIRT1063545	hsa-miR-106a	CLIP-seq
MIRT1063546	hsa-miR-106b	CLIP-seq
MIRT1063550	hsa-miR-150	CLIP-seq
MIRT1063551	hsa-miR-17	CLIP-seq
MIRT1063554	hsa-miR-20a	CLIP-seq
MIRT1063555	hsa-miR-20b	CLIP-seq
MIRT1063582	hsa-miR-519d	CLIP-seq
MIRT1063583	hsa-miR-520g	CLIP-seq
MIRT1063584	hsa-miR-520h	CLIP-seq
MIRT1063589	hsa-miR-93	CLIP-seq
MIRT1063545	hsa-miR-106a	CLIP-seq
MIRT1063546	hsa-miR-106b	CLIP-seq
MIRT1063550	hsa-miR-150	CLIP-seq
MIRT1063551	hsa-miR-17	CLIP-seq
MIRT1063554	hsa-miR-20a	CLIP-seq
MIRT1063555	hsa-miR-20b	CLIP-seq
MIRT1063582	hsa-miR-519d	CLIP-seq
MIRT1063583	hsa-miR-520g	CLIP-seq
MIRT1063584	hsa-miR-520h	CLIP-seq
MIRT1063589	hsa-miR-93	CLIP-seq
MIRT1063545	hsa-miR-106a	CLIP-seq
MIRT1063546	hsa-miR-106b	CLIP-seq
MIRT1063550	hsa-miR-150	CLIP-seq
MIRT1063551	hsa-miR-17	CLIP-seq
MIRT1063554	hsa-miR-20a	CLIP-seq
MIRT1063555	hsa-miR-20b	CLIP-seq
MIRT1063582	hsa-miR-519d	CLIP-seq
MIRT1063583	hsa-miR-520g	CLIP-seq
MIRT1063584	hsa-miR-520h	CLIP-seq
MIRT1063589	hsa-miR-93	CLIP-seq
MIRT1063545	hsa-miR-106a	CLIP-seq
MIRT1063546	hsa-miR-106b	CLIP-seq
MIRT1063549	hsa-miR-1273e	CLIP-seq
MIRT2015019	hsa-miR-1289	CLIP-seq
MIRT2015020	hsa-miR-1324	CLIP-seq
MIRT1063550	hsa-miR-150	CLIP-seq
MIRT1063551	hsa-miR-17	CLIP-seq
MIRT1063552	hsa-miR-1827	CLIP-seq
MIRT1063554	hsa-miR-20a	CLIP-seq
MIRT1063555	hsa-miR-20b	CLIP-seq
MIRT1063557	hsa-miR-2964a-3p	CLIP-seq
MIRT1063558	hsa-miR-302f	CLIP-seq
MIRT1063559	hsa-miR-3122	CLIP-seq
MIRT1063560	hsa-miR-3135	CLIP-seq
MIRT1063564	hsa-miR-3622a-3p	CLIP-seq
MIRT1063565	hsa-miR-3622b-3p	CLIP-seq
MIRT1063566	hsa-miR-3689a-3p	CLIP-seq
MIRT1063567	hsa-miR-3689c	CLIP-seq
MIRT1063568	hsa-miR-3689d	CLIP-seq
MIRT1063569	hsa-miR-3913-5p	CLIP-seq
MIRT1063573	hsa-miR-4433	CLIP-seq
MIRT1063574	hsa-miR-4459	CLIP-seq
MIRT1063576	hsa-miR-4722-5p	CLIP-seq
MIRT1063577	hsa-miR-4728-5p	CLIP-seq
MIRT1063578	hsa-miR-4755-3p	CLIP-seq
MIRT1063579	hsa-miR-4768-3p	CLIP-seq
MIRT1063580	hsa-miR-4793-3p	CLIP-seq
MIRT1063581	hsa-miR-508-5p	CLIP-seq
MIRT1063582	hsa-miR-519d	CLIP-seq
MIRT1063583	hsa-miR-520g	CLIP-seq
MIRT1063584	hsa-miR-520h	CLIP-seq
MIRT1063585	hsa-miR-544b	CLIP-seq
MIRT1063587	hsa-miR-593	CLIP-seq
MIRT2015021	hsa-miR-665	CLIP-seq
MIRT1063588	hsa-miR-766	CLIP-seq
MIRT1063589	hsa-miR-93	CLIP-seq
MIRT1063590	hsa-miR-940	CLIP-seq
MIRT1063545	hsa-miR-106a	CLIP-seq
MIRT1063546	hsa-miR-106b	CLIP-seq
MIRT1063549	hsa-miR-1273e	CLIP-seq
MIRT1063550	hsa-miR-150	CLIP-seq
MIRT1063551	hsa-miR-17	CLIP-seq
MIRT1063552	hsa-miR-1827	CLIP-seq
MIRT1063554	hsa-miR-20a	CLIP-seq
MIRT1063555	hsa-miR-20b	CLIP-seq
MIRT1063557	hsa-miR-2964a-3p	CLIP-seq
MIRT1063558	hsa-miR-302f	CLIP-seq
MIRT2247347	hsa-miR-3119	CLIP-seq
MIRT1063559	hsa-miR-3122	CLIP-seq
MIRT1063560	hsa-miR-3135	CLIP-seq
MIRT2247348	hsa-miR-3610	CLIP-seq
MIRT1063564	hsa-miR-3622a-3p	CLIP-seq
MIRT1063565	hsa-miR-3622b-3p	CLIP-seq
MIRT1063566	hsa-miR-3689a-3p	CLIP-seq
MIRT1063567	hsa-miR-3689c	CLIP-seq
MIRT1063568	hsa-miR-3689d	CLIP-seq
MIRT1063569	hsa-miR-3913-5p	CLIP-seq
MIRT1063570	hsa-miR-3926	CLIP-seq
MIRT2247349	hsa-miR-3929	CLIP-seq
MIRT2247350	hsa-miR-4419b	CLIP-seq
MIRT1063573	hsa-miR-4433	CLIP-seq
MIRT1063574	hsa-miR-4459	CLIP-seq
MIRT2247351	hsa-miR-4478	CLIP-seq
MIRT2247352	hsa-miR-4649-3p	CLIP-seq
MIRT1063576	hsa-miR-4722-5p	CLIP-seq
MIRT1063577	hsa-miR-4728-5p	CLIP-seq
MIRT1063579	hsa-miR-4768-3p	CLIP-seq
MIRT1063580	hsa-miR-4793-3p	CLIP-seq
MIRT2247353	hsa-miR-485-5p	CLIP-seq
MIRT1063581	hsa-miR-508-5p	CLIP-seq
MIRT1063582	hsa-miR-519d	CLIP-seq
MIRT1063583	hsa-miR-520g	CLIP-seq
MIRT1063584	hsa-miR-520h	CLIP-seq
MIRT1063585	hsa-miR-544b	CLIP-seq
MIRT1063586	hsa-miR-548s	CLIP-seq
MIRT1063588	hsa-miR-766	CLIP-seq
MIRT1063589	hsa-miR-93	CLIP-seq
MIRT1063590	hsa-miR-940	CLIP-seq
MIRT1063545	hsa-miR-106a	CLIP-seq
MIRT1063546	hsa-miR-106b	CLIP-seq
MIRT1063549	hsa-miR-1273e	CLIP-seq
MIRT1063550	hsa-miR-150	CLIP-seq
MIRT1063551	hsa-miR-17	CLIP-seq
MIRT1063552	hsa-miR-1827	CLIP-seq
MIRT1063554	hsa-miR-20a	CLIP-seq
MIRT1063555	hsa-miR-20b	CLIP-seq
MIRT1063557	hsa-miR-2964a-3p	CLIP-seq
MIRT1063558	hsa-miR-302f	CLIP-seq
MIRT1063560	hsa-miR-3135	CLIP-seq
MIRT1063561	hsa-miR-3152-5p	CLIP-seq
MIRT1063564	hsa-miR-3622a-3p	CLIP-seq
MIRT1063565	hsa-miR-3622b-3p	CLIP-seq
MIRT1063568	hsa-miR-3689d	CLIP-seq
MIRT2247349	hsa-miR-3929	CLIP-seq
MIRT2247350	hsa-miR-4419b	CLIP-seq
MIRT1063573	hsa-miR-4433	CLIP-seq
MIRT1063574	hsa-miR-4459	CLIP-seq
MIRT2247351	hsa-miR-4478	CLIP-seq
MIRT2247352	hsa-miR-4649-3p	CLIP-seq
MIRT1063576	hsa-miR-4722-5p	CLIP-seq
MIRT1063579	hsa-miR-4768-3p	CLIP-seq
MIRT1063580	hsa-miR-4793-3p	CLIP-seq
MIRT2247353	hsa-miR-485-5p	CLIP-seq
MIRT1063581	hsa-miR-508-5p	CLIP-seq
MIRT1063582	hsa-miR-519d	CLIP-seq
MIRT1063583	hsa-miR-520g	CLIP-seq
MIRT1063584	hsa-miR-520h	CLIP-seq
MIRT1063585	hsa-miR-544b	CLIP-seq
MIRT1063588	hsa-miR-766	CLIP-seq
MIRT1063589	hsa-miR-93	CLIP-seq
MIRT1063590	hsa-miR-940	CLIP-seq
MIRT2451696	hsa-miR-1228	CLIP-seq
MIRT1063552	hsa-miR-1827	CLIP-seq
MIRT1063559	hsa-miR-3122	CLIP-seq
MIRT1063560	hsa-miR-3135	CLIP-seq
MIRT2451697	hsa-miR-3613-3p	CLIP-seq
MIRT1063566	hsa-miR-3689a-3p	CLIP-seq
MIRT1063567	hsa-miR-3689c	CLIP-seq
MIRT2451698	hsa-miR-371-5p	CLIP-seq
MIRT2451699	hsa-miR-371b-5p	CLIP-seq
MIRT1063569	hsa-miR-3913-5p	CLIP-seq
MIRT1063574	hsa-miR-4459	CLIP-seq
MIRT1063576	hsa-miR-4722-5p	CLIP-seq
MIRT1063577	hsa-miR-4728-5p	CLIP-seq
MIRT1063580	hsa-miR-4793-3p	CLIP-seq
MIRT2451700	hsa-miR-495	CLIP-seq
MIRT1063581	hsa-miR-508-5p	CLIP-seq
MIRT1063588	hsa-miR-766	CLIP-seq
MIRT1063590	hsa-miR-940	CLIP-seq
MIRT2451696	hsa-miR-1228	CLIP-seq
MIRT1063549	hsa-miR-1273e	CLIP-seq
MIRT1063552	hsa-miR-1827	CLIP-seq
MIRT1063557	hsa-miR-2964a-3p	CLIP-seq
MIRT1063558	hsa-miR-302f	CLIP-seq
MIRT1063559	hsa-miR-3122	CLIP-seq
MIRT1063560	hsa-miR-3135	CLIP-seq
MIRT2451697	hsa-miR-3613-3p	CLIP-seq
MIRT1063564	hsa-miR-3622a-3p	CLIP-seq
MIRT1063565	hsa-miR-3622b-3p	CLIP-seq
MIRT1063566	hsa-miR-3689a-3p	CLIP-seq
MIRT1063567	hsa-miR-3689c	CLIP-seq
MIRT1063568	hsa-miR-3689d	CLIP-seq
MIRT2451698	hsa-miR-371-5p	CLIP-seq
MIRT2451699	hsa-miR-371b-5p	CLIP-seq
MIRT1063569	hsa-miR-3913-5p	CLIP-seq
MIRT1063574	hsa-miR-4459	CLIP-seq
MIRT2550758	hsa-miR-4497	CLIP-seq
MIRT1063576	hsa-miR-4722-5p	CLIP-seq
MIRT1063577	hsa-miR-4728-5p	CLIP-seq
MIRT1063579	hsa-miR-4768-3p	CLIP-seq
MIRT1063580	hsa-miR-4793-3p	CLIP-seq
MIRT1063581	hsa-miR-508-5p	CLIP-seq
MIRT1063585	hsa-miR-544b	CLIP-seq
MIRT1063588	hsa-miR-766	CLIP-seq
MIRT1063590	hsa-miR-940	CLIP-seq
MIRT2451696	hsa-miR-1228	CLIP-seq
MIRT1063549	hsa-miR-1273e	CLIP-seq
MIRT1063552	hsa-miR-1827	CLIP-seq
MIRT1063557	hsa-miR-2964a-3p	CLIP-seq
MIRT1063558	hsa-miR-302f	CLIP-seq
MIRT1063559	hsa-miR-3122	CLIP-seq
MIRT1063560	hsa-miR-3135	CLIP-seq
MIRT2451697	hsa-miR-3613-3p	CLIP-seq
MIRT1063564	hsa-miR-3622a-3p	CLIP-seq
MIRT1063565	hsa-miR-3622b-3p	CLIP-seq
MIRT1063566	hsa-miR-3689a-3p	CLIP-seq
MIRT1063567	hsa-miR-3689c	CLIP-seq
MIRT1063568	hsa-miR-3689d	CLIP-seq
MIRT2451698	hsa-miR-371-5p	CLIP-seq
MIRT2451699	hsa-miR-371b-5p	CLIP-seq
MIRT1063569	hsa-miR-3913-5p	CLIP-seq
MIRT1063573	hsa-miR-4433	CLIP-seq
MIRT1063574	hsa-miR-4459	CLIP-seq
MIRT2550758	hsa-miR-4497	CLIP-seq
MIRT2682725	hsa-miR-4667-3p	CLIP-seq
MIRT1063576	hsa-miR-4722-5p	CLIP-seq
MIRT1063577	hsa-miR-4728-5p	CLIP-seq
MIRT1063579	hsa-miR-4768-3p	CLIP-seq
MIRT1063580	hsa-miR-4793-3p	CLIP-seq
MIRT2451700	hsa-miR-495	CLIP-seq
MIRT1063581	hsa-miR-508-5p	CLIP-seq
MIRT1063585	hsa-miR-544b	CLIP-seq
MIRT1063588	hsa-miR-766	CLIP-seq
MIRT1063590	hsa-miR-940	CLIP-seq

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Transcription factor	Regulation	Reference
HOXA10	Repression	20478621
STAT3	Unknown	23224145

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IDA	33397952
GO:0005125	Function	Cytokine activity	IEA
GO:0005142	Function	Interleukin-11 receptor binding	IEA
GO:0005142	Function	Interleukin-11 receptor binding	NAS	2145578
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 26551460, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	33397952
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0008083	Function	Growth factor activity	IBA
GO:0008083	Function	Growth factor activity	IDA	2145578
GO:0008083	Function	Growth factor activity	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	2145578
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0030183	Process	B cell differentiation	NAS	2145578
GO:0030219	Process	Megakaryocyte differentiation	NAS	2145578
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IDA	7508917
GO:0038154	Process	Interleukin-11-mediated signaling pathway	IDA	33397952
GO:0043410	Process	Positive regulation of MAPK cascade	IBA
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	7508917
GO:0045444	Process	Fat cell differentiation	NAS	1828438
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	7508917
GO:0046888	Process	Negative regulation of hormone secretion	IDA	7867561
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	7508917
GO:1903659	Process	Regulation of complement-dependent cytotoxicity	IMP	16034134
GO:2000352	Process	Negative regulation of endothelial cell apoptotic process	IMP	16034134

MIM	HGNC	e!Ensembl
147681	5966	ENSG00000095752

P20809

Protein name

Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin)

Protein function

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepato

PDB

4MHL , 6O4O , 8DPS , 8DPT , 8DPU , 8DPV , 8DPW , 8QY4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07400	IL11	26 → 199	Interleukin 11	Domain

Sequence

MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQL
RDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLK
TLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGG
LHLTLDWAVRGLLLLKTRL

Sequence length

199

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Hematopoietic cell lineage Rheumatoid arthritis		IL-6-type cytokine receptor ligand interactions

IL11 (interleukin 11)