Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3589
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL11
Synonyms (NCBI Gene) Gene synonyms aliases
AGIF, IL-11
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.42
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cy
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005829 hsa-miR-204-5p ELISA, Microarray 21282569
MIRT005829 hsa-miR-204-5p Luciferase reporter assay 22629385
MIRT007023 hsa-miR-211-5p Luciferase reporter assay 22629385
MIRT007025 hsa-miR-379-5p Luciferase reporter assay 22629385
MIRT022448 hsa-miR-124-3p Microarray 18668037
Transcription factors
Transcription factor Regulation Reference
HOXA10 Repression 20478621
STAT3 Unknown 23224145
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IBA 21873635
GO:0005142 Function Interleukin-11 receptor binding NAS 2145578
GO:0005515 Function Protein binding IPI 16189514, 25416956, 26551460, 32296183
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147681 5966 ENSG00000095752
Protein
UniProt ID P20809
Protein name Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin)
Protein function Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepato
PDB 4MHL , 6O4O , 8DPS , 8DPT , 8DPU , 8DPV , 8DPW , 8QY4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07400 IL11 26 199 Interleukin 11 Domain
Sequence
Sequence length 199
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
Hematopoietic cell lineage
Rheumatoid arthritis
  IL-6-type cytokine receptor ligand interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Craniosynostosis and dental anomalies CRANIOSYNOSTOSIS AND DENTAL ANOMALIES rs387906784, rs387906785, rs387906786, rs387906787 21741611
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 24002086 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Acro Osteolysis Associate 21099351, 25808168
Adenocarcinoma Associate 27524264, 32869505
Adenocarcinoma of Lung Associate 27524264, 34497605
Adenoma Associate 16482637
Arthritis Rheumatoid Associate 10632674, 10926858, 22355377, 29327326, 39879889, 9566801
Asthma Associate 12079505, 19251839, 26876177
Autoimmune Diseases Associate 35273577
Bone Diseases Associate 22629385, 25808168, 28143986
Bone Marrow Diseases Associate 37626330
Bone Resorption Associate 34360848