Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3588
Gene name Gene Name - the full gene name approved by the HGNC.	Interleukin 10 receptor subunit beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IL10RB
Synonyms (NCBI Gene) Gene synonyms aliases	CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IBD25, IL-10R2, IL-10RB
Disease Acronyms (UniProt) Disease acronyms from UniProt database	IBD25
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.11
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal tra

Show/Hide all(7)

SNP ID	Visualize variation	Clinical significance	Consequence
rs2834167	A>G,T	Benign, risk-factor	Missense variant, coding sequence variant, stop gained
rs45545138	G>A	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs121909601	G>A	Pathogenic	Coding sequence variant, stop gained
rs387907326	G>A,T	Pathogenic	Stop gained, missense variant, coding sequence variant
rs778708008	T>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1329427406	G>A	Likely-pathogenic	Coding sequence variant, stop gained
rs1373354533	G>A	Pathogenic	Stop gained, coding sequence variant

Show/Hide all(219)

miRTarBase ID	miRNA	Experiments	Reference
MIRT679405	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT620783	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT679404	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT679403	hsa-miR-4770	HITS-CLIP	23824327
MIRT679402	hsa-miR-6088	HITS-CLIP	23824327
MIRT679401	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT679400	hsa-miR-1273f	HITS-CLIP	23824327
MIRT679399	hsa-miR-4534	HITS-CLIP	23824327
MIRT679398	hsa-miR-8082	HITS-CLIP	23824327
MIRT679397	hsa-miR-1289	HITS-CLIP	23824327
MIRT679396	hsa-miR-4294	HITS-CLIP	23824327
MIRT679395	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT679394	hsa-miR-3198	HITS-CLIP	23824327
MIRT679393	hsa-miR-4309	HITS-CLIP	23824327
MIRT679392	hsa-miR-8055	HITS-CLIP	23824327
MIRT679391	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT620786	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT648717	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT648716	hsa-miR-4532	HITS-CLIP	23824327
MIRT620785	hsa-miR-5193	HITS-CLIP	23824327
MIRT620784	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT648715	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT620783	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT648714	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT648713	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT620782	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT648712	hsa-miR-4284	HITS-CLIP	23824327
MIRT620781	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620786	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT620785	hsa-miR-5193	HITS-CLIP	23824327
MIRT620784	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620783	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT620782	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT620781	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT679400	hsa-miR-1273f	HITS-CLIP	27418678
MIRT679397	hsa-miR-1289	HITS-CLIP	27418678
MIRT679391	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT620783	hsa-miR-1304-3p	HITS-CLIP	27418678
MIRT679404	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT679394	hsa-miR-3198	HITS-CLIP	27418678
MIRT679396	hsa-miR-4294	HITS-CLIP	27418678
MIRT679393	hsa-miR-4309	HITS-CLIP	27418678
MIRT679399	hsa-miR-4534	HITS-CLIP	27418678
MIRT679401	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT679403	hsa-miR-4770	HITS-CLIP	27418678
MIRT679402	hsa-miR-6088	HITS-CLIP	27418678
MIRT679405	hsa-miR-6514-5p	HITS-CLIP	27418678
MIRT679392	hsa-miR-8055	HITS-CLIP	27418678
MIRT679398	hsa-miR-8082	HITS-CLIP	27418678
MIRT679405	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT620783	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT679404	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT679403	hsa-miR-4770	HITS-CLIP	23824327
MIRT679402	hsa-miR-6088	HITS-CLIP	23824327
MIRT679401	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT679400	hsa-miR-1273f	HITS-CLIP	23824327
MIRT679399	hsa-miR-4534	HITS-CLIP	23824327
MIRT679398	hsa-miR-8082	HITS-CLIP	23824327
MIRT679397	hsa-miR-1289	HITS-CLIP	23824327
MIRT679396	hsa-miR-4294	HITS-CLIP	23824327
MIRT679395	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT679394	hsa-miR-3198	HITS-CLIP	23824327
MIRT679393	hsa-miR-4309	HITS-CLIP	23824327
MIRT679392	hsa-miR-8055	HITS-CLIP	23824327
MIRT679391	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT620786	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT648717	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT648716	hsa-miR-4532	HITS-CLIP	23824327
MIRT620785	hsa-miR-5193	HITS-CLIP	23824327
MIRT620784	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT648715	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT620783	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT648714	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT648713	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT620782	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT648712	hsa-miR-4284	HITS-CLIP	23824327
MIRT620781	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620786	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT620785	hsa-miR-5193	HITS-CLIP	23824327
MIRT620784	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620783	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT620782	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT620781	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT1063505	hsa-miR-103a	CLIP-seq
MIRT1063506	hsa-miR-107	CLIP-seq
MIRT1063507	hsa-miR-1206	CLIP-seq
MIRT1063508	hsa-miR-122	CLIP-seq
MIRT1063509	hsa-miR-1226	CLIP-seq
MIRT1063510	hsa-miR-1279	CLIP-seq
MIRT1063511	hsa-miR-136	CLIP-seq
MIRT1063512	hsa-miR-15a	CLIP-seq
MIRT1063513	hsa-miR-15b	CLIP-seq
MIRT1063514	hsa-miR-16	CLIP-seq
MIRT1063515	hsa-miR-194	CLIP-seq
MIRT1063516	hsa-miR-195	CLIP-seq
MIRT1063517	hsa-miR-197	CLIP-seq
MIRT1063518	hsa-miR-29a	CLIP-seq
MIRT1063519	hsa-miR-29b	CLIP-seq
MIRT1063520	hsa-miR-29c	CLIP-seq
MIRT1063521	hsa-miR-3135b	CLIP-seq
MIRT1063522	hsa-miR-3149	CLIP-seq
MIRT1063523	hsa-miR-3187-3p	CLIP-seq
MIRT1063524	hsa-miR-3545-3p	CLIP-seq
MIRT1063525	hsa-miR-3652	CLIP-seq
MIRT1063526	hsa-miR-3663-3p	CLIP-seq
MIRT1063527	hsa-miR-3663-5p	CLIP-seq
MIRT1063528	hsa-miR-371-3p	CLIP-seq
MIRT1063529	hsa-miR-411	CLIP-seq
MIRT1063530	hsa-miR-424	CLIP-seq
MIRT1063531	hsa-miR-4430	CLIP-seq
MIRT1063532	hsa-miR-4435	CLIP-seq
MIRT1063533	hsa-miR-4463	CLIP-seq
MIRT1063534	hsa-miR-4530	CLIP-seq
MIRT1063535	hsa-miR-4635	CLIP-seq
MIRT1063536	hsa-miR-4680-5p	CLIP-seq
MIRT1063537	hsa-miR-4701-5p	CLIP-seq
MIRT1063538	hsa-miR-4755-3p	CLIP-seq
MIRT1063539	hsa-miR-497	CLIP-seq
MIRT1063540	hsa-miR-5096	CLIP-seq
MIRT1063541	hsa-miR-548s	CLIP-seq
MIRT1063542	hsa-miR-588	CLIP-seq
MIRT1063543	hsa-miR-629	CLIP-seq
MIRT1063544	hsa-miR-634	CLIP-seq
MIRT2014995	hsa-miR-1182	CLIP-seq
MIRT1063508	hsa-miR-122	CLIP-seq
MIRT2014996	hsa-miR-1245	CLIP-seq
MIRT1063510	hsa-miR-1279	CLIP-seq
MIRT1063517	hsa-miR-197	CLIP-seq
MIRT2014997	hsa-miR-1976	CLIP-seq
MIRT2014998	hsa-miR-299-3p	CLIP-seq
MIRT1063521	hsa-miR-3135b	CLIP-seq
MIRT2014999	hsa-miR-3168	CLIP-seq
MIRT2015000	hsa-miR-3192	CLIP-seq
MIRT1063524	hsa-miR-3545-3p	CLIP-seq
MIRT1063525	hsa-miR-3652	CLIP-seq
MIRT1063527	hsa-miR-3663-5p	CLIP-seq
MIRT1063528	hsa-miR-371-3p	CLIP-seq
MIRT2015001	hsa-miR-4269	CLIP-seq
MIRT2015002	hsa-miR-4279	CLIP-seq
MIRT2015003	hsa-miR-4314	CLIP-seq
MIRT1063531	hsa-miR-4430	CLIP-seq
MIRT1063532	hsa-miR-4435	CLIP-seq
MIRT2015004	hsa-miR-4454	CLIP-seq
MIRT2015005	hsa-miR-4514	CLIP-seq
MIRT1063535	hsa-miR-4635	CLIP-seq
MIRT2015006	hsa-miR-4646-5p	CLIP-seq
MIRT2015007	hsa-miR-4650-3p	CLIP-seq
MIRT1063536	hsa-miR-4680-5p	CLIP-seq
MIRT2015008	hsa-miR-4692	CLIP-seq
MIRT2015009	hsa-miR-4722-3p	CLIP-seq
MIRT2015010	hsa-miR-4742-5p	CLIP-seq
MIRT1063538	hsa-miR-4755-3p	CLIP-seq
MIRT2015011	hsa-miR-4763-5p	CLIP-seq
MIRT2015012	hsa-miR-4777-5p	CLIP-seq
MIRT1063540	hsa-miR-5096	CLIP-seq
MIRT2015013	hsa-miR-518d-5p	CLIP-seq
MIRT2015014	hsa-miR-519b-5p	CLIP-seq
MIRT2015015	hsa-miR-519c-5p	CLIP-seq
MIRT2015016	hsa-miR-520c-5p	CLIP-seq
MIRT2015017	hsa-miR-526a	CLIP-seq
MIRT2015018	hsa-miR-576-3p	CLIP-seq
MIRT1063543	hsa-miR-629	CLIP-seq
MIRT1063508	hsa-miR-122	CLIP-seq
MIRT2247344	hsa-miR-1291	CLIP-seq
MIRT2247345	hsa-miR-1307	CLIP-seq
MIRT1063521	hsa-miR-3135b	CLIP-seq
MIRT2247346	hsa-miR-328	CLIP-seq
MIRT1063525	hsa-miR-3652	CLIP-seq
MIRT1063528	hsa-miR-371-3p	CLIP-seq
MIRT1063531	hsa-miR-4430	CLIP-seq
MIRT2247344	hsa-miR-1291	CLIP-seq
MIRT2247345	hsa-miR-1307	CLIP-seq
MIRT2247346	hsa-miR-328	CLIP-seq
MIRT2451692	hsa-miR-3135	CLIP-seq
MIRT1063522	hsa-miR-3149	CLIP-seq
MIRT1063529	hsa-miR-411	CLIP-seq
MIRT1063533	hsa-miR-4463	CLIP-seq
MIRT2451693	hsa-miR-4735-5p	CLIP-seq
MIRT2451694	hsa-miR-4775	CLIP-seq
MIRT2451695	hsa-miR-590-3p	CLIP-seq
MIRT2451692	hsa-miR-3135	CLIP-seq
MIRT1063522	hsa-miR-3149	CLIP-seq
MIRT1063529	hsa-miR-411	CLIP-seq
MIRT2451693	hsa-miR-4735-5p	CLIP-seq
MIRT2451694	hsa-miR-4775	CLIP-seq
MIRT2451695	hsa-miR-590-3p	CLIP-seq
MIRT1063507	hsa-miR-1206	CLIP-seq
MIRT2014997	hsa-miR-1976	CLIP-seq
MIRT2451692	hsa-miR-3135	CLIP-seq
MIRT1063522	hsa-miR-3149	CLIP-seq
MIRT1063529	hsa-miR-411	CLIP-seq
MIRT2015001	hsa-miR-4269	CLIP-seq
MIRT2015002	hsa-miR-4279	CLIP-seq
MIRT1063533	hsa-miR-4463	CLIP-seq
MIRT2015005	hsa-miR-4514	CLIP-seq
MIRT2015008	hsa-miR-4692	CLIP-seq
MIRT2015009	hsa-miR-4722-3p	CLIP-seq
MIRT2451693	hsa-miR-4735-5p	CLIP-seq
MIRT2015010	hsa-miR-4742-5p	CLIP-seq
MIRT2451694	hsa-miR-4775	CLIP-seq
MIRT2550757	hsa-miR-4787-3p	CLIP-seq
MIRT2451695	hsa-miR-590-3p	CLIP-seq
MIRT1063507	hsa-miR-1206	CLIP-seq
MIRT2014997	hsa-miR-1976	CLIP-seq
MIRT2451692	hsa-miR-3135	CLIP-seq
MIRT1063522	hsa-miR-3149	CLIP-seq
MIRT1063529	hsa-miR-411	CLIP-seq
MIRT2015001	hsa-miR-4269	CLIP-seq
MIRT2015002	hsa-miR-4279	CLIP-seq
MIRT1063533	hsa-miR-4463	CLIP-seq
MIRT2015005	hsa-miR-4514	CLIP-seq
MIRT2015008	hsa-miR-4692	CLIP-seq
MIRT2015009	hsa-miR-4722-3p	CLIP-seq
MIRT2451693	hsa-miR-4735-5p	CLIP-seq
MIRT2015010	hsa-miR-4742-5p	CLIP-seq
MIRT2451694	hsa-miR-4775	CLIP-seq
MIRT2550757	hsa-miR-4787-3p	CLIP-seq
MIRT2451695	hsa-miR-590-3p	CLIP-seq
MIRT1063543	hsa-miR-629	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004896	Function	Cytokine receptor activity	IBA	21873635
GO:0004920	Function	Interleukin-10 receptor activity	IBA	21873635
GO:0004920	Function	Interleukin-10 receptor activity	TAS	10954742
GO:0005515	Function	Protein binding	IPI	12483210, 12513909, 15120653, 16982608, 20462497
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	TAS	10954742
GO:0006955	Process	Immune response	TAS	9463407
GO:0007165	Process	Signal transduction	TAS	10954742
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0032002	Component	Interleukin-28 receptor complex	NAS	12483210
GO:0038023	Function	Signaling receptor activity	TAS	8314576
GO:0046427	Process	Positive regulation of receptor signaling pathway via JAK-STAT	IDA	16982608
GO:0051607	Process	Defense response to virus	IEA

MIM	HGNC	e!Ensembl
123889	5965	ENSG00000243646

Protein

UniProt ID

Q08334

Protein name

Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD an

Protein function

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The liga

PDB

3LQM , 5T5W , 6X93 , 9BPU , 9BPV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01108	Tissue_fac	2 → 100	Tissue factor	Family
PF09294	Interfer-bind	111 → 213	Interferon-alpha/beta receptor, fibronectin type III	Domain

Sequence

MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYR
IFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQV
EVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLRN
LEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMASVFMVCLALLG
CFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDENDVFDKLSVIAE
DSESGKQNPGDSCSLGTPPGQGPQS

Sequence length

325

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway Toxoplasmosis Tuberculosis Human cytomegalovirus infection		Other interleukin signaling Interleukin-10 signaling Interleukin-20 family signaling

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Inflammatory bowel disease	Inflammatory Bowel Diseases, INFLAMMATORY BOWEL DISEASE 25, AUTOSOMAL RECESSIVE	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	21519361, 27302973, 27336593, 22549091, 19890111

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Inflammatory Bowel Disease	inflammatory bowel disease 25	GenCC
Narcolepsy	Narcolepsy	GWAS
Multiple Sclerosis	Multiple Sclerosis	GWAS

Show/Hide Text Mining Associations (60)

Disease Name	Relationship Type	References
Associations from Text Mining
Acquired Immunodeficiency Syndrome	Associate	20976276
Adenocarcinoma of Lung	Associate	27058892
Adenomyosis	Associate	25337217
Arthritis	Associate	22550014
Arthritis Rheumatoid	Associate	24286242
Autoimmune Diseases	Associate	24023707
Behcet Syndrome	Stimulate	35455984
Breast Neoplasms	Associate	36475797
Carcinoma Non Small Cell Lung	Associate	37146414
Cerebral Hemorrhage	Associate	40404687
Cholelithiasis	Associate	39366640
Colitis	Associate	19890111
Colitis Ulcerative	Associate	24379584, 27350736
Common Variable Immunodeficiency	Associate	18254984
COVID 19	Associate	33246355, 33604698, 33837377, 33949668, 34799557, 35255492, 36127160, 37085563, 37442134, 37497655
Crohn Disease	Associate	22550014, 33595362
Depressive Disorder	Associate	23852407
Diabetes Mellitus Type 2	Associate	39202464
Disease	Associate	27302973
Disseminated Intravascular Coagulation	Associate	35255492
Down Syndrome	Associate	33260695
Drug Hypersensitivity	Associate	39202464
Elejalde Disease	Associate	35455984
Endometriosis	Stimulate	24133578
Enterocolitis	Associate	19890111
Fatigue	Associate	23852407
Graft vs Host Disease	Inhibit	16109775
Graft vs Host Disease	Associate	19409109
Heart Defects Congenital	Associate	33260695
Heart Diseases	Associate	33260695
Hepatitis B	Associate	16757563
HIV Infections	Associate	20976276
Inflammation	Associate	25056661, 26448050, 27665382, 39695715
Inflammatory Bowel Disease 25 Autosomal Recessive	Associate	27350736, 36308662, 37503744
Inflammatory Bowel Diseases	Associate	19890111, 27350736, 28785144, 31819956, 32925557, 36002022
Leprosy	Associate	24578538
Liver Failure	Associate	36308662
Liver Failure Acute	Associate	36308662
Lung Diseases	Associate	33246355
Lupus Erythematosus Systemic	Associate	37511050
Lymphoma B Cell	Associate	24089328, 26448050
Lymphoma Large B Cell Diffuse	Associate	24089328
Lymphoma Non Hodgkin	Associate	21418175
Melanoma	Associate	20103601, 36475797
Melanoma Cutaneous Malignant	Associate	19626699
Myocardial Ischemia	Associate	40429759
Narcolepsy	Associate	24204295, 32669953
Neoplasms	Associate	24023707, 25056661, 35874683, 36475797, 39769247
Neoplasms	Inhibit	27058892
Obesity	Associate	35205336
Ovarian Neoplasms	Associate	39972314
Overweight	Associate	35205336
Pancreatic Neoplasms	Associate	24419231, 38538250
Pancreatic Neoplasms	Stimulate	33062039
Polyps	Associate	37085563
Post Acute COVID 19 Syndrome	Inhibit	37497655
Primary Immunodeficiency Diseases	Associate	38644452
Prostatic Hyperplasia	Associate	21532858
Schizophrenia	Inhibit	30630651
Thymus Neoplasms	Associate	39769247

IL10RB (interleukin 10 receptor subunit beta)