CXCL8 (C-X-C motif chemokine ligand 8)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 3576
Gene name C-X-C motif chemokine ligand 8
Gene symbol CXCL8
Synonyms (NCBI Gene)
GCP-1GCP1IL8LECTLUCTLYNAPMDNCFMONAPNAFNAP-1NAP1SCYB8
Chromosome 4
Chromosome location 4q13.3
Summary The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, e
miRNA miRNA information provided by mirtarbase database.
11
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (11)
miRTarBase ID miRNA Experiments Reference
MIRT438087 hsa-miR-93-5p Luciferase reporter assayqRT-PCR 24433094
MIRT438087 hsa-miR-93-5p Luciferase reporter assayqRT-PCR 24433094
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
Transcription factors Transcription factors information provided by TRRUST V2 database.
39
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (39)
Transcription factor Regulation Reference
ATF4 Unknown 16931790
CEBPB Activation 15085176;15688424
CEBPB Unknown 11120852
DDIT3 Unknown 18772138
DEK Unknown 16829531
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
54
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (54)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis TAS 11483765
GO:0002237 Process Response to molecule of bacterial origin IDA 19912257
GO:0005125 Function Cytokine activity IEA
GO:0005153 Function Interleukin-8 receptor binding IPI 1840701
GO:0005515 Function Protein binding IPI 10880251, 22904195, 23597562, 24501198, 26829648, 28381538
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
146930 6025 ENSG00000169429
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P10145
Protein name Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Ne
Protein function Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activat
PDB 1ICW , 1IKL , 1IKM , 1IL8 , 1ILP , 1ILQ , 1QE6 , 1ROD , 2IL8 , 3IL8 , 4XDX , 5D14 , 5WDZ , 6LFM , 6LFO , 6N2U , 6WZM , 6XMN , 8IC0 , 8XWN , 8XX6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 32 → 92 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Sequence
Sequence length 99
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
NF-kappa B signaling pathway
Phospholipase D signaling pathway
Cellular senescence
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
IL-17 signaling pathway
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Alcoholic liver disease
Epithelial cell signaling in Helicobacter pylori infection
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pertussis
Legionellosis
Yersinia infection
Chagas disease
Malaria
Amoebiasis
Hepatitis B
Human cytomegalovirus infection
Influenza A
Kaposi sarcoma-associated herpesvirus infection
Coronavirus disease - COVID-19
Pathways in cancer
Transcriptional misregulation in cancer
Bladder cancer
Rheumatoid arthritis
Lipid and atherosclerosis 		  Senescence-Associated Secretory Phenotype (SASP)
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
ATF4 activates genes in response to endoplasmic reticulum stress
G alpha (i) signalling events
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cholangiocarcinoma other rs4073 RCV003312795
CXCL8-related disorder Likely benign rs188378669 RCV003922240
Show/Hide Text Mining Associations (986)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
3 Hydroxyacyl CoA Dehydrogenase Deficiency Stimulate 18653246
Abortion Habitual Associate 22505054
Abortion Spontaneous Associate 35090453
Abscess Stimulate 34539639
Abscess Associate 8178948
Acanthamoeba Keratitis Associate 33755043
Achlorhydria Associate 26045613
Achondrogenesis type 2 Associate 31277141
Acne Vulgaris Associate 16528362, 26547713, 31281837, 31662521
Acquired Immunodeficiency Syndrome Associate 10775602, 17360650, 20507572, 22664113