IL7 (interleukin 7)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3574
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL7
Synonyms (NCBI Gene) Gene synonyms aliases
IL-7, IMD130
Disease Acronyms (UniProt) Disease acronyms from UniProt database
IMD130
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.13
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs1486611027 T>A,C Risk-factor Coding sequence variant, stop gained, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(32)
miRTarBase ID miRNA Experiments Reference
MIRT018556 hsa-miR-335-5p Microarray 18185580
MIRT022978 hsa-miR-124-3p Microarray 18668037
MIRT024567 hsa-miR-215-5p Microarray 19074876
MIRT026781 hsa-miR-192-5p Microarray 19074876
MIRT447670 hsa-miR-513b-3p PAR-CLIP 22100165
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
MYB Activation 11675351
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(27)
GO ID Ontology Definition Evidence Reference
GO:0001961 Process Positive regulation of cytokine-mediated signaling pathway IDA 11418668
GO:0002360 Process T cell lineage commitment IEA
GO:0005125 Function Cytokine activity IDA 11418668
GO:0005139 Function Interleukin-7 receptor binding IEA
GO:0005515 Function Protein binding IPI 8266077, 19141282
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
146660 6023 ENSG00000104432
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P13232
Protein name Interleukin-7 (IL-7)
Protein function Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:25870237, Pu
PDB 3DI2 , 3DI3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01415 IL7 26 → 177 Interleukin 7 Domain
Sequence
Sequence length 177
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer 		  Interleukin-7 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Cafe-au-lait spot Cafe au lait spots, multiple rs1057518792, rs1555613206, rs1555608663
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259
Epidermodysplasia verruciformis Epidermodysplasia Verruciformis, Epidermodysplasia verruciformis rs121908330, rs121908327, rs121908329, rs769471844, rs1555655146, rs1567989416, rs1567997496, rs143773090, rs773779601, rs1598895511, rs1598923748, rs1486611027, rs1392702424, rs202217062 25981006
Multiple sclerosis Multiple Sclerosis, Multiple Sclerosis, Acute Fulminating rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039
View all (4 more)		 17660816
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Epidermodysplasia Verruciformis epidermodysplasia verruciformis, susceptibility to, 5, epidermodysplasia verruciformis GenCC
Show/Hide Text Mining Associations (193)
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 32647892
Acute On Chronic Liver Failure Associate 33584648
Allan Herndon Dudley syndrome Associate 24768357
Alzheimer Disease Associate 30193587, 33194959
Angina Unstable Inhibit 12871422
Arterial Occlusive Diseases Associate 33776989
Arthritis Infectious Associate 23053510
Arthritis Juvenile Associate 15939793
Arthritis Rheumatoid Associate 10403280, 12525379, 15642153, 17185327, 17665400, 19714586, 20465565, 21647866, 22355377, 23325887, 24740301, 26314565, 9691097
Arthritis Rheumatoid Inhibit 15642146, 25533722