Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	3567
Gene name	Interleukin 5
Gene symbol	IL5
Synonyms (NCBI Gene)	EDFIL-5TRF
Chromosome	5
Chromosome location	5q31.1
Summary	This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased producti

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017691	hsa-miR-335-5p	Microarray	18185580
MIRT039253	hsa-miR-454-5p	CLASH	23622248
MIRT719916	hsa-miR-3662	HITS-CLIP	19536157
MIRT719915	hsa-miR-8063	HITS-CLIP	19536157
MIRT719914	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT719913	hsa-miR-1248	HITS-CLIP	19536157
MIRT719912	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT719911	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT719910	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT719909	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT719908	hsa-miR-4279	HITS-CLIP	19536157
MIRT513556	hsa-miR-4772-3p	PAR-CLIP	23446348
MIRT513555	hsa-miR-9-5p	PAR-CLIP	23446348
MIRT513554	hsa-miR-604	PAR-CLIP	23446348
MIRT513553	hsa-miR-6762-3p	PAR-CLIP	23446348
MIRT513552	hsa-miR-647	PAR-CLIP	23446348
MIRT513550	hsa-miR-6842-3p	PAR-CLIP	23446348
MIRT513556	hsa-miR-4772-3p	PAR-CLIP	27292025
MIRT513556	hsa-miR-4772-3p	PAR-CLIP	27292025
MIRT513554	hsa-miR-604	PAR-CLIP	27292025
MIRT513554	hsa-miR-604	PAR-CLIP	27292025
MIRT513552	hsa-miR-647	PAR-CLIP	27292025
MIRT513552	hsa-miR-647	PAR-CLIP	27292025
MIRT513553	hsa-miR-6762-3p	PAR-CLIP	27292025
MIRT513553	hsa-miR-6762-3p	PAR-CLIP	27292025
MIRT513550	hsa-miR-6842-3p	PAR-CLIP	27292025
MIRT513550	hsa-miR-6842-3p	PAR-CLIP	27292025
MIRT513555	hsa-miR-9-5p	PAR-CLIP	27292025
MIRT513555	hsa-miR-9-5p	PAR-CLIP	27292025
MIRT719916	hsa-miR-3662	HITS-CLIP	19536157
MIRT719915	hsa-miR-8063	HITS-CLIP	19536157
MIRT719914	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT719913	hsa-miR-1248	HITS-CLIP	19536157
MIRT719912	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT719911	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT719910	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT719909	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT719908	hsa-miR-4279	HITS-CLIP	19536157
MIRT513556	hsa-miR-4772-3p	PAR-CLIP	23446348
MIRT513555	hsa-miR-9-5p	PAR-CLIP	23446348
MIRT513554	hsa-miR-604	PAR-CLIP	23446348
MIRT513553	hsa-miR-6762-3p	PAR-CLIP	23446348
MIRT513552	hsa-miR-647	PAR-CLIP	23446348
MIRT513550	hsa-miR-6842-3p	PAR-CLIP	23446348
MIRT1064995	hsa-miR-4796-5p	CLIP-seq
MIRT2247760	hsa-miR-1229	CLIP-seq
MIRT2247761	hsa-miR-4418	CLIP-seq
MIRT2247762	hsa-miR-509-3-5p	CLIP-seq
MIRT2247763	hsa-miR-509-5p	CLIP-seq

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Transcription factor	Regulation	Reference
CEBPA	Unknown	10453008
CEBPB	Unknown	10453008
EP300	Unknown	16922677
ETS1	Activation	10212281
ETS2	Activation	10212281;19487701
FOSL2	Unknown	10491186
GATA3	Activation	10212281
GATA3	Unknown	16498264;17270283;20522714
GATA4	Activation	7791790;9209438
HDAC4	Unknown	16922677
JUND	Unknown	10491186
MAF	Unknown	16498264
POU2F1	Unknown	10491186
POU2F2	Unknown	10491186
SATB1	Repression	20522714
SPI1	Activation	19487701
YY1	Activation	10518827
YY1	Unknown	17270283

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002639	Process	Positive regulation of immunoglobulin production	IEA
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IDA	33099778
GO:0005125	Function	Cytokine activity	IEA
GO:0005137	Function	Interleukin-5 receptor binding	IEA
GO:0005137	Function	Interleukin-5 receptor binding	TAS	3024129
GO:0005515	Function	Protein binding	IPI	1495999, 22153509
GO:0005576	Component	Extracellular region	IDA	20041150
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	33099778
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	3024129
GO:0006954	Process	Inflammatory response	TAS	3498940
GO:0006955	Process	Immune response	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0030222	Process	Eosinophil differentiation	IDA	11823534
GO:0030890	Process	Positive regulation of B cell proliferation	IEA
GO:0038043	Process	Interleukin-5-mediated signaling pathway	IBA
GO:0038043	Process	Interleukin-5-mediated signaling pathway	IDA	1495999, 7613138, 11823534, 22528658
GO:0038043	Process	Interleukin-5-mediated signaling pathway	IDA	33099778
GO:0038043	Process	Interleukin-5-mediated signaling pathway	IEA
GO:0045645	Process	Positive regulation of eosinophil differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046427	Process	Positive regulation of receptor signaling pathway via JAK-STAT	IEA
GO:0071803	Process	Positive regulation of podosome assembly	IDA	15220135

MIM	HGNC	e!Ensembl
147850	6016	ENSG00000113525

P05113

Protein name

Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)

Protein function

Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells

PDB

1HUL , 3QT2 , 3VA2 , 8TLD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02025	IL5	22 → 133	Interleukin 5	Domain

Tissue specificity

TISSUE SPECIFICITY: Present in peripheral blood mononuclear cells. {ECO:0000269|PubMed:32211550}.

Sequence

MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNH
QLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQ
EFLGVMNTEWIIES

Sequence length

134

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th1 and Th2 cell differentiation T cell receptor signaling pathway Fc epsilon RI signaling pathway Intestinal immune network for IgA production Pathways in cancer Asthma Autoimmune thyroid disease Inflammatory bowel disease Allograft rejection		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling

IL5 (interleukin 5)