IL5 (interleukin 5)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3567
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL5
Synonyms (NCBI Gene) Gene synonyms aliases
EDF, IL-5, TRF
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased producti
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(49)
miRTarBase ID miRNA Experiments Reference
MIRT017691 hsa-miR-335-5p Microarray 18185580
MIRT039253 hsa-miR-454-5p CLASH 23622248
MIRT719916 hsa-miR-3662 HITS-CLIP 19536157
MIRT719915 hsa-miR-8063 HITS-CLIP 19536157
MIRT719914 hsa-miR-1237-3p HITS-CLIP 19536157
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
Transcription factor Regulation Reference
CEBPA Unknown 10453008
CEBPB Unknown 10453008
EP300 Unknown 16922677
ETS1 Activation 10212281
ETS2 Activation 10212281;19487701
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(29)
GO ID Ontology Definition Evidence Reference
GO:0002639 Process Positive regulation of immunoglobulin production IEA
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity IDA 33099778
GO:0005125 Function Cytokine activity IEA
GO:0005137 Function Interleukin-5 receptor binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147850 6016 ENSG00000113525
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P05113
Protein name Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)
Protein function Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells
PDB 1HUL , 3QT2 , 3VA2 , 8TLD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02025 IL5 22 → 133 Interleukin 5 Domain
Tissue specificity TISSUE SPECIFICITY: Present in peripheral blood mononuclear cells. {ECO:0000269|PubMed:32211550}.
Sequence
Sequence length 134
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
Hematopoietic cell lineage
IL-17 signaling pathway
Th1 and Th2 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Intestinal immune network for IgA production
Pathways in cancer
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease
Allograft rejection 		  Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma, Nonatopic asthma, Asthma (moderate or severe), Age of onset of childhood onset asthma N/A N/A GWAS
Show/Hide Text Mining Associations (243)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Inhibit 11399513
Acquired Immunodeficiency Syndrome Associate 8450057
Acute Phase Reaction Associate 1997656
Adenocarcinoma Inhibit 36790524
Airway Remodeling Associate 15826950
Allan Herndon Dudley syndrome Stimulate 24768357
Allergic Fungal Sinusitis Associate 23587334, 29417576, 30375439, 33629532, 35752781
Alveolar echinococcosis Associate 9459621
Alzheimer Disease Associate 17992457, 30193587
Alzheimer disease type 2 Associate 11579103