Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	3565
Gene name	Interleukin 4
Gene symbol	IL4
Synonyms (NCBI Gene)	BCGF-1BCGF1BSF-1BSF1IL-4
Chromosome	5
Chromosome location	5q31.1
Summary	The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytok

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018167	hsa-miR-335-5p	Microarray	18185580
MIRT736064	hsa-miR-320a	Luciferase reporter assayWestern blottingqRT-PCR	31432141

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Transcription factor	Regulation	Reference
CEBPB	Activation	7594540
CEBPB	Unknown	15048722
CIITA	Activation	10946277
CIITA	Repression	10946277;17645498
CREBBP	Activation	10946277
GATA3	Unknown	12876556;16498264;22226971
IRF2	Unknown	7930616
JUNB	Activation	21799768
MAF	Activation	11956291
MAF	Unknown	16498264
NFKB1	Unknown	12516545
POU2F1	Repression	11781715
RELA	Unknown	12516545
SATB1	Activation	21799768
SPIC	Activation	16647686
STAT6	Activation	12082548;16647686;20214667
STAT6	Unknown	12605697;12776189;14993689;19419769;20225206
TBX21	Repression	17541280;18504404;19348920
TBX21	Unknown	22521571
YY1	Activation	11687571

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	11967989
GO:0005125	Function	Cytokine activity	IDA	10219247
GO:0005125	Function	Cytokine activity	IEA
GO:0005126	Function	Cytokine receptor binding	IEA
GO:0005136	Function	Interleukin-4 receptor binding	IEA
GO:0005136	Function	Interleukin-4 receptor binding	TAS	3016727, 11418631
GO:0005515	Function	Protein binding	IPI	8266078, 10219247, 18243101, 23597562
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	3279117
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	3016727, 11418631
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	TAS	3016727
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IGI	12574355
GO:0008083	Function	Growth factor activity	IEA
GO:0008083	Function	Growth factor activity	NAS	11418631
GO:0008203	Process	Cholesterol metabolic process	ISS	11971948
GO:0008284	Process	Positive regulation of cell population proliferation	IGI	31432141
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0010633	Process	Negative regulation of epithelial cell migration	IDA	11698262
GO:0016239	Process	Positive regulation of macroautophagy	ISS
GO:0030183	Process	B cell differentiation	TAS	11418631
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030335	Process	Positive regulation of cell migration	IGI	31432141
GO:0030890	Process	Positive regulation of B cell proliferation	ISS
GO:0032720	Process	Negative regulation of tumor necrosis factor production	ISS
GO:0032733	Process	Positive regulation of interleukin-10 production	IGI	30634164
GO:0032736	Process	Positive regulation of interleukin-13 production	IDA	19346497
GO:0035771	Process	Interleukin-4-mediated signaling pathway	IBA
GO:0035771	Process	Interleukin-4-mediated signaling pathway	IDA	7760829, 7929391, 10219247, 17200144
GO:0035771	Process	Interleukin-4-mediated signaling pathway	IDA	10219247, 12574355
GO:0042092	Process	Type 2 immune response	TAS	11676128
GO:0042102	Process	Positive regulation of T cell proliferation	ISS
GO:0042110	Process	T cell activation	IGI	18337562
GO:0042113	Process	B cell activation	IEA
GO:0042116	Process	Macrophage activation	IGI	30634164
GO:0043011	Process	Myeloid dendritic cell differentiation	IDA	16116184
GO:0043066	Process	Negative regulation of apoptotic process	ISS
GO:0045191	Process	Regulation of isotype switching	TAS	11418631
GO:0045321	Process	Leukocyte activation	IEA
GO:0045348	Process	Positive regulation of MHC class II biosynthetic process	ISS
GO:0045582	Process	Positive regulation of T cell differentiation	IDA	20554961
GO:0045671	Process	Negative regulation of osteoclast differentiation	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	16606666, 18579517
GO:0045893	Process	Positive regulation of DNA-templated transcription	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	18579517, 19346497, 20554961
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	12574355
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0048260	Process	Positive regulation of receptor-mediated endocytosis	ISS
GO:0048295	Process	Positive regulation of isotype switching to IgE isotypes	ISS
GO:0048304	Process	Positive regulation of isotype switching to IgG isotypes	ISS
GO:0050728	Process	Negative regulation of inflammatory response	IBA
GO:0050728	Process	Negative regulation of inflammatory response	IGI	30634164
GO:0050776	Process	Regulation of immune response	IBA
GO:0050776	Process	Regulation of immune response	ISS
GO:0051239	Process	Regulation of multicellular organismal process	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA
GO:0097028	Process	Dendritic cell differentiation	IDA	21149635
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	24906148
GO:0150076	Process	Neuroinflammatory response	ISS
GO:0150079	Process	Negative regulation of neuroinflammatory response	IC
GO:1900223	Process	Positive regulation of amyloid-beta clearance	ISS
GO:1901857	Process	Positive regulation of cellular respiration	ISS
GO:1903660	Process	Negative regulation of complement-dependent cytotoxicity	IMP	16034134
GO:1903845	Process	Negative regulation of cellular response to transforming growth factor beta stimulus	IDA	11967989
GO:2000352	Process	Negative regulation of endothelial cell apoptotic process	IMP	16034134
GO:2000553	Process	Positive regulation of T-helper 2 cell cytokine production	IDA	20554961
GO:2001171	Process	Positive regulation of ATP biosynthetic process	ISS

MIM	HGNC	e!Ensembl
147780	6014	ENSG00000113520

P05112

Protein name

Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)

Protein function

Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:1993171, PubMed:3016727)

PDB

1BBN , 1BCN , 1CYL , 1HIJ , 1HIK , 1HZI , 1IAR , 1ITI , 1ITL , 1ITM , 1RCB , 2B8U , 2B8X , 2B8Y , 2B8Z , 2B90 , 2B91 , 2CYK , 2D48 , 2INT , 3BPL , 3BPN , 3QB7 , 4YDY , 5FHX , 6OEL , 8A4F , 8CGF , 8CH7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00727	IL4	26 → 149	Interleukin 4	Domain

Sequence

MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
NSCPVKEANQSTLENFLERLKTIMREKYSKCSS

Sequence length

153

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Fc epsilon RI signaling pathway Intestinal immune network for IgA production Leishmaniasis Pathways in cancer Asthma Autoimmune thyroid disease Inflammatory bowel disease Allograft rejection		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling

IL4 (interleukin 4)