IL4 (interleukin 4)

Gene

• Entrez ID: 3565
• Gene name: Interleukin 4
• Gene symbol: IL4
• Synonyms (NCBI Gene): BCGF-1, BCGF1, BSF-1, BSF1, IL-4
• Chromosome: 5
• Chromosome location: 5q31.1
• Summary: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytok

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018167	hsa-miR-335-5p	Microarray	18185580
MIRT736064	hsa-miR-320a	Luciferase reporter assay, Western blotting, qRT-PCR	31432141

Transcription factors

Transcription factor	Regulation	Reference
CEBPB	Activation	7594540
CEBPB	Unknown	15048722
CIITA	Activation	10946277
CIITA	Repression	10946277;17645498
CREBBP	Activation	10946277
GATA3	Unknown	12876556;16498264;22226971
IRF2	Unknown	7930616
JUNB	Activation	21799768
MAF	Activation	11956291
MAF	Unknown	16498264
NFKB1	Unknown	12516545
POU2F1	Repression	11781715
RELA	Unknown	12516545
SATB1	Activation	21799768
SPIC	Activation	16647686
STAT6	Activation	12082548;16647686;20214667
STAT6	Unknown	12605697;12776189;14993689;19419769;20225206
TBX21	Repression	17541280;18504404;19348920
TBX21	Unknown	22521571
YY1	Activation	11687571

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	11967989
GO:0001774	Process	Microglial cell activation	IBA	21873635
GO:0002227	Process	Innate immune response in mucosa	IBA	21873635
GO:0002230	Process	Positive regulation of defense response to virus by host	IBA	21873635
GO:0002674	Process	Negative regulation of acute inflammatory response	IBA	21873635
GO:0002677	Process	Negative regulation of chronic inflammatory response	IBA	21873635
GO:0005125	Function	Cytokine activity	IBA	21873635
GO:0005136	Function	Interleukin-4 receptor binding	TAS	11418631
GO:0005515	Function	Protein binding	IPI	8266078, 10219247, 18243101, 23597562
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	TAS	11418631
GO:0006955	Process	Immune response	TAS	3016727
GO:0008083	Function	Growth factor activity	NAS	11418631
GO:0008203	Process	Cholesterol metabolic process	ISS	11971948
GO:0008284	Process	Positive regulation of cell population proliferation	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IGI	31432141
GO:0010628	Process	Positive regulation of gene expression	IGI	12574355
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0010633	Process	Negative regulation of epithelial cell migration	IBA	21873635
GO:0010633	Process	Negative regulation of epithelial cell migration	IDA	11698262
GO:0016239	Process	Positive regulation of macroautophagy	IBA	21873635
GO:0016239	Process	Positive regulation of macroautophagy	ISS
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030183	Process	B cell differentiation	TAS	11418631
GO:0030335	Process	Positive regulation of cell migration	IGI	31432141
GO:0030890	Process	Positive regulation of B cell proliferation	ISS
GO:0031296	Process	B cell costimulation	IBA	21873635
GO:0032720	Process	Negative regulation of tumor necrosis factor production	ISS
GO:0032733	Process	Positive regulation of interleukin-10 production	IBA	21873635
GO:0032733	Process	Positive regulation of interleukin-10 production	IGI	30634164
GO:0032736	Process	Positive regulation of interleukin-13 production	IBA	21873635
GO:0032736	Process	Positive regulation of interleukin-13 production	IDA	19346497
GO:0035745	Process	T-helper 2 cell cytokine production	IBA	21873635
GO:0035745	Process	T-helper 2 cell cytokine production	IDA	20554961
GO:0042092	Process	Type 2 immune response	TAS	11676128
GO:0042102	Process	Positive regulation of T cell proliferation	ISS
GO:0042110	Process	T cell activation	IGI	18337562
GO:0042116	Process	Macrophage activation	IGI	30634164
GO:0042325	Process	Regulation of phosphorylation	ISS
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IBA	21873635
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IGI	12574355
GO:0042976	Process	Activation of Janus kinase activity	IBA	21873635
GO:0042976	Process	Activation of Janus kinase activity	IGI	12574355
GO:0043011	Process	Myeloid dendritic cell differentiation	IBA	21873635
GO:0043011	Process	Myeloid dendritic cell differentiation	IDA	16116184
GO:0043031	Process	Negative regulation of macrophage activation	IBA	21873635
GO:0043066	Process	Negative regulation of apoptotic process	ISS
GO:0043306	Process	Positive regulation of mast cell degranulation	IBA	21873635
GO:0045064	Process	T-helper 2 cell differentiation	IBA	21873635
GO:0045191	Process	Regulation of isotype switching	TAS	11418631
GO:0045348	Process	Positive regulation of MHC class II biosynthetic process	IBA	21873635
GO:0045348	Process	Positive regulation of MHC class II biosynthetic process	ISS
GO:0045582	Process	Positive regulation of T cell differentiation	IBA	21873635
GO:0045582	Process	Positive regulation of T cell differentiation	IDA	20554961
GO:0045671	Process	Negative regulation of osteoclast differentiation	ISS
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	16606666, 18579517
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IBA	21873635
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	18579517, 19346497, 20554961
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0048260	Process	Positive regulation of receptor-mediated endocytosis	IBA	21873635
GO:0048260	Process	Positive regulation of receptor-mediated endocytosis	ISS
GO:0048295	Process	Positive regulation of isotype switching to IgE isotypes	IBA	21873635
GO:0048295	Process	Positive regulation of isotype switching to IgE isotypes	ISS
GO:0048304	Process	Positive regulation of isotype switching to IgG isotypes	IBA	21873635
GO:0048304	Process	Positive regulation of isotype switching to IgG isotypes	ISS
GO:0050728	Process	Negative regulation of inflammatory response	IGI	30634164
GO:0050776	Process	Regulation of immune response	ISS
GO:0071677	Process	Positive regulation of mononuclear cell migration	IBA	21873635
GO:0097028	Process	Dendritic cell differentiation	IDA	21149635
GO:0097192	Process	Extrinsic apoptotic signaling pathway in absence of ligand	IBA	21873635
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	24906148
GO:0150076	Process	Neuroinflammatory response	ISS
GO:0150079	Process	Negative regulation of neuroinflammatory response	IC
GO:1900223	Process	Positive regulation of amyloid-beta clearance	IBA	21873635
GO:1900223	Process	Positive regulation of amyloid-beta clearance	ISS
GO:1901741	Process	Positive regulation of myoblast fusion	IBA	21873635
GO:1901857	Process	Positive regulation of cellular respiration	ISS
GO:1903660	Process	Negative regulation of complement-dependent cytotoxicity	IBA	21873635
GO:1903660	Process	Negative regulation of complement-dependent cytotoxicity	IMP	16034134
GO:1903845	Process	Negative regulation of cellular response to transforming growth factor beta stimulus	IDA	11967989
GO:2000320	Process	Negative regulation of T-helper 17 cell differentiation	IBA	21873635
GO:2000352	Process	Negative regulation of endothelial cell apoptotic process	IBA	21873635
GO:2000352	Process	Negative regulation of endothelial cell apoptotic process	IMP	16034134
GO:2000424	Process	Positive regulation of eosinophil chemotaxis	IBA	21873635
GO:2001171	Process	Positive regulation of ATP biosynthetic process	ISS
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IBA	21873635

Other IDs

• MIM: 147780
• HGNC: 6014
• e!Ensembl: ENSG00000113520

Protein

• UniProt ID: P05112
• Protein name: Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
• Protein function: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:1993171, PubMed:3016727)
• PDB: 1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX, 6OEL, 8A4F, 8CGF, 8CH7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00727	IL4	26 → 149	Interleukin 4	Domain

• Sequence:

  MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
  KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
  NSCPVKEANQSTLENFLERLKTIMREKYSKCSS

• Sequence length: 153

Pathways

KEGG:

Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
Hematopoietic cell lineage
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Intestinal immune network for IgA production
Leishmaniasis
Pathways in cancer
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease
Allograft rejection

Reactome:

Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542	16360218
Autoimmune diseases	Autoimmune Diseases	rs869025224	7871386, 8898950, 19077085
Cardiomyopathy	Cardiomyopathies, Primary, Cardiomyopathies	rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377, rs2856655, rs587776700, rs387906397, rs137854607, rs28935197, rs199473684, rs121964858, rs74315379, rs74315380, rs104894724, rs104894727, rs104894728, rs104894729, rs104894730, rs121917760, rs267607125, rs104894503, rs267607155, rs267607156, rs121918597, rs121918600, rs28933979, rs121918070, rs76992529, rs111033559, rs111033560, rs104894368, rs104894369, rs104894370, rs121913624, rs3218713, rs121913625, rs121913626, rs121913627, rs121913628, rs121913629, rs121913630, rs121913631, rs121913632, rs3218714, rs121913637, rs121913638, rs121913641, rs121913642, rs121913651, rs267606911, rs267606908, rs730880850, rs61046466, rs57520892, rs28933091, rs28933092, rs28933093, rs121913008, rs121913003, rs121912996, rs121912997, rs193922680, rs387906875, rs199474703, rs199476315, rs199476316, rs199476317, rs199476321, rs199476311, rs193922683, rs193922668, rs386134243, rs267607578, rs36211723, rs193922390, rs193922672, rs193922697, rs387907267, rs45546039, rs387907218, rs397515870, rs397515893, rs397515894, rs397515903, rs397515905, rs375882485, rs397515907, rs397515912, rs397515916, rs397515925, rs397515926, rs397515934, rs397515937, rs397515943, rs397515944, rs397515947, rs397515954, rs112738974, rs111729952, rs397515960, rs397515963, rs397515973, rs397515974, rs397515977, rs376395543, rs397515979, rs397515982, rs397515990, rs397515991, rs397515992, rs397516005, rs113358486, rs397516006, rs397516007, rs397516008, rs373746463, rs397516019, rs397516023, rs397516029, rs397516031, rs397516037, rs397516040, rs397516042, rs397516044, rs397516049, rs397516057, rs397516059, rs397516068, rs397516070, rs397516072, rs397516073, rs397516074, rs397516076, rs397516077, rs397516080, rs397516082, rs397516083, rs397516088, rs397516089, rs397516103, rs397516123, rs397516127, rs371898076, rs397516132, rs397516142, rs3218716, rs397516154, rs397516161, rs397516165, rs397516170, rs397516178, rs397516179, rs397516187, rs397516201, rs397516202, rs145213771, rs397516207, rs397516209, rs397516212, rs397516248, rs397516252, rs397516254, rs397516258, rs397516260, rs45516091, rs397516264, rs397516269, rs397516347, rs397516349, rs397516352, rs397516353, rs397516355, rs397516356, rs397516357, rs397516364, rs397516370, rs397516371, rs397516373, rs397516386, rs397516406, rs397516454, rs397516456, rs397516461, rs397516463, rs397516464, rs45525839, rs397516471, rs45578238, rs111377893, rs397516607, rs62636495, rs397516784, rs397516881, rs397516913, rs397516915, rs397516927, rs397516940, rs397516943, rs397516945, rs397516955, rs397516956, rs397516973, rs397516986, rs397516989, rs372827156, rs397516992, rs397516993, rs397516994, rs397516997, rs397517003, rs397517008, rs397517010, rs397517012, rs397517021, rs397517065, rs397517547, rs397517576, rs397517580, rs397517584, rs397517586, rs397517587, rs397517589, rs397517601, rs397517620, rs397517624, rs397517626, rs397517628, rs72646831, rs397517633, rs397517643, rs72646846, rs397517664, rs397517679, rs397517689, rs397517695, rs397517696, rs397517698, rs397517721, rs397517735, rs397517741, rs397517749, rs397517750, rs397517758, rs397517776, rs397517787, rs397517830, rs397517887, rs397517888, rs397517889, rs58013325, rs397517895, rs56984562, rs267607646, rs58917027, rs267607594, rs397517904, rs61195471, rs60682848, rs267607573, rs397517908, rs58978449, rs397517909, rs267607593, rs397517911, rs56816490, rs397517915, rs267607554, rs397514742, rs886041395, rs397515482, rs267607490, rs58999456, rs267607555, rs61672878, rs267607618, rs267607577, rs57730570, rs267607582, rs267607581, rs61444459, rs59270054, rs61661343, rs267607570, rs59026483, rs267607571, rs59332535, rs199473161, rs398123262, rs869320740, rs606231324, rs587782927, rs201754030, rs58389804, rs587782958, rs587782961, rs587782962, rs587782986, rs138049878, rs376897125, rs368765949, rs111569862, rs727504247, rs727503537, rs727504535, rs727504550, rs727504679, rs727503546, rs730880365, rs727504646, rs727505014, rs727505288, rs727503557, rs727503559, rs730880343, rs727503615, rs727504825, rs727503565, rs727504655, rs727505352, rs727504466, rs727504531, rs727503567, rs371678190, rs727503586, rs727505319, rs727503547, rs727505076, rs727505224, rs727503552, rs727504856, rs727504782, rs727504660, rs557312035, rs727505284, rs727504851, rs727504589, rs727504499, rs727504843, rs727504452, rs727503697, rs150974575, rs727504498, rs727503598, rs727503602, rs727503607, rs727504801, rs727504738, rs727505115, rs727505283, rs727505109, rs727504271, rs727504321, rs727504289, rs727503172, rs727503180, rs727503182, rs727504265, rs727504334, rs727503192, rs397515932, rs727504287, rs200411226, rs727503204, rs727504269, rs367947846, rs730880335, rs727502897, rs727503166, rs111683277, rs727503195, rs727503203, rs727503212, rs727503738, rs727504381, rs727504356, rs727503261, rs727504238, rs148808089, rs45544633, rs727503246, rs397516171, rs727503253, rs202141173, rs727504310, rs727503258, rs727503260, rs727504320, rs727504240, rs727503263, rs727503269, rs727503278, rs727504432, rs727504243, rs727504285, rs727503499, rs727503504, rs727504242, rs727504379, rs727504389, rs727504275, rs727504557, rs727502994, rs727504184, rs730880336, rs730880362, rs730880199, rs730880246, rs72648265, rs730880243, rs730880242, rs730880241, rs574660186, rs730880245, rs730880082, rs730880092, rs730880093, rs730880055, rs397515939, rs730881119, rs397516020, rs730880675, rs730880719, rs730880672, rs730880671, rs730880718, rs730880666, rs730880717, rs730880655, rs730880715, rs730880654, rs730880714, rs730880651, rs730880648, rs730880713, rs730880546, rs730880695, rs730880533, rs730880531, rs730880639, rs730880689, rs730880686, rs730880629, rs368121566, rs375607980, rs730880704, rs730880698, rs730880750, rs730880748, rs730880875, rs730880845, rs1565623093, rs786204339, rs786204336, rs786204392, rs786204388, rs786204950, rs786204951, rs794727381, rs760576804, rs112188483, rs794728597, rs794728606, rs794728593, rs59564495, rs190140598, rs794728826, rs794728803, rs794728106, rs149701627, rs1554108152, rs770873593, rs794728124, rs141026028, rs794728094, rs794729098, rs794729116, rs764817683, rs751288871, rs201405287, rs794729137, rs794729133, rs766209297, rs767987619, rs769220833, rs794729120, rs112240298, rs748382770, rs794729365, rs794729301, rs757451467, rs794729359, rs794729354, rs794729353, rs794729285, rs794729284, rs794729338, rs794729332, rs368452607, rs794729278, rs794729325, rs794729324, rs754866489, rs794729265, rs751502842, rs794729320, rs794729380, rs748313513, rs797046064, rs863225113, rs863225106, rs761507504, rs864622224, rs1057515421, rs751039219, rs869025555, rs869025546, rs869025554, rs869025559, rs869025545, rs869025558, rs869025557, rs200797552, rs869025550, rs869025549, rs869025544, rs869025552, rs869025548, rs869025556, rs770029258, rs869025523, rs869025398, rs869025399, rs869025395, rs869025365, rs869025469, rs869025483, rs749838192, rs869312028, rs869312037, rs869312038, rs869312039, rs869312040, rs869312041, rs869312042, rs869312044, rs869312046, rs373040154, rs869312047, rs869312048, rs869312049, rs869312050, rs869312051, rs869312052, rs869312054, rs869312055, rs777602537, rs869312056, rs869312057, rs869312058, rs869312059, rs869312060, rs770038577, rs869312061, rs869312062, rs869312063, rs869312064, rs869312065, rs869312066, rs869312067, rs869312068, rs869312069, rs771562210, rs869312070, rs869312071, rs759231562, rs869312072, rs869312073, rs764243269, rs768345594, rs869312074, rs869312075, rs869312076, rs869312077, rs869312078, rs869312079, rs869312080, rs772121356, rs869312081, rs869312082, rs72648250, rs869312083, rs869312084, rs869312085, rs869312086, rs869312087, rs869312100, rs779129892, rs756367933, rs869312102, rs869312103, rs869312104, rs869312105, rs869312106, rs770767998, rs869312107, rs775186117, rs869312108, rs869312109, rs869312110, rs869312111, rs755261062, rs869312112, rs763824247, rs869312113, rs869312114, rs869312115, rs869312116, rs774604740, rs869312117, rs779996703, rs869312118, rs869312119, rs869312120, rs869312121, rs869312122, rs869312045, rs753948675, rs878854371, rs794728589, rs876657650, rs727503512, rs876658027, rs876657672, rs876657671, rs868494032, rs876657670, rs780512337, rs876657669, rs876657668, rs876657666, rs876657665, rs876657664, rs876657663, rs148894066, rs876657634, rs869248137, rs876657705, rs876657704, rs727503213, rs869025496, rs876657662, rs876657884, rs36211715, rs878855234, rs879255521, rs879255639, rs886038928, rs751746401, rs886039030, rs869038795, rs886039343, rs2069544, rs1114167341, rs1114167340, rs886041322, rs886042331, rs886043718, rs747662439, rs886043924, rs773840992, rs886044536, rs1057517903, rs754354190, rs779650200, rs902082118, rs1057518920, rs1057519457, rs1057523045, rs370072439, rs1064792916, rs1060500495, rs1060500575, rs926741242, rs774763657, rs746877365, rs1060500610, rs1060501484, rs1060501479, rs1064792928, rs1060501443, rs1060499604, rs1064793814, rs1064796347, rs977277400, rs1064793429, rs745811346, rs1064794350, rs1555142963, rs1064793983, rs769665204, rs751261054, rs769139957, rs1131691873, rs1131691655, rs1131691673, rs1464253797, rs1408345511, rs1553603152, rs1554398705, rs1322596650, rs1553539995, rs1553611989, rs749961489, rs1444727212, rs1243301263, rs971618751, rs1553662326, rs1389777522, rs764985774, rs1554108287, rs1554105911, rs1249913357, rs1554108012, rs111806457, rs1402879259, rs748416758, rs794727046, rs1425855043, rs869178171, rs1432810664, rs749465164, rs878898365, rs1419374180, rs770878165, rs1553503113, rs1553691320, rs1553577362, rs1553603456, rs1417036453, rs1553741321, rs1553479603, rs1553607425, rs974671846, rs1420159591, rs745688425, rs1554875409, rs1555144459, rs1555338080, rs1555338574, rs1555148035, rs200889953, rs1401116572, rs1285329277, rs974510652, rs1263987728, rs1555122928, rs992189342, rs1555142971, rs1553261855, rs1553265647, rs1553488049, rs1553644307, rs1553663867, rs1553940122, rs28763965, rs758891557, rs762110595, rs1555436118, rs1555435531, rs565910322, rs376766195, rs1562168768, rs763443331, rs1562169661, rs1370579526, rs1561703922, rs1564773559, rs1559003939, rs1559598775, rs1559415567, rs1559877046, rs776970935, rs553526525, rs1561698362, rs1561694696, rs1561702640, rs730880751, rs1060505018, rs766330686, rs1565631430, rs1565050320, rs876657767, rs1565053085, rs1565053147, rs1557778277, rs1557776329, rs886039136, rs771262904, rs727504314, rs1563000044, rs541612157, rs766265889, rs1558988204, rs1559051231, rs1559262463, rs1559448864, rs1559469421, rs1559556267, rs1559746821, rs1559873786, rs1561323791, rs1561445221, rs1561686893, rs1561698714, rs1561702549, rs1565623439, rs1565623713, rs1565626367, rs1565627110, rs1565627145, rs397515889, rs1565628520, rs774316050, rs1592798444, rs1565590309, rs1566967399, rs1569552936, rs1559712733, rs1561690319, rs1561701721, rs869125101, rs1595843553, rs1576018303, rs746115846, rs777315336, rs1431206462, rs1572358674, rs1477669354, rs1575584918, rs1575614351, rs72648222, rs1575799625, rs1576014673, rs1576147786, rs747469275, rs1581805658, rs1227662860, rs1585169831, rs1592729525, rs762753884, rs1596155145, rs1572358821, rs991187915, rs1575649368, rs1060500562, rs1450218521, rs775256998, rs1572332762, rs1571627006, rs1575253896, rs1575616801, rs1575775337, rs1575948935, rs1574083547, rs1574087037, rs1589632398, rs1585171818, rs1603365762, rs768079285, rs1575663327, rs1575796530, rs1574659116, rs267607001, rs1567093598, rs1572359848, rs1060500505, rs1575512482, rs1575872984, rs1161735211, rs1576141328, rs906494713, rs1576685753, rs1266489077, rs1581813564, rs778808038, rs397516363, rs1596386673, rs1575610911, rs727503266, rs1603377936, rs777702465, rs1708504899, rs2054381012, rs1575285509, rs1695435412, rs1699247877, rs879139686, rs2060187635, rs761380979, rs1464886350, rs1956192035, rs752522753, rs1205836993, rs2095894178	7578376
Dermatitis	Dermatitis, Dermatitis, Atopic, Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	31330126, 11886533, 12230500, 18249437, 12484431, 21804303
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	19169254
Pulmonary fibrosis	Pulmonary Fibrosis	rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578	15322207, 12574379
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	12753568, 16091861, 21255481, 18574615, 22528336

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma		18357729	ClinVar, GWAS
Cirrhosis	Cirrhosis		24286936	ClinVar
Eczema	Eczema			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Abnormal Karyotype	Stimulate	9792304
Abortion Spontaneous	Associate	17482605
Acne Vulgaris	Associate	22705603
Acquired Immunodeficiency Syndrome	Associate	10602033, 10823849, 11699717, 32532356, 8149667, 8450057, 9576185
Acrodermatitis	Associate	11121150
Acute Kidney Injury	Associate	23511138
Acute Phase Reaction	Associate	1997656
Adenocarcinoma	Associate	16884377, 18210751
Adenocarcinoma	Stimulate	30105735
Adenocarcinoma of Lung	Associate	12517954, 31909418, 7641214
Adenomyosis	Associate	32933042
Aggressive Periodontitis	Associate	21198753, 21931203
Aging Premature	Associate	36982253
Agricultural Workers' Diseases	Associate	21857939
AIDS related Kaposi sarcoma	Inhibit	9205948
Allergic Fungal Sinusitis	Associate	24115141, 25573836, 30316748, 31650822
Alopecia Areata	Inhibit	26551570
Alopecia Areata	Associate	33099387, 33807704
Alzheimer Disease	Associate	26626881, 30336198, 36982253, 38167125, 39385222
Alzheimer Disease	Stimulate	33803478
Amaurosis Fugax	Associate	18307518
Anemia Aplastic	Associate	14675414, 28459238
Anemia Refractory	Inhibit	2783863
Anemia Sickle Cell	Associate	20130127, 27026283, 33776989
Aneurysm	Associate	30686933
Angina Stable	Associate	28260995
Anthracosis	Associate	21857939
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis	Associate	15762890
Aortic Aneurysm Abdominal	Stimulate	29567028
Aortic Aneurysm Abdominal	Associate	30686933
Arterial Occlusive Diseases	Stimulate	20130127
Arterial Occlusive Diseases	Associate	33776989
Arthritis	Associate	22687048, 23092393
Arthritis Juvenile	Associate	10765921, 16788246, 28012239, 32787920
Arthritis Psoriatic	Associate	34305455, 36610660, 8601720
Arthritis Reactive	Associate	8078923
Arthritis Rheumatoid	Associate	10233738, 10343540, 10366101, 10728756, 11168012, 12115161, 1379131, 14726963, 15140775, 15593184, 15593228, 17302909, 21294892, 22355377, 23983153, 24707478, 26149185, 28975976, 33066816, 33426089, 34239365, 37934808, 39202369, 9486005
Arthritis Rheumatoid	Inhibit	15899036
Arthritis Rheumatoid	Stimulate	23091349
Asthma	Associate	10219247, 10651947, 10747856, 11005866, 11413353, 11509632, 12517954, 15187156, 1530827, 16336695, 16640778, 16788246, 16792687, 16794249, 17083726, 17303794, 17303923, 17563406, 18088017, 18243101, 18539194, 19217272, 19447894, 19483109, 19862939, 19910025, 20128416, 20139223, 20926789, 21103062, 21179211, 21197090, 21387019, 22053598, 22249152, 22533235, 23045480, 23245479, 23327606, 23527710, 23573270, 23654077, 23804543, 23964553, 23984295, 24075231, 24641294, 25299150, 25402004, 25543042, 25768087, 25769910, 25838094, 26102239, 26547705, 26760128, 26781462, 26831416, 27525870, 27819719, 28199345, 28386156, 28424066, 28598986, 29692868, 29761786, 29809062, 30013989, 30537802, 30876376, 31539147, 32292999, 33277970, 33446603, 33450610, 33529503, 33774455, 33852838, 33878997, 34484176, 34714718, 34916261, 34981786, 35140898, 35579040, 36575422, 37076662, 37865742, 38049812, 40375219, 40420775, 7807013, 9593769, 9768594, 9811173
Asthma	Stimulate	16449261, 22189956, 24107080, 30381539, 31047104, 38253462
Asthma	Inhibit	18780949
Asthma Occupational	Associate	23535363
Astrocytoma	Associate	10946814
Astrocytoma	Stimulate	11939722
Atherosclerosis	Associate	11566179, 15502879
Atrial Fibrillation	Associate	37263975
Autism Spectrum Disorder	Stimulate	26392128, 30430410
Autoimmune Diseases	Associate	11309160, 14503851, 15497451, 16380445, 23110190, 32231389, 8988234, 9689101
Autoimmune Diseases	Inhibit	25646481
Autoimmune Pancreatitis	Associate	31033594
Bacterial Infections	Associate	34925324, 39269158
Barrett Esophagus	Associate	11889061, 22509265, 24578343
Behcet Syndrome	Associate	10513814, 21323696, 23559861
Behcet Syndrome	Stimulate	24984193
Berylliosis	Associate	12449171
Biliary Atresia	Associate	27364859
Bipolar Disorder	Associate	31534116
Bipolar Disorder	Stimulate	37058046
Blood Loss Surgical	Associate	35585570
Bone Diseases	Associate	19657367
Brain Diseases	Stimulate	9143252
Brain Neoplasms	Associate	12427253
Breast Neoplasms	Associate	12082548, 15100288, 20418110, 21939504, 23562473, 24375061, 24502445, 24670917, 28400477, 30814616, 32354899, 36046784, 9545345
Bronchial Hyperreactivity	Associate	16792687
Bronchiolitis Obliterans Syndrome	Inhibit	21669298
Bronchiolitis Obliterans Syndrome	Associate	23685278
Bronchitis	Associate	35027973
Bronchitis Chronic	Associate	14582911
Bronchopulmonary Dysplasia	Stimulate	27814345
Brucellosis	Associate	20404074
Burkitt Lymphoma	Associate	20876453
Carcinogenesis	Associate	16884377, 23359190, 24815430, 26383107, 26537085, 30105735
Carcinoid Tumor	Associate	27786259
Carcinoma Basal Cell	Stimulate	17508019
Carcinoma Basal Cell	Associate	8450029
Carcinoma Giant Cell	Associate	27918730
Carcinoma Hepatocellular	Associate	14568946, 25295591, 28665449, 32100006, 33906302, 35525950, 37904170, 8864852, 9949173
Carcinoma Hepatocellular	Inhibit	19126646
Carcinoma Hepatocellular	Stimulate	30105735
Carcinoma Large Cell	Stimulate	30105735
Carcinoma Non Small Cell Lung	Associate	10612755, 25450271, 29062084, 30105735, 40091029, 40199139
Carcinoma Renal Cell	Associate	19548368, 22317767, 23935100, 24885059, 25973044, 32469992, 37919459, 7656270, 7743667, 8004818, 8423237, 8776617
Carcinoma Renal Cell	Stimulate	40612864
Carcinoma Squamous Cell	Associate	25427637, 25450271, 37177979
Carcinoma Squamous Cell	Stimulate	30105735
Cardiomyopathies	Inhibit	28026044
Cardiovascular Diseases	Stimulate	36159840
Carpal Tunnel Syndrome	Associate	34224495
Cartilage Diseases	Associate	22503813
Cartilage Diseases	Inhibit	24819779
Central Cord Syndrome	Associate	27918730
Central Nervous System Diseases	Associate	39364412
Cerebral Infarction	Stimulate	18422734, 33378050
Cerebral Infarction	Associate	23766027
Chagas Cardiomyopathy	Associate	34592495
Chanarin Dorfman Syndrome	Stimulate	39307292
Chlamydial Pneumonia	Stimulate	15557667
Cholestasis	Associate	11910576
Chorioamnionitis	Associate	25938217
Chronic Disease	Stimulate	34220309
Chronic Pain	Associate	16871547
Chronic Periodontitis	Associate	21198766, 21815905, 25530681, 27195298, 28053321, 28114408
Chronic Periodontitis	Inhibit	26211001, 30427403
Cicatrix	Associate	8809130
Ciliary Discoordination Due To Random Ciliary Orientation	Associate	32532356
Clear cell metastatic renal cell carcinoma	Associate	28117391
Cleft Lip	Associate	31443525
Colitis	Stimulate	29922282
Colitis Ulcerative	Associate	19757042, 34298022, 9737666
Colitis Ulcerative	Stimulate	26072972
Collagenosis Familial Reactive Perforating	Associate	37638036
Colonic Diseases	Associate	24970802
Colonic Neoplasms	Associate	39252305, 8423237, 8530527
Colorectal Neoplasms	Associate	10817509, 15188028, 18210751, 24277698, 28210081, 28498822, 29085228, 29358861, 29368606, 30227113, 35979362, 36362361, 8530527
Colorectal Neoplasms	Stimulate	20201040
Common Variable Immunodeficiency	Associate	16640663, 26684629, 9042433
Communicable Diseases	Associate	23110190, 32532356
Conjunctival Diseases	Associate	19700933
Conjunctivitis Allergic	Associate	25999672
Coronary Artery Disease	Associate	24699314
Coronary Restenosis	Inhibit	31729103
Corticosteroid Binding Globulin Deficiency	Stimulate	27013170
Cough	Associate	33878997
Cough	Stimulate	34719421
COVID 19	Associate	32532356, 33041191, 33042157, 33052054, 33092653, 33122784, 33751722, 35008594, 35250975, 35855804, 37483627, 37569646, 37686182
COVID 19	Stimulate	34157151, 34831403, 36430210
Coxa Magna	Associate	30697966
Craniosynostoses	Inhibit	18416964
Critical Illness	Associate	33041191
Crohn Disease	Associate	12231473, 22167015, 23349929
Cystitis Interstitial	Associate	30973927
Cysts	Associate	29898177
Cytokine Release Syndrome	Associate	28114408
Cytomegalovirus Infections	Associate	32532356
Death	Associate	32532356
Demyelinating Diseases	Associate	29596844
Dengue	Associate	31521850, 31527878
Depressive Disorder	Inhibit	10759780
Depressive Disorder	Associate	18276105
Depressive Disorder	Stimulate	37058046
Depressive Disorder Major	Associate	37058046
Dermatitis Allergic Contact	Stimulate	19785613
Dermatitis Atopic	Associate	10620139, 11886533, 11989619, 12230500, 12406333, 1401997, 1531645, 15889128, 1714926, 1721013, 2002256, 2007785, 22533231, 26288354, 27212784, 28734739, 30286163, 30641038, 31049964, 31443688, 31596431, 32957324, 33321923, 33484701, 34070943, 35807451, 36610660, 38594991, 7665922, 8040343, 8082305, 8618052, 9030880, 9496691, 9643293, 9856820
Dermatitis Atopic	Stimulate	11028864, 17512043, 33807704, 33865911, 9409644
Dermatitis Atopic	Inhibit	22427475
Dermatitis Atopic 1	Associate	11028864, 16166103, 27498343, 27530865, 8082305
Dermatitis Atopic 1	Stimulate	16804630, 34916261
Dermatitis Atopic 3	Associate	1530827, 23654077, 26781462
Dermatitis Toxicodendron	Associate	7923918
Dermatomyositis	Associate	15829578, 19953283, 36197661
Dermatomyositis	Stimulate	28652434
dhat syndrome	Associate	39213757
Diabetes Gestational	Associate	36709877
Diabetes Mellitus	Inhibit	11309160, 28454543
Diabetes Mellitus	Associate	11681488, 36758483
Diabetes Mellitus Insulin Dependent 19	Associate	33727573
Diabetes Mellitus Type 1	Associate	10393957, 10840051, 11681488, 12748907, 15140063, 19956098, 26981545, 35404688
Diabetes Mellitus Type 1	Inhibit	36768715
Diabetes Mellitus Type 1	Stimulate	39273664
Diabetes Mellitus Type 2	Associate	24167373, 39202464
Diabetes Mellitus Type 2	Stimulate	30451213
Diabetic Nephropathies	Associate	28060893
Diabetic Nephropathies	Stimulate	31355294, 32723296
Diabetic Retinopathy	Associate	24991184
Diabetic Retinopathy	Inhibit	27525838
Diffuse Intrinsic Pontine Glioma	Associate	29621254
Disease	Associate	10219772, 11982596, 12410804, 15247173, 16166103, 19906894, 31809599
Disease Progression	Associate	27534531, 30961940
Drug Eruptions	Associate	34157151
Drug Hypersensitivity	Associate	10219247, 10651947, 10747856, 11509632, 12653157, 15470022, 15889128, 16640778, 16794249, 17303923, 17598032, 18243101, 19657353, 23521868, 24576111, 25573836, 27677865, 28250252, 33277970, 35307016, 35456412, 36725846, 37178857, 7529260, 7542574, 7579337, 9176402
Drug Hypersensitivity	Stimulate	18782262, 20451041, 21211656, 35113319
Drug Related Side Effects and Adverse Reactions	Inhibit	16518599, 9837907
Dry Eye Syndromes	Associate	29283120
Duane Retraction Syndrome	Inhibit	21203348
Dupuytren Contracture	Associate	33913534
Dyskinesia Familial with Facial Myokymia	Associate	7963654
Dyskinesias	Associate	28053372
Echinococcosis	Associate	10540165
Eczema	Associate	19122650, 28598986, 33277970
Embolism Amniotic Fluid	Associate	25938217
Encephalitis	Stimulate	26166120
Encephalitis	Associate	28935853
Encephalitis Japanese	Associate	40536377
Encephalocele	Stimulate	20222111
Endocrine System Diseases	Stimulate	21623768
Endometrial Neoplasms	Associate	16359969
Endometriosis	Associate	16359969, 32933042
Endometriosis	Stimulate	29308924, 9176444
Enterocolitis	Stimulate	20011655
Enterocolitis Necrotizing	Inhibit	23472217
Eosinophilia	Associate	15889128, 17166416, 31300640, 37548395
Eosinophilic enteropathy	Associate	25234644
Eosinophilic Esophagitis	Associate	21211656, 26258919, 29129581, 29790577, 30455683, 32197970, 37933466
Eosinophilic pustular folliculitis	Stimulate	11501668
Epilepsies Partial	Associate	27115869
Epilepsy Post Traumatic	Associate	30455683
Erythema Nodosum	Associate	11121122
Esophageal Neoplasms	Stimulate	25144454
Esophageal Neoplasms	Associate	32744314
Esophageal Squamous Cell Carcinoma	Associate	11889061, 32744314, 33895482
Esophageal Squamous Cell Carcinoma	Inhibit	32744314, 33895482
Exanthema	Associate	36159840
Fabry Disease	Associate	31221509
Fatigue	Associate	24632226, 24872120
Fatty Liver	Associate	33906302
Fever	Associate	28935853
Fibrosis	Stimulate	12905481, 19654941
Fibrosis	Associate	24141615, 33906302, 9593769
Food Hypersensitivity	Associate	24576111, 29922282
Food Hypersensitivity	Stimulate	35458127
Food Intolerance	Associate	23797532
Frontotemporal Dementia	Associate	36890594
Galactosemias	Stimulate	24398680
Gastritis	Associate	27677314
general anxiety disorder	Associate	35866837
Glaucoma	Stimulate	32043817
Glioblastoma	Associate	18490770, 23663500, 26180083, 36272241
Glioma	Associate	10952023, 11870521, 18093335, 24787244, 24859836, 25170298, 39364412, 8798406, 9140115
Glomerulonephritis IGA	Associate	20551088, 24398680, 25647400, 7908616, 8565271
Glomerulonephritis Membranous	Associate	15954921, 35172688
Glossitis Benign Migratory	Associate	21483819
Glucocorticoid Receptor Deficiency	Associate	40234868
Glycogen Storage Disease Type IV	Stimulate	27738386
Graft vs Host Disease	Associate	8496391
Granuloma	Associate	10768979, 25141207, 29898177
Granuloma	Stimulate	25204704
Granulomatosis with Polyangiitis	Associate	10211889
Granulomatous Disease Chronic	Associate	18005266
Graves Disease	Associate	16675443, 30956992, 9717983
Graves Disease	Stimulate	25120780
Guillain Barre Syndrome	Associate	33751722
Hand Foot and Mouth Disease	Associate	26166120
Harlequin type ichthyosis	Associate	34614112
Hashimoto Disease	Stimulate	21623768
Heart Failure	Inhibit	35409075
Heart Valve Diseases	Associate	15509528
Helicobacter Infections	Associate	16085918
Hemangioma Cavernous Central Nervous System	Associate	25472749
Hematologic Diseases	Associate	15286007, 2783863
Hepatitis Autoimmune	Inhibit	31191516
Hepatitis B	Inhibit	10460611
Hepatitis B	Associate	19625194, 25295591, 26986131, 32532356
Hepatitis B Chronic	Associate	25295591, 8706330
Hepatitis C	Associate	32532356
Hepatitis C Chronic	Associate	11910576, 32532356
Hepatolenticular Degeneration	Stimulate	40214068
Hereditary Breast and Ovarian Cancer Syndrome	Inhibit	8932345
Hereditary leiomyomatosis and renal cell cancer	Associate	11815953
Hereditary pancreatitis	Associate	27677314
Herpes Labialis	Associate	32735468
Histiocytosis Langerhans Cell	Associate	10590064, 16487180
HIV Infections	Inhibit	10973452, 7530762
HIV Infections	Associate	12515722, 19726615, 20416280, 21200019, 2470786, 24732878, 26166114, 26501424, 35632739, 7500020, 7554396, 7964515, 8149667, 8450057
HIV Infections	Stimulate	18573939, 20201040
Hodgkin Disease	Associate	16954503, 1951632
HTLV I Infections	Associate	10823849
Hypereosinophilic Syndrome	Associate	10886202
Hyperglycemia	Associate	27294162
Hyperlipoproteinemia Type II	Associate	23259529
Hypersensitivity Delayed	Inhibit	25646481
Hypersensitivity Immediate	Associate	12207324, 8618052
Hypertension	Associate	25973747
Hypertrophy	Stimulate	37409959
Hypopigmentation	Associate	22992805
Hypothyroidism	Stimulate	39185088
Hypoxia	Stimulate	26323509
Ichthyosis Bullosa of Siemens	Associate	23268291
Idiopathic Interstitial Pneumonias	Associate	15113854, 15161635
Idiopathic Pulmonary Fibrosis	Associate	10515397, 17056243, 17309781, 23262513, 34461906, 7664490, 9150314
Idiopathic Pulmonary Fibrosis	Stimulate	19654941
IgA Deficiency	Associate	19738033, 9649225
IgA Vasculitis	Associate	8694577
Ige Responsiveness Atopic	Associate	19131452, 19910025, 25573836, 29761786, 33277970, 33529503, 34261469, 35307016
Immunoglobulin G4 Related Disease	Associate	25571893, 28205524, 28434701, 31033594, 36831337, 39625839
Immunoglobulin G4 Related Disease	Stimulate	26311608
Immunologic Deficiency Syndromes	Associate	8986719
Infections	Inhibit	11668182, 24605787
Infections	Stimulate	12562394, 29768624
Infections	Associate	15958076, 16185274, 16264039, 21439068, 23563829, 23964142, 25858686, 34287050, 39269158, 40626361
Infertility	Associate	39580416
Infertility Female	Associate	39580416
Inflammation	Inhibit	10233738, 11238560, 11738291, 11968047, 12846752, 15308734, 17302909, 21765444, 23046796, 23110190, 24819779, 24991184, 25619315, 25973044, 27195298, 27488002, 27491770, 27919440, 28114408, 28542352, 29250672, 30032131, 30227113, 30291537, 30338340, 30697966, 31814225, 33231770, 33597460, 34440860, 34577154, 35404688, 36012487, 36604634, 36683689, 37274074, 37928270, 38101522, 40342405, 7927746, 8436908, 9092569, 9472675
Inflammation	Associate	10982806, 11121122, 11132771, 11501668, 12207324, 12517954, 14503851, 14726963, 15013759, 15470022, 15502879, 15545055, 18433468, 19447894, 19483109, 19636293, 19931589, 20529823, 20816019, 21397857, 21430300, 22541248, 22705603, 23045480, 23327606, 23359190, 23601964, 23766027, 23923066, 24115141, 24502445, 25295591, 25402004, 25482871, 25646481, 25862016, 25938217, 26198819, 26383107, 26439628, 26448050, 26781462, 26831416, 27015414, 27077658, 27364859, 27416040, 27534531, 27556208, 27624002, 27677314, 27677865, 27845745, 27978840, 28012239, 28053321, 28355218, 28359265, 28373098, 28373981, 28421819, 28714566, 28944895, 29268771, 29408308, 29521059, 29898177, 30105735, 30194992, 30248387, 30336198, 30430410, 30488542, 30526523, 30537802, 30662337, 30788684, 30961940, 31185305, 31289202, 31534116, 31732533, 31924810, 32532356, 32884012, 32985509, 33117343, 33751722, 34157151, 34261469, 34448644, 34502384, 34777330, 34888378, 34960806, 34999610, 35255925, 35409019, 35432838, 35456412, 36115766, 36197661, 36459489, 36634709, 36890594, 36952641, 37178857, 37253337, 37289055, 37316763, 37540585, 37563607, 37664926, 37871483, 39766355, 39889896, 39907396, 39929713, 40105091, 40234868, 7790026, 8040343, 8693436, 8706330, 8809149, 8866593, 9010272, 9129035, 9593769, 9743220, 9771406
Inflammation	Stimulate	24911279, 34484176
Inflammatory Bowel Diseases	Associate	20878190, 30537794, 35212366
Influenza Human	Associate	26696552
Insulin Resistance	Associate	29258102
Intestinal Diseases	Associate	19520737
Intraabdominal Infections	Associate	31480453
Intrahepatic Cholestasis of Pregnancy	Inhibit	24489901
Intussusception	Associate	34284276
Iron Deficiencies	Associate	11737064
Irritable Bowel Syndrome	Associate	22816602, 24667736
Irritable Bowel Syndrome	Stimulate	23268291
Ischemic Stroke	Associate	35673992
Job Syndrome	Associate	12694256
Job Syndrome	Stimulate	9768594
Keratoconus	Associate	22413749, 30245588, 36051483, 39390037
Keratosis Seborrheic	Associate	8450029
Kidney Failure Chronic	Associate	21644211, 30227113
Klinefelter Syndrome	Associate	28369266
Laboratory Infection	Associate	29490771
Laminopathies	Associate	32585971
Laryngotracheal Stenosis Progressive with Short Stature and Arthropathy	Associate	28485188
Leiomyoma	Associate	21138652
Leishmaniasis Diffuse Cutaneous	Stimulate	8443970
Leprosy	Associate	20713631, 23563829, 23936569, 26367014
Leprosy Lepromatous	Associate	30642265
Leukemia	Associate	1385474, 1402678, 22532845, 3262382, 3262383, 7540066
Leukemia	Stimulate	1712640
Leukemia	Inhibit	19567201
Leukemia B Cell	Associate	15591113, 19694722
Leukemia Erythroblastic Acute	Associate	7789528
Leukemia Hairy Cell	Associate	2242429
Leukemia Lymphocytic Chronic B Cell	Inhibit	10403909, 1402678
Leukemia Lymphocytic Chronic B Cell	Associate	10812244, 11175813, 11678896, 12444172, 12644014, 1381243, 14687023, 1532590, 15802533, 16973957, 18024373, 19387007, 19815839, 20716767, 22927247, 24166938, 2478656, 24966942, 25280001, 25909590, 26376785, 27002119, 27226435, 27697994, 28570130, 29479062, 30082430, 30478302, 3135368, 3262382, 34831232, 36248816, 7530690, 7629299, 7919349, 8555496, 9028325, 9074413, 9266941, 9616167
Leukemia Lymphoma Adult T Cell	Associate	18702873, 3262383, 34334531, 8514609
Leukemia Lymphoma Adult T Cell	Stimulate	23962110
Leukemia Mast Cell	Associate	7751024
Leukemia Myeloid	Associate	2783863
Leukemia Myeloid Acute	Associate	11559933, 1688720, 1712640, 2070083, 25795133, 37653079, 7949182, 9716596
Leukemia Myeloid Acute	Inhibit	2783863
Leukemia Myelomonocytic Chronic	Associate	30026572
Leukemia Prolymphocytic T Cell	Associate	10086799, 10520029, 23710828, 3262382, 35959629, 37528310, 7503945, 7530690
Leukemia Prolymphocytic T Cell	Inhibit	10403909
Leukemia Promyelocytic Acute	Associate	18005266
Leukemia T Cell	Associate	14687023
Leukocyte Disorders	Stimulate	32862238
Leukocytosis	Inhibit	22734496
Leukoencephalopathies	Stimulate	38054663
Leukoplakia Oral	Associate	28053372
Lichen Planus Oral	Associate	24158143, 28278185, 30329194, 7738356
Lichen Planus Oral	Inhibit	26594049, 29813046
Liver Cirrhosis	Stimulate	31069827
Liver Cirrhosis Biliary	Associate	8565296
Liver Failure	Associate	28838891
Lung Diseases	Associate	12905481
Lung Diseases Interstitial	Stimulate	19654941
Lung Neoplasms	Associate	15470022, 18286287, 18785202, 30729744
Lupus Erythematosus Systemic	Inhibit	11122256
Lupus Erythematosus Systemic	Associate	12568118, 19399944, 23913957, 27488002, 31781106, 33882880, 36165181, 36741410
Lupus Erythematosus Systemic	Stimulate	24062776, 24683191, 34239365
Lupus Nephritis	Associate	12568118
Lupus Nephritis	Inhibit	15373921
Lymphangiectasis Intestinal	Associate	9862365
Lymphedema	Associate	24502445
Lymphoma	Associate	16418334, 1833595, 34334531, 35851155, 40163757
Lymphoma B Cell	Associate	11675349, 1443042, 15044251, 1737107, 22228637, 2521354, 26448050, 27235588, 9584180
Lymphoma B Cell	Stimulate	18245523
Lymphoma B Cell Marginal Zone	Associate	9137085
Lymphoma Follicular	Associate	18682601, 20944673, 22015774, 23297127, 25428220, 25733581, 26448050, 26965583, 33133070, 35851155
Lymphoma Large B Cell Diffuse	Associate	12509382, 15591113, 19515749, 19694722
Lymphoma Mantle Cell	Associate	25216518
Lymphoma Non Hodgkin	Associate	10952023, 16449530, 16973957, 19066394, 21418175
Lymphoma T Cell	Associate	16449530
Lymphoma T Cell Cutaneous	Stimulate	18245523
Lymphoma T Cell Cutaneous	Associate	20505746, 22297640, 33941102, 34220814, 7963654
Lymphoma T Cell Peripheral	Associate	9488618
Macrophage Activation Syndrome	Associate	12449174
Macular Degeneration	Stimulate	27266510, 39547643
Macular Degeneration	Associate	35352887
Malaria	Associate	15373917, 23110190, 26448013
Malaria Cerebral	Associate	15373917
Malignant Teratocarcinosarcoma	Associate	24510479, 31650822
Mast Cell Activation Disorders	Associate	2397501, 31708535
Measles	Associate	20201040
Medulloblastoma	Associate	11870521
Melanoma	Associate	11845255, 19240164, 32246006, 7923247, 8205560
Melanoma	Stimulate	20052413
Melanoma	Inhibit	24463459, 8242663
Melioidosis	Associate	28628607
Meningitis Cryptococcal	Associate	31914800
Meningitis Viral	Associate	27914455
Meningococcal Infections	Associate	23595505
Meningoencephalitis	Associate	7890425
Mental Disorders	Associate	22450224
Metabolic Syndrome	Inhibit	40234868
Mood Disorders	Associate	18276105
Mouth Diseases	Associate	25204704
Mouth Neoplasms	Associate	15900573
Mucocutaneous Lymph Node Syndrome	Inhibit	15270865
Mucocutaneous Lymph Node Syndrome	Associate	15889128, 21048327, 40455761
Mucocutaneous Lymph Node Syndrome	Stimulate	30704426, 32884012
Multiple Myeloma	Associate	12358903, 14717778, 18468680, 23232072, 31870332, 9792304
Multiple Myeloma	Inhibit	1912585
Multiple Sclerosis	Associate	17420820, 22366824
Myasthenia Gravis	Associate	27387891, 32508812, 33436376
Myasthenia Gravis	Stimulate	33813453
Mycosis Fungoides	Associate	18245523, 24171863, 2527911, 33941102
Mycosis Fungoides	Stimulate	40163757
Myelodysplastic Syndromes	Inhibit	10606893
Myelodysplastic Syndromes	Associate	16091127, 36600245
Myocardial Infarction	Inhibit	18662263
Myocardial Infarction	Associate	18662263, 28260995
Myositis	Associate	17405833, 19906894, 39946176
Myotonic Dystrophy	Associate	21414848, 35393495
Myotonic Dystrophy	Inhibit	26211001
Nasal Polyps	Associate	19639723, 21538928, 24911279, 25573836, 27166273, 31870738, 35682987, 35747690, 37385124
Nasal Polyps	Stimulate	31928947, 33287173
Neoplasm Metastasis	Associate	15714203
Neoplasm Metastasis	Inhibit	19567201, 24463459
Neoplasms	Associate	10886511, 11870521, 12888337, 12942579, 14764031, 15100288, 16158955, 16418334, 17222831, 18210751, 18276105, 18286287, 18490770, 19240164, 1951632, 19694722, 20201040, 20944673, 21939504, 22749497, 23451142, 23686488, 24277698, 24375061, 25418473, 25628470, 25973044, 26537085, 27993206, 28061450, 28117391, 28376875, 29236307, 29747685, 30082430, 30227113, 30587522, 31138333, 31760090, 32100006, 32832545, 34190692, 35053403, 35932642, 36272241, 36868036, 37865999, 39252305, 39366933, 39561563, 7656270, 7691245, 7963654, 8314773, 8595155, 8640845, 8932345, 9028325, 9192989, 9488618
Neoplasms	Stimulate	11509647, 33985854, 40612864
Neoplasms	Inhibit	11675349, 17302909, 2053591, 20664541, 2121695, 23297127, 25942601, 29478100, 8287600, 8423237
Neoplasms Adipose Tissue	Associate	28293435
Neoplasms Basal Cell	Associate	26645717
Neoplasms Plasma Cell	Associate	2306518
Neoplastic Syndromes Hereditary	Associate	15654830
Nephrosis congenital	Associate	35208588, 35293350
Nephrosis Lipoid	Associate	1299237, 14688382
Nephrotic Syndrome	Associate	35293350
Nervous System Diseases	Associate	32038109
Neuroblastoma	Associate	10100634, 28687069, 8640845
Neurocognitive Disorders	Associate	18702873
Neuromuscular Junction Diseases	Associate	37734479
Non alcoholic Fatty Liver Disease	Associate	37342340
Nose Diseases	Associate	19488556, 33919374
Obesity	Stimulate	23804543
Obesity	Associate	28293435, 28454543
Oral Ulcer	Associate	37653793
Osteoarthritis	Associate	20219689, 23780780, 34502384
Osteoarthritis	Inhibit	24819779, 37928270
Osteoarthritis Knee	Stimulate	31898441
Osteomyelitis	Associate	18971305, 35711689
Osteoporosis	Associate	25384921
Ovarian Neoplasms	Associate	33921111, 34181334, 7622110, 7648722
Overtraining Syndrome	Inhibit	38319611
Pain	Stimulate	34224495
Pain	Associate	34602367, 35531763
Pancreatic Neoplasms	Associate	15714203, 31548328, 35409019, 37455016, 37865999
Pancreatitis	Associate	19906894
Papilloma	Associate	36154611
Papillomavirus Infections	Stimulate	35463689
Paracoccidioidomycosis	Associate	25204704
Parkinson Disease	Stimulate	25329911
Parkinson Disease	Associate	38231411, 40626361
Pdgfra Associated Chronic Eosinophilic Leukemia	Stimulate	31928947
Peanut Hypersensitivity	Associate	12671056, 25823600
Pemphigoid Benign Mucous Membrane	Associate	23557074
Pemphigoid Bullous	Associate	11710918, 29335495, 35140724
Pemphigus	Associate	35222408
Peri Implantitis	Stimulate	37466520
Periapical Periodontitis	Associate	29898177
Periodontal Diseases	Associate	27195298
Periodontitis	Associate	23046796, 28114408, 31978095
Periodontitis	Stimulate	9010272
Peritonitis	Stimulate	34360900
Persian Gulf Syndrome	Associate	23800166, 25514671
Persistent Infection	Stimulate	32408187
Plasma Cell Granuloma Pulmonary	Associate	11918694
Pneumoconiosis	Associate	21857939
Pneumonia	Associate	22734496, 35836993
Pneumonia Mycoplasma	Associate	40420775
Pneumonia Pneumocystis	Associate	31225812
Polycystic Ovary Syndrome	Inhibit	34646235
Polycythemia Vera	Associate	24463275
Polymyositis	Associate	19953283
Polypoidal Choroidal Vasculopathy	Stimulate	27266510
Polyps	Stimulate	32352715
Postural Orthostatic Tachycardia Syndrome	Associate	40022872
Pre Eclampsia	Stimulate	17767018
Pre Eclampsia	Associate	28387873
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	1385474
Precursor Cell Lymphoblastic Leukemia Lymphoma	Inhibit	11157494
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	1385474, 17378240, 1884023
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	11918534, 12536236
Prodromal Symptoms	Associate	22126569
Prostatic Hyperplasia	Associate	12920242, 37501430
Prostatic Neoplasms	Stimulate	16334148, 21430300
Prostatic Neoplasms	Associate	18819102, 21846818, 23754304, 28317149, 28631559, 29298992
Protein Energy Malnutrition	Associate	38017491
Pruritus	Associate	33766508
Psoriasis	Stimulate	18245523
Psoriasis	Associate	19169254, 21412260, 25646481, 36610660
Pulmonary Arterial Hypertension	Associate	30661465
Pulmonary Disease Chronic Obstructive	Inhibit	19279357
Pulmonary Disease Chronic Obstructive	Associate	19447894, 31320835, 33435988, 37928768, 40234868
Pulmonary Disease Chronic Obstructive	Stimulate	39766355
Pulmonary Embolism	Stimulate	33969714
Pulmonary Fibrosis	Associate	25535123
Pulmonary Heart Disease	Associate	24141615
Purpura	Associate	16166103
Purpura Thrombocytopenic Idiopathic	Associate	14670926, 15755291, 21385171, 22111667, 26749059, 27554456, 28511637, 36281771, 40534165
Purpura Thrombocytopenic Idiopathic	Inhibit	20100010, 23869085, 26111958, 31651870
Recurrent respiratory papillomatosis	Associate	36154611
Renal Insufficiency Chronic	Associate	22230215, 32046176, 37711613, 38017491
Reproductive Tract Infections	Stimulate	23555586
Respiratory Distress Syndrome	Associate	25619315, 39365167
Respiratory Sounds	Associate	25768087
Respiratory Syncytial Virus Infections	Associate	17460443, 19131452
Respiratory Tract Diseases	Associate	23654077, 27534531, 30961940, 35456412
Retinal Vein Occlusion	Associate	31814701
Rett Syndrome	Associate	20934504
Rett Syndrome	Stimulate	26236424
Rhabdomyosarcoma	Associate	23797008
Rheumatic Diseases	Associate	1829991
Rheumatic Heart Disease	Associate	15509528, 28791349
Rhinitis	Stimulate	25858686
Rhinitis	Associate	26577568, 28598986, 7927488
Rhinitis Allergic	Associate	19488556, 20074473, 22533231, 23654077, 24075353, 31185305, 32295284, 33406021, 36127783, 36149748
Rhinitis Allergic	Stimulate	26708394
Rhinitis Allergic Perennial	Stimulate	9119992
Root Resorption	Inhibit	28782095
Sarcoidosis	Associate	11091281, 7586698
Sarcoma	Associate	8423237
Schizophrenia	Associate	31534116, 32038109
Scleroderma Diffuse	Associate	1829991
Scleroderma Systemic	Stimulate	10366109, 11840447
Scleroderma Systemic	Associate	11710721, 12905481, 13130479, 14729510, 34504485, 8941674
Seizures	Associate	29729582
Seizures Febrile	Stimulate	29729582
Sepsis	Associate	28628607, 37304268
Sertoli Cell Only Syndrome	Associate	15591113
Severe Acute Respiratory Syndrome	Associate	39766355
Severe Combined Immunodeficiency	Associate	12435740, 8506326, 8986719
Severe Dengue	Stimulate	31521850
Sezary Syndrome	Associate	11168816, 7923918, 9649208
Shock Cardiogenic	Associate	35729851
Silicosis	Associate	22365405
Sjogren's Syndrome	Associate	16166103, 39480501, 39819714
Sjogren's Syndrome	Stimulate	25346207, 31086200
Skin Diseases	Associate	20713631, 22992805, 34220814, 8941669
Skin Diseases	Stimulate	8040343
Sleep Wake Disorders	Stimulate	24115141
Smoke Inhalation Injury	Inhibit	22805115
Spinal Cord Injuries	Associate	35412793
Spondylarthropathies	Associate	10733472
Spondylitis Ankylosing	Associate	27813599
Squamous Cell Carcinoma of Head and Neck	Stimulate	18547033
Squamous Cell Carcinoma of Head and Neck	Associate	26537085, 31970439, 37321663
Status Asthmaticus	Associate	11132771, 11985520, 12952249, 16001979, 16210593, 16640778, 20491797, 20926789, 21387019, 22189956, 23527710, 26831416, 28373098, 29761786, 30644695, 31047104, 31986951, 33450610, 35111161, 36634709, 7807013, 8050173, 8080605
Status Asthmaticus	Stimulate	21310879, 24075231, 26547705, 29453280
Still's Disease Adult Onset	Associate	15361391
Still's Disease Adult Onset	Stimulate	34319596
Stomach Diseases	Associate	32630408
Stomach Neoplasms	Associate	19520737, 22126569, 24815430, 26383107, 27677314, 29358861, 30526523, 32832545
Stomach Neoplasms	Stimulate	24741632
Stress Disorders Post Traumatic	Stimulate	30777365
Stroke	Stimulate	34201498
Stroke	Associate	35673992, 37263975
Syndrome	Associate	17166416
Synovitis	Associate	9358757
Syphilis	Associate	32532356
Takayasu Arteritis	Associate	15498051
Thrombocythemia Essential	Stimulate	24463275
Thymus Neoplasms	Associate	12072494
Thyroid Cancer Papillary	Associate	32151175
Thyroid Neoplasms	Associate	16452205
Thyroiditis Autoimmune	Associate	21623768, 9546811
Tooth Mobility	Associate	27460425
Triple Negative Breast Neoplasms	Associate	35255925
Tuberculosis	Associate	12115643, 14678204, 17159260, 18848499, 33597460, 33720848, 35305574, 37565285
Tuberculosis	Stimulate	31097521
Tuberculosis	Inhibit	37909551
Tuberculosis Meningeal	Stimulate	12562391
Tuberculosis Meningeal	Associate	15708307, 23826366
Tuberculosis Meningeal	Inhibit	27682872
Tuberculosis Multidrug Resistant	Associate	27238179
Tuberculosis Pulmonary	Associate	16840026, 17159260, 22771610, 27238179, 33597460, 35293343
Tuberculosis Pulmonary	Inhibit	19703020
Ureteral Calculi	Associate	30484290
Urinary Tract Infections	Stimulate	30484290
Urticaria	Associate	9392005
Uterine Cervical Neoplasms	Associate	27220278
Uterine Cervicitis	Stimulate	35463689
Uveal melanoma	Associate	35163491
Uveomeningoencephalitic Syndrome	Stimulate	33314028
Vascular System Injuries	Stimulate	15502879
Vascular System Injuries	Associate	30451213
Vasculitis	Stimulate	34950150
Vasculitis	Associate	36794867
Vasculitis Lymphocytic Cutaneous Small Vessel	Associate	25862016
Venous Insufficiency	Inhibit	29439934
Venous Thrombosis	Associate	23559861
Virus Diseases	Associate	16264039, 33674737
Vitamin D Deficiency	Associate	21819409
Waldenstrom Macroglobulinemia	Associate	16317092
West Nile Fever	Associate	33671821
Wiskott Aldrich Syndrome	Associate	2539277
Wolffian tumor	Associate	30336198
Wounds and Injuries	Stimulate	11224628
Wounds and Injuries	Associate	11423465
X Linked Combined Immunodeficiency Diseases	Associate	19189700, 7803808, 8557662, 8605324, 8781427, 9054429, 9885222
Yellow Fever	Stimulate	19906894
Zika Virus Infection	Associate	36859461