IL4 (interleukin 4)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3565
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL4
Synonyms (NCBI Gene) Gene synonyms aliases
BCGF-1, BCGF1, BSF-1, BSF1, IL-4
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytok
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT018167 hsa-miR-335-5p Microarray 18185580
MIRT736064 hsa-miR-320a Luciferase reporter assay, Western blotting, qRT-PCR 31432141
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
Transcription factor Regulation Reference
CEBPB Activation 7594540
CEBPB Unknown 15048722
CIITA Activation 10946277
CIITA Repression 10946277;17645498
CREBBP Activation 10946277
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 11967989
GO:0005125 Function Cytokine activity IDA 10219247
GO:0005125 Function Cytokine activity IEA
GO:0005126 Function Cytokine receptor binding IEA
GO:0005136 Function Interleukin-4 receptor binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147780 6014 ENSG00000113520
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P05112
Protein name Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
Protein function Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:1993171, PubMed:3016727)
PDB 1BBN , 1BCN , 1CYL , 1HIJ , 1HIK , 1HZI , 1IAR , 1ITI , 1ITL , 1ITM , 1RCB , 2B8U , 2B8X , 2B8Y , 2B8Z , 2B90 , 2B91 , 2CYK , 2D48 , 2INT , 3BPL , 3BPN , 3QB7 , 4YDY , 5FHX , 6OEL , 8A4F , 8CGF , 8CH7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00727 IL4 26 → 149 Interleukin 4 Domain
Sequence
Sequence length 153
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
Hematopoietic cell lineage
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Intestinal immune network for IgA production
Leishmaniasis
Pathways in cancer
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease
Allograft rejection 		  Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma, Asthma (childhood onset) N/A N/A GWAS
Eczema Eczema N/A N/A GWAS
Psoriasis Psoriasis N/A N/A GWAS
Show/Hide Text Mining Associations (586)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abnormal Karyotype Stimulate 9792304
Abortion Spontaneous Associate 17482605
Acne Vulgaris Associate 22705603
Acquired Immunodeficiency Syndrome Associate 10602033, 10823849, 11699717, 32532356, 8149667, 8450057, 9576185
Acrodermatitis Associate 11121150
Acute Kidney Injury Associate 23511138
Acute Phase Reaction Associate 1997656
Adenocarcinoma Associate 16884377, 18210751
Adenocarcinoma Stimulate 30105735
Adenocarcinoma of Lung Associate 12517954, 31909418, 7641214