IL3 (interleukin 3)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3562
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL3
Synonyms (NCBI Gene) Gene synonyms aliases
IL-3, MCGF, MULTI-CSF
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiat
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(40)
miRTarBase ID miRNA Experiments Reference
MIRT029305 hsa-miR-26b-5p Microarray 19088304
MIRT053457 hsa-miR-452-5p Microarray 23807165
MIRT1064862 hsa-miR-1229 CLIP-seq
MIRT1064863 hsa-miR-1286 CLIP-seq
MIRT1064864 hsa-miR-129-5p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
Transcription factor Regulation Reference
CEBPA Unknown 10453008
CEBPB Unknown 10453008
DNMT1 Repression 15735013
EGR1 Activation 8035792
ETS1 Unknown 8704203
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001959 Process Regulation of cytokine-mediated signaling pathway TAS
GO:0005125 Function Cytokine activity IEA
GO:0005135 Function Interleukin-3 receptor binding TAS 2544122
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147740 6011 ENSG00000164399
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P08700
Protein name Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor)
Protein function Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). Also stimu
PDB 1JLI , 5UV8 , 5UWC , 6NMY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02059 IL3 20 → 137 Interleukin-3 Domain
Tissue specificity TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer cells.
Sequence
Sequence length 152
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Apoptosis
JAK-STAT signaling pathway
Hematopoietic cell lineage
Fc epsilon RI signaling pathway
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Asthma 		  Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
RUNX1 regulates transcription of genes involved in interleukin signaling
Interleukin receptor SHC signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Anemia Anemia rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)		 12090760, 8202718
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 18804346, 18547720, 19281803, 17667962, 17179997
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Crohn Disease Crohn Disease GWAS
Show/Hide Text Mining Associations (97)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 30893922
Acute Phase Reaction Associate 1997656, 29920351
Alzheimer Disease Associate 18769539
Anemia Aplastic Associate 1375845, 2039816
Anemia Diamond Blackfan Associate 12718904
Anemia Refractory Associate 3497400
Anemia Sickle Cell Associate 9929101
Aneurysm Associate 23746831
Arthritis Rheumatoid Associate 11179015, 22355377, 27323078
Arthritis Rheumatoid Stimulate 18361097