FASLG (Fas ligand)

Gene

• Entrez ID: 356
• Gene name: Fas ligand
• Gene symbol: FASLG
• Synonyms (NCBI Gene): ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A
• Chromosome: 1
• Chromosome location: 1q24.3
• Summary: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation,

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs763110	C>T	Risk-factor	Upstream transcript variant
rs56302117	T>G	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, missense variant
rs80358236	TGCCTCTGGAATGGGAAGACACCTATGGAATTGTCCTGCTTTCTGGAGTGAAGTATAAGAAGGGTGGCCTTGTGATCAATGAAA>-	Pathogenic	3 prime UTR variant, inframe deletion, coding sequence variant
rs140406512	C>A,T	Conflicting-interpretations-of-pathogenicity	Intron variant, coding sequence variant, missense variant
rs201525996	A>G	Benign, conflicting-interpretations-of-pathogenicity	Intron variant
rs587776450	T>-	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay, Western blot	21820586
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	23177026
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	23177026
MIRT029780	hsa-miR-26b-5p	Microarray	19088304
MIRT006989	hsa-miR-21-5p	Reporter assay;Western blot;Other	20371612
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay, Western blot	23504349
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	24821435
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	24821435
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	24821435
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	24821435
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay	25118289
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay	25118289
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay	25118289
MIRT006989	hsa-miR-21-5p	Luciferase reporter assay	25118289
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT658286	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT658285	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT629088	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT629087	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT629086	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT629085	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT629084	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT629083	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT629082	hsa-miR-7703	HITS-CLIP	23824327
MIRT629081	hsa-miR-4325	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT658286	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT658285	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT658286	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT658285	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT629088	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT629087	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT629086	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT629085	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT629084	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT629083	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT629082	hsa-miR-7703	HITS-CLIP	23824327
MIRT629081	hsa-miR-4325	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT737672	hsa-let-7e-5p	Luciferase reporter assay	26826505
MIRT731263	hsa-let-7e-5p	Luciferase reporter assay	26826505
MIRT731263	hsa-let-7e-5p	Luciferase reporter assay	26826505
MIRT731263	hsa-let-7e-5p	Luciferase reporter assay	26826505
MIRT731263	hsa-let-7e-5p	Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR, Flow cytometry	33168041
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT658286	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT658285	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT629088	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT629087	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT629086	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT629085	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT629084	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT629083	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT629082	hsa-miR-7703	HITS-CLIP	23824327
MIRT629081	hsa-miR-4325	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT658286	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT658285	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT658286	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT658285	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT629088	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT629087	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT629086	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT629085	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT629084	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT629083	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT629082	hsa-miR-7703	HITS-CLIP	23824327
MIRT629081	hsa-miR-4325	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT611045	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT611044	hsa-miR-8485	HITS-CLIP	23824327
MIRT611043	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611042	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611041	hsa-miR-603	HITS-CLIP	23824327
MIRT611040	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT611039	hsa-miR-3941	HITS-CLIP	23824327
MIRT737677	hsa-let-7a	CLIP-seq
MIRT737678	hsa-let-7b	CLIP-seq
MIRT737679	hsa-let-7c	CLIP-seq
MIRT737680	hsa-let-7d	CLIP-seq
MIRT737672	hsa-let-7e	CLIP-seq
MIRT737681	hsa-let-7f	CLIP-seq
MIRT737675	hsa-let-7g	CLIP-seq
MIRT737674	hsa-let-7i	CLIP-seq
MIRT737683	hsa-miR-1224-3p	CLIP-seq
MIRT989499	hsa-miR-329	CLIP-seq
MIRT737684	hsa-miR-3922-5p	CLIP-seq
MIRT737676	hsa-miR-4458	CLIP-seq
MIRT737673	hsa-miR-4500	CLIP-seq
MIRT737686	hsa-miR-451b	CLIP-seq
MIRT737685	hsa-miR-4708-3p	CLIP-seq
MIRT737682	hsa-miR-98	CLIP-seq
MIRT989499	hsa-miR-329	CLIP-seq
MIRT1993283	hsa-miR-105	CLIP-seq
MIRT989499	hsa-miR-329	CLIP-seq
MIRT2227116	hsa-miR-25	CLIP-seq
MIRT2227117	hsa-miR-32	CLIP-seq
MIRT989499	hsa-miR-329	CLIP-seq
MIRT2227118	hsa-miR-363	CLIP-seq
MIRT2227119	hsa-miR-367	CLIP-seq
MIRT2227120	hsa-miR-92a	CLIP-seq
MIRT2227121	hsa-miR-92b	CLIP-seq
MIRT2227116	hsa-miR-25	CLIP-seq
MIRT2227117	hsa-miR-32	CLIP-seq
MIRT2227118	hsa-miR-363	CLIP-seq
MIRT2227119	hsa-miR-367	CLIP-seq
MIRT2428744	hsa-miR-875-3p	CLIP-seq
MIRT2227120	hsa-miR-92a	CLIP-seq
MIRT2227121	hsa-miR-92b	CLIP-seq
MIRT989499	hsa-miR-329	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF2	Unknown	19670268;9710625
CEBPB	Unknown	12496392
CIITA	Unknown	14563113
CREM	Repression	11754361
EGR1	Unknown	14563113
EGR2	Repression	19651900
FOXO3	Activation	11756562
IRF1	Unknown	14563113
JUN	Unknown	14563113;19670268;9710625
MAX	Unknown	10734130
MYC	Activation	12655294
MYC	Unknown	10734130;14563113
NFKB1	Activation	12655294;16770006
NFKB1	Unknown	10671224;14563113;15160330
NR4A1	Unknown	14563113
PDCD11	Unknown	14563113
PPARG	Activation	18293083
RELA	Activation	12655294;16770006
RELA	Unknown	10671224;14563113;15160330
SP1	Activation	12655294
SP1	Unknown	14563113;15004200

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	17557115
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	TAS	7826947
GO:0005123	Function	Death receptor binding	IEA
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IDA	9333124
GO:0005125	Function	Cytokine activity	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	12198154, 12887920, 16318909, 16498403, 16595635, 17761170, 19807924, 21803845, 24025841, 25241761, 25416956, 26871637, 28514442, 32296183, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	9228058
GO:0005615	Component	Extracellular space	IDA	18835034
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	17557115
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005886	Component	Plasma membrane	IDA	12201652
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7826947
GO:0005901	Component	Caveola	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	8787672
GO:0006925	Process	Inflammatory cell apoptotic process	IEA
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	TAS	7826947
GO:0007267	Process	Cell-cell signaling	TAS	7826947
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IBA
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IDA	9184224, 9333124, 26582200
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IDA	18835034
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IEA
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IDA	18835034
GO:0030644	Process	Intracellular chloride ion homeostasis	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	14749367
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21625644
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEP	12761501
GO:0043202	Component	Lysosomal lumen	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	IEA
GO:0046666	Process	Retinal cell programmed cell death	IEA
GO:0048388	Process	Endosomal lumen acidification	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0060205	Component	Cytoplasmic vesicle lumen	IEA
GO:0070062	Component	Extracellular exosome	IDA	17076679
GO:0070231	Process	T cell apoptotic process	IDA	17076679
GO:0070266	Process	Necroptotic process	IDA	11101870
GO:0070848	Process	Response to growth factor	IEA
GO:0071346	Process	Cellular response to type II interferon	IEA
GO:0097190	Process	Apoptotic signaling pathway	IDA	11101870
GO:0097190	Process	Apoptotic signaling pathway	IEA
GO:0097190	Process	Apoptotic signaling pathway	IMP	18293083
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IDA	22891283
GO:0097527	Process	Necroptotic signaling pathway	IDA	11101870
GO:1903514	Process	Release of sequestered calcium ion into cytosol by endoplasmic reticulum	IDA	26582200
GO:1905782	Process	Positive regulation of phosphatidylserine exposure on apoptotic cell surface	IDA	24904167
GO:2000353	Process	Positive regulation of endothelial cell apoptotic process	IDA	18835034
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IBA

Other IDs

• MIM: 134638
• HGNC: 11936
• e!Ensembl: ENSG00000117560

Protein

• UniProt ID: P48023
• Protein name: Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor n
• Protein function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (
• PDB: 4MSV, 5L19, 5L36
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00229	TNF	160 → 281	TNF(Tumour Necrosis Factor) family	Domain

• Sequence:

  MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPP
  PPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQ
  MHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGG
  LVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWA
  RSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL

• Sequence length: 281

Pathways

KEGG:

Platinum drug resistance
MAPK signaling pathway
Ras signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity
Neurotrophin signaling pathway
Non-alcoholic fatty liver disease
Alcoholic liver disease
Type I diabetes mellitus
Pathways of neurodegeneration - multiple diseases
Pathogenic Escherichia coli infection
Chagas disease
African trypanosomiasis
Hepatitis C
Hepatitis B
Measles
Human cytomegalovirus infection
Influenza A
Human papillomavirus infection
Herpes simplex virus 1 infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Proteoglycans in cancer
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
Lipid and atherosclerosis

Reactome:

Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFs bind their physiological receptors
Interleukin-4 and Interleukin-13 signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
FOXO-mediated transcription of cell death genes

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Autoimmune lymphoproliferative syndrome type 1	Likely pathogenic; Pathogenic	rs1413244355, rs773045347, rs2527587918, rs80358236	RCV001789806 RCV001948225 RCV003517699 RCV001789750
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IB	Pathogenic	rs80358236	RCV000017959
Lung cancer	Likely pathogenic	rs1413244355	RCV004820889

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
FASLG-related disorder	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity; Benign	rs750792722, rs374974805, rs140406512, rs140595317, rs199500307, rs755648147, rs1394873281, rs1394511823, rs80358238, rs749237778, rs777720730	RCV003918864 RCV003930894 RCV004755851 RCV003982996 RCV004756521 RCV003901672 RCV003979483 RCV003934124 RCV004755745 RCV003392479 RCV003898059
Immunodeficiency 98 with autoinflammation, X-linked	Benign; Likely benign	rs530390117	RCV002283549
LUNG CANCER, SUSCEPTIBILITY TO	risk factor	rs763110	RCV000017960

Associations from Text Mining
Disease Name	Relationship Type	References
Abortion Habitual	Associate	30937706
Abortion Habitual	Stimulate	30942389
Abortion Spontaneous	Stimulate	30942389
Abortion Spontaneous	Inhibit	39408839
Acquired Immunodeficiency Syndrome	Associate	11122242, 9002958
Acro Osteolysis	Associate	12823344
Acrocephalosyndactylia	Stimulate	23330016
Acute Coronary Syndrome	Associate	11849855, 28348007
Acute Kidney Injury	Stimulate	37569838
Acute Lung Injury	Stimulate	12414525
Acute Lung Injury	Associate	18310897
Adenocarcinoma	Stimulate	11477113
Adenocarcinoma	Associate	12124829, 21390183, 25596086
Adenocarcinoma of Lung	Associate	29207489
Adenoma	Associate	10780525, 11477113, 16219172
Adenoma	Stimulate	11005209
Adenoma Islet Cell	Inhibit	11889077
Aicardi Goutieres syndrome	Associate	30597845
Altitude Sickness	Associate	35875936
Alveolitis Extrinsic Allergic	Inhibit	22252758
Alzheimer Disease	Stimulate	20643858
Anal Gland Neoplasms	Associate	28785150
Anaphylaxis	Inhibit	30189430
Anemia	Associate	10203105, 11222356, 11830480, 32628088
Anemia Aplastic	Associate	11564081, 12404285
Anemia Hemolytic	Associate	10203105
Angina Unstable	Associate	11849855
Appendicitis	Associate	26374830
Arthritis	Associate	22687048
Arthritis Juvenile	Associate	20462799
Arthritis Rheumatoid	Associate	12746897, 14691302, 15457448, 17459170, 19196465, 23918525, 9333124, 9764613, 9767455
Asbestosis	Stimulate	22252758
Ataxia Telangiectasia	Associate	24603338
Atherosclerosis	Associate	11407740, 11786516, 17053166
Atrophy	Associate	18383830
Autoimmune Diseases	Associate	10632670, 12149230, 12496392, 16108814, 16180659, 23850805, 28250925
Autoimmune Lymphoproliferative Syndrome	Associate	11380411, 15870181, 17062728, 17605793, 19176318, 22857792, 26113417, 27060458, 32599613, 33995372, 34438083, 35628184, 37838774
Autoimmune Lymphoproliferative Syndrome	Stimulate	9136951
Behcet Syndrome	Associate	16237110
Blood Platelet Disorders	Associate	34741638
Bone Diseases	Associate	10440912, 9333124
Bone Marrow Failure Disorders	Associate	9792306
Bowen's Disease	Associate	12089736
Brain Neoplasms	Associate	20501759, 26858129, 8878461, 9217971
Breast Neoplasms	Associate	10391843, 10651943, 11070347, 11571297, 12223126, 14982861, 17352235, 19341712, 21069948, 22842170, 22909995, 23326385, 24289581, 24916571, 25472583, 27524883, 29185091, 32143617, 35864548, 36766731, 37334575, 38041032
Bronchiolitis	Stimulate	15196254
Burkitt Lymphoma	Associate	37569852
Carcinogenesis	Associate	11477113, 15937082, 16004605, 16091761, 16224150, 20222173, 22022540, 23280017, 26617948
Carcinoma	Inhibit	11005209
Carcinoma Basal Cell	Inhibit	12089736
Carcinoma Basal Cell	Associate	12787140, 16638418, 9389732
Carcinoma Ductal	Stimulate	22842170
Carcinoma Ductal Breast	Associate	19015953
Carcinoma Hepatocellular	Associate	10735508, 14669310, 15849812, 15849828, 16080799, 16273601, 16419152, 24761872, 25596532, 27431384, 28246474, 30085405, 35283421, 9353266
Carcinoma Medullary	Stimulate	18469794
Carcinoma Non Small Cell Lung	Associate	10817513, 12458337, 16224150, 17668204, 18757527, 21744322, 26823709
Carcinoma Non Small Cell Lung	Stimulate	18757527
Carcinoma Ovarian Epithelial	Associate	10817504, 17465232, 22161157
Carcinoma Renal Cell	Associate	10782148, 10944605, 12460460, 12941126, 17132225, 31097685, 35165523, 39465721
Carcinoma Squamous Cell	Associate	11442750, 12089736, 15698511, 16456813, 21808135, 25976983
Carcinoma Transitional Cell	Associate	12651606
Cardiofaciocutaneous syndrome	Associate	12404285
Cardiomegaly	Inhibit	17966039
Cardiomegaly	Associate	17966039
Carotid Artery Diseases	Inhibit	15063428
Celiac Disease	Associate	26859134
Chemical and Drug Induced Liver Injury	Associate	10540162, 27243827
Cholangiocarcinoma	Associate	11854917, 29089545
Cholangitis Sclerosing	Associate	29089545
Choroidal Effusions	Associate	18925324
Chromosome 6 ring syndrome	Associate	10203105
Churg Strauss Syndrome	Associate	10487849
Clear cell metastatic renal cell carcinoma	Associate	11206267
Colitis Ulcerative	Stimulate	26374830
Colitis Ulcerative	Associate	31330513, 8686766
Colonic Neoplasms	Associate	10567875, 10744679, 11477113, 11592778, 12865931, 14614330, 16273638, 18648368, 20039457, 9177233, 9223329
Colorectal Neoplasms	Associate	10079247, 10098769, 11592778, 11927015, 12610520, 14520470, 15004200, 15274324, 15962391, 15991293, 16273638, 18648368, 19067240, 21071349, 22022540, 23615374, 26211005, 26759270, 28300842, 28929494, 29684585, 30016783, 30214631, 31796117, 9895372
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	19067240
Congenital contractural arachnodactyly	Associate	29089545
Coronary Artery Disease	Associate	34777632
COVID 19	Associate	33260035, 33905951, 34741638, 36119078
Crohn Disease	Stimulate	26374830
Crohn Disease	Associate	28785150
Cystic Fibrosis	Associate	10567629
Cytomegalovirus Infections	Associate	14725906, 22733023
Cytomegalovirus Infections	Stimulate	16918537
Death	Associate	12414525, 12694389, 23894399, 25950471, 26400345, 29092660
Death	Stimulate	20877355
Death Sudden	Associate	11970950
Death Sudden Cardiac	Associate	18758635
Dermatitis	Associate	16858424, 21430507
Dermatitis Atopic	Inhibit	11091268
Dermatitis Atopic	Associate	12542799, 30286163
Dermatitis Contact	Associate	33318199
Dermatitis Herpetiformis	Associate	16388717, 22778762
Diabetes Mellitus	Associate	23335850
Diabetes Mellitus	Stimulate	24172699
Diabetes Mellitus Type 1	Inhibit	16180659
Diabetes Mellitus Type 1	Associate	22519592, 9334358
Diabetes Mellitus Type 2	Associate	24178789, 30024959
DiGeorge Syndrome	Associate	9697985
Disease	Stimulate	10792370
Disease	Associate	11511560, 15819704, 25052311
Drug Eruptions	Associate	17139262, 17977827
Drug Fever	Stimulate	9111585
Drug Hypersensitivity	Associate	16595663, 33318199
Drug Related Side Effects and Adverse Reactions	Associate	10209509, 10540162, 10780664, 10812243, 10999463, 15320888, 15819704, 17257501, 17490628, 20682655, 30333226, 30925759, 34404616, 37894816, 9119748
Drug Related Side Effects and Adverse Reactions	Stimulate	11830480, 12517928, 18497573, 9472635
Drug Resistant Epilepsy	Associate	9792306
Dysentery Bacillary	Associate	12011015
Eczema	Associate	16858424, 17977827
Emphysema	Associate	17822550
Encephalitis	Associate	23639073
Endometriosis	Associate	31566051
Enterocolitis Neutropenic	Associate	14965872
Epilepsy Temporal Lobe	Associate	27006531
Epstein Barr Virus Infections	Associate	11504544, 20193111
Esophageal Neoplasms	Associate	16186185, 16425431, 24473454, 26819081
Esophageal Squamous Cell Carcinoma	Associate	19728877, 24473454
Exanthema	Associate	16412052
Fetal Growth Retardation	Inhibit	34697371
Fever	Stimulate	31450899
Fever	Associate	36119078
Fibroadenoma	Associate	22842170
Fibrocartilaginous embolism	Associate	23801893, 23923075, 32143617
Fibrosis	Associate	11204278, 22252758
Fibrosis	Inhibit	27243827
Fractures Spontaneous	Associate	23938324
Fuchs' Endothelial Dystrophy	Associate	25169582
Gallbladder Neoplasms	Associate	15968727
Gastritis	Associate	10691918, 9788963
Gastrointestinal Neoplasms	Associate	25333257
Gastrointestinal Stromal Tumors	Associate	18941456
GATA2 Deficiency	Associate	12466128, 19375652
Genetic Diseases Inborn	Associate	32628088
Glaucoma Open Angle	Associate	8889553
Glioblastoma	Associate	11092528, 11883844, 24130787, 24561085, 9217971
Glioma	Associate	10780669, 11522296, 11770895, 11883844, 22060015, 24130787, 25556484, 29164574, 8878461, 9111585, 9217971, 9409814, 9472635
Glomerulonephritis IGA	Associate	29137483
Glycosuria Renal	Associate	10999463
Graft vs Host Disease	Associate	10192442, 14993881, 21430507
Granulomatous Disease Chronic	Associate	9645360
Graves Disease	Associate	18324486, 19008632, 33912135
Guillain Barre Syndrome	Associate	29432441
Hashimoto Disease	Associate	11005209, 12480911, 18324486
Hashimoto Disease	Stimulate	16219172
Head and Neck Neoplasms	Associate	38200037
Hearing Disorders	Associate	32628088
Heart Failure	Associate	22790687
Heart Neoplasms	Associate	26617948
Helicobacter Infections	Associate	18946358
HELLP Syndrome	Associate	21501125
Hemangiosarcoma	Associate	11549589
Hepatitis C	Associate	10540162, 22449797, 27243827
Hepatitis Chronic	Stimulate	15457575
Hereditary leiomyomatosis and renal cell cancer	Associate	10658674, 15078899, 15096587
Hippocampal Sclerosis	Associate	27006531
Histiocytosis Langerhans Cell	Associate	10440912
HIV Infections	Inhibit	10481067
HIV Infections	Associate	11375056, 11800643, 12390316, 16155003, 31762906, 9002958, 9028959, 9159165, 9649560
HIV Infections	Stimulate	33093334
Hodgkin Disease	Associate	15096587, 9533769
Hyperlipidemia Familial Combined	Associate	15063428
Hyperlipoproteinemia Type I	Associate	17605793
Hyponatremia	Associate	36119078
Hypoxia	Associate	35875936
Idiopathic Pulmonary Fibrosis	Associate	11334117, 27218286
Idiopathic Pulmonary Fibrosis	Stimulate	22252758
Immunologic Deficiency Syndromes	Associate	9002958
Infections	Stimulate	11292757
Infections	Associate	17036384, 32373555
Infectious Mononucleosis	Associate	10792379
Inferior Wall Myocardial Infarction	Associate	24969587
Inflammation	Associate	10079247, 11104808, 11675676, 11849855, 14514471, 15063428, 15539085, 15816613, 16861346, 21430507, 23639073, 23909556, 24903614, 25950471, 26400345, 27243827, 28460464, 31654316, 34741638, 8686766, 9333124, 9566799
Inflammation	Stimulate	16858424, 17977827, 25501066
Inflammatory Bowel Diseases	Associate	26374830
Inflammatory Breast Neoplasms	Associate	18248671
Insulin Resistance	Associate	24178789, 30024959
Intervertebral Disc Degeneration	Inhibit	23801893
Intervertebral Disc Degeneration	Associate	24228099, 32143617
Intervertebral Disc Displacement	Associate	23141929
Intestinal Diseases	Associate	18383830
Intestinal Neoplasms	Associate	18473402
Keratoconus	Associate	25169582
Keratosis Actinic	Associate	11442750
Klatskin Tumor	Associate	11854917
Laryngeal Neoplasms	Associate	33415169
Lead Poisoning Nervous System	Stimulate	9566799
Leprosy	Associate	16978419
Leukemia	Associate	10075697, 10517493, 10556200, 28537657
Leukemia Large Granular Lymphocytic	Associate	10807792, 10887130, 12480700, 16484592, 31467122, 9136951, 9845544
Leukemia Large Granular Lymphocytic	Stimulate	23667543
Leukemia Lymphocytic Chronic B Cell	Associate	33639675, 9596676
Leukemia Lymphoma Adult T Cell	Associate	20706274, 35041720, 9573032
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	10517493, 10556200, 26563376, 27009330
Leukemia Myelogenous Chronic BCR ABL Positive	Inhibit	22585600
Leukemia Myeloid	Associate	10556200
Leukemia Myeloid Acute	Associate	10517493, 10556200, 10812243, 22183068, 28013316, 9012700
Leukemia Prolymphocytic T Cell	Associate	10520029, 9450802
Leukemia Promyelocytic Acute	Associate	11698395, 11918536
Leukemia T Cell	Associate	10607716, 11918536, 9409752
Leukoencephalopathies	Associate	28624961, 8879222
Light Fixation Seizure Syndrome	Associate	27682872
Liver Cirrhosis Biliary	Stimulate	24759184
Liver Diseases	Associate	27243827
Liver Diseases Alcoholic	Associate	7595193
Liver Failure	Associate	10540162, 28410274
Lung Diseases	Associate	12414525, 15833141, 26617708, 36119078
Lung Diseases Interstitial	Stimulate	22252758
Lung Injury	Associate	15161631, 26617708
Lung Neoplasms	Associate	15937082, 16186185, 17708363, 18757527, 24128051, 31978067
Lupus Erythematosus Discoid	Associate	16638418, 26261624
Lupus Erythematosus Systemic	Associate	10632670, 10643709, 11905854, 12421989, 12496392, 20529085, 24348139, 8787672, 9344329
Lupus Erythematosus Systemic	Stimulate	19644848, 26261624, 33198645
Lupus Nephritis	Stimulate	11905854
Lymphatic Diseases	Associate	8787672
Lymphatic Metastasis	Stimulate	15962391, 23534738, 26400345
Lymphatic Metastasis	Associate	23280017, 25596086, 27524883
Lymphoma	Associate	10595932, 11046041, 16494623, 17210689, 33168041, 33513976
Lymphoma Extranodal NK T Cell	Associate	31908105
Lymphoma Follicular	Associate	10782148, 33168041
Lymphoma Large B Cell Diffuse	Associate	14982861, 16494623
Lymphoma Large Cell Anaplastic	Associate	16304056
Lymphoma Primary Effusion	Associate	27893813
Lymphoma T Cell Cutaneous	Associate	15816832, 25140833
Lymphopenia	Stimulate	15654826
Lymphopenia	Associate	32628088, 9566799
Lymphoproliferative Disorders	Associate	12149230, 17966039, 8787672
Malaria Falciparum	Associate	26617708
Malformations of Cortical Development	Associate	23639073
Malformations of Cortical Development Group I	Associate	20476668
Melanoma	Associate	10383736, 10802053, 11121134, 11369232, 11511316, 12021310, 12610520, 15654977, 15930731, 16306044, 16487513, 17545621, 19725869, 24862567, 38307835, 9892185
Melanoma	Inhibit	17342088
Melanoma Cutaneous Malignant	Associate	37401304
Mikulicz' Disease	Associate	17966039
Mitochondrial Diseases	Associate	34852799
Mouth Neoplasms	Associate	12021310, 21808135, 24337492, 25634589
Multiple Myeloma	Associate	11222356, 11830480, 12823344, 37138866, 9207432, 9916933
Multiple Sclerosis	Associate	12694389, 21437244, 25950471, 26407760, 8879222
Multiple Sclerosis	Inhibit	28008595
Muscular Atrophy Spinal	Associate	22723941
Muscular Dystrophy Duchenne	Stimulate	20476668
Myelodysplastic Syndromes	Stimulate	12404285
Myelodysplastic Syndromes	Associate	9792306
Myocardial Infarction	Associate	11849855, 11970950, 14711179
Myocardial Stunning	Associate	18758635
Myositis	Associate	19740320
Myotonic Dystrophy	Associate	21414848
Nasopharyngeal Carcinoma	Associate	15330177, 24194922
Neonatal herpes	Associate	26458812
Neoplasm Invasiveness	Stimulate	11442750, 21071349
Neoplasm Metastasis	Associate	10079247, 10098769, 15962391, 16004605, 19015953, 23280017, 26617948, 37334575, 9177233
Neoplasm Metastasis	Inhibit	12854132, 17352235
Neoplasms	Associate	10075697, 10079247, 10098769, 10383736, 10391843, 10567875, 10735508, 10780525, 10780669, 10782148, 10891490, 10946816, 11005209, 11121134, 11549589, 11854917, 11883844, 11927015, 12021310, 12115319, 12124829, 12223126, 12517928, 12610520, 12651606, 12787140, 12823344, 12854132, 12865931, 12902349, 12941126, 14520470, 14614330, 14669310, 15004200, 15272306, 15345718, 15378505, 15494722, 15698511, 15816613, 15831912, 15937082, 15962391, 15968727, 16004605, 16052233, 16186185, 16273638, 16357524, 16452205, 16529843, 17257501, 17465232, 17551095, 17667919, 17668204, 17708363, 18163957, 18336591, 18469794, 18648368, 19067240, 19155494, 19180118, 19289577, 19890350, 20191142, 20193111, 21071349, 21088216, 21390183, 21526501, 21744322, 21808135, 22022540, 22842170, 23076876, 23177026, 23326385, 23534738, 23667543, 23894399, 24473454, 24561085, 24761872, 25100434, 25472583, 25596086, 26211005, 26759270, 27323411, 27625332, 27628319, 28273453, 28627601, 29092660, 30214631, 30585273, 30912767, 31537619, 31819434, 32212814, 32606315, 33023539, 33168041, 33381488, 33639675, 34531849, 34957697, 36124496, 37334575, 37443405, 37542121, 37699334, 37838774, 37894816, 37919293, 38307835, 9177233, 9207432, 9616229, 9680369, 9827928, 9895372
Neoplasms	Inhibit	15991280
Neoplasms	Stimulate	18364356, 9846984
Neoplasms Cystic Mucinous and Serous	Associate	10780525
Neoplasms Hormone Dependent	Associate	22842170
Neoplasms Second Primary	Associate	20501759, 26858129
Neoplasms Squamous Cell	Associate	23534738
Nerve Degeneration	Stimulate	21430507
Neuroblastoma	Associate	21298033, 23951214
Neuroendocrine Tumors	Associate	18366613
Neutropenia	Associate	10807792, 12480700, 18819843, 31467122, 9136951
Neutropenia severe chronic	Associate	10807792, 15755293
NOG Related Symphalangism Spectrum Disorder	Associate	12651606
Non alcoholic Fatty Liver Disease	Associate	23405244
Obesity	Associate	24178789
Oculopalatocerebral Syndrome	Associate	26858129
Oncogene Addiction	Stimulate	12230495
Optic Nerve Glioma	Associate	11050476
Oropharyngeal Neoplasms	Associate	25976983
Osteoarthritis	Associate	12932288, 25807424
Osteoarthritis Knee	Associate	12932288
Osteosarcoma	Associate	19066961
Ovarian Neoplasms	Associate	10780525, 12637505, 12725530, 15662527, 17465232, 17667919, 19959214, 22161157, 23076876, 31537619, 39608974, 9616229
Pancreatic Neoplasms	Associate	10714630, 11115536, 11310825, 12173320, 19664137, 32606315
Pancreatitis	Associate	32606315
Pancreatitis Chronic	Associate	11310825, 11889077
Panniculitis Lupus Erythematosus	Associate	26261624
Papilloma	Associate	26458812
Penile Induration	Associate	23356197
Peritonitis	Associate	12787425
Persistent Infection	Associate	16180659
Personality Disorders	Stimulate	15378505
Plaque Atherosclerotic	Associate	11970950
Pleural Effusion	Associate	22159518
Polycystic Ovary Syndrome	Associate	35393909
Pre Eclampsia	Inhibit	21501125
Primary Immunodeficiency Diseases	Associate	38644452
Prostatic Intraepithelial Neoplasia	Stimulate	12124829
Prostatic Neoplasms	Associate	11020350, 17295927, 19055752, 29211704, 33326414, 38087324
Prostatic stromal proliferation of uncertain malignant potential	Associate	10780525
Prostatitis	Associate	12124829, 28984341
Pulmonary Disease Chronic Obstructive	Associate	17118637, 33260035
Pulmonary Edema	Associate	12414525, 26617708
Purpura Thrombocytopenic Idiopathic	Stimulate	16212887
Purpura Thrombocytopenic Idiopathic	Associate	16368066, 17548576
Pyoderma Gangrenosum	Associate	24903614
Pyoderma Gangrenosum	Stimulate	25501066
Respiratory Distress Syndrome	Stimulate	12414525
Respiratory Distress Syndrome	Associate	15161631, 28410274
Retinoblastoma	Associate	15378505, 27625332
Rhabdomyosarcoma	Associate	23191987
Rupture	Associate	11970950
Sarcoidosis	Associate	26376720
Sarcoidosis Pulmonary	Inhibit	22252758
Sarcoidosis Pulmonary	Associate	26376720
Sarcoma	Associate	11549589, 18506556
Sarcoma Ewing	Associate	17695539, 22382690, 9846984
Schistosomiasis	Associate	14965872
Sertoli Cell Only Syndrome	Associate	16494623, 17123522
Sezary Syndrome	Associate	18314443, 21270445
Silicosis	Associate	14514471, 36350953
Sjogren's Syndrome	Associate	11204278, 12100038, 12528117, 17966039, 37353767, 9764611, 9844061
Sjogren's Syndrome	Inhibit	17966039
Skin Diseases	Stimulate	12787140
Skin Diseases	Inhibit	21430507
Sleep Deprivation	Associate	8652825
Spondylitis Ankylosing	Associate	29960293
Squamous Cell Carcinoma of Head and Neck	Associate	15039212, 18547033, 20501759, 23534738, 23894399, 26400345, 27628319, 32628088, 37798436
Status Asthmaticus	Associate	9449721
Stevens Johnson Syndrome	Stimulate	17139262
Stevens Johnson Syndrome	Associate	17977827, 22992806
Still's Disease Adult Onset	Associate	18050226
Stomach Diseases	Associate	10858249, 14595120, 18383830
Stomach Neoplasms	Associate	11206267, 12854132, 15991280, 18383830, 20193111, 20222173, 21526501, 26393583, 26617948, 28627601, 34957697, 36124496, 9895372
Stomach Ulcer	Associate	17036384
Superinfection	Associate	30912767
Synovitis	Associate	11407740
Tertiary Lymphoid Structures	Stimulate	37443405
Testicular Neoplasms	Associate	21509038
Thyroid Neoplasms	Associate	11005209
Thyroiditis	Associate	11675676, 19008632
Thyroiditis Autoimmune	Associate	16219172
Tuberculosis	Associate	12780692, 16556259, 28250925
Tuberculosis Central Nervous System	Stimulate	22111973
Tuberculosis Meningeal	Inhibit	27682872
Tuberculosis Meningeal	Associate	28250925
Tuberculosis Meningeal	Stimulate	30180814
Tuberculosis Pulmonary	Stimulate	23936496
Ulcer	Associate	26374830
Urethral Neoplasms	Associate	16091761
Urinary Bladder Neoplasms	Associate	16101181, 22517918, 23948181
Urinary Tract Infections	Stimulate	16918537
Uterine Cervical Dysplasia	Associate	16456813
Uterine Cervical Dysplasia	Inhibit	17433060
Uterine Cervical Neoplasms	Associate	16186185, 16456813, 21119362, 23076876, 23280017, 26345794, 26458812, 32212814
Uterine Cervicitis	Associate	23280017
Uterine Cervicitis	Stimulate	26345794
Varicocele	Stimulate	20165911
Virus Diseases	Associate	17139262
Vitiligo	Associate	18548110, 34107850
Vomiting	Associate	28686330
Vulvar Neoplasms	Associate	37382757
Wounds and Injuries	Associate	27431384