IL2 (interleukin 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 3558
Gene name Interleukin 2
Gene symbol IL2
Synonyms (NCBI Gene)
IL-2TCGFlymphokine
Chromosome 4
Chromosome location 4q27
Summary This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, th
miRNA miRNA information provided by mirtarbase database.
3
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT025034 hsa-miR-181c-5p Reporter assay;qRT-PCR;Other 21112091
MIRT041627 hsa-miR-484 CLASH 23622248
MIRT054292 hsa-miR-155-5p qRT-PCR 22785227
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
BACH2 Unknown 18769450
CREB1 Unknown 8814256
CREM Repression 15841182
CREM Unknown 12370343
EGR1 Unknown 12560487
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002366 Process Leukocyte activation involved in immune response IDA 16204630
GO:0002376 Process Immune system process IEA
GO:0002639 Process Positive regulation of immunoglobulin production IEA
GO:0002639 Process Positive regulation of immunoglobulin production IGI 22962438
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147680 6001 ENSG00000109471
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P60568
Protein name Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
Protein function Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:6438535). Binds to a receptor co
PDB 1IRL , 1M47 , 1M48 , 1M49 , 1M4A , 1M4B , 1M4C , 1NBP , 1PW6 , 1PY2 , 1QVN , 1Z92 , 2B5I , 2ERJ , 3INK , 3QAZ , 3QB1 , 4NEJ , 4NEM , 5LQB , 5M5E , 5UTZ , 6LX3 , 6LXW , 6VWU , 6YE3 , 7DR4 , 7M2G , 7RA9 , 7RAA , 7YZJ , 7ZMZ , 8SOW , 8SOZ , 8WYR , 8WYS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00715 IL2 7 → 150 Interleukin 2 Domain
Sequence
Sequence length 153
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
PI3K-Akt signaling pathway
C-type lectin receptor signaling pathway
JAK-STAT signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Yersinia infection
Chagas disease
Measles
Human T-cell leukemia virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Autoimmune thyroid disease
Inflammatory bowel disease
Allograft rejection
Graft-versus-host disease 		  RAF/MAP kinase cascade
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Interleukin-2 signaling
Interleukin receptor SHC signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Breast neoplasm Pathogenic rs2484754163, rs2484759187 RCV002285229
RCV002285230
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
IL2-related disorder Likely benign rs146566026 RCV003924111
Show/Hide Text Mining Associations (580)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Spontaneous Stimulate 33731680
Abortion Spontaneous Associate 36096448
Acquired Immunodeficiency Syndrome Associate 1477028, 20498045, 2144349, 23806696, 2581997, 3001715, 32532356, 36003311, 3924451, 3924452, 6609030, 6610444, 8207793, 8450057, 9502779
Acquired Immunodeficiency Syndrome Inhibit 2295695, 3115647, 3159524
Acute Coronary Syndrome Inhibit 26663396
Acute Disease Associate 1628427
Acute Disease Stimulate 29636753
Acute Kidney Injury Associate 39696008
Addison Disease Associate 25347332
Adenocarcinoma Associate 9119749