IL2 (interleukin 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3558
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL2
Synonyms (NCBI Gene) Gene synonyms aliases
IL-2, TCGF, lymphokine
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q27
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, th
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT025034 hsa-miR-181c-5p Reporter assay;qRT-PCR;Other 21112091
MIRT041627 hsa-miR-484 CLASH 23622248
MIRT054292 hsa-miR-155-5p qRT-PCR 22785227
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
BACH2 Unknown 18769450
CREB1 Unknown 8814256
CREM Repression 15841182
CREM Unknown 12370343
EGR1 Unknown 12560487
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002366 Process Leukocyte activation involved in immune response IDA 16204630
GO:0002376 Process Immune system process IEA
GO:0002639 Process Positive regulation of immunoglobulin production IEA
GO:0002639 Process Positive regulation of immunoglobulin production IGI 22962438
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147680 6001 ENSG00000109471
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P60568
Protein name Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
Protein function Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:6438535). Binds to a receptor co
PDB 1IRL , 1M47 , 1M48 , 1M49 , 1M4A , 1M4B , 1M4C , 1NBP , 1PW6 , 1PY2 , 1QVN , 1Z92 , 2B5I , 2ERJ , 3INK , 3QAZ , 3QB1 , 4NEJ , 4NEM , 5LQB , 5M5E , 5UTZ , 6LX3 , 6LXW , 6VWU , 6YE3 , 7DR4 , 7M2G , 7RA9 , 7RAA , 7YZJ , 7ZMZ , 8SOW , 8SOZ , 8WYR , 8WYS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00715 IL2 7 → 150 Interleukin 2 Domain
Sequence
Sequence length 153
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
PI3K-Akt signaling pathway
C-type lectin receptor signaling pathway
JAK-STAT signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Yersinia infection
Chagas disease
Measles
Human T-cell leukemia virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Autoimmune thyroid disease
Inflammatory bowel disease
Allograft rejection
Graft-versus-host disease 		  RAF/MAP kinase cascade
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Interleukin-2 signaling
Interleukin receptor SHC signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (15)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Allergic Sensitization Allergic sensitization N/A N/A GWAS
Alopecia Areata Alopecia areata N/A N/A GWAS
Asthma Asthma in any disease, Asthma, Asthma (adult onset), Asthma onset (childhood vs adult), Asthma (age of onset), Asthma (childhood onset), Atopic asthma N/A N/A GWAS
Bipolar Disorder Bipolar I disorder, Bipolar disorder N/A N/A GWAS
Show/Hide Text Mining Associations (580)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Spontaneous Stimulate 33731680
Abortion Spontaneous Associate 36096448
Acquired Immunodeficiency Syndrome Associate 1477028, 20498045, 2144349, 23806696, 2581997, 3001715, 32532356, 36003311, 3924451, 3924452, 6609030, 6610444, 8207793, 8450057, 9502779
Acquired Immunodeficiency Syndrome Inhibit 2295695, 3115647, 3159524
Acute Coronary Syndrome Inhibit 26663396
Acute Disease Associate 1628427
Acute Disease Stimulate 29636753
Acute Kidney Injury Associate 39696008
Addison Disease Associate 25347332
Adenocarcinoma Associate 9119749