Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3556
Gene name Gene Name - the full gene name approved by the HGNC.	Interleukin 1 receptor accessory protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IL1RAP
Synonyms (NCBI Gene) Gene synonyms aliases	C3orf13, IL-1RAcP, IL1R3
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q28
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differ

Show/Hide all(177)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005831	hsa-miR-204-5p	Microarray	21282569
MIRT020058	hsa-miR-375	Microarray	20215506
MIRT024630	hsa-miR-215-5p	Microarray	19074876
MIRT026944	hsa-miR-192-5p	Microarray	19074876
MIRT036392	hsa-miR-1228-3p	CLASH	23622248
MIRT437619	hsa-miR-146a-5p	Microarray, qRT-PCR	22815788
MIRT437625	hsa-miR-146b-5p	Microarray, qRT-PCR	22815788
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22291592
MIRT448178	hsa-miR-4635	PAR-CLIP	22291592
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22291592
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22291592
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT448178	hsa-miR-4635	PAR-CLIP	22100165
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22100165
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT448178	hsa-miR-4635	PAR-CLIP	22100165
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22100165
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22291592
MIRT448178	hsa-miR-4635	PAR-CLIP	22291592
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22291592
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22291592
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT448178	hsa-miR-4635	PAR-CLIP	22100165
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22100165
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT448178	hsa-miR-4635	PAR-CLIP	22100165
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22100165
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT1064296	hsa-miR-1206	CLIP-seq
MIRT1064297	hsa-miR-1261	CLIP-seq
MIRT1064298	hsa-miR-1270	CLIP-seq
MIRT1064299	hsa-miR-1290	CLIP-seq
MIRT1064300	hsa-miR-141	CLIP-seq
MIRT1064301	hsa-miR-181a	CLIP-seq
MIRT1064302	hsa-miR-181b	CLIP-seq
MIRT1064303	hsa-miR-181c	CLIP-seq
MIRT1064304	hsa-miR-181d	CLIP-seq
MIRT1064305	hsa-miR-192	CLIP-seq
MIRT1064306	hsa-miR-194	CLIP-seq
MIRT1064307	hsa-miR-200a	CLIP-seq
MIRT1064308	hsa-miR-208a	CLIP-seq
MIRT1064309	hsa-miR-208b	CLIP-seq
MIRT1064310	hsa-miR-21	CLIP-seq
MIRT1064311	hsa-miR-215	CLIP-seq
MIRT1064312	hsa-miR-23a	CLIP-seq
MIRT1064313	hsa-miR-23b	CLIP-seq
MIRT1064314	hsa-miR-23c	CLIP-seq
MIRT1064315	hsa-miR-27a	CLIP-seq
MIRT1064316	hsa-miR-27b	CLIP-seq
MIRT1064317	hsa-miR-299-3p	CLIP-seq
MIRT1064318	hsa-miR-3143	CLIP-seq
MIRT1064319	hsa-miR-3158-3p	CLIP-seq
MIRT1064320	hsa-miR-3163	CLIP-seq
MIRT1064321	hsa-miR-3167	CLIP-seq
MIRT1064322	hsa-miR-346	CLIP-seq
MIRT1064323	hsa-miR-34b	CLIP-seq
MIRT1064324	hsa-miR-3607-5p	CLIP-seq
MIRT1064325	hsa-miR-3661	CLIP-seq
MIRT1064326	hsa-miR-3691-5p	CLIP-seq
MIRT1064327	hsa-miR-3924	CLIP-seq
MIRT1064328	hsa-miR-3940-5p	CLIP-seq
MIRT1064329	hsa-miR-3976	CLIP-seq
MIRT1064330	hsa-miR-4262	CLIP-seq
MIRT1064331	hsa-miR-4263	CLIP-seq
MIRT1064332	hsa-miR-4288	CLIP-seq
MIRT1064333	hsa-miR-4432	CLIP-seq
MIRT1064334	hsa-miR-4491	CLIP-seq
MIRT1064335	hsa-miR-4507	CLIP-seq
MIRT1064336	hsa-miR-451b	CLIP-seq
MIRT1064337	hsa-miR-4646-5p	CLIP-seq
MIRT1064338	hsa-miR-4652-3p	CLIP-seq
MIRT1064339	hsa-miR-4655-5p	CLIP-seq
MIRT1064340	hsa-miR-4657	CLIP-seq
MIRT1064341	hsa-miR-4662a-3p	CLIP-seq
MIRT1064342	hsa-miR-4666-5p	CLIP-seq
MIRT1064343	hsa-miR-4683	CLIP-seq
MIRT1064344	hsa-miR-4711-3p	CLIP-seq
MIRT1064345	hsa-miR-4729	CLIP-seq
MIRT1064346	hsa-miR-4731-5p	CLIP-seq
MIRT1064347	hsa-miR-4752	CLIP-seq
MIRT1064348	hsa-miR-4766-3p	CLIP-seq
MIRT1064349	hsa-miR-4778-5p	CLIP-seq
MIRT1064350	hsa-miR-4789-5p	CLIP-seq
MIRT1064351	hsa-miR-4799-5p	CLIP-seq
MIRT1064352	hsa-miR-4803	CLIP-seq
MIRT1064353	hsa-miR-499-5p	CLIP-seq
MIRT1064354	hsa-miR-513a-5p	CLIP-seq
MIRT1064355	hsa-miR-539	CLIP-seq
MIRT1064356	hsa-miR-543	CLIP-seq
MIRT1064357	hsa-miR-548ac	CLIP-seq
MIRT1064358	hsa-miR-548ad	CLIP-seq
MIRT1064359	hsa-miR-548ae	CLIP-seq
MIRT1064360	hsa-miR-548aj	CLIP-seq
MIRT1064361	hsa-miR-548am	CLIP-seq
MIRT1064362	hsa-miR-548d-3p	CLIP-seq
MIRT1064363	hsa-miR-548x	CLIP-seq
MIRT1064364	hsa-miR-548z	CLIP-seq
MIRT1064365	hsa-miR-563	CLIP-seq
MIRT1064366	hsa-miR-568	CLIP-seq
MIRT1064367	hsa-miR-576-5p	CLIP-seq
MIRT1064368	hsa-miR-579	CLIP-seq
MIRT1064369	hsa-miR-582-5p	CLIP-seq
MIRT1064370	hsa-miR-590-5p	CLIP-seq
MIRT1064371	hsa-miR-620	CLIP-seq
MIRT1064372	hsa-miR-631	CLIP-seq
MIRT1064373	hsa-miR-632	CLIP-seq
MIRT1064374	hsa-miR-664	CLIP-seq
MIRT1064375	hsa-miR-876-5p	CLIP-seq
MIRT1064376	hsa-miR-1249	CLIP-seq
MIRT1064308	hsa-miR-208a	CLIP-seq
MIRT1064309	hsa-miR-208b	CLIP-seq
MIRT1064377	hsa-miR-3065-5p	CLIP-seq
MIRT1064318	hsa-miR-3143	CLIP-seq
MIRT1064378	hsa-miR-3149	CLIP-seq
MIRT1064379	hsa-miR-34c-3p	CLIP-seq
MIRT1064380	hsa-miR-3616-5p	CLIP-seq
MIRT1064381	hsa-miR-3647-5p	CLIP-seq
MIRT1064382	hsa-miR-3663-3p	CLIP-seq
MIRT1064383	hsa-miR-3671	CLIP-seq
MIRT1064327	hsa-miR-3924	CLIP-seq
MIRT1064384	hsa-miR-421	CLIP-seq
MIRT1064385	hsa-miR-4275	CLIP-seq
MIRT1064386	hsa-miR-4307	CLIP-seq
MIRT1064333	hsa-miR-4432	CLIP-seq
MIRT1064336	hsa-miR-451b	CLIP-seq
MIRT1064387	hsa-miR-4666-3p	CLIP-seq
MIRT1064342	hsa-miR-4666-5p	CLIP-seq
MIRT1064388	hsa-miR-4709-5p	CLIP-seq
MIRT1064389	hsa-miR-4795-5p	CLIP-seq
MIRT1064352	hsa-miR-4803	CLIP-seq
MIRT1064390	hsa-miR-494	CLIP-seq
MIRT1064353	hsa-miR-499-5p	CLIP-seq
MIRT1064358	hsa-miR-548ad	CLIP-seq
MIRT1064366	hsa-miR-568	CLIP-seq
MIRT1064391	hsa-miR-573	CLIP-seq
MIRT1064392	hsa-miR-607	CLIP-seq
MIRT1064393	hsa-miR-935	CLIP-seq
MIRT1064394	hsa-miR-4292	CLIP-seq
MIRT1064395	hsa-miR-4308	CLIP-seq
MIRT1064337	hsa-miR-4646-5p	CLIP-seq
MIRT1550105	hsa-miR-29a	CLIP-seq
MIRT1550106	hsa-miR-29b	CLIP-seq
MIRT1550107	hsa-miR-29c	CLIP-seq
MIRT1550108	hsa-miR-3183	CLIP-seq
MIRT1550109	hsa-miR-4266	CLIP-seq
MIRT1550110	hsa-miR-4469	CLIP-seq
MIRT1550111	hsa-miR-4723-3p	CLIP-seq
MIRT1550112	hsa-miR-4777-3p	CLIP-seq
MIRT1550113	hsa-miR-642a	CLIP-seq
MIRT1550114	hsa-miR-767-5p	CLIP-seq
MIRT1064323	hsa-miR-34b	CLIP-seq
MIRT2247647	hsa-miR-1245b-5p	CLIP-seq
MIRT2247648	hsa-miR-1303	CLIP-seq
MIRT2247649	hsa-miR-3142	CLIP-seq
MIRT2247650	hsa-miR-3182	CLIP-seq
MIRT2247651	hsa-miR-4303	CLIP-seq
MIRT2247652	hsa-miR-4649-3p	CLIP-seq
MIRT2247653	hsa-miR-877	CLIP-seq
MIRT2551056	hsa-miR-1208	CLIP-seq
MIRT2551057	hsa-miR-221	CLIP-seq
MIRT2551058	hsa-miR-222	CLIP-seq
MIRT2551059	hsa-miR-3680	CLIP-seq
MIRT1064344	hsa-miR-4711-3p	CLIP-seq
MIRT2551060	hsa-miR-4798-3p	CLIP-seq
MIRT2551061	hsa-miR-592	CLIP-seq
MIRT2551062	hsa-miR-599	CLIP-seq
MIRT2551056	hsa-miR-1208	CLIP-seq
MIRT2551057	hsa-miR-221	CLIP-seq
MIRT2551058	hsa-miR-222	CLIP-seq
MIRT2551059	hsa-miR-3680	CLIP-seq
MIRT1064344	hsa-miR-4711-3p	CLIP-seq
MIRT2551060	hsa-miR-4798-3p	CLIP-seq
MIRT2551061	hsa-miR-592	CLIP-seq
MIRT2551062	hsa-miR-599	CLIP-seq

Show/Hide all(43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002114	Function	Interleukin-33 receptor activity	IEA
GO:0002376	Process	Immune system process	IEA
GO:0004908	Function	Interleukin-1 receptor activity	IBA
GO:0004908	Function	Interleukin-1 receptor activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IC	10854325
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7775431
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	9065432
GO:0006955	Process	Immune response	TAS	9065432
GO:0007165	Process	Signal transduction	IEA
GO:0009986	Component	Cell surface	IBA
GO:0015026	Function	Coreceptor activity	IDA	10854325
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0032736	Process	Positive regulation of interleukin-13 production	IEA
GO:0032753	Process	Positive regulation of interleukin-4 production	IEA
GO:0032754	Process	Positive regulation of interleukin-5 production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IDA	11960013, 18802081, 20532808
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IDA	17675517
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IEA
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IMP	31435003
GO:0045087	Process	Innate immune response	IEA
GO:0045202	Component	Synapse	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0051965	Process	Positive regulation of synapse assembly	ISS
GO:0061809	Function	NAD+ nucleosidase activity, cyclic ADP-ribose generating	IEA
GO:0065003	Process	Protein-containing complex assembly	TAS	7775431
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IDA	10854325, 14625308
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IDA	9065432
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099151	Process	Regulation of postsynaptic density assembly	IEA
GO:0099545	Process	Trans-synaptic signaling by trans-synaptic complex	IEA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:1905606	Process	Regulation of presynapse assembly	IEA

MIM	HGNC	e!Ensembl
602626	5995	ENSG00000196083

Protein

UniProt ID

Q9NPH3

Protein name

Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)

Protein function

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-de

PDB

3O4O , 4DEP , 7FCC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18452	Ig_6	88 → 137	Immunoglobulin domain	Domain
PF13927	Ig_3	242 → 336		Domain
PF01582	TIR	404 → 570	TIR domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with ac

Sequence

MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST
AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT
YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG
CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA
VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE
SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL
ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF
VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL
LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK
QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV

Sequence length

570

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Cytokine-cytokine receptor interaction Th17 cell differentiation Inflammatory mediator regulation of TRP channels		PIP3 activates AKT signaling Receptor-type tyrosine-protein phosphatases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-36 pathway Interleukin-33 signaling Interleukin-1 signaling

IL1RAP (interleukin 1 receptor accessory protein)