IL1A (interleukin 1 alpha)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3552
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 1 alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL1A
Synonyms (NCBI Gene) Gene synonyms aliases
IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q14.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macropha
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(33)
miRTarBase ID miRNA Experiments Reference
MIRT004689 hsa-miR-191-5p Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR 20924108
MIRT004689 hsa-miR-191-5p Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR 20924108
MIRT017051 hsa-miR-335-5p Microarray 18185580
MIRT054374 hsa-miR-142-3p Luciferase reporter assay, Western blot 22870299
MIRT054374 hsa-miR-142-3p Luciferase reporter assay, Western blot 22870299
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
Transcription factor Regulation Reference
FOS Unknown 8688489
JUN Unknown 8688489
NFKB1 Repression 17612514
RELA Repression 17612514
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(55)
GO ID Ontology Definition Evidence Reference
GO:0001660 Process Fever generation IEA
GO:0001819 Process Positive regulation of cytokine production IDA 1739124
GO:0002248 Process Connective tissue replacement involved in inflammatory response wound healing IEA
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147760 5991 ENSG00000115008
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P01583
Protein name Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)
Protein function Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:26439902). After binding to its receptor IL1R1
PDB 2ILA , 2KKI , 2L5X , 5UC6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02394 IL1_propep 1 → 109 Interleukin-1 propeptide Family
PF00340 IL1 155 → 266 Interleukin-1 / 18 Domain
Sequence
Sequence length 271
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  MAPK signaling pathway
Cytokine-cytokine receptor interaction
Necroptosis
Cellular senescence
Osteoclast differentiation
Hematopoietic cell lineage
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Type I diabetes mellitus
Alzheimer disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Pertussis
Leishmaniasis
Tuberculosis
Measles
Influenza A
Inflammatory bowel disease
Rheumatoid arthritis
Graft-versus-host disease
Fluid shear stress and atherosclerosis 		  Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 processing
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling
Purinergic signaling in leishmaniasis infection
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Endometriosis Endometriosis N/A N/A GWAS
Show/Hide Text Mining Associations (563)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 1616367, 26268530, 37747561
Abortion Habitual Associate 22505054, 30893922
Achlorhydria Associate 10746728
Acidosis Associate 23144702
Acne Vulgaris Associate 29771405, 32627753
Acquired Immunodeficiency Syndrome Associate 15327898, 2789293, 3159524
Acro Osteolysis Associate 2844218
Acute Disease Stimulate 22674409
Acute Disease Associate 26559268
Acute Lung Injury Associate 21126389