IL1A (interleukin 1 alpha)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 3552
Gene name Interleukin 1 alpha
Gene symbol IL1A
Synonyms (NCBI Gene)
IL-1 alphaIL-1AIL1IL1-ALPHAIL1F1
Chromosome 2
Chromosome location 2q14.1
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macropha
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT004689 hsa-miR-191-5p ImmunohistochemistryImmunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCR 20924108
MIRT004689 hsa-miR-191-5p ImmunohistochemistryImmunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCR 20924108
MIRT017051 hsa-miR-335-5p Microarray 18185580
MIRT054374 hsa-miR-142-3p Luciferase reporter assayWestern blot 22870299
MIRT054374 hsa-miR-142-3p Luciferase reporter assayWestern blot 22870299
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
FOS Unknown 8688489
JUN Unknown 8688489
NFKB1 Repression 17612514
RELA Repression 17612514
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001660 Process Fever generation IEA
GO:0001819 Process Positive regulation of cytokine production IDA 1739124
GO:0002248 Process Connective tissue replacement involved in inflammatory response wound healing IEA
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147760 5991 ENSG00000115008
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01583
Protein name Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)
Protein function Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:26439902). After binding to its receptor IL1R1
PDB 2ILA , 2KKI , 2L5X , 5UC6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02394 IL1_propep 1 → 109 Interleukin-1 propeptide Family
PF00340 IL1 155 → 266 Interleukin-1 / 18 Domain
Sequence
Sequence length 271
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  MAPK signaling pathway
Cytokine-cytokine receptor interaction
Necroptosis
Cellular senescence
Osteoclast differentiation
Hematopoietic cell lineage
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Type I diabetes mellitus
Alzheimer disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Pertussis
Leishmaniasis
Tuberculosis
Measles
Influenza A
Inflammatory bowel disease
Rheumatoid arthritis
Graft-versus-host disease
Fluid shear stress and atherosclerosis 		  Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 processing
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling
Purinergic signaling in leishmaniasis infection
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
IL1A-related disorder Likely benign; Benign; Uncertain significance rs369264124, rs17561, rs142134831, rs1397684554, rs376303319 RCV003929732
RCV003982272
RCV003942146
RCV003947039
RCV003972265
Malignant lymphoma, large B-cell, diffuse Benign rs17561 RCV005937255
Uterine carcinosarcoma Benign rs17561 RCV005937256
Show/Hide Text Mining Associations (563)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 1616367, 26268530, 37747561
Abortion Habitual Associate 22505054, 30893922
Achlorhydria Associate 10746728
Acidosis Associate 23144702
Acne Vulgaris Associate 29771405, 32627753
Acquired Immunodeficiency Syndrome Associate 15327898, 2789293, 3159524
Acro Osteolysis Associate 2844218
Acute Disease Stimulate 22674409
Acute Disease Associate 26559268
Acute Lung Injury Associate 21126389