KLK3 (kallikrein related peptidase 3)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 354
Gene name Kallikrein related peptidase 3
Gene symbol KLK3
Synonyms (NCBI Gene)
APSKLK2A1PSAhK3
Chromosome 19
Chromosome location 19q13.33
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one o
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT017222 hsa-miR-335-5p Microarray 18185580
MIRT1099048 hsa-miR-3150a-3p CLIP-seq
MIRT1099049 hsa-miR-3175 CLIP-seq
MIRT1099050 hsa-miR-4514 CLIP-seq
MIRT1099051 hsa-miR-4645-5p CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
AATF Unknown 23146908
AR Activation 10547578;11006269;11504717;11571582;12958311;16425097;16434977;16724108;17566103;20069563;21780100;22179832;23667504;8626436
AR Repression 16342680;9316650
AR Unknown 11059779;11238180;11532861;12376473;12539223;12648523;12651911;15368351;15543614;15557561;15640095;17011549;17075604;17094454;17426252;17433535;18780293;18829551;19274665;21308712;21981678;22245379;22473899;23884959;24307657;7514587;9052414;9211894
AR Unknown 24937452
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002803 Process Positive regulation of antibacterial peptide production IDA 18714013
GO:0003073 Process Regulation of systemic arterial blood pressure IBA
GO:0004175 Function Endopeptidase activity IDA 18714013
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
176820 6364 ENSG00000142515
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07288
Protein name Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)
Protein function Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
PDB 2ZCH , 2ZCK , 2ZCL , 3QUM , 9F1I
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 25 → 253 Trypsin Domain
Sequence
Sequence length 261
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Pathways in cancer
Prostate cancer 		  Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Hepatocellular carcinoma Benign rs7252245 RCV005935457
Hereditary angioedema with normal C1Inh not provided rs1599990489, rs1599996938 RCV001027413
RCV001027414
KLK3-related disorder Likely benign; Benign rs368709777, rs73932617, rs7252245, rs12946, rs1135766, rs79245399, rs376483907, rs549637095, rs61729813, rs147547638, rs2003783, rs11573, rs61750343, rs35192866 RCV003912316
RCV003974106
RCV003964392
RCV003974009
RCV003977399
RCV003931569
RCV003941374
RCV003937129
RCV003922216
RCV003932268
RCV003979304
RCV003974759
RCV003971453
RCV003976364
Lung cancer Benign rs7252245 RCV005935460
Show/Hide Text Mining Associations (81)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 10188912, 10539914, 15258333, 15379952, 15859643, 17177156, 20126616, 25186610, 26881627, 32295536, 32735556, 33817721, 7534765
Adenoma Pleomorphic Associate 30120721
Alzheimer Disease Associate 24768341
Asthma Associate 23040885
Bone Diseases Associate 9043017
Bone Marrow Diseases Associate 9043017
Breast Diseases Associate 19108411
Breast Neoplasms Associate 10070886, 10188912, 10507775, 10646889, 11259089, 12439720, 16977795, 17317033, 18515984, 18516323, 20863373, 31664946, 7534765, 7545416, 8883411
View all (2 more)
Breast Neoplasms Inhibit 11882474
Breast Neoplasms Male Associate 14680496, 15623486, 20863373