KLK3 (kallikrein related peptidase 3)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
354
Gene name Gene Name - the full gene name approved by the HGNC.
Kallikrein related peptidase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KLK3
Synonyms (NCBI Gene) Gene synonyms aliases
APS, KLK2A1, PSA, hK3
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one o
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
miRTarBase ID miRNA Experiments Reference
MIRT017222 hsa-miR-335-5p Microarray 18185580
MIRT1099048 hsa-miR-3150a-3p CLIP-seq
MIRT1099049 hsa-miR-3175 CLIP-seq
MIRT1099050 hsa-miR-4514 CLIP-seq
MIRT1099051 hsa-miR-4645-5p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(29)
Transcription factor Regulation Reference
AATF Unknown 23146908
AR Activation 10547578;11006269;11504717;11571582;12958311;16425097;16434977;16724108;17566103;20069563;21780100;22179832;23667504;8626436
AR Repression 16342680;9316650
AR Unknown 11059779;11238180;11532861;12376473;12539223;12648523;12651911;15368351;15543614;15557561;15640095;17011549;17075604;17094454;17426252;17433535;18780293;18829551;19274665;21308712;21981678;22245379;22473899;23884959;24307657;7514587;9052414;9211894
AR Unknown 24937452
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002803 Process Positive regulation of antibacterial peptide production IDA 18714013
GO:0003073 Process Regulation of systemic arterial blood pressure IBA
GO:0004175 Function Endopeptidase activity IDA 18714013
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
176820 6364 ENSG00000142515
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P07288
Protein name Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)
Protein function Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
PDB 2ZCH , 2ZCK , 2ZCL , 3QUM , 9F1I
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 25 → 253 Trypsin Domain
Sequence
Sequence length 261
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Pathways in cancer
Prostate cancer 		  Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Angioedema Hereditary angioedema with normal C1Inh N/A N/A ClinVar
Prostate cancer Prostate cancer, Prostate cancer (early onset), Prostate cancer aggressiveness, Prostate cancer (late onset) N/A N/A GWAS
Show/Hide Text Mining Associations (81)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 10188912, 10539914, 15258333, 15379952, 15859643, 17177156, 20126616, 25186610, 26881627, 32295536, 32735556, 33817721, 7534765
Adenoma Pleomorphic Associate 30120721
Alzheimer Disease Associate 24768341
Asthma Associate 23040885
Bone Diseases Associate 9043017
Bone Marrow Diseases Associate 9043017
Breast Diseases Associate 19108411
Breast Neoplasms Associate 10070886, 10188912, 10507775, 10646889, 11259089, 12439720, 16977795, 17317033, 18515984, 18516323, 20863373, 31664946, 7534765, 7545416, 8883411
View all (2 more)
Breast Neoplasms Inhibit 11882474
Breast Neoplasms Male Associate 14680496, 15623486, 20863373