Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
353500
Gene name Gene Name - the full gene name approved by the HGNC.
Bone morphogenetic protein 8a
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BMP8A
Synonyms (NCBI Gene) Gene synonyms aliases
OP-2, Op2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021585 hsa-miR-142-3p Microarray 17612493
MIRT517421 hsa-miR-1910-3p PAR-CLIP 23446348
MIRT517420 hsa-miR-6511a-5p PAR-CLIP 23446348
MIRT517419 hsa-miR-25-3p PAR-CLIP 23446348
MIRT517418 hsa-miR-32-5p PAR-CLIP 23446348
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification IEA
GO:0002024 Process Diet induced thermogenesis IDA 22579288
GO:0005125 Function Cytokine activity IBA 21873635
GO:0005615 Component Extracellular space IBA 21873635
GO:0008083 Function Growth factor activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
620847 21650 ENSG00000183682
Protein
UniProt ID Q7Z5Y6
Protein name Bone morphogenetic protein 8A (BMP-8A)
Protein function Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation o
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00688 TGFb_propeptide 29 251 TGF-beta propeptide Family
PF00019 TGF_beta 300 401 Transforming growth factor beta like domain Domain
Sequence
Sequence length 402
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Hippo signaling pathway
Thermogenesis
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 30940143 ClinVar
Diabetes Diabetes GWAS
Alzheimer disease Alzheimer disease GWAS
Astrocytoma Astrocytoma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Inhibit 33579314
Death Associate 22977190
Peripheral Arterial Disease Associate 27082954
Rhabdomyosarcoma Associate 22419069