Gene Gene information from NCBI Gene database.
Entrez ID 353274
Gene name Zinc finger protein 445
Gene symbol ZNF445
Synonyms (NCBI Gene)
ZFP445ZKSCAN15ZNF168ZSCAN47
Chromosome 3
Chromosome location 3p21.31
miRNA miRNA information provided by mirtarbase database.
791
miRTarBase ID miRNA Experiments Reference
MIRT025192 hsa-miR-181a-5p Sequencing 20371350
MIRT662027 hsa-miR-6865-3p HITS-CLIP 23824327
MIRT662026 hsa-miR-6832-3p HITS-CLIP 23824327
MIRT662025 hsa-miR-1253 HITS-CLIP 23824327
MIRT662024 hsa-miR-6770-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003682 Function Chromatin binding IEA
GO:0005515 Function Protein binding IPI 31413325, 33961781
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 30602440
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619508 21018 ENSG00000185219
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P59923
Protein name Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15)
Protein function Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA met
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02023 SCAN 51 140 SCAN domain Domain
PF01352 KRAB 233 273 KRAB box Family
PF00096 zf-C2H2 485 507 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 541 563 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 625 647 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 681 703 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 709 731 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 762 784 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 790 812 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 868 890 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 896 918 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 978 1000 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1006 1028 Zinc finger, C2H2 type Domain
Sequence
MPPGRWHAAYPAQAQSSRERGRLQTVKKEEEDESYTPVQAARPQTLNRPGQELFRQLFRQ
LRYHESSGPLETLSRLRELCRWWLRPDVLSKAQILELLVLEQFLSILPGELRVWVQLHNP
ESGEEAVALLEELQRDLDGT
SWRDPGPAQSPDVHWMGTGALRSAQIWSLASPLRSSSALG
DHLEPPYEIEARDFLAGQSDTPAAQMPALFPREGCPGDQVTPTRSLTAQLQETMTFKDVE
VTFSQDEWGWLDSAQRNLYRDVMLENYRNMASL
VGPFTKPALISWLEAREPWGLNMQAAQ
PKGNPVAAPTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSR
QKDQCENPIQVRVKKEETNFSHRTGKDSEVSGSNSLDLKHVTYLRVSGRKESLKHGCGKH
FRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQSLHT
VGVSFKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHTGVKP
YKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCS
QCRKSFHCKSYVLEHQRIHTQEKPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECRE
GFRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAY
RSAFIVHKKKH
AMKRKPEGGPSFSQDTVFQVPQSSHSKEEPYKCSQCGKAFRNHSFLLIH
QRVH
TGEKPYKCRECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEKRF
WCQECGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQW
CGKEFIGRHTLSSHQRKH
TRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACS
QSSRLTGLQDISIGKKCHKCSICGKTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSN
LARHMKNH
IRD
Sequence length 1031
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Birk Barel Mental Retardation Dysmorphism Syndrome Associate 34039421, 35296332
★☆☆☆☆
Found in Text Mining only
Pre Eclampsia Associate 35296332
★☆☆☆☆
Found in Text Mining only
Temple syndrome Associate 34039421
★☆☆☆☆
Found in Text Mining only