Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
353189
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier organic anion transporter family member 4C1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLCO4C1
Synonyms (NCBI Gene) Gene synonyms aliases
OATP-H, OATP-M1, OATP4C1, OATPX, PRO2176, SLC21A20
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 149
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017791 hsa-miR-335-5p Microarray 18185580
MIRT019369 hsa-miR-148b-3p Microarray 17612493
MIRT040244 hsa-miR-615-3p CLASH 23622248
MIRT707478 hsa-miR-124-5p HITS-CLIP 21572407
MIRT707477 hsa-miR-4455 HITS-CLIP 21572407
Transcription factors
Transcription factor Regulation Reference
GATA3 Unknown 23874392
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0007275 Process Multicellular organism development IEA
GO:0007283 Process Spermatogenesis IEA
GO:0015347 Function Sodium-independent organic anion transmembrane transporter activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609013 23612 ENSG00000173930
Protein
UniProt ID Q6ZQN7
Protein name Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20)
Protein function Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:2061
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03137 OATP 106 664 Organic Anion Transporter Polypeptide (OATP) family Family
PF07648 Kazal_2 502 547 Kazal-type serine protease inhibitor domain Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney. {ECO:0000269|PubMed:14993604}.
Sequence
Sequence length 724
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Transport of organic anions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
28566273
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Ovarian cancer Ovarian cancer Conditional KD of IL6 in the OCCA xenograft model delays tumor growth GWAS, CBGDA
Restless Legs Syndrome Restless Legs Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Colonic Neoplasms Associate 34182539
Colorectal Neoplasms Associate 33203797
Endometrial Neoplasms Associate 32020231
Head and Neck Neoplasms Associate 24786473
Neoplasm Metastasis Associate 32020231
Neoplasms Associate 31288850
Obesity Associate 28489853
Prostatic Neoplasms Associate 31288850