LCE3B (late cornified envelope 3B)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
353143
Gene name Gene Name - the full gene name approved by the HGNC.
Late cornified envelope 3B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LCE3B
Synonyms (NCBI Gene) Gene synonyms aliases
LEP14
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0031424 Process Keratinization IEA
GO:0031640 Process Killing of cells of other organism IDA 28634035
GO:0050829 Process Defense response to Gram-negative bacterium IDA 28634035
GO:0050830 Process Defense response to Gram-positive bacterium IDA 28634035
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
612614 29462 ENSG00000187238
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q5TA77
Protein name Late cornified envelope protein 3B (Late envelope protein 14)
Protein function A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, bo
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14672 LCE 19 → 95 Late cornified envelope Family
Tissue specificity TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta. {ECO:0000269|PubMed:15854049}.
Sequence
Sequence length 95
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Formation of the cornified envelope
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 19169253
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Psoriasis vulgaris Psoriasis vulgaris GWAS
Show/Hide Text Mining Associations (8)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Psoriatic Associate 20331852
Arthritis Rheumatoid Associate 20213803
Autoimmune Diseases Associate 23594316
Dermatitis Allergic Contact Associate 21995181
Eczema Associate 21995181
Hypersensitivity Delayed Associate 21995181
Psoriasis Associate 19439430, 20213803, 20331852, 20376060, 22622420, 23594316, 27919236, 34089377
Skin Diseases Associate 20331852