Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	353116
Gene name	Rab interacting lysosomal protein like 1
Gene symbol	RILPL1
Synonyms (NCBI Gene)	GOSPELOPDM4RLP1
Chromosome	12
Chromosome location	12q24.31

164

Show/Hide all (164)

miRTarBase ID	miRNA	Experiments	Reference
MIRT455117	hsa-miR-548ao-3p	HITS-CLIP	19536157
MIRT713497	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT713495	hsa-miR-6086	HITS-CLIP	19536157
MIRT713496	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT713494	hsa-miR-658	HITS-CLIP	19536157
MIRT713493	hsa-miR-25-5p	HITS-CLIP	19536157
MIRT713492	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT713491	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT713490	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT676805	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676804	hsa-miR-4324	HITS-CLIP	23824327
MIRT676803	hsa-miR-544b	HITS-CLIP	23824327
MIRT676802	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676801	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676800	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676799	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676798	hsa-miR-1976	HITS-CLIP	23824327
MIRT676797	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676796	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676795	hsa-miR-1200	HITS-CLIP	23824327
MIRT676794	hsa-miR-4279	HITS-CLIP	23824327
MIRT676793	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT676792	hsa-miR-1302	HITS-CLIP	23824327
MIRT676791	hsa-miR-4298	HITS-CLIP	23824327
MIRT671607	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT671606	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT671605	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT671604	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT671603	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT671602	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT671601	hsa-miR-5693	HITS-CLIP	23824327
MIRT671600	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT671599	hsa-miR-4284	HITS-CLIP	23824327
MIRT671598	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671597	hsa-miR-7977	HITS-CLIP	23824327
MIRT455117	hsa-miR-548ao-3p	PAR-CLIP	23592263
MIRT455116	hsa-miR-508-5p	PAR-CLIP	23592263
MIRT455115	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT455114	hsa-miR-766-3p	PAR-CLIP	23592263
MIRT455113	hsa-miR-4793-3p	PAR-CLIP	23592263
MIRT455112	hsa-miR-7703	PAR-CLIP	23592263
MIRT455115	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT713497	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT713491	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT455113	hsa-miR-4793-3p	PAR-CLIP	27292025
MIRT455117	hsa-miR-548ao-3p	PAR-CLIP	27292025
MIRT713495	hsa-miR-6086	PAR-CLIP	27292025
MIRT713496	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT713490	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT455112	hsa-miR-7703	PAR-CLIP	27292025
MIRT734837	hsa-miR-145-3p	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)Immunofluorescence	33542215
MIRT455117	hsa-miR-548ao-3p	HITS-CLIP	19536157
MIRT713497	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT713495	hsa-miR-6086	HITS-CLIP	19536157
MIRT713496	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT713494	hsa-miR-658	HITS-CLIP	19536157
MIRT713493	hsa-miR-25-5p	HITS-CLIP	19536157
MIRT713492	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT713491	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT713490	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT676805	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676804	hsa-miR-4324	HITS-CLIP	23824327
MIRT676803	hsa-miR-544b	HITS-CLIP	23824327
MIRT676802	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676801	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676800	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676799	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676798	hsa-miR-1976	HITS-CLIP	23824327
MIRT676797	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676796	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676795	hsa-miR-1200	HITS-CLIP	23824327
MIRT676794	hsa-miR-4279	HITS-CLIP	23824327
MIRT676793	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT676792	hsa-miR-1302	HITS-CLIP	23824327
MIRT676791	hsa-miR-4298	HITS-CLIP	23824327
MIRT671607	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT671606	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT671605	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT671604	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT671603	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT671602	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT671601	hsa-miR-5693	HITS-CLIP	23824327
MIRT671600	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT671599	hsa-miR-4284	HITS-CLIP	23824327
MIRT671598	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671597	hsa-miR-7977	HITS-CLIP	23824327
MIRT455117	hsa-miR-548ao-3p	PAR-CLIP	23592263
MIRT455116	hsa-miR-508-5p	PAR-CLIP	23592263
MIRT455115	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT455114	hsa-miR-766-3p	PAR-CLIP	23592263
MIRT455113	hsa-miR-4793-3p	PAR-CLIP	23592263
MIRT455112	hsa-miR-7703	PAR-CLIP	23592263
MIRT1306708	hsa-miR-1226	CLIP-seq
MIRT1306709	hsa-miR-129-3p	CLIP-seq
MIRT1306710	hsa-miR-1303	CLIP-seq
MIRT1306711	hsa-miR-149	CLIP-seq
MIRT1306712	hsa-miR-185	CLIP-seq
MIRT1306713	hsa-miR-2278	CLIP-seq
MIRT1306714	hsa-miR-299-3p	CLIP-seq
MIRT1306715	hsa-miR-3064-5p	CLIP-seq
MIRT1306716	hsa-miR-3120-5p	CLIP-seq
MIRT1306717	hsa-miR-3126-3p	CLIP-seq
MIRT1306718	hsa-miR-3127-5p	CLIP-seq
MIRT1306719	hsa-miR-3130-3p	CLIP-seq
MIRT1306720	hsa-miR-346	CLIP-seq
MIRT1306721	hsa-miR-3651	CLIP-seq
MIRT1306722	hsa-miR-4288	CLIP-seq
MIRT1306723	hsa-miR-4292	CLIP-seq
MIRT1306724	hsa-miR-4306	CLIP-seq
MIRT1306725	hsa-miR-4328	CLIP-seq
MIRT1306726	hsa-miR-4491	CLIP-seq
MIRT1306727	hsa-miR-4523	CLIP-seq
MIRT1306728	hsa-miR-4644	CLIP-seq
MIRT1306729	hsa-miR-4657	CLIP-seq
MIRT1306730	hsa-miR-4687-5p	CLIP-seq
MIRT1306731	hsa-miR-4732-5p	CLIP-seq
MIRT1306732	hsa-miR-4733-3p	CLIP-seq
MIRT1306733	hsa-miR-4794	CLIP-seq
MIRT1306734	hsa-miR-632	CLIP-seq
MIRT1306735	hsa-miR-760	CLIP-seq
MIRT1306736	hsa-miR-936	CLIP-seq
MIRT1306725	hsa-miR-4328	CLIP-seq
MIRT2315535	hsa-miR-300	CLIP-seq
MIRT2315536	hsa-miR-3120-3p	CLIP-seq
MIRT2315537	hsa-miR-3192	CLIP-seq
MIRT2315538	hsa-miR-3194-3p	CLIP-seq
MIRT2315539	hsa-miR-326	CLIP-seq
MIRT2315540	hsa-miR-330-3p	CLIP-seq
MIRT2315541	hsa-miR-330-5p	CLIP-seq
MIRT2315542	hsa-miR-361-5p	CLIP-seq
MIRT2315543	hsa-miR-3677-5p	CLIP-seq
MIRT2315544	hsa-miR-381	CLIP-seq
MIRT2315545	hsa-miR-3908	CLIP-seq
MIRT2315546	hsa-miR-4265	CLIP-seq
MIRT2315547	hsa-miR-4296	CLIP-seq
MIRT2315548	hsa-miR-4314	CLIP-seq
MIRT2315549	hsa-miR-4315	CLIP-seq
MIRT2315550	hsa-miR-4322	CLIP-seq
MIRT2315551	hsa-miR-4646-5p	CLIP-seq
MIRT2315552	hsa-miR-4666-3p	CLIP-seq
MIRT2315553	hsa-miR-4789-5p	CLIP-seq
MIRT2315554	hsa-miR-520d-5p	CLIP-seq
MIRT2315555	hsa-miR-524-5p	CLIP-seq
MIRT2315556	hsa-miR-622	CLIP-seq
MIRT2315557	hsa-miR-767-3p	CLIP-seq
MIRT2315558	hsa-miR-873	CLIP-seq
MIRT2611838	hsa-miR-124	CLIP-seq
MIRT2611839	hsa-miR-145	CLIP-seq
MIRT2611840	hsa-miR-221	CLIP-seq
MIRT2611841	hsa-miR-222	CLIP-seq
MIRT2315542	hsa-miR-361-5p	CLIP-seq
MIRT2611842	hsa-miR-382	CLIP-seq
MIRT2611843	hsa-miR-3925-3p	CLIP-seq
MIRT2611844	hsa-miR-4312	CLIP-seq
MIRT2611845	hsa-miR-4763-5p	CLIP-seq
MIRT2611846	hsa-miR-506	CLIP-seq
MIRT2611847	hsa-miR-518a-5p	CLIP-seq
MIRT2611848	hsa-miR-527	CLIP-seq
MIRT2611849	hsa-miR-548v	CLIP-seq
MIRT2611850	hsa-miR-550a	CLIP-seq
MIRT2611851	hsa-miR-645	CLIP-seq
MIRT2611852	hsa-miR-766	CLIP-seq
MIRT2315558	hsa-miR-873	CLIP-seq
MIRT2611853	hsa-miR-922	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003382	Process	Epithelial cell morphogenesis	IEA
GO:0003382	Process	Epithelial cell morphogenesis	ISS
GO:0005515	Function	Protein binding	IPI	29125462, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	ISS
GO:0005814	Component	Centriole	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005929	Component	Cilium	IDA
GO:0005929	Component	Cilium	IEA
GO:0005929	Component	Cilium	ISS
GO:0007263	Process	Nitric oxide mediated signal transduction	ISS
GO:0015031	Process	Protein transport	IEA
GO:0031267	Function	Small GTPase binding	IBA
GO:0036064	Component	Ciliary basal body	IBA
GO:0036064	Component	Ciliary basal body	IDA
GO:0042995	Component	Cell projection	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0051959	Function	Dynein light intermediate chain binding	IBA
GO:0060271	Process	Cilium assembly	IBA
GO:1903445	Process	Protein transport from ciliary membrane to plasma membrane	IEA
GO:1903445	Process	Protein transport from ciliary membrane to plasma membrane	ISS

MIM	HGNC	e!Ensembl
614092	26814	ENSG00000188026

Q5EBL4

Protein name

RILP-like protein 1 (Rab-interacting lysosomal-like protein 1)

Protein function

Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09744	Jnk-SapK_ap_N	27 → 175	JNK_SAPK-associated protein-1	Family
PF11461	RILP	295 → 350	Rab interacting lysosomal protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed at lower level in liver and kidney. {ECO:0000269|PubMed:14668488}.

Sequence

MEEERGSALAAESALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCEAIARLMPKVVRV
LEILEVLVSRHHVAPELDELRLELDRLRLERMDRIEKERKHQKELELVEDVWRGEAQDLL
SQIAQLQEENKQLMTNLSHKDVNFSEEEFQKHEGMSERERQVMKKLKEVVDKQRDEIRAK
DRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEM
GSLRAELGKLRERLQGEHSQNGEEEPETEPVGEESISDAEKVAMDLKDPNRPRFTLQELR
DVLHERNELKSKVFLLQEELAYYKSEEMEEENRIPQPPPIAHPRTSPQPESGIKRLFSFF
SRDKKRLANTQRNVHIQESFGQWANTHRDDGYTEQGQEALQHL

Sequence length

403

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OCULOPHARYNGODISTAL MYOPATHY	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Oculopharyngodistal myopathy 4	Uncertain significance	ClinVar ClinVar, Disgenet, GenCC, HPO ClinVar, Disgenet, GenCC, HPO ClinVar, Disgenet, GenCC, HPO	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
RILPL1-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Leukemia Myeloid Acute	Associate	36212177	★★★★★ ★☆☆☆☆ Found in Text Mining only
Oculopharyngodistal Myopathy	Associate	35148830, 37864208	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

RILPL1 (Rab interacting lysosomal protein like 1)