Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3514
Gene name Gene Name - the full gene name approved by the HGNC.	Immunoglobulin kappa constant
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IGKC
Synonyms (NCBI Gene) Gene synonyms aliases	HCAK1, IGKCD, Km
Disease Acronyms (UniProt) Disease acronyms from UniProt database	IGKCD
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p11.2

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001895	Process	Retina homeostasis	HEP	23580065
GO:0002377	Process	Immunoglobulin production	IBA	21873635
GO:0003823	Function	Antigen binding	IBA	21873635
GO:0003823	Function	Antigen binding	NAS	5489770, 6779204
GO:0005576	Component	Extracellular region	NAS	6779204
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470, 22664934, 23580065
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006898	Process	Receptor-mediated endocytosis	TAS
GO:0006910	Process	Phagocytosis, recognition	IBA	21873635
GO:0006911	Process	Phagocytosis, engulfment	IBA	21873635
GO:0006955	Process	Immune response	IBA	21873635
GO:0006955	Process	Immune response	NAS	5489770, 6779204
GO:0006956	Process	Complement activation	TAS
GO:0006958	Process	Complement activation, classical pathway	IBA	21873635
GO:0006958	Process	Complement activation, classical pathway	TAS
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0019814	Component	Immunoglobulin complex	IEA
GO:0030449	Process	Regulation of complement activation	TAS
GO:0034987	Function	Immunoglobulin receptor binding	IBA	21873635
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0042571	Component	Immunoglobulin complex, circulating	IBA	21873635
GO:0042742	Process	Defense response to bacterium	IBA	21873635
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0050776	Process	Regulation of immune response	TAS
GO:0050853	Process	B cell receptor signaling pathway	IBA	21873635
GO:0050871	Process	Positive regulation of B cell activation	IBA	21873635
GO:0050900	Process	Leukocyte migration	TAS
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0072562	Component	Blood microparticle	HDA	22516433

MIM	HGNC	e!Ensembl
147200	5716	ENSG00000211592

Protein

UniProt ID

P01834

Protein name

Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI)

Protein function

Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins s

PDB

1A4J , 1A4K , 1CLY , 1D5B , 1D5I , 1D6V , 1DFB , 1GAF , 1HEZ , 1HKL , 1HZH , 1I7Z , 1MIM , 1N0X , 1UCB , 2NY7 , 2O5X , 2O5Y , 2O5Z , 2QQK , 2QQL , 2QQN , 2QSC , 2R56 , 2RFX , 2VXQ , 3B2U , 3B2V , 3BDY , 3BE1 , 3BKY , 3BN9 , 3BQU , 3C08 , 3C09 , 3CFJ , 3CFK , 3CSY , 3D0L , 3D85 , 3DVG , 3DVN , 3EYF , 3EYO , 3EYQ , 3IU3 , 3O11 , 3QCT , 3QCU , 3QCV , 3RU8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07654	C1-set	8 → 94	Immunoglobulin C1-set domain	Domain

Sequence

RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQD
SKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Sequence length

107

Interactions

View interactions

IGKC (immunoglobulin kappa constant)