IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker))

Gene

• Entrez ID: 3501
• Gene name: Immunoglobulin heavy constant gamma 2 (G2m marker)
• Gene symbol: IGHG2
• Synonyms (NCBI Gene): -
• Chromosome: 14
• Chromosome location: 14q32.33

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	NAS	20176268
GO:0002376	Process	Immune system process	IEA
GO:0003823	Function	Antigen binding	IBA
GO:0005515	Function	Protein binding	IPI	16457820
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	22664934, 23580065
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005615	Component	Extracellular space	NAS	20176268
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	20176268
GO:0006958	Process	Complement activation, classical pathway	IBA
GO:0016020	Component	Membrane	IEA
GO:0019731	Process	Antibacterial humoral response	IBA
GO:0019814	Component	Immunoglobulin complex	IEA
GO:0034987	Function	Immunoglobulin receptor binding	IBA
GO:0042571	Component	Immunoglobulin complex, circulating	IBA
GO:0050853	Process	B cell receptor signaling pathway	NAS	20176268
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071735	Component	IgG immunoglobulin complex	NAS	20176268
GO:0072562	Component	Blood microparticle	HDA	22516433

Other IDs

• MIM: 147110
• HGNC: 5526
• e!Ensembl: ENSG00000211893

Protein

• UniProt ID: P01859
• Protein name: Immunoglobulin heavy constant gamma 2 (Ig gamma-2 chain C region) (Ig gamma-2 chain C region DOT) (Ig gamma-2 chain C region TIL) (Ig gamma-2 chain C region ZIE)
• Protein function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins s
• PDB: 2QSC, 4HAF, 4HAG, 4L4J, 7LUS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07654	C1-set	8 → 90	Immunoglobulin C1-set domain	Domain
  PF07654	C1-set	119 → 207	Immunoglobulin C1-set domain	Domain
  PF07654	C1-set	227 → 311	Immunoglobulin C1-set domain	Domain

• Sequence:

  ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS
  GLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVF
  LFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFR
  VVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKN
  QVSLTCLVKGFYPSDISVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGN
  VFSCSVMHEALHNHYTQKSLSLSPGK

• Sequence length: 326

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Decreased circulating IgG2 concentration	Pathogenic	rs766666014	RCV000015931

Associations from Text Mining
Disease Name	Relationship Type	References
Autoimmune Diseases	Associate	37843500
Infections	Associate	37434783
Neoplasms	Inhibit	36155774
Post Acute COVID 19 Syndrome	Associate	38518681
Sarcoma	Associate	36155774
Substance Related Disorders	Associate	37843500