CCN1 (cellular communication network factor 1)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3491
Gene name Gene Name - the full gene name approved by the HGNC.
Cellular communication network factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCN1
Synonyms (NCBI Gene) Gene synonyms aliases
CYR61, GIG1, IGFBP10
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p22.3
Summary Summary of gene provided in NCBI Entrez Gene.
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell prolife
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(43)
GO ID Ontology Definition Evidence Reference
GO:0001649 Process Osteoblast differentiation IEA
GO:0001934 Process Positive regulation of protein phosphorylation IDA 20675382
GO:0002041 Process Intussusceptive angiogenesis IEA
GO:0003181 Process Atrioventricular valve morphogenesis IEA
GO:0003278 Process Apoptotic process involved in heart morphogenesis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602369 2654 ENSG00000142871
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O00622
Protein name CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1)
Protein function Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodel
PDB 4D0Z , 4D11
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00219 IGFBP 26 → 78 Insulin-like growth factor binding protein Domain
PF00093 VWC 100 → 163 von Willebrand factor type C domain Family
PF19035 TSP1_CCN 229 → 272 CCN3 Nov like TSP1 domain Domain
PF00007 Cys_knot 283 → 375 Cystine-knot domain Domain
Sequence
Sequence length 381
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 27935865
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 19192274
Show/Hide Text Mining Associations (137)
Associations from Text Mining
Disease Name Relationship Type References
Acrocephalosyndactylia Associate 33906697
Acute Coronary Syndrome Stimulate 29155984
Acute Coronary Syndrome Associate 33906697
Acute Kidney Injury Associate 28116298
Adenocarcinoma Associate 21138874
Adenocarcinoma Stimulate 27583562
Angina Unstable Associate 29155984
Arterio Arterial Fistula Stimulate 33648532
Arthritis Associate 25187949
Arthritis Psoriatic Associate 25187949