Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3491
Gene name Gene Name - the full gene name approved by the HGNC.	Cellular communication network factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CCN1
Synonyms (NCBI Gene) Gene synonyms aliases	CYR61, GIG1, IGFBP10
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p22.3
Summary Summary of gene provided in NCBI Entrez Gene.	The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell prolife

Show/Hide all(54)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0002041	Process	Intussusceptive angiogenesis	IEA
GO:0003181	Process	Atrioventricular valve morphogenesis	IEA
GO:0003278	Process	Apoptotic process involved in heart morphogenesis	IEA
GO:0003281	Process	Ventricular septum development	IEA
GO:0005178	Function	Integrin binding	IBA
GO:0005178	Function	Integrin binding	IEA
GO:0005201	Function	Extracellular matrix structural constituent	RCA	28327460
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	IDA	20675382
GO:0008201	Function	Heparin binding	IBA
GO:0008201	Function	Heparin binding	IEA
GO:0009891	Process	Positive regulation of biosynthetic process	IEA
GO:0010556	Process	Regulation of macromolecule biosynthetic process	IEA
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0019838	Function	Growth factor binding	IEA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030335	Process	Positive regulation of cell migration	IDA	20675382
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030501	Process	Positive regulation of bone mineralization	IDA	20675382
GO:0030513	Process	Positive regulation of BMP signaling pathway	IGI	20675382
GO:0031012	Component	Extracellular matrix	HDA	23658023, 28327460
GO:0031012	Component	Extracellular matrix	IBA
GO:0033690	Process	Positive regulation of osteoblast proliferation	IDA	20675382
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045597	Process	Positive regulation of cell differentiation	IBA
GO:0045597	Process	Positive regulation of cell differentiation	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	IDA	20675382
GO:0045778	Process	Positive regulation of ossification	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20675382
GO:0050840	Function	Extracellular matrix binding	IEA
GO:0051094	Process	Positive regulation of developmental process	IEA
GO:0060413	Process	Atrial septum morphogenesis	IEA
GO:0060591	Process	Chondroblast differentiation	IEA
GO:0060710	Process	Chorio-allantoic fusion	IEA
GO:0060716	Process	Labyrinthine layer blood vessel development	IEA
GO:0061036	Process	Positive regulation of cartilage development	IEA
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IDA	20675382
GO:0072593	Process	Reactive oxygen species metabolic process	IEA
GO:0098609	Process	Cell-cell adhesion	IEA
GO:2000026	Process	Regulation of multicellular organismal development	IEA
GO:2000304	Process	Positive regulation of ceramide biosynthetic process	IEA

MIM	HGNC	e!Ensembl
602369	2654	ENSG00000142871

Protein

UniProt ID

O00622

Protein name

CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1)

Protein function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodel

PDB

4D0Z , 4D11

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00219	IGFBP	26 → 78	Insulin-like growth factor binding protein	Domain
PF00093	VWC	100 → 163	von Willebrand factor type C domain	Family
PF19035	TSP1_CCN	229 → 272	CCN3 Nov like TSP1 domain	Domain
PF00007	Cys_knot	283 → 375	Cystine-knot domain	Domain

Sequence

MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQL
NEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQ
CTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLG
KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCS
KTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY
AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP
HANEAAFPFYRLFNDIHKFRD

Sequence length

381

Interactions

View interactions

	Reactome
			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

CCN1 (cellular communication network factor 1)