IGFBP7 (insulin like growth factor binding protein 7)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3490
Gene name Gene Name - the full gene name approved by the HGNC.
Insulin like growth factor binding protein 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IGFBP7
Synonyms (NCBI Gene) Gene synonyms aliases
AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(37)
miRTarBase ID miRNA Experiments Reference
MIRT022719 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT023758 hsa-miR-1-3p Proteomics 18668040
MIRT1550070 hsa-miR-190 CLIP-seq
MIRT1550071 hsa-miR-190b CLIP-seq
MIRT1550072 hsa-miR-3140-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(31)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IDA 28671670
GO:0001525 Process Angiogenesis IDA 38218180
GO:0001558 Process Regulation of cell growth IEA
GO:0005201 Function Extracellular matrix structural constituent RCA 20551380, 25037231, 27559042
GO:0005515 Function Protein binding IPI 9388210
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602867 5476 ENSG00000163453
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q16270
Protein name Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF)
Protein function Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180). {ECO:0000269|PubMed:8117260, ECO:0000269|PubMed:
PDB 8IVD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00219 IGFBP 32 → 87 Insulin-like growth factor binding protein Domain
PF07648 Kazal_2 108 → 156 Kazal-type serine protease inhibitor domain Domain
PF07679 I-set 160 → 265 Immunoglobulin I-set domain Domain
Sequence
Sequence length 282
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Senescence-Associated Secretory Phenotype (SASP)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis Retinal arterial macroaneurysm with supravascular pulmonic stenosis rs866994863 N/A
Retinal arterial macroaneurysms familial retinal arterial macroaneurysm rs866994863 N/A
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Schizophrenia Schizophrenia N/A N/A GWAS
Show/Hide Text Mining Associations (112)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
46 XX Testicular Disorders of Sex Development Associate 20977730
Abdominal Injuries Associate 32286426
Acute Kidney Injury Associate 24067438, 24675717, 28003188, 29145491, 30389130, 35891358
Adenocarcinoma Associate 21829465, 24357797
Adenocarcinoma Stimulate 31822054
Adenocarcinoma of Lung Associate 32475626
Arthritis Psoriatic Inhibit 19710688
Atrial Fibrillation Associate 34798808
Barrett Esophagus Associate 24357797
Bipolar Disorder Associate 21876473