IGFBP3 (insulin like growth factor binding protein 3)

Gene

• Entrez ID: 3486
• Gene name: Insulin like growth factor binding protein 3
• Gene symbol: IGFBP3
• Synonyms (NCBI Gene): BP-53, IBP-3, IBP3, IGFBP-3
• Chromosome: 7
• Chromosome location: 7p12.3
• Summary: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (I

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019713	hsa-miR-375	Microarray	20215506
MIRT022363	hsa-miR-124-3p	Microarray	18668037
MIRT054206	hsa-miR-210-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23028679
MIRT702750	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT702749	hsa-miR-4773	HITS-CLIP	23313552
MIRT702748	hsa-miR-371b-3p	HITS-CLIP	23313552
MIRT702747	hsa-miR-759	HITS-CLIP	23313552
MIRT702746	hsa-miR-1909-5p	HITS-CLIP	23313552
MIRT702745	hsa-miR-18b-3p	HITS-CLIP	23313552
MIRT702744	hsa-miR-7977	HITS-CLIP	23313552
MIRT702743	hsa-miR-3157-3p	HITS-CLIP	23313552
MIRT736697	hsa-miR-409-3p	Luciferase reporter assay, Western blotting, qRT-PCR	33041662
MIRT737221	hsa-miR-133a-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR, In situ hybridization	32703944
MIRT702750	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT702749	hsa-miR-4773	HITS-CLIP	23313552
MIRT702748	hsa-miR-371b-3p	HITS-CLIP	23313552
MIRT702747	hsa-miR-759	HITS-CLIP	23313552
MIRT702746	hsa-miR-1909-5p	HITS-CLIP	23313552
MIRT702745	hsa-miR-18b-3p	HITS-CLIP	23313552
MIRT702744	hsa-miR-7977	HITS-CLIP	23313552
MIRT702743	hsa-miR-3157-3p	HITS-CLIP	23313552
MIRT054206	hsa-miR-210-3p	Microarray, qRT-PCR	35816043
MIRT756284	hsa-miR-376a-3p	ELISA	37511378
MIRT756285	hsa-miR-26a-1-3p	ELISA	37511378
MIRT1062114	hsa-miR-1245	CLIP-seq
MIRT1062115	hsa-miR-21	CLIP-seq
MIRT1062116	hsa-miR-3606	CLIP-seq
MIRT1062117	hsa-miR-4756-3p	CLIP-seq
MIRT1062118	hsa-miR-520d-5p	CLIP-seq
MIRT1062119	hsa-miR-524-5p	CLIP-seq
MIRT1062120	hsa-miR-590-5p	CLIP-seq
MIRT1062121	hsa-miR-921	CLIP-seq
MIRT1549925	hsa-miR-124	CLIP-seq
MIRT1549926	hsa-miR-196a	CLIP-seq
MIRT1549927	hsa-miR-196b	CLIP-seq
MIRT1549928	hsa-miR-19a	CLIP-seq
MIRT1549929	hsa-miR-19b	CLIP-seq
MIRT1549930	hsa-miR-2113	CLIP-seq
MIRT1549931	hsa-miR-2682	CLIP-seq
MIRT1549932	hsa-miR-3143	CLIP-seq
MIRT1549933	hsa-miR-34a	CLIP-seq
MIRT1549934	hsa-miR-34c-5p	CLIP-seq
MIRT1549935	hsa-miR-3670	CLIP-seq
MIRT1549936	hsa-miR-3672	CLIP-seq
MIRT1549937	hsa-miR-3675-3p	CLIP-seq
MIRT1549938	hsa-miR-3714	CLIP-seq
MIRT1549939	hsa-miR-3910	CLIP-seq
MIRT1549940	hsa-miR-3921	CLIP-seq
MIRT1549941	hsa-miR-3927	CLIP-seq
MIRT1549942	hsa-miR-431	CLIP-seq
MIRT1549943	hsa-miR-4427	CLIP-seq
MIRT1549944	hsa-miR-449a	CLIP-seq
MIRT1549945	hsa-miR-449b	CLIP-seq
MIRT1549946	hsa-miR-449c	CLIP-seq
MIRT1549947	hsa-miR-4653-5p	CLIP-seq
MIRT1549948	hsa-miR-4680-3p	CLIP-seq
MIRT1549949	hsa-miR-4786-5p	CLIP-seq
MIRT1549950	hsa-miR-487a	CLIP-seq
MIRT1549951	hsa-miR-506	CLIP-seq
MIRT1549952	hsa-miR-526b	CLIP-seq
MIRT1549953	hsa-miR-543	CLIP-seq
MIRT1549954	hsa-miR-593	CLIP-seq
MIRT1549955	hsa-miR-769-5p	CLIP-seq
MIRT1549956	hsa-miR-940	CLIP-seq
MIRT1549925	hsa-miR-124	CLIP-seq
MIRT1549928	hsa-miR-19a	CLIP-seq
MIRT1549929	hsa-miR-19b	CLIP-seq
MIRT1549930	hsa-miR-2113	CLIP-seq
MIRT1549933	hsa-miR-34a	CLIP-seq
MIRT1549934	hsa-miR-34c-5p	CLIP-seq
MIRT1549938	hsa-miR-3714	CLIP-seq
MIRT1549939	hsa-miR-3910	CLIP-seq
MIRT1549944	hsa-miR-449a	CLIP-seq
MIRT1549945	hsa-miR-449b	CLIP-seq
MIRT1549951	hsa-miR-506	CLIP-seq
MIRT1549953	hsa-miR-543	CLIP-seq
MIRT1549925	hsa-miR-124	CLIP-seq
MIRT2246620	hsa-miR-138	CLIP-seq
MIRT1549928	hsa-miR-19a	CLIP-seq
MIRT1549929	hsa-miR-19b	CLIP-seq
MIRT1549930	hsa-miR-2113	CLIP-seq
MIRT2246621	hsa-miR-3137	CLIP-seq
MIRT2246622	hsa-miR-3189-3p	CLIP-seq
MIRT1549933	hsa-miR-34a	CLIP-seq
MIRT1549934	hsa-miR-34c-5p	CLIP-seq
MIRT2246623	hsa-miR-3614-5p	CLIP-seq
MIRT2246624	hsa-miR-3617	CLIP-seq
MIRT1549935	hsa-miR-3670	CLIP-seq
MIRT1549938	hsa-miR-3714	CLIP-seq
MIRT1549939	hsa-miR-3910	CLIP-seq
MIRT1549944	hsa-miR-449a	CLIP-seq
MIRT1549945	hsa-miR-449b	CLIP-seq
MIRT2246625	hsa-miR-4635	CLIP-seq
MIRT2246626	hsa-miR-4659a-3p	CLIP-seq
MIRT2246627	hsa-miR-4659b-3p	CLIP-seq
MIRT2246628	hsa-miR-4676-5p	CLIP-seq
MIRT2246629	hsa-miR-4709-3p	CLIP-seq
MIRT2246630	hsa-miR-4778-3p	CLIP-seq
MIRT2246631	hsa-miR-485-5p	CLIP-seq
MIRT1549951	hsa-miR-506	CLIP-seq
MIRT1549953	hsa-miR-543	CLIP-seq
MIRT2246632	hsa-miR-552	CLIP-seq
MIRT2246633	hsa-miR-563	CLIP-seq
MIRT2246634	hsa-miR-575	CLIP-seq
MIRT2246635	hsa-miR-641	CLIP-seq
MIRT1549935	hsa-miR-3670	CLIP-seq
MIRT2389302	hsa-miR-4677-3p	CLIP-seq
MIRT2389303	hsa-miR-665	CLIP-seq
MIRT2429817	hsa-miR-1179	CLIP-seq
MIRT2429818	hsa-miR-1184	CLIP-seq
MIRT2429819	hsa-miR-1193	CLIP-seq
MIRT2429820	hsa-miR-1205	CLIP-seq
MIRT2429821	hsa-miR-1227	CLIP-seq
MIRT1549925	hsa-miR-124	CLIP-seq
MIRT2429822	hsa-miR-1243	CLIP-seq
MIRT2429823	hsa-miR-1249	CLIP-seq
MIRT2429824	hsa-miR-1257	CLIP-seq
MIRT2429825	hsa-miR-1262	CLIP-seq
MIRT2429826	hsa-miR-1273c	CLIP-seq
MIRT2429827	hsa-miR-1283	CLIP-seq
MIRT2429828	hsa-miR-1305	CLIP-seq
MIRT2246620	hsa-miR-138	CLIP-seq
MIRT2429829	hsa-miR-140-3p	CLIP-seq
MIRT2429830	hsa-miR-142-5p	CLIP-seq
MIRT2429831	hsa-miR-143	CLIP-seq
MIRT2429832	hsa-miR-186	CLIP-seq
MIRT2429833	hsa-miR-1914	CLIP-seq
MIRT2429834	hsa-miR-197	CLIP-seq
MIRT2429835	hsa-miR-199a-5p	CLIP-seq
MIRT2429836	hsa-miR-199b-5p	CLIP-seq
MIRT1549928	hsa-miR-19a	CLIP-seq
MIRT1549929	hsa-miR-19b	CLIP-seq
MIRT1549930	hsa-miR-2113	CLIP-seq
MIRT2429837	hsa-miR-2114	CLIP-seq
MIRT2429838	hsa-miR-2117	CLIP-seq
MIRT2429839	hsa-miR-216b	CLIP-seq
MIRT2429840	hsa-miR-218	CLIP-seq
MIRT2429841	hsa-miR-219-2-3p	CLIP-seq
MIRT2429842	hsa-miR-2355-5p	CLIP-seq
MIRT2429843	hsa-miR-2964a-5p	CLIP-seq
MIRT2429844	hsa-miR-300	CLIP-seq
MIRT2429845	hsa-miR-3065-5p	CLIP-seq
MIRT2429846	hsa-miR-3117-3p	CLIP-seq
MIRT2429847	hsa-miR-3126-5p	CLIP-seq
MIRT2429848	hsa-miR-3133	CLIP-seq
MIRT2246621	hsa-miR-3137	CLIP-seq
MIRT1549932	hsa-miR-3143	CLIP-seq
MIRT2429849	hsa-miR-3145-3p	CLIP-seq
MIRT2429850	hsa-miR-3152-5p	CLIP-seq
MIRT2429851	hsa-miR-3158-5p	CLIP-seq
MIRT2429852	hsa-miR-3159	CLIP-seq
MIRT2429853	hsa-miR-3169	CLIP-seq
MIRT2429854	hsa-miR-3173-3p	CLIP-seq
MIRT2246622	hsa-miR-3189-3p	CLIP-seq
MIRT2429855	hsa-miR-320a	CLIP-seq
MIRT2429856	hsa-miR-320b	CLIP-seq
MIRT2429857	hsa-miR-320c	CLIP-seq
MIRT2429858	hsa-miR-320d	CLIP-seq
MIRT2429859	hsa-miR-323b-3p	CLIP-seq
MIRT2429860	hsa-miR-325	CLIP-seq
MIRT2429861	hsa-miR-337-3p	CLIP-seq
MIRT2429862	hsa-miR-340	CLIP-seq
MIRT1549933	hsa-miR-34a	CLIP-seq
MIRT1549934	hsa-miR-34c-5p	CLIP-seq
MIRT2429863	hsa-miR-3545-3p	CLIP-seq
MIRT2429864	hsa-miR-3609	CLIP-seq
MIRT2429865	hsa-miR-3613-3p	CLIP-seq
MIRT2429866	hsa-miR-3613-5p	CLIP-seq
MIRT2246623	hsa-miR-3614-5p	CLIP-seq
MIRT2246624	hsa-miR-3617	CLIP-seq
MIRT2429867	hsa-miR-3647-3p	CLIP-seq
MIRT2429868	hsa-miR-3654	CLIP-seq
MIRT2429869	hsa-miR-3657	CLIP-seq
MIRT2429870	hsa-miR-3667-3p	CLIP-seq
MIRT1549935	hsa-miR-3670	CLIP-seq
MIRT1549937	hsa-miR-3675-3p	CLIP-seq
MIRT2429871	hsa-miR-3679-3p	CLIP-seq
MIRT2429872	hsa-miR-3685	CLIP-seq
MIRT2429873	hsa-miR-3690	CLIP-seq
MIRT1549938	hsa-miR-3714	CLIP-seq
MIRT2429874	hsa-miR-371-5p	CLIP-seq
MIRT2429875	hsa-miR-371b-5p	CLIP-seq
MIRT2429876	hsa-miR-376c	CLIP-seq
MIRT2429877	hsa-miR-381	CLIP-seq
MIRT2429878	hsa-miR-384	CLIP-seq
MIRT1549939	hsa-miR-3910	CLIP-seq
MIRT1549940	hsa-miR-3921	CLIP-seq
MIRT2429879	hsa-miR-3978	CLIP-seq
MIRT2429880	hsa-miR-421	CLIP-seq
MIRT2429881	hsa-miR-4254	CLIP-seq
MIRT2429882	hsa-miR-4260	CLIP-seq
MIRT2429883	hsa-miR-4263	CLIP-seq
MIRT2429884	hsa-miR-4273	CLIP-seq
MIRT2429885	hsa-miR-4277	CLIP-seq
MIRT2429886	hsa-miR-4283	CLIP-seq
MIRT2429887	hsa-miR-4289	CLIP-seq
MIRT2429888	hsa-miR-4419a	CLIP-seq
MIRT2429889	hsa-miR-4422	CLIP-seq
MIRT2429890	hsa-miR-4425	CLIP-seq
MIRT1549943	hsa-miR-4427	CLIP-seq
MIRT2429891	hsa-miR-4428	CLIP-seq
MIRT2429892	hsa-miR-4429	CLIP-seq
MIRT2429893	hsa-miR-4437	CLIP-seq
MIRT2429894	hsa-miR-4446-5p	CLIP-seq
MIRT2429895	hsa-miR-4447	CLIP-seq
MIRT2429896	hsa-miR-4472	CLIP-seq
MIRT2429897	hsa-miR-4476	CLIP-seq
MIRT2429898	hsa-miR-448	CLIP-seq
MIRT2429899	hsa-miR-4481	CLIP-seq
MIRT2429900	hsa-miR-4489	CLIP-seq
MIRT2429901	hsa-miR-4491	CLIP-seq
MIRT1549944	hsa-miR-449a	CLIP-seq
MIRT1549945	hsa-miR-449b	CLIP-seq
MIRT2429902	hsa-miR-450b-3p	CLIP-seq
MIRT2429903	hsa-miR-4510	CLIP-seq
MIRT2429904	hsa-miR-4521	CLIP-seq
MIRT2429905	hsa-miR-4522	CLIP-seq
MIRT2429906	hsa-miR-455-5p	CLIP-seq
MIRT2246625	hsa-miR-4635	CLIP-seq
MIRT2429907	hsa-miR-4639-5p	CLIP-seq
MIRT1549947	hsa-miR-4653-5p	CLIP-seq
MIRT2429908	hsa-miR-4655-5p	CLIP-seq
MIRT2429909	hsa-miR-4657	CLIP-seq
MIRT2246626	hsa-miR-4659a-3p	CLIP-seq
MIRT2246627	hsa-miR-4659b-3p	CLIP-seq
MIRT2429910	hsa-miR-4666-3p	CLIP-seq
MIRT2429911	hsa-miR-4669	CLIP-seq
MIRT2429912	hsa-miR-4671-5p	CLIP-seq
MIRT2429913	hsa-miR-4674	CLIP-seq
MIRT2246628	hsa-miR-4676-5p	CLIP-seq
MIRT2389302	hsa-miR-4677-3p	CLIP-seq
MIRT1549948	hsa-miR-4680-3p	CLIP-seq
MIRT2429914	hsa-miR-4684-5p	CLIP-seq
MIRT2429915	hsa-miR-4691-5p	CLIP-seq
MIRT2429916	hsa-miR-4696	CLIP-seq
MIRT2429917	hsa-miR-4701-3p	CLIP-seq
MIRT2246629	hsa-miR-4709-3p	CLIP-seq
MIRT2429918	hsa-miR-4710	CLIP-seq
MIRT2429919	hsa-miR-4712-3p	CLIP-seq
MIRT2429920	hsa-miR-4713-3p	CLIP-seq
MIRT2429921	hsa-miR-4745-5p	CLIP-seq
MIRT2429922	hsa-miR-4759	CLIP-seq
MIRT2429923	hsa-miR-4762-3p	CLIP-seq
MIRT2429924	hsa-miR-4770	CLIP-seq
MIRT2429925	hsa-miR-4774-3p	CLIP-seq
MIRT2246630	hsa-miR-4778-3p	CLIP-seq
MIRT2429926	hsa-miR-4781-3p	CLIP-seq
MIRT1549949	hsa-miR-4786-5p	CLIP-seq
MIRT2429927	hsa-miR-4792	CLIP-seq
MIRT2429928	hsa-miR-4799-5p	CLIP-seq
MIRT2246631	hsa-miR-485-5p	CLIP-seq
MIRT1549950	hsa-miR-487a	CLIP-seq
MIRT2429929	hsa-miR-495	CLIP-seq
MIRT2429930	hsa-miR-498	CLIP-seq
MIRT1549951	hsa-miR-506	CLIP-seq
MIRT2429931	hsa-miR-513c	CLIP-seq
MIRT2429932	hsa-miR-514b-5p	CLIP-seq
MIRT2429933	hsa-miR-515-5p	CLIP-seq
MIRT2429934	hsa-miR-516a-5p	CLIP-seq
MIRT1549953	hsa-miR-543	CLIP-seq
MIRT2429935	hsa-miR-544	CLIP-seq
MIRT2429936	hsa-miR-548ac	CLIP-seq
MIRT2429937	hsa-miR-548ah	CLIP-seq
MIRT2429938	hsa-miR-548d-3p	CLIP-seq
MIRT2429939	hsa-miR-548m	CLIP-seq
MIRT2429940	hsa-miR-548z	CLIP-seq
MIRT2429941	hsa-miR-550b	CLIP-seq
MIRT2246632	hsa-miR-552	CLIP-seq
MIRT2246633	hsa-miR-563	CLIP-seq
MIRT2429942	hsa-miR-568	CLIP-seq
MIRT2246634	hsa-miR-575	CLIP-seq
MIRT2429943	hsa-miR-576-5p	CLIP-seq
MIRT1549954	hsa-miR-593	CLIP-seq
MIRT2429944	hsa-miR-607	CLIP-seq
MIRT2429945	hsa-miR-628-3p	CLIP-seq
MIRT2429946	hsa-miR-628-5p	CLIP-seq
MIRT2429947	hsa-miR-629	CLIP-seq
MIRT2246635	hsa-miR-641	CLIP-seq
MIRT2429948	hsa-miR-653	CLIP-seq
MIRT2389303	hsa-miR-665	CLIP-seq
MIRT2429949	hsa-miR-769-3p	CLIP-seq
MIRT1549955	hsa-miR-769-5p	CLIP-seq
MIRT2429950	hsa-miR-875-3p	CLIP-seq
MIRT2429951	hsa-miR-885-5p	CLIP-seq
MIRT2429952	hsa-miR-933	CLIP-seq
MIRT2429953	hsa-miR-942	CLIP-seq
MIRT1549953	hsa-miR-543	CLIP-seq
MIRT2550525	hsa-miR-103a	CLIP-seq
MIRT2550526	hsa-miR-107	CLIP-seq
MIRT2429818	hsa-miR-1184	CLIP-seq
MIRT2429819	hsa-miR-1193	CLIP-seq
MIRT2550527	hsa-miR-1200	CLIP-seq
MIRT2550528	hsa-miR-1202	CLIP-seq
MIRT2429820	hsa-miR-1205	CLIP-seq
MIRT2550529	hsa-miR-1238	CLIP-seq
MIRT2550530	hsa-miR-1248	CLIP-seq
MIRT2550531	hsa-miR-125a-5p	CLIP-seq
MIRT2550532	hsa-miR-125b	CLIP-seq
MIRT2429825	hsa-miR-1262	CLIP-seq
MIRT2550533	hsa-miR-1268	CLIP-seq
MIRT2550534	hsa-miR-1268b	CLIP-seq
MIRT2550535	hsa-miR-1285	CLIP-seq
MIRT2429828	hsa-miR-1305	CLIP-seq
MIRT2550536	hsa-miR-1343	CLIP-seq
MIRT2429829	hsa-miR-140-3p	CLIP-seq
MIRT2429831	hsa-miR-143	CLIP-seq
MIRT2550537	hsa-miR-1470	CLIP-seq
MIRT2429833	hsa-miR-1914	CLIP-seq
MIRT2429835	hsa-miR-199a-5p	CLIP-seq
MIRT2429836	hsa-miR-199b-5p	CLIP-seq
MIRT2429838	hsa-miR-2117	CLIP-seq
MIRT2550538	hsa-miR-214	CLIP-seq
MIRT2429839	hsa-miR-216b	CLIP-seq
MIRT2429840	hsa-miR-218	CLIP-seq
MIRT2550539	hsa-miR-2278	CLIP-seq
MIRT2429842	hsa-miR-2355-5p	CLIP-seq
MIRT2550540	hsa-miR-2861	CLIP-seq
MIRT2429843	hsa-miR-2964a-5p	CLIP-seq
MIRT2429844	hsa-miR-300	CLIP-seq
MIRT2429845	hsa-miR-3065-5p	CLIP-seq
MIRT2550541	hsa-miR-3124-3p	CLIP-seq
MIRT2550542	hsa-miR-3140-5p	CLIP-seq
MIRT1549932	hsa-miR-3143	CLIP-seq
MIRT2429849	hsa-miR-3145-3p	CLIP-seq
MIRT2429851	hsa-miR-3158-5p	CLIP-seq
MIRT2429852	hsa-miR-3159	CLIP-seq
MIRT2429854	hsa-miR-3173-3p	CLIP-seq
MIRT2550543	hsa-miR-3187-5p	CLIP-seq
MIRT2429860	hsa-miR-325	CLIP-seq
MIRT2550544	hsa-miR-326	CLIP-seq
MIRT2550545	hsa-miR-330-5p	CLIP-seq
MIRT2429861	hsa-miR-337-3p	CLIP-seq
MIRT2550546	hsa-miR-339-5p	CLIP-seq
MIRT2429866	hsa-miR-3613-5p	CLIP-seq
MIRT2550547	hsa-miR-3619-5p	CLIP-seq
MIRT2429867	hsa-miR-3647-3p	CLIP-seq
MIRT2429869	hsa-miR-3657	CLIP-seq
MIRT2429870	hsa-miR-3667-3p	CLIP-seq
MIRT1549935	hsa-miR-3670	CLIP-seq
MIRT1549937	hsa-miR-3675-3p	CLIP-seq
MIRT2429872	hsa-miR-3685	CLIP-seq
MIRT2429873	hsa-miR-3690	CLIP-seq
MIRT2429876	hsa-miR-376c	CLIP-seq
MIRT2550548	hsa-miR-378g	CLIP-seq
MIRT2429877	hsa-miR-381	CLIP-seq
MIRT2429878	hsa-miR-384	CLIP-seq
MIRT2550549	hsa-miR-3940-5p	CLIP-seq
MIRT2550550	hsa-miR-3972	CLIP-seq
MIRT2429880	hsa-miR-421	CLIP-seq
MIRT2429881	hsa-miR-4254	CLIP-seq
MIRT2429882	hsa-miR-4260	CLIP-seq
MIRT2550551	hsa-miR-4264	CLIP-seq
MIRT2429884	hsa-miR-4273	CLIP-seq
MIRT2429886	hsa-miR-4283	CLIP-seq
MIRT2550552	hsa-miR-4287	CLIP-seq
MIRT2429887	hsa-miR-4289	CLIP-seq
MIRT2550553	hsa-miR-4293	CLIP-seq
MIRT2550554	hsa-miR-4319	CLIP-seq
MIRT2550555	hsa-miR-4421	CLIP-seq
MIRT2429890	hsa-miR-4425	CLIP-seq
MIRT2429891	hsa-miR-4428	CLIP-seq
MIRT2550556	hsa-miR-4436b-3p	CLIP-seq
MIRT2429893	hsa-miR-4437	CLIP-seq
MIRT2429895	hsa-miR-4447	CLIP-seq
MIRT2550557	hsa-miR-4448	CLIP-seq
MIRT2550558	hsa-miR-4469	CLIP-seq
MIRT2429896	hsa-miR-4472	CLIP-seq
MIRT2429899	hsa-miR-4481	CLIP-seq
MIRT2550559	hsa-miR-4486	CLIP-seq
MIRT2429900	hsa-miR-4489	CLIP-seq
MIRT2550560	hsa-miR-4497	CLIP-seq
MIRT2550561	hsa-miR-4507	CLIP-seq
MIRT2429902	hsa-miR-450b-3p	CLIP-seq
MIRT2429904	hsa-miR-4521	CLIP-seq
MIRT2429905	hsa-miR-4522	CLIP-seq
MIRT2550562	hsa-miR-4527	CLIP-seq
MIRT2429906	hsa-miR-455-5p	CLIP-seq
MIRT2429907	hsa-miR-4639-5p	CLIP-seq
MIRT2550563	hsa-miR-4640-5p	CLIP-seq
MIRT2429908	hsa-miR-4655-5p	CLIP-seq
MIRT2429910	hsa-miR-4666-3p	CLIP-seq
MIRT2550564	hsa-miR-4667-3p	CLIP-seq
MIRT2429911	hsa-miR-4669	CLIP-seq
MIRT2429913	hsa-miR-4674	CLIP-seq
MIRT2389302	hsa-miR-4677-3p	CLIP-seq
MIRT2429914	hsa-miR-4684-5p	CLIP-seq
MIRT2550565	hsa-miR-4685-3p	CLIP-seq
MIRT2550566	hsa-miR-4690-3p	CLIP-seq
MIRT2429915	hsa-miR-4691-5p	CLIP-seq
MIRT2550567	hsa-miR-4699-5p	CLIP-seq
MIRT2429917	hsa-miR-4701-3p	CLIP-seq
MIRT2550568	hsa-miR-4701-5p	CLIP-seq
MIRT2550569	hsa-miR-4704-3p	CLIP-seq
MIRT2246629	hsa-miR-4709-3p	CLIP-seq
MIRT2429919	hsa-miR-4712-3p	CLIP-seq
MIRT2550570	hsa-miR-4726-5p	CLIP-seq
MIRT2550571	hsa-miR-4732-3p	CLIP-seq
MIRT2429921	hsa-miR-4745-5p	CLIP-seq
MIRT2550572	hsa-miR-4757-5p	CLIP-seq
MIRT2429923	hsa-miR-4762-3p	CLIP-seq
MIRT2429924	hsa-miR-4770	CLIP-seq
MIRT2550573	hsa-miR-4776-3p	CLIP-seq
MIRT2550574	hsa-miR-4779	CLIP-seq
MIRT2429926	hsa-miR-4781-3p	CLIP-seq
MIRT1549949	hsa-miR-4786-5p	CLIP-seq
MIRT2550575	hsa-miR-4793-5p	CLIP-seq
MIRT1549950	hsa-miR-487a	CLIP-seq
MIRT2429929	hsa-miR-495	CLIP-seq
MIRT2429930	hsa-miR-498	CLIP-seq
MIRT2429934	hsa-miR-516a-5p	CLIP-seq
MIRT1549953	hsa-miR-543	CLIP-seq
MIRT2550576	hsa-miR-545	CLIP-seq
MIRT2429939	hsa-miR-548m	CLIP-seq
MIRT2550577	hsa-miR-548p	CLIP-seq
MIRT2429941	hsa-miR-550b	CLIP-seq
MIRT2429942	hsa-miR-568	CLIP-seq
MIRT2550578	hsa-miR-585	CLIP-seq
MIRT2550579	hsa-miR-588	CLIP-seq
MIRT1549954	hsa-miR-593	CLIP-seq
MIRT2550580	hsa-miR-612	CLIP-seq
MIRT2429945	hsa-miR-628-3p	CLIP-seq
MIRT2429947	hsa-miR-629	CLIP-seq
MIRT2550581	hsa-miR-635	CLIP-seq
MIRT2389303	hsa-miR-665	CLIP-seq
MIRT2550582	hsa-miR-670	CLIP-seq
MIRT2550583	hsa-miR-761	CLIP-seq
MIRT2429949	hsa-miR-769-3p	CLIP-seq
MIRT1549955	hsa-miR-769-5p	CLIP-seq
MIRT2550584	hsa-miR-873	CLIP-seq
MIRT2429952	hsa-miR-933	CLIP-seq
MIRT2550525	hsa-miR-103a	CLIP-seq
MIRT2550526	hsa-miR-107	CLIP-seq
MIRT2429818	hsa-miR-1184	CLIP-seq
MIRT2429819	hsa-miR-1193	CLIP-seq
MIRT2550527	hsa-miR-1200	CLIP-seq
MIRT2550528	hsa-miR-1202	CLIP-seq
MIRT2429820	hsa-miR-1205	CLIP-seq
MIRT2550529	hsa-miR-1238	CLIP-seq
MIRT2550530	hsa-miR-1248	CLIP-seq
MIRT2550531	hsa-miR-125a-5p	CLIP-seq
MIRT2550532	hsa-miR-125b	CLIP-seq
MIRT2429825	hsa-miR-1262	CLIP-seq
MIRT2550533	hsa-miR-1268	CLIP-seq
MIRT2550534	hsa-miR-1268b	CLIP-seq
MIRT2550535	hsa-miR-1285	CLIP-seq
MIRT2429828	hsa-miR-1305	CLIP-seq
MIRT2550536	hsa-miR-1343	CLIP-seq
MIRT2429829	hsa-miR-140-3p	CLIP-seq
MIRT2429831	hsa-miR-143	CLIP-seq
MIRT2550537	hsa-miR-1470	CLIP-seq
MIRT2429833	hsa-miR-1914	CLIP-seq
MIRT2429835	hsa-miR-199a-5p	CLIP-seq
MIRT2429836	hsa-miR-199b-5p	CLIP-seq
MIRT2429838	hsa-miR-2117	CLIP-seq
MIRT2550538	hsa-miR-214	CLIP-seq
MIRT2429839	hsa-miR-216b	CLIP-seq
MIRT2429840	hsa-miR-218	CLIP-seq
MIRT2550539	hsa-miR-2278	CLIP-seq
MIRT2429842	hsa-miR-2355-5p	CLIP-seq
MIRT2550540	hsa-miR-2861	CLIP-seq
MIRT2429843	hsa-miR-2964a-5p	CLIP-seq
MIRT2429845	hsa-miR-3065-5p	CLIP-seq
MIRT2550541	hsa-miR-3124-3p	CLIP-seq
MIRT2550542	hsa-miR-3140-5p	CLIP-seq
MIRT1549932	hsa-miR-3143	CLIP-seq
MIRT2429849	hsa-miR-3145-3p	CLIP-seq
MIRT2429851	hsa-miR-3158-5p	CLIP-seq
MIRT2429852	hsa-miR-3159	CLIP-seq
MIRT2429854	hsa-miR-3173-3p	CLIP-seq
MIRT2550543	hsa-miR-3187-5p	CLIP-seq
MIRT2429855	hsa-miR-320a	CLIP-seq
MIRT2429856	hsa-miR-320b	CLIP-seq
MIRT2429857	hsa-miR-320c	CLIP-seq
MIRT2429858	hsa-miR-320d	CLIP-seq
MIRT2429860	hsa-miR-325	CLIP-seq
MIRT2550544	hsa-miR-326	CLIP-seq
MIRT2550545	hsa-miR-330-5p	CLIP-seq
MIRT2429861	hsa-miR-337-3p	CLIP-seq
MIRT2550546	hsa-miR-339-5p	CLIP-seq
MIRT2550547	hsa-miR-3619-5p	CLIP-seq
MIRT2429867	hsa-miR-3647-3p	CLIP-seq
MIRT2429869	hsa-miR-3657	CLIP-seq
MIRT2429870	hsa-miR-3667-3p	CLIP-seq
MIRT1549935	hsa-miR-3670	CLIP-seq
MIRT1549937	hsa-miR-3675-3p	CLIP-seq
MIRT2429872	hsa-miR-3685	CLIP-seq
MIRT2429873	hsa-miR-3690	CLIP-seq
MIRT2429876	hsa-miR-376c	CLIP-seq
MIRT2550548	hsa-miR-378g	CLIP-seq
MIRT2429878	hsa-miR-384	CLIP-seq
MIRT2550549	hsa-miR-3940-5p	CLIP-seq
MIRT2550550	hsa-miR-3972	CLIP-seq
MIRT2429880	hsa-miR-421	CLIP-seq
MIRT2429881	hsa-miR-4254	CLIP-seq
MIRT2550551	hsa-miR-4264	CLIP-seq
MIRT2429884	hsa-miR-4273	CLIP-seq
MIRT2550552	hsa-miR-4287	CLIP-seq
MIRT2429887	hsa-miR-4289	CLIP-seq
MIRT2550553	hsa-miR-4293	CLIP-seq
MIRT2550554	hsa-miR-4319	CLIP-seq
MIRT2550555	hsa-miR-4421	CLIP-seq
MIRT2429890	hsa-miR-4425	CLIP-seq
MIRT2429891	hsa-miR-4428	CLIP-seq
MIRT2429892	hsa-miR-4429	CLIP-seq
MIRT2550556	hsa-miR-4436b-3p	CLIP-seq
MIRT2429893	hsa-miR-4437	CLIP-seq
MIRT2429895	hsa-miR-4447	CLIP-seq
MIRT2550557	hsa-miR-4448	CLIP-seq
MIRT2550558	hsa-miR-4469	CLIP-seq
MIRT2429896	hsa-miR-4472	CLIP-seq
MIRT2429899	hsa-miR-4481	CLIP-seq
MIRT2550559	hsa-miR-4486	CLIP-seq
MIRT2550560	hsa-miR-4497	CLIP-seq
MIRT2550561	hsa-miR-4507	CLIP-seq
MIRT2429902	hsa-miR-450b-3p	CLIP-seq
MIRT2429904	hsa-miR-4521	CLIP-seq
MIRT2429905	hsa-miR-4522	CLIP-seq
MIRT2550562	hsa-miR-4527	CLIP-seq
MIRT2429906	hsa-miR-455-5p	CLIP-seq
MIRT2429907	hsa-miR-4639-5p	CLIP-seq
MIRT2550563	hsa-miR-4640-5p	CLIP-seq
MIRT2429908	hsa-miR-4655-5p	CLIP-seq
MIRT2550564	hsa-miR-4667-3p	CLIP-seq
MIRT2429911	hsa-miR-4669	CLIP-seq
MIRT2429913	hsa-miR-4674	CLIP-seq
MIRT2389302	hsa-miR-4677-3p	CLIP-seq
MIRT2429914	hsa-miR-4684-5p	CLIP-seq
MIRT2550565	hsa-miR-4685-3p	CLIP-seq
MIRT2550566	hsa-miR-4690-3p	CLIP-seq
MIRT2429915	hsa-miR-4691-5p	CLIP-seq
MIRT2550567	hsa-miR-4699-5p	CLIP-seq
MIRT2429917	hsa-miR-4701-3p	CLIP-seq
MIRT2550568	hsa-miR-4701-5p	CLIP-seq
MIRT2550569	hsa-miR-4704-3p	CLIP-seq
MIRT2246629	hsa-miR-4709-3p	CLIP-seq
MIRT2429919	hsa-miR-4712-3p	CLIP-seq
MIRT2550570	hsa-miR-4726-5p	CLIP-seq
MIRT2550571	hsa-miR-4732-3p	CLIP-seq
MIRT2429921	hsa-miR-4745-5p	CLIP-seq
MIRT2550572	hsa-miR-4757-5p	CLIP-seq
MIRT2429923	hsa-miR-4762-3p	CLIP-seq
MIRT2429924	hsa-miR-4770	CLIP-seq
MIRT2550573	hsa-miR-4776-3p	CLIP-seq
MIRT2550574	hsa-miR-4779	CLIP-seq
MIRT1549949	hsa-miR-4786-5p	CLIP-seq
MIRT2550575	hsa-miR-4793-5p	CLIP-seq
MIRT1549950	hsa-miR-487a	CLIP-seq
MIRT2429929	hsa-miR-495	CLIP-seq
MIRT2429930	hsa-miR-498	CLIP-seq
MIRT2429934	hsa-miR-516a-5p	CLIP-seq
MIRT1549953	hsa-miR-543	CLIP-seq
MIRT2550576	hsa-miR-545	CLIP-seq
MIRT2429939	hsa-miR-548m	CLIP-seq
MIRT2550577	hsa-miR-548p	CLIP-seq
MIRT2550578	hsa-miR-585	CLIP-seq
MIRT2550579	hsa-miR-588	CLIP-seq
MIRT1549954	hsa-miR-593	CLIP-seq
MIRT2550580	hsa-miR-612	CLIP-seq
MIRT2429945	hsa-miR-628-3p	CLIP-seq
MIRT2429947	hsa-miR-629	CLIP-seq
MIRT2550581	hsa-miR-635	CLIP-seq
MIRT2389303	hsa-miR-665	CLIP-seq
MIRT2550582	hsa-miR-670	CLIP-seq
MIRT2550583	hsa-miR-761	CLIP-seq
MIRT2429949	hsa-miR-769-3p	CLIP-seq
MIRT1549955	hsa-miR-769-5p	CLIP-seq
MIRT2550584	hsa-miR-873	CLIP-seq
MIRT2429952	hsa-miR-933	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Unknown	23859805
CDX2	Repression	17297462
DLX5	Unknown	17278996
DNMT3A	Repression	19070387
EP300	Activation	12200149
FLI1	Repression	15282325
HDAC1	Activation	12200149
HOXC6	Repression	15637592
MECP2	Repression	17278996
NCOR1	Repression	23098689
SP1	Activation	12200149
SP3	Activation	12200149
TP53	Activation	10101800
VDR	Repression	23770368
VDR	Unknown	14963110

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0001558	Process	Regulation of cell growth	IEA
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0001933	Process	Negative regulation of protein phosphorylation	IDA	17591901
GO:0001968	Function	Fibronectin binding	IBA
GO:0001968	Function	Fibronectin binding	IEA
GO:0005515	Function	Protein binding	IPI	9388210, 14561895, 20353938, 23178489, 26216267, 30184438, 32814053
GO:0005520	Function	Insulin-like growth factor binding	IEA
GO:0005520	Function	Insulin-like growth factor binding	NAS	12599210
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	17119061
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	17434920
GO:0005634	Component	Nucleus	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0006468	Process	Protein phosphorylation	IDA	17434920
GO:0006915	Process	Apoptotic process	IEA
GO:0008160	Function	Protein tyrosine phosphatase activator activity	IDA	11940579
GO:0008285	Process	Negative regulation of cell population proliferation	IGI	19258508
GO:0009968	Process	Negative regulation of signal transduction	NAS	11940579
GO:0010906	Process	Regulation of glucose metabolic process	IEA
GO:0014912	Process	Negative regulation of smooth muscle cell migration	IDA	10766744
GO:0014912	Process	Negative regulation of smooth muscle cell migration	IEA
GO:0016942	Component	Insulin-like growth factor binding protein complex	IC	10766744
GO:0019838	Function	Growth factor binding	IEA
GO:0031994	Function	Insulin-like growth factor I binding	IBA
GO:0031994	Function	Insulin-like growth factor I binding	IEA
GO:0031994	Function	Insulin-like growth factor I binding	IPI	10766744
GO:0031995	Function	Insulin-like growth factor II binding	IBA
GO:0040008	Process	Regulation of growth	IEA
GO:0042567	Component	Insulin-like growth factor ternary complex	IDA	9497324
GO:0042567	Component	Insulin-like growth factor ternary complex	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	11971816
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0043567	Process	Regulation of insulin-like growth factor receptor signaling pathway	IBA
GO:0043568	Process	Positive regulation of insulin-like growth factor receptor signaling pathway	IEA
GO:0044342	Process	Type B pancreatic cell proliferation	IEA
GO:0045663	Process	Positive regulation of myoblast differentiation	IDA	12599210
GO:0046872	Function	Metal ion binding	NAS	14576163
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IDA	10766744
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IEA

Other IDs

• MIM: 146732
• HGNC: 5472
• e!Ensembl: ENSG00000146674

Protein

• UniProt ID: P17936
• Protein name: Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
• Protein function: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a
• PDB: 7WRQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00219	IGFBP	40 → 94	Insulin-like growth factor binding protein	Domain
  PF00086	Thyroglobulin_1	213 → 285	Thyroglobulin type-1 repeat	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed by most tissues. Present in plasma.
• Sequence:

  MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
  LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
  SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
  KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
  DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

• Sequence length: 291

Pathways

KEGG:

p53 signaling pathway
Cellular senescence
Growth hormone synthesis, secretion and action
Transcriptional misregulation in cancer

Reactome:

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
TP53 Regulates Transcription of Death Receptors and Ligands
Post-translational protein phosphorylation