MCRIP1 (MAPK regulated corepressor interacting protein 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 348262
Gene name MAPK regulated corepressor interacting protein 1
Gene symbol MCRIP1
Synonyms (NCBI Gene)
FAM195BGRAN2MCRIP
Chromosome 17
Chromosome location 17q25.3
miRNA miRNA information provided by mirtarbase database.
46
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (46)
miRTarBase ID miRNA Experiments Reference
MIRT482667 hsa-miR-6758-5p PAR-CLIP 20371350
MIRT482666 hsa-miR-6856-5p PAR-CLIP 20371350
MIRT482664 hsa-miR-4779 PAR-CLIP 20371350
MIRT482665 hsa-miR-4459 PAR-CLIP 20371350
MIRT482663 hsa-miR-3150b-3p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25728771, 26184334
GO:0005634 Component Nucleus IDA 25728771, 26184334
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 26184334
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
616514 28007 ENSG00000225663
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
C9JLW8
Protein name Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B)
Protein function The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 re
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14799 FAM195 4 → 94 FAM195 family Family
Sequence
Sequence length 97
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SYSTEMIC LUPUS ERYTHEMATOSUS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations