Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3482
Gene name	Insulin like growth factor 2 receptor
Gene symbol	IGF2R
Synonyms (NCBI Gene)	CD222CI-M6PRCIMPRM6P-RM6P/IGF2RMPR 300MPR1MPR300MPRI
Chromosome	6
Chromosome location	6q25.3
Summary	This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121434587	G>T	Pathogenic	Missense variant, coding sequence variant
rs121434588	G>A	Pathogenic	Missense variant, coding sequence variant

402

Show/Hide all (402)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001451	hsa-miR-16-5p	pSILAC	18668040
MIRT016136	hsa-miR-657	Reporter assay	18602895
MIRT020747	hsa-miR-155-5p	Proteomics	18668040
MIRT021356	hsa-miR-9-5p	Microarray	17612493
MIRT029460	hsa-miR-26b-5p	Microarray	19088304
MIRT001451	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT045878	hsa-miR-128-3p	CLASH	23622248
MIRT042556	hsa-miR-423-3p	CLASH	23622248
MIRT036067	hsa-miR-1271-5p	CLASH	23622248
MIRT054454	hsa-miR-211-5p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	24039954
MIRT713900	hsa-miR-649	HITS-CLIP	19536157
MIRT713899	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT713898	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT713896	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT713895	hsa-miR-561-5p	HITS-CLIP	19536157
MIRT713918	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT713917	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT713916	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT713915	hsa-miR-6895-5p	HITS-CLIP	19536157
MIRT713914	hsa-miR-4512	HITS-CLIP	19536157
MIRT713913	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT713912	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT713911	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT713910	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT713909	hsa-miR-3666	HITS-CLIP	19536157
MIRT713908	hsa-miR-4295	HITS-CLIP	19536157
MIRT713907	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT713906	hsa-miR-3146	HITS-CLIP	19536157
MIRT713905	hsa-miR-5008-5p	HITS-CLIP	19536157
MIRT679245	hsa-miR-6089	HITS-CLIP	19536157
MIRT713904	hsa-miR-4480	HITS-CLIP	19536157
MIRT713903	hsa-miR-6877-5p	HITS-CLIP	19536157
MIRT713902	hsa-miR-1296-5p	HITS-CLIP	19536157
MIRT713901	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT713900	hsa-miR-649	HITS-CLIP	19536157
MIRT713899	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT713898	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT713897	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT713896	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT713895	hsa-miR-561-5p	HITS-CLIP	19536157
MIRT607437	hsa-miR-8485	HITS-CLIP	22927820
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	22927820
MIRT672625	hsa-miR-342-3p	HITS-CLIP	22927820
MIRT440462	hsa-miR-377-3p	HITS-CLIP	22927820
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT672624	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT679245	hsa-miR-6089	HITS-CLIP	23824327
MIRT672616	hsa-miR-4284	HITS-CLIP	23824327
MIRT672617	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672614	hsa-miR-7977	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT672624	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672623	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT672622	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT672621	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT672620	hsa-miR-612	HITS-CLIP	23824327
MIRT672619	hsa-miR-6860	HITS-CLIP	23824327
MIRT672618	hsa-miR-564	HITS-CLIP	23824327
MIRT672616	hsa-miR-4284	HITS-CLIP	23824327
MIRT672617	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672614	hsa-miR-7977	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	24906430
MIRT457094	hsa-miR-548m	PAR-CLIP	23592263
MIRT457093	hsa-miR-2681-3p	PAR-CLIP	23592263
MIRT457092	hsa-miR-96-3p	PAR-CLIP	23592263
MIRT316722	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT440463	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440462	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440461	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT440463	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440462	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440461	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT607437	hsa-miR-8485	HITS-CLIP	27418678
MIRT607437	hsa-miR-8485	HITS-CLIP	27418678
MIRT735290	hsa-miR-28-3p	qRT-PCR	32425976
MIRT713900	hsa-miR-649	HITS-CLIP	19536157
MIRT713899	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT713898	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT713896	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT713895	hsa-miR-561-5p	HITS-CLIP	19536157
MIRT713918	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT713917	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT713916	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT713915	hsa-miR-6895-5p	HITS-CLIP	19536157
MIRT713914	hsa-miR-4512	HITS-CLIP	19536157
MIRT713913	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT713912	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT713911	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT713910	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT713909	hsa-miR-3666	HITS-CLIP	19536157
MIRT713908	hsa-miR-4295	HITS-CLIP	19536157
MIRT713907	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT713906	hsa-miR-3146	HITS-CLIP	19536157
MIRT713905	hsa-miR-5008-5p	HITS-CLIP	19536157
MIRT679245	hsa-miR-6089	HITS-CLIP	19536157
MIRT713904	hsa-miR-4480	HITS-CLIP	19536157
MIRT713903	hsa-miR-6877-5p	HITS-CLIP	19536157
MIRT713902	hsa-miR-1296-5p	HITS-CLIP	19536157
MIRT713901	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT713900	hsa-miR-649	HITS-CLIP	19536157
MIRT713899	hsa-miR-1178-5p	HITS-CLIP	19536157
MIRT713898	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT713897	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT713896	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT713895	hsa-miR-561-5p	HITS-CLIP	19536157
MIRT607437	hsa-miR-8485	HITS-CLIP	22927820
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	22927820
MIRT672625	hsa-miR-342-3p	HITS-CLIP	22927820
MIRT440462	hsa-miR-377-3p	HITS-CLIP	22927820
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT672624	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT679245	hsa-miR-6089	HITS-CLIP	23824327
MIRT672616	hsa-miR-4284	HITS-CLIP	23824327
MIRT672617	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672614	hsa-miR-7977	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT672626	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT672625	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT440462	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT672624	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT672623	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT672622	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT672621	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT672620	hsa-miR-612	HITS-CLIP	23824327
MIRT672619	hsa-miR-6860	HITS-CLIP	23824327
MIRT672618	hsa-miR-564	HITS-CLIP	23824327
MIRT672616	hsa-miR-4284	HITS-CLIP	23824327
MIRT672617	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672614	hsa-miR-7977	HITS-CLIP	23824327
MIRT607437	hsa-miR-8485	HITS-CLIP	23824327
MIRT457094	hsa-miR-548m	PAR-CLIP	23592263
MIRT457093	hsa-miR-2681-3p	PAR-CLIP	23592263
MIRT457092	hsa-miR-96-3p	PAR-CLIP	23592263
MIRT316722	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT1062022	hsa-miR-1205	CLIP-seq
MIRT1062023	hsa-miR-1207-5p	CLIP-seq
MIRT1062024	hsa-miR-1228	CLIP-seq
MIRT1062025	hsa-miR-1266	CLIP-seq
MIRT1062026	hsa-miR-1296	CLIP-seq
MIRT1062027	hsa-miR-130a	CLIP-seq
MIRT1062028	hsa-miR-130b	CLIP-seq
MIRT1062029	hsa-miR-1470	CLIP-seq
MIRT1062030	hsa-miR-1471	CLIP-seq
MIRT1062031	hsa-miR-15a	CLIP-seq
MIRT1062032	hsa-miR-15b	CLIP-seq
MIRT1062033	hsa-miR-16	CLIP-seq
MIRT1062034	hsa-miR-1909	CLIP-seq
MIRT1062035	hsa-miR-1913	CLIP-seq
MIRT1062036	hsa-miR-195	CLIP-seq
MIRT1062037	hsa-miR-1973	CLIP-seq
MIRT1062038	hsa-miR-19a	CLIP-seq
MIRT1062039	hsa-miR-19b	CLIP-seq
MIRT1062040	hsa-miR-22	CLIP-seq
MIRT1062041	hsa-miR-224	CLIP-seq
MIRT1062042	hsa-miR-2277-3p	CLIP-seq
MIRT1062043	hsa-miR-2681	CLIP-seq
MIRT1062044	hsa-miR-300	CLIP-seq
MIRT1062045	hsa-miR-301a	CLIP-seq
MIRT1062046	hsa-miR-301b	CLIP-seq
MIRT1062047	hsa-miR-3141	CLIP-seq
MIRT1062048	hsa-miR-3189-5p	CLIP-seq
MIRT1062049	hsa-miR-3194-3p	CLIP-seq
MIRT1062050	hsa-miR-324-3p	CLIP-seq
MIRT1062051	hsa-miR-331-3p	CLIP-seq
MIRT1062052	hsa-miR-338-3p	CLIP-seq
MIRT1062053	hsa-miR-3591-3p	CLIP-seq
MIRT1062054	hsa-miR-3605-3p	CLIP-seq
MIRT1062055	hsa-miR-3660	CLIP-seq
MIRT1062056	hsa-miR-3662	CLIP-seq
MIRT1062057	hsa-miR-3671	CLIP-seq
MIRT1062058	hsa-miR-3689d	CLIP-seq
MIRT1062059	hsa-miR-370	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT1062061	hsa-miR-381	CLIP-seq
MIRT1062062	hsa-miR-3942-5p	CLIP-seq
MIRT1062063	hsa-miR-3977	CLIP-seq
MIRT1062064	hsa-miR-421	CLIP-seq
MIRT1062065	hsa-miR-424	CLIP-seq
MIRT1062066	hsa-miR-4258	CLIP-seq
MIRT1062067	hsa-miR-4269	CLIP-seq
MIRT1062068	hsa-miR-4422	CLIP-seq
MIRT1062069	hsa-miR-4443	CLIP-seq
MIRT1062070	hsa-miR-4449	CLIP-seq
MIRT1062071	hsa-miR-4469	CLIP-seq
MIRT1062072	hsa-miR-4518	CLIP-seq
MIRT1062073	hsa-miR-4526	CLIP-seq
MIRT1062074	hsa-miR-4530	CLIP-seq
MIRT1062075	hsa-miR-454	CLIP-seq
MIRT1062076	hsa-miR-4635	CLIP-seq
MIRT1062077	hsa-miR-4659a-3p	CLIP-seq
MIRT1062078	hsa-miR-4659b-3p	CLIP-seq
MIRT1062079	hsa-miR-4666-3p	CLIP-seq
MIRT1062080	hsa-miR-4667-3p	CLIP-seq
MIRT1062081	hsa-miR-4687-3p	CLIP-seq
MIRT1062082	hsa-miR-4699-5p	CLIP-seq
MIRT1062083	hsa-miR-4703-5p	CLIP-seq
MIRT1062084	hsa-miR-4709-3p	CLIP-seq
MIRT1062085	hsa-miR-4718	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT1062087	hsa-miR-4758-3p	CLIP-seq
MIRT1062088	hsa-miR-4763-3p	CLIP-seq
MIRT1062089	hsa-miR-4773	CLIP-seq
MIRT1062090	hsa-miR-4796-5p	CLIP-seq
MIRT1062091	hsa-miR-497	CLIP-seq
MIRT1062092	hsa-miR-499-3p	CLIP-seq
MIRT1062093	hsa-miR-499a-3p	CLIP-seq
MIRT1062094	hsa-miR-510	CLIP-seq
MIRT1062095	hsa-miR-519a	CLIP-seq
MIRT1062096	hsa-miR-545	CLIP-seq
MIRT1062097	hsa-miR-553	CLIP-seq
MIRT1062098	hsa-miR-582-3p	CLIP-seq
MIRT1062099	hsa-miR-603	CLIP-seq
MIRT1062100	hsa-miR-636	CLIP-seq
MIRT1062101	hsa-miR-642b	CLIP-seq
MIRT1062102	hsa-miR-647	CLIP-seq
MIRT1062103	hsa-miR-659	CLIP-seq
MIRT1062104	hsa-miR-766	CLIP-seq
MIRT1062105	hsa-miR-9	CLIP-seq
MIRT1062044	hsa-miR-300	CLIP-seq
MIRT1062053	hsa-miR-3591-3p	CLIP-seq
MIRT1062061	hsa-miR-381	CLIP-seq
MIRT1062062	hsa-miR-3942-5p	CLIP-seq
MIRT1062079	hsa-miR-4666-3p	CLIP-seq
MIRT1062083	hsa-miR-4703-5p	CLIP-seq
MIRT1062089	hsa-miR-4773	CLIP-seq
MIRT1062090	hsa-miR-4796-5p	CLIP-seq
MIRT1062029	hsa-miR-1470	CLIP-seq
MIRT2014652	hsa-miR-203	CLIP-seq
MIRT2014653	hsa-miR-205	CLIP-seq
MIRT1062052	hsa-miR-338-3p	CLIP-seq
MIRT2014654	hsa-miR-3607-3p	CLIP-seq
MIRT2014655	hsa-miR-361-3p	CLIP-seq
MIRT2014656	hsa-miR-3620	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT2014657	hsa-miR-412	CLIP-seq
MIRT2014658	hsa-miR-4311	CLIP-seq
MIRT2014659	hsa-miR-4452	CLIP-seq
MIRT1062071	hsa-miR-4469	CLIP-seq
MIRT2014660	hsa-miR-4484	CLIP-seq
MIRT1062074	hsa-miR-4530	CLIP-seq
MIRT1062080	hsa-miR-4667-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT2014661	hsa-miR-548an	CLIP-seq
MIRT2014662	hsa-miR-548p	CLIP-seq
MIRT2014663	hsa-miR-653	CLIP-seq
MIRT1062104	hsa-miR-766	CLIP-seq
MIRT1062105	hsa-miR-9	CLIP-seq
MIRT1062022	hsa-miR-1205	CLIP-seq
MIRT2246599	hsa-miR-1273f	CLIP-seq
MIRT2246600	hsa-miR-1283	CLIP-seq
MIRT2246601	hsa-miR-143	CLIP-seq
MIRT1062031	hsa-miR-15a	CLIP-seq
MIRT1062032	hsa-miR-15b	CLIP-seq
MIRT1062033	hsa-miR-16	CLIP-seq
MIRT1062034	hsa-miR-1909	CLIP-seq
MIRT1062036	hsa-miR-195	CLIP-seq
MIRT1062038	hsa-miR-19a	CLIP-seq
MIRT1062039	hsa-miR-19b	CLIP-seq
MIRT2014653	hsa-miR-205	CLIP-seq
MIRT1062041	hsa-miR-224	CLIP-seq
MIRT2246602	hsa-miR-2861	CLIP-seq
MIRT1062044	hsa-miR-300	CLIP-seq
MIRT2246603	hsa-miR-3126-5p	CLIP-seq
MIRT1062047	hsa-miR-3141	CLIP-seq
MIRT2246604	hsa-miR-3151	CLIP-seq
MIRT1062049	hsa-miR-3194-3p	CLIP-seq
MIRT1062053	hsa-miR-3591-3p	CLIP-seq
MIRT2014654	hsa-miR-3607-3p	CLIP-seq
MIRT2014656	hsa-miR-3620	CLIP-seq
MIRT1062057	hsa-miR-3671	CLIP-seq
MIRT2246605	hsa-miR-3686	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT1062061	hsa-miR-381	CLIP-seq
MIRT2246606	hsa-miR-3929	CLIP-seq
MIRT1062062	hsa-miR-3942-5p	CLIP-seq
MIRT1062063	hsa-miR-3977	CLIP-seq
MIRT2014657	hsa-miR-412	CLIP-seq
MIRT1062065	hsa-miR-424	CLIP-seq
MIRT2014658	hsa-miR-4311	CLIP-seq
MIRT2246607	hsa-miR-4419a	CLIP-seq
MIRT2246608	hsa-miR-4419b	CLIP-seq
MIRT1062068	hsa-miR-4422	CLIP-seq
MIRT2246609	hsa-miR-4476	CLIP-seq
MIRT2246610	hsa-miR-4478	CLIP-seq
MIRT2246611	hsa-miR-4481	CLIP-seq
MIRT2014660	hsa-miR-4484	CLIP-seq
MIRT2246612	hsa-miR-4510	CLIP-seq
MIRT2246613	hsa-miR-4533	CLIP-seq
MIRT1062076	hsa-miR-4635	CLIP-seq
MIRT2246614	hsa-miR-4652-3p	CLIP-seq
MIRT1062077	hsa-miR-4659a-3p	CLIP-seq
MIRT1062078	hsa-miR-4659b-3p	CLIP-seq
MIRT1062079	hsa-miR-4666-3p	CLIP-seq
MIRT1062082	hsa-miR-4699-5p	CLIP-seq
MIRT1062083	hsa-miR-4703-5p	CLIP-seq
MIRT2246615	hsa-miR-4708-5p	CLIP-seq
MIRT1062084	hsa-miR-4709-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT2246616	hsa-miR-4745-5p	CLIP-seq
MIRT2246617	hsa-miR-4770	CLIP-seq
MIRT1062089	hsa-miR-4773	CLIP-seq
MIRT2246618	hsa-miR-4790-3p	CLIP-seq
MIRT1062090	hsa-miR-4796-5p	CLIP-seq
MIRT1062091	hsa-miR-497	CLIP-seq
MIRT1062096	hsa-miR-545	CLIP-seq
MIRT2014661	hsa-miR-548an	CLIP-seq
MIRT2014662	hsa-miR-548p	CLIP-seq
MIRT1062099	hsa-miR-603	CLIP-seq
MIRT2246619	hsa-miR-873	CLIP-seq
MIRT1062029	hsa-miR-1470	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT1062071	hsa-miR-4469	CLIP-seq
MIRT1062080	hsa-miR-4667-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT2550512	hsa-miR-1200	CLIP-seq
MIRT1062023	hsa-miR-1207-5p	CLIP-seq
MIRT2550513	hsa-miR-1226	CLIP-seq
MIRT1062024	hsa-miR-1228	CLIP-seq
MIRT2550514	hsa-miR-18a	CLIP-seq
MIRT2550515	hsa-miR-18b	CLIP-seq
MIRT2550516	hsa-miR-197	CLIP-seq
MIRT1062042	hsa-miR-2277-3p	CLIP-seq
MIRT1062043	hsa-miR-2681	CLIP-seq
MIRT1062049	hsa-miR-3194-3p	CLIP-seq
MIRT1062059	hsa-miR-370	CLIP-seq
MIRT1062060	hsa-miR-377	CLIP-seq
MIRT2550517	hsa-miR-3944-5p	CLIP-seq
MIRT2550518	hsa-miR-4426	CLIP-seq
MIRT2014659	hsa-miR-4452	CLIP-seq
MIRT1062076	hsa-miR-4635	CLIP-seq
MIRT2550519	hsa-miR-4647	CLIP-seq
MIRT2550520	hsa-miR-4662b	CLIP-seq
MIRT1062081	hsa-miR-4687-3p	CLIP-seq
MIRT1062082	hsa-miR-4699-5p	CLIP-seq
MIRT1062084	hsa-miR-4709-3p	CLIP-seq
MIRT2550521	hsa-miR-4733-3p	CLIP-seq
MIRT2550522	hsa-miR-4735-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT1062088	hsa-miR-4763-3p	CLIP-seq
MIRT1062092	hsa-miR-499-3p	CLIP-seq
MIRT1062093	hsa-miR-499a-3p	CLIP-seq
MIRT2550523	hsa-miR-513c	CLIP-seq
MIRT2550524	hsa-miR-514b-5p	CLIP-seq
MIRT1062097	hsa-miR-553	CLIP-seq
MIRT1062098	hsa-miR-582-3p	CLIP-seq
MIRT1062105	hsa-miR-9	CLIP-seq
MIRT2550512	hsa-miR-1200	CLIP-seq
MIRT1062023	hsa-miR-1207-5p	CLIP-seq
MIRT1062024	hsa-miR-1228	CLIP-seq
MIRT2550514	hsa-miR-18a	CLIP-seq
MIRT2550515	hsa-miR-18b	CLIP-seq
MIRT1062042	hsa-miR-2277-3p	CLIP-seq
MIRT1062043	hsa-miR-2681	CLIP-seq
MIRT2682668	hsa-miR-3144-5p	CLIP-seq
MIRT1062049	hsa-miR-3194-3p	CLIP-seq
MIRT2682669	hsa-miR-3622a-5p	CLIP-seq
MIRT1062059	hsa-miR-370	CLIP-seq
MIRT2682670	hsa-miR-3910	CLIP-seq
MIRT2550517	hsa-miR-3944-5p	CLIP-seq
MIRT2682671	hsa-miR-4423-3p	CLIP-seq
MIRT2550518	hsa-miR-4426	CLIP-seq
MIRT2682672	hsa-miR-4470	CLIP-seq
MIRT2014660	hsa-miR-4484	CLIP-seq
MIRT2682673	hsa-miR-4509	CLIP-seq
MIRT1062076	hsa-miR-4635	CLIP-seq
MIRT2550519	hsa-miR-4647	CLIP-seq
MIRT2550520	hsa-miR-4662b	CLIP-seq
MIRT1062081	hsa-miR-4687-3p	CLIP-seq
MIRT1062082	hsa-miR-4699-5p	CLIP-seq
MIRT1062084	hsa-miR-4709-3p	CLIP-seq
MIRT2550522	hsa-miR-4735-3p	CLIP-seq
MIRT1062086	hsa-miR-4736	CLIP-seq
MIRT2682674	hsa-miR-4742-5p	CLIP-seq
MIRT1062088	hsa-miR-4763-3p	CLIP-seq
MIRT1062089	hsa-miR-4773	CLIP-seq
MIRT1062092	hsa-miR-499-3p	CLIP-seq
MIRT1062093	hsa-miR-499a-3p	CLIP-seq
MIRT2550523	hsa-miR-513c	CLIP-seq
MIRT2550524	hsa-miR-514b-5p	CLIP-seq
MIRT2682675	hsa-miR-515-5p	CLIP-seq
MIRT2682676	hsa-miR-542-5p	CLIP-seq
MIRT2014661	hsa-miR-548an	CLIP-seq
MIRT1062097	hsa-miR-553	CLIP-seq
MIRT1062098	hsa-miR-582-3p	CLIP-seq
MIRT1062105	hsa-miR-9	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
USF2	Activation	12857727

Show/Hide all (63)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0001889	Process	Liver development	IEA
GO:0001965	Function	G-protein alpha-subunit binding	IEA
GO:0001972	Function	Retinoic acid binding	IEA
GO:0005010	Function	Insulin-like growth factor receptor activity	TAS	10799489
GO:0005515	Function	Protein binding	IDA	10900005
GO:0005515	Function	Protein binding	IPI	10900005, 11387475, 11390366, 16977309, 17850746, 18046459, 37100772, 37158588, 37219487
GO:0005520	Function	Insulin-like growth factor binding	IBA
GO:0005520	Function	Insulin-like growth factor binding	IEA
GO:0005537	Function	D-mannose binding	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005641	Component	Nuclear envelope lumen	IEA
GO:0005768	Component	Endosome	IDA	15078902
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IMP	17959629
GO:0005770	Component	Late endosome	IBA
GO:0005770	Component	Late endosome	IDA	22456507
GO:0005770	Component	Late endosome	IEA
GO:0005794	Component	Golgi apparatus	IDA	18817523
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IBA
GO:0005802	Component	Trans-Golgi network	IEA
GO:0005802	Component	Trans-Golgi network	IMP	17959629
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS	10799489
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006898	Process	Receptor-mediated endocytosis	TAS	10799489
GO:0007041	Process	Lysosomal transport	IBA
GO:0007041	Process	Lysosomal transport	IEA
GO:0007165	Process	Signal transduction	TAS	7753549
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0009986	Component	Cell surface	IDA	10900005
GO:0010008	Component	Endosome membrane	IDA	18817523
GO:0010008	Component	Endosome membrane	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0030118	Component	Clathrin coat	IEA
GO:0030133	Component	Transport vesicle	TAS
GO:0030139	Component	Endocytic vesicle	IDA	10900005
GO:0030140	Component	Trans-Golgi network transport vesicle	IDA	15078902
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031100	Process	Animal organ regeneration	IEA
GO:0031995	Function	Insulin-like growth factor II binding	IEA
GO:0032526	Process	Response to retinoic acid	IEA
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0038023	Function	Signaling receptor activity	IEA
GO:0038023	Function	Signaling receptor activity	TAS	7753549
GO:0042802	Function	Identical protein binding	IPI	22681933
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0044794	Process	Host-mediated activation of viral process	IMP	20889566
GO:0048009	Process	Insulin-like growth factor receptor signaling pathway	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051219	Function	Phosphoprotein binding	IDA	10900005
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:1904772	Process	Response to tetrachloromethane	IEA
GO:1905394	Function	Retromer complex binding	IDA	18817523

MIM	HGNC	e!Ensembl
147280	5467	ENSG00000197081

P11717

Protein name

Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (

Protein function

Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate re

PDB

1E6F , 1GP0 , 1GP3 , 1GQB , 1JPL , 1JWG , 1LF8 , 2CNJ , 2L29 , 2L2A , 2M68 , 2M6T , 2V5N , 2V5O , 2V5P , 5IEI , 6N5X , 6N5Y , 6P8I , 6V02 , 6Z30 , 6Z31 , 6Z32 , 8AFZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00878	CIMR	123 → 270	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	277 → 421	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	423 → 573	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	575 → 716	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	720 → 876	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	882 → 1026	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	1031 → 1178	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	1179 → 1320	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	1322 → 1462	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	1465 → 1599	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	1603 → 1750	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	1755 → 1894	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00040	fn2	1903 → 1942	Fibronectin type II domain	Domain
PF00878	CIMR	1946 → 2083	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	2085 → 2233	Cation-independent mannose-6-phosphate receptor repeat	Family
PF00878	CIMR	2237 → 2290	Cation-independent mannose-6-phosphate receptor repeat	Family

Sequence

MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKN
NVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQ
GTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEE
LRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGH
QAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKL
TAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYL
FYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDEC
SSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDG
KKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAV
DKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTS
GEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFY
INVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERH
TPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDL
SSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGS
FTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNS
HPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSG
IGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFIT
LTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPS
PVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVG
SCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQ
LQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFR
VCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCH
KVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFD
LSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRV
RDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCEYTFAW
PTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCP
PGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEARP
TNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESE
DDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEI
YLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVR
MDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSG
TKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIE
SRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFE
WKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCS
ERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTV
GRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRA
SGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQDG
DLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPL
GVGFDSENPGDDGQMHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLT
TCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALS
SLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKAR
KGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI

Sequence length

2491

Interactions

View interactions

	KEGG		Reactome
	Virion - Herpesvirus Lysosome Endocytosis		Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hepatocellular carcinoma	Pathogenic; Likely pathogenic	rs121434587, rs121434588, rs1783569729	RCV000015918 RCV000015919 RCV001170050
Premature ovarian failure	Likely pathogenic	rs756631085	RCV001270203

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Beckwith-Wiedemann syndrome	Uncertain significance	rs376138460	RCV003990877
Familial cancer of breast	Likely benign	rs151180572	RCV005927459
Lung cancer	Likely benign	rs151180572	RCV005927462
Myoepithelial tumor	Uncertain significance	rs8191819	RCV002463931
Prostate cancer	Uncertain significance	rs193920850	RCV000149008
Thymoma	Likely benign	rs151180572	RCV005927460
Thyroid cancer, nonmedullary, 1	Likely benign	rs151180572	RCV005927461
Uterine corpus endometrial carcinoma	Likely benign	rs151180572	RCV005927463

Show/Hide Text Mining Associations (73)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	17399767, 19626700
Adrenocortical Carcinoma	Associate	30838516
Alcoholism	Associate	18616667
Alzheimer Disease	Associate	33704916
Anemia Aplastic	Associate	39179703
Arterial Occlusive Diseases	Stimulate	11854734
Autoimmune Diseases	Associate	10594701
Beckwith Wiedemann Syndrome	Associate	26505556
Birt Hogg Dube Syndrome	Stimulate	33143702
Breast Neoplasms	Associate	12149131, 19435860, 20347606, 26458823, 36140725, 37684436, 8286193, 9413941
Carcinogenesis	Associate	12149131, 17850746, 9294214
Carcinoma Ductal Breast	Associate	9413941
Carcinoma Hepatocellular	Associate	18322954, 23071652, 33495404, 7639583, 9294214, 9413941
Carcinoma Intraductal Noninfiltrating	Associate	26718977
Carcinoma Non Small Cell Lung	Associate	25402559
Carcinoma Squamous Cell	Associate	23347038
Cardiomyopathy Hypertrophic	Inhibit	23498131
Cardiovascular Diseases	Associate	30642433
Ceroid lipofuscinosis neuronal 5	Associate	22431521
Chediak Higashi Syndrome	Associate	26478006
Chemical and Drug Induced Liver Injury	Associate	33595041
Colorectal Neoplasms	Associate	22377707
COVID 19	Stimulate	32894568
Dementia	Associate	30642433
Diabetes Gestational	Associate	31424259
Diabetes Mellitus Type 2	Associate	25867398, 25922844
Dysplastic Nevus Syndrome	Associate	9294214
Endometrial Neoplasms	Associate	17399767
Esophageal Neoplasms	Associate	19626700
Fetal Growth Retardation	Associate	20104244
Glioblastoma	Associate	26956052, 27770278
Head and Neck Neoplasms	Associate	12589712, 39619326
Heart Failure	Associate	37684436
Hepatitis C	Associate	16627984
HIV Infections	Associate	25890304
Idiopathic Noncirrhotic Portal Hypertension	Inhibit	12618883
Idiopathic Noncirrhotic Portal Hypertension	Associate	9294214
Insulin Resistance	Associate	11283790, 25922844
Laryngeal Neoplasms	Associate	36299463
Liver Cirrhosis	Associate	9294214
Liver Diseases	Associate	9294214
Liver Neoplasms	Associate	9294214
Lung Neoplasms	Associate	12142546, 30642433
Lymphoma Primary Effusion	Associate	30541844
Melanoma	Associate	19414391, 21109473, 34571863
Metabolic Syndrome	Inhibit	25867398
Metabolic Syndrome	Associate	25867398, 34093434
Microcephalic Osteodysplastic Primordial Dwarfism Type II	Associate	37569667
Multiple Myeloma	Associate	8896422
Myasthenia Gravis	Associate	35802752
Mycoses	Associate	28713781
Neoplasm Metastasis	Associate	21109473, 23347038
Neoplasms	Associate	10446221, 12142546, 12149131, 12857727, 16432260, 18322954, 19414391, 19626700, 20347606, 20416304, 22377707, 22849543, 23347038, 24637962, 25402559
Neoplasms	Inhibit	12589712, 17475626, 17850746, 19435860, 22681933, 31748500, 36140725
Neoplasms	Stimulate	36299463
Osteogenesis Imperfecta Type VII	Associate	23347038
Osteosarcoma	Associate	21751203
Ovarian Diseases	Associate	21846690
Ovarian Neoplasms	Associate	16432260, 22849543, 36722270
Pancreatic Neoplasms	Associate	20416304
Parkinson Disease	Associate	24152121
Polycystic Ovary Syndrome	Associate	22904171
Precursor Cell Lymphoblastic Leukemia Lymphoma	Stimulate	22878902
Prostatic Neoplasms	Associate	31337649
Puberty Precocious	Associate	30249230
Sarcoma Kaposi	Associate	30541844
Skin Neoplasms	Associate	37562257
Squamous Cell Carcinoma of Head and Neck	Associate	12589712
Stomach Neoplasms	Associate	19626700, 25329677
Thymoma	Associate	35802752
Tuberculosis Multidrug Resistant	Associate	30939201
Turcot syndrome	Associate	10861262
Uterine Cervical Neoplasms	Stimulate	31748500

IGF2R (insulin like growth factor 2 receptor)