Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	348
Gene name	Apolipoprotein E
Gene symbol	APOE
Synonyms (NCBI Gene)	AD2APO-EApoE4LDLCQ5LPG
Chromosome	19
Chromosome location	19q13.32
Summary	The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19

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SNP ID	Visualize variation	Clinical significance	Consequence
rs7412	C>T	Drug-response, pathogenic, uncertain-significance, other, risk-factor	Coding sequence variant, missense variant
rs405509	T>G	Drug-response, risk-factor	Upstream transcript variant
rs429358	T>C	Association, drug-response, pathogenic, uncertain-significance, other, protective, likely-pathogenic, risk-factor	Coding sequence variant, missense variant
rs769450	G>A	Drug-response	Intron variant
rs769452	T>A,C	Conflicting-interpretations-of-pathogenicity, pathogenic	Coding sequence variant, missense variant
rs769455	C>T	Benign, pathogenic, pathogenic-likely-pathogenic	Coding sequence variant, missense variant
rs28931576	A>G,T	Pathogenic	Coding sequence variant, missense variant
rs28931577	G>A	Pathogenic	Coding sequence variant, missense variant
rs28931578	G>A,C,T	Pathogenic	Coding sequence variant, missense variant
rs28931579	A>C	Pathogenic	Coding sequence variant, missense variant
rs121918392	G>A	Pathogenic	Coding sequence variant, missense variant
rs121918393	C>A,T	Protective, pathogenic	Coding sequence variant, missense variant
rs121918394	A>C,G	Pathogenic	Coding sequence variant, missense variant
rs121918395	C>A,T	Pathogenic	Coding sequence variant, missense variant
rs121918396	G>A	Pathogenic	Coding sequence variant, stop gained
rs121918397	G>A,C	Pathogenic	Coding sequence variant, missense variant
rs121918398	G>A	Pathogenic	Coding sequence variant, missense variant
rs121918399	C>T	Pathogenic	Coding sequence variant, missense variant
rs140808909	G>A	Pathogenic	Missense variant, coding sequence variant
rs190853081	G>A	Pathogenic	Missense variant, coding sequence variant
rs199768005	T>A	Pathogenic	Missense variant, coding sequence variant
rs200703101	G>C,T	Likely-pathogenic	Missense variant, coding sequence variant
rs201672011	G>A	Pathogenic	Missense variant, coding sequence variant
rs267606661	C>G,T	Pathogenic	Missense variant, coding sequence variant
rs267606662	G>C	Pathogenic	Missense variant, coding sequence variant
rs267606663	G>A,C	Pathogenic	Missense variant, coding sequence variant
rs267606664	G>A,C	Pathogenic	Missense variant, coding sequence variant
rs387906567	C>G,T	Pathogenic	Coding sequence variant, missense variant
rs397514253	A>G	Pathogenic	Splice acceptor variant
rs397514254	->GAGGTGCAGGCCATGCTCGGC	Pathogenic	Inframe insertion, coding sequence variant
rs515726148	TCC>-	Pathogenic	Inframe deletion, coding sequence variant

Show/Hide all (66)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053553	hsa-miR-199a-5p	ELISALuciferase reporter assayMicroarray	23142051
MIRT053554	hsa-miR-1908-5p	ELISALuciferase reporter assayMicroarray	23142051
MIRT053558	hsa-miR-199a-3p	ELISALuciferase reporter assayMicroarray	23142051
MIRT2476378	hsa-miR-1182	CLIP-seq
MIRT2476379	hsa-miR-1205	CLIP-seq
MIRT2476380	hsa-miR-1469	CLIP-seq
MIRT2476381	hsa-miR-1827	CLIP-seq
MIRT2476382	hsa-miR-1908	CLIP-seq
MIRT2476383	hsa-miR-2277-5p	CLIP-seq
MIRT2476384	hsa-miR-3180	CLIP-seq
MIRT2476385	hsa-miR-3180-3p	CLIP-seq
MIRT2476386	hsa-miR-3196	CLIP-seq
MIRT2476387	hsa-miR-3612	CLIP-seq
MIRT2476388	hsa-miR-3622a-5p	CLIP-seq
MIRT2476389	hsa-miR-4459	CLIP-seq
MIRT2476390	hsa-miR-4477a	CLIP-seq
MIRT2476391	hsa-miR-4479	CLIP-seq
MIRT2476392	hsa-miR-4505	CLIP-seq
MIRT2476393	hsa-miR-4651	CLIP-seq
MIRT2476394	hsa-miR-4695-5p	CLIP-seq
MIRT2476395	hsa-miR-4706	CLIP-seq
MIRT2476396	hsa-miR-4722-5p	CLIP-seq
MIRT2476397	hsa-miR-4731-5p	CLIP-seq
MIRT2476398	hsa-miR-4738-3p	CLIP-seq
MIRT2476399	hsa-miR-4749-5p	CLIP-seq
MIRT2476400	hsa-miR-564	CLIP-seq
MIRT2476401	hsa-miR-604	CLIP-seq
MIRT2476402	hsa-miR-608	CLIP-seq
MIRT2476403	hsa-miR-615-5p	CLIP-seq
MIRT2476404	hsa-miR-647	CLIP-seq
MIRT2476405	hsa-miR-650	CLIP-seq
MIRT2476406	hsa-miR-658	CLIP-seq
MIRT2476407	hsa-miR-663	CLIP-seq
MIRT2476408	hsa-miR-665	CLIP-seq
MIRT2476409	hsa-miR-940	CLIP-seq
MIRT2476378	hsa-miR-1182	CLIP-seq
MIRT2476379	hsa-miR-1205	CLIP-seq
MIRT2476381	hsa-miR-1827	CLIP-seq
MIRT2476382	hsa-miR-1908	CLIP-seq
MIRT2476383	hsa-miR-2277-5p	CLIP-seq
MIRT2476384	hsa-miR-3180	CLIP-seq
MIRT2476385	hsa-miR-3180-3p	CLIP-seq
MIRT2476386	hsa-miR-3196	CLIP-seq
MIRT2476387	hsa-miR-3612	CLIP-seq
MIRT2476388	hsa-miR-3622a-5p	CLIP-seq
MIRT2476389	hsa-miR-4459	CLIP-seq
MIRT2476390	hsa-miR-4477a	CLIP-seq
MIRT2476391	hsa-miR-4479	CLIP-seq
MIRT2476392	hsa-miR-4505	CLIP-seq
MIRT2476393	hsa-miR-4651	CLIP-seq
MIRT2476394	hsa-miR-4695-5p	CLIP-seq
MIRT2476395	hsa-miR-4706	CLIP-seq
MIRT2476396	hsa-miR-4722-5p	CLIP-seq
MIRT2476397	hsa-miR-4731-5p	CLIP-seq
MIRT2476398	hsa-miR-4738-3p	CLIP-seq
MIRT2476399	hsa-miR-4749-5p	CLIP-seq
MIRT2476400	hsa-miR-564	CLIP-seq
MIRT2476401	hsa-miR-604	CLIP-seq
MIRT2476402	hsa-miR-608	CLIP-seq
MIRT2476403	hsa-miR-615-5p	CLIP-seq
MIRT2476404	hsa-miR-647	CLIP-seq
MIRT2476405	hsa-miR-650	CLIP-seq
MIRT2476406	hsa-miR-658	CLIP-seq
MIRT2476407	hsa-miR-663	CLIP-seq
MIRT2476408	hsa-miR-665	CLIP-seq
MIRT2476409	hsa-miR-940	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
ATF4	Activation	22028770
FOXM1	Unknown	11229886
SP1	Unknown	11229886

242

Show/Hide all (242)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000302	Process	Response to reactive oxygen species	NAS	11743999
GO:0001540	Function	Amyloid-beta binding	IDA	8089103, 11305869, 25207746
GO:0001540	Function	Amyloid-beta binding	IPI	9003062, 9211985, 22138302
GO:0001937	Process	Negative regulation of endothelial cell proliferation	IDA	9685360
GO:0002021	Process	Response to dietary excess	IEA
GO:0005102	Function	Signaling receptor binding	IPI	27477018
GO:0005198	Function	Structural molecule activity	TAS	22138302
GO:0005319	Function	Lipid transporter activity	IDA	17305370
GO:0005515	Function	Protein binding	IPI	7566652, 7972031, 8245722, 12950167, 14754908, 15182176, 15615705, 17116874, 19758344, 20030366, 21163940, 21593558, 22528093, 24447298, 25122793, 26387950, 26468283, 26921451, 28514442, 28887769, 29507344, 30341064, 30448281, 31270237, 32814053, 33961781
GO:0005543	Function	Phospholipid binding	IBA
GO:0005543	Function	Phospholipid binding	IDA	4066713
GO:0005576	Component	Extracellular region	HDA	27068509, 27559042
GO:0005576	Component	Extracellular region	IDA	8089103, 16805831
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470, 20551380
GO:0005615	Component	Extracellular space	IDA	30333625
GO:0005615	Component	Extracellular space	IDA	8340399
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	ISS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	NAS	8083695
GO:0005737	Component	Cytoplasm	TAS	9622609
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	TAS
GO:0005771	Component	Multivesicular body	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	25122793
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005794	Component	Golgi apparatus	IDA	25122793
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006641	Process	Triglyceride metabolic process	IDA	9649566
GO:0006641	Process	Triglyceride metabolic process	IMP	3771793
GO:0006707	Process	Cholesterol catabolic process	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	IDA	1917954
GO:0006898	Process	Receptor-mediated endocytosis	TAS	22138302
GO:0006979	Process	Response to oxidative stress	IEA
GO:0007010	Process	Cytoskeleton organization	TAS	9622609
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	16443932
GO:0007271	Process	Synaptic transmission, cholinergic	TAS	9622609
GO:0007616	Process	Long-term memory	IGI	24412220
GO:0008201	Function	Heparin binding	IDA	2745454, 7635945
GO:0008201	Function	Heparin binding	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IBA
GO:0008203	Process	Cholesterol metabolic process	IDA	9649566
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IMP	3771793
GO:0008289	Function	Lipid binding	IDA	4066713
GO:0008289	Function	Lipid binding	IEA
GO:0010467	Process	Gene expression	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010544	Process	Negative regulation of platelet activation	IDA	8995232
GO:0010596	Process	Negative regulation of endothelial cell migration	IMP	23142051
GO:0010629	Process	Negative regulation of gene expression	IEA
GO:0010629	Process	Negative regulation of gene expression	ISS
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	IDA	9685360
GO:0010875	Process	Positive regulation of cholesterol efflux	IDA	12042316, 14754908
GO:0010875	Process	Positive regulation of cholesterol efflux	IEA
GO:0010875	Process	Positive regulation of cholesterol efflux	IGI	12401887
GO:0010877	Process	Lipid transport involved in lipid storage	IEA
GO:0010877	Process	Lipid transport involved in lipid storage	ISS
GO:0010976	Process	Positive regulation of neuron projection development	IDA	7592957, 23845000
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0010977	Process	Negative regulation of neuron projection development	IDA	7592957
GO:0015909	Process	Long-chain fatty acid transport	IDA	24345162
GO:0016020	Component	Membrane	HDA	19946888
GO:0016209	Function	Antioxidant activity	IDA	9685360
GO:0017038	Process	Protein import	IDA	24446231
GO:0019068	Process	Virion assembly	IMP	25122793
GO:0019899	Function	Enzyme binding	IPI	15654758
GO:0030195	Process	Negative regulation of blood coagulation	IDA	8995232
GO:0030425	Component	Dendrite	NAS	8083695
GO:0030516	Process	Regulation of axon extension	TAS	9622609
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031012	Component	Extracellular matrix	IDA	9488694
GO:0031175	Process	Neuron projection development	IDA	8939961
GO:0032438	Process	Melanosome organization	IEA
GO:0032438	Process	Melanosome organization	IMP	26387950
GO:0032489	Process	Regulation of Cdc42 protein signal transduction	IDA	16443932
GO:0032805	Process	Positive regulation of low-density lipoprotein particle receptor catabolic process	IDA	15950758
GO:0033344	Process	Cholesterol efflux	IBA
GO:0033344	Process	Cholesterol efflux	IDA	11162594, 16443932, 23620513
GO:0033344	Process	Cholesterol efflux	IEA
GO:0033700	Process	Phospholipid efflux	IBA
GO:0033700	Process	Phospholipid efflux	IDA	11162594
GO:0034360	Component	Chylomicron remnant	IDA	7683668
GO:0034361	Component	Very-low-density lipoprotein particle	IBA
GO:0034361	Component	Very-low-density lipoprotein particle	IDA	2280190, 7683668, 8071364, 8245722, 9211985, 17154273, 22138302
GO:0034361	Component	Very-low-density lipoprotein particle	IEA
GO:0034362	Component	Low-density lipoprotein particle	IBA
GO:0034362	Component	Low-density lipoprotein particle	IDA	2280190, 8245722, 9211985, 22138302
GO:0034362	Component	Low-density lipoprotein particle	IEA
GO:0034363	Component	Intermediate-density lipoprotein particle	IDA	2280190, 9211985, 17336988, 22138302
GO:0034364	Component	High-density lipoprotein particle	IBA
GO:0034364	Component	High-density lipoprotein particle	IDA	210174, 2280190, 8071364, 9211985, 14754908, 22138302
GO:0034364	Component	High-density lipoprotein particle	IEA
GO:0034365	Component	Discoidal high-density lipoprotein particle	TAS	22383525
GO:0034372	Process	Very-low-density lipoprotein particle remodeling	IDA	15654758
GO:0034372	Process	Very-low-density lipoprotein particle remodeling	IEA
GO:0034372	Process	Very-low-density lipoprotein particle remodeling	IGI	12401887
GO:0034374	Process	Low-density lipoprotein particle remodeling	IEA
GO:0034375	Process	High-density lipoprotein particle remodeling	IGI	12401887
GO:0034380	Process	High-density lipoprotein particle assembly	IDA	14754908, 17305370
GO:0034382	Process	Chylomicron remnant clearance	IDA	1911868, 7683668
GO:0034382	Process	Chylomicron remnant clearance	IMP	7175379
GO:0034384	Process	High-density lipoprotein particle clearance	IDA	210175
GO:0034447	Process	Very-low-density lipoprotein particle clearance	IDA	1917954, 2762297, 7683668
GO:0034447	Process	Very-low-density lipoprotein particle clearance	IMP	9649566
GO:0035641	Process	Locomotory exploration behavior	IMP	24412220
GO:0038060	Process	Nitric oxide-cGMP-mediated signaling	IDA	8995232
GO:0042157	Process	Lipoprotein metabolic process	IEA
GO:0042157	Process	Lipoprotein metabolic process	IEA
GO:0042158	Process	Lipoprotein biosynthetic process	IDA	23620513
GO:0042158	Process	Lipoprotein biosynthetic process	IEA
GO:0042159	Process	Lipoprotein catabolic process	IEA
GO:0042311	Process	Vasodilation	IEA
GO:0042470	Component	Melanosome	IDA	26387950
GO:0042627	Component	Chylomicron	IBA
GO:0042627	Component	Chylomicron	IDA	8245722, 16935699
GO:0042627	Component	Chylomicron	IEA
GO:0042632	Process	Cholesterol homeostasis	IDA	9649566
GO:0042632	Process	Cholesterol homeostasis	IEA
GO:0042632	Process	Cholesterol homeostasis	IGI	24412220
GO:0042802	Function	Identical protein binding	IDA	4066713, 8340399
GO:0042803	Function	Protein homodimerization activity	IPI	8089103, 8245722, 9211985
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0042982	Process	Amyloid precursor protein metabolic process	IDA	21593558
GO:0043025	Component	Neuronal cell body	NAS	8083695
GO:0043083	Component	Synaptic cleft	IDA	22637583
GO:0043254	Process	Regulation of protein-containing complex assembly	IDA	25207746
GO:0043395	Function	Heparan sulfate proteoglycan binding	IDA	7683668, 9488694, 23676495
GO:0043395	Function	Heparan sulfate proteoglycan binding	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	IDA	9685360
GO:0043537	Process	Negative regulation of blood vessel endothelial cell migration	IDA	9685360
GO:0043691	Process	Reverse cholesterol transport	IDA	8127890
GO:0044794	Process	Host-mediated activation of viral process	IMP	25122793
GO:0044877	Function	Protein-containing complex binding	IDA	25207746
GO:0045088	Process	Regulation of innate immune response	IEA
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	IDA	8995232
GO:0045541	Process	Negative regulation of cholesterol biosynthetic process	IDA	1917954
GO:0045807	Process	Positive regulation of endocytosis	IDA	7683668, 8300609
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	28111074
GO:0046889	Process	Positive regulation of lipid biosynthetic process	IDA	12042316
GO:0046907	Process	Intracellular transport	TAS	9622609
GO:0046911	Function	Metal chelating activity	IDA	9685360
GO:0046983	Function	Protein dimerization activity	IPI	22138302
GO:0048018	Function	Receptor ligand activity	IDA	27477018
GO:0048156	Function	Tau protein binding	IPI	7566652
GO:0048168	Process	Regulation of neuronal synaptic plasticity	TAS	9622609
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IEA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	ISS
GO:0048844	Process	Artery morphogenesis	IEA
GO:0050709	Process	Negative regulation of protein secretion	IMP	27044754
GO:0050728	Process	Negative regulation of inflammatory response	IDA	8995232
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0050750	Function	Low-density lipoprotein particle receptor binding	IDA	210175, 1530612, 7635945
GO:0050750	Function	Low-density lipoprotein particle receptor binding	IPI	17326667
GO:0050750	Function	Low-density lipoprotein particle receptor binding	NAS	20005821
GO:0050807	Process	Regulation of synapse organization	IEA
GO:0051044	Process	Positive regulation of membrane protein ectodomain proteolysis	IDA	15950758
GO:0051044	Process	Positive regulation of membrane protein ectodomain proteolysis	IGI	25015123
GO:0051055	Process	Negative regulation of lipid biosynthetic process	IDA	12042316
GO:0051246	Process	Regulation of protein metabolic process	IGI	24412220
GO:0051248	Process	Negative regulation of protein metabolic process	IGI	16805831
GO:0051651	Process	Maintenance of location in cell	IEA
GO:0055088	Process	Lipid homeostasis	IEA
GO:0055089	Process	Fatty acid homeostasis	IDA	24345162
GO:0055090	Process	Acylglycerol homeostasis	IBA
GO:0060228	Function	Phosphatidylcholine-sterol O-acyltransferase activator activity	IBA
GO:0060228	Function	Phosphatidylcholine-sterol O-acyltransferase activator activity	IDA	15654758
GO:0060228	Function	Phosphatidylcholine-sterol O-acyltransferase activator activity	IEA
GO:0060840	Process	Artery development	IEA
GO:0060999	Process	Positive regulation of dendritic spine development	IDA	24328732
GO:0061000	Process	Negative regulation of dendritic spine development	IDA	24328732
GO:0061136	Process	Regulation of proteasomal protein catabolic process	IMP	28111074
GO:0061771	Process	Response to caloric restriction	IGI	24412220
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0070062	Component	Extracellular exosome	IDA	26387950
GO:0070326	Function	Very-low-density lipoprotein particle receptor binding	IDA	1384047
GO:0070326	Function	Very-low-density lipoprotein particle receptor binding	IPI	12950167
GO:0070328	Process	Triglyceride homeostasis	IEA
GO:0070328	Process	Triglyceride homeostasis	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	28111074
GO:0071402	Process	Cellular response to lipoprotein particle stimulus	IDA	27477018
GO:0071402	Process	Cellular response to lipoprotein particle stimulus	IDA	27477018
GO:0071682	Component	Endocytic vesicle lumen	TAS
GO:0071813	Function	Lipoprotein particle binding	IEA
GO:0071830	Process	Triglyceride-rich lipoprotein particle clearance	IEA
GO:0071830	Process	Triglyceride-rich lipoprotein particle clearance	IMP	23676495
GO:0071831	Process	Intermediate-density lipoprotein particle clearance	IDA	1917954
GO:0072359	Process	Circulatory system development	IEA
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IDA	16805831
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IGI	16805831
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	TAS	22988876
GO:0090181	Process	Regulation of cholesterol metabolic process	IGI	24412220
GO:0090205	Process	Positive regulation of cholesterol metabolic process	IDA	15654758
GO:0090205	Process	Positive regulation of cholesterol metabolic process	IEA
GO:0090209	Process	Negative regulation of triglyceride metabolic process	IEA
GO:0090370	Process	Negative regulation of cholesterol efflux	IDA	12042316
GO:0097006	Process	Regulation of plasma lipoprotein particle levels	IEA
GO:0097113	Process	AMPA glutamate receptor clustering	IDA	24328732
GO:0097114	Process	NMDA glutamate receptor clustering	IDA	24328732
GO:0097487	Component	Multivesicular body, internal vesicle	IDA	26387950
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	22637583
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0120020	Function	Cholesterol transfer activity	IBA
GO:0120020	Function	Cholesterol transfer activity	IEA
GO:0140077	Process	Positive regulation of lipoprotein transport	IDA	8300609
GO:1900221	Process	Regulation of amyloid-beta clearance	IDA	24446231
GO:1900223	Process	Positive regulation of amyloid-beta clearance	IEA
GO:1900223	Process	Positive regulation of amyloid-beta clearance	ISS
GO:1900272	Process	Negative regulation of long-term synaptic potentiation	IDA	16273551
GO:1901627	Process	Negative regulation of postsynaptic membrane organization	IDA	24259049
GO:1901631	Process	Positive regulation of presynaptic membrane organization	IDA	24259049
GO:1902004	Process	Positive regulation of amyloid-beta formation	IDA	24154541, 24259049
GO:1902430	Process	Negative regulation of amyloid-beta formation	IDA	24154541, 24259049
GO:1902951	Process	Negative regulation of dendritic spine maintenance	IDA	24328732
GO:1902952	Process	Positive regulation of dendritic spine maintenance	IDA	24328732
GO:1902991	Process	Regulation of amyloid precursor protein catabolic process	IDA	28164773
GO:1902995	Process	Positive regulation of phospholipid efflux	IDA	12042316
GO:1902998	Process	Positive regulation of neurofibrillary tangle assembly	IDA	24154541
GO:1902999	Process	Negative regulation of phospholipid efflux	IDA	12042316
GO:1903001	Process	Negative regulation of lipid transport across blood-brain barrier	IDA	24345162
GO:1903002	Process	Positive regulation of lipid transport across blood-brain barrier	IDA	24345162
GO:1903561	Component	Extracellular vesicle	HDA	24769233
GO:1903561	Component	Extracellular vesicle	IBA
GO:1904646	Process	Cellular response to amyloid-beta	IDA	23459077, 29518356
GO:1905890	Process	Regulation of cellular response to very-low-density lipoprotein particle stimulus	IDA	7592957
GO:1905906	Process	Regulation of amyloid fibril formation	IDA	25207746
GO:1905907	Process	Negative regulation of amyloid fibril formation	IEA
GO:1905907	Process	Negative regulation of amyloid fibril formation	ISS
GO:1905908	Process	Positive regulation of amyloid fibril formation	TAS	9228033, 20005821
GO:1990777	Component	Lipoprotein particle	IDA	22138302
GO:2000822	Process	Regulation of behavioral fear response	IMP	24412220

MIM	HGNC	e!Ensembl
107741	613	ENSG00000130203

P02649

Protein name

Apolipoprotein E (Apo-E)

Protein function

APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:14754908, PubMed:1911868, PubMed:6860692). APOE is

PDB

1B68 , 1BZ4 , 1EA8 , 1GS9 , 1H7I , 1LE2 , 1LE4 , 1LPE , 1NFN , 1NFO , 1OEF , 1OEG , 1OR2 , 1OR3 , 2KC3 , 2KNY , 2L7B , 6IWB , 6NCN , 6NCO , 7FCR , 7FCS , 7UVJ , 8AX8 , 8AX9 , 8CDY , 8CE0 , 8GRX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01442	Apolipoprotein	81 → 288	Apolipoprotein A1/A4/E domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Produced by several tissues and cell types and mainly found associated with lipid particles in the plasma, the interstitial fluid and lymph (PubMed:25173806). Mainly synthesized by liver hepatocytes (PubMed:25173806). Significant quant

Sequence

MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT
LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA
RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY
QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG
SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK
VQAAVGTSAAPVPSDNH

Sequence length

317

Interactions

View interactions

	KEGG		Reactome
	Cholesterol metabolism Alzheimer disease		Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport

213

Show/Hide Causal Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormal circulating lipid concentration	Likely pathogenic	rs200703101	RCV000417087
APOE-related disorder	Pathogenic	rs515726148	RCV004755773
APOE2 VARIANT	Pathogenic	rs28931578	RCV000019460
APOE2-DUNEDIN	Pathogenic	rs121918395	RCV000019442
APOE4 VARIANT	Pathogenic	rs121918398	RCV000019461
Cardiovascular phenotype	Pathogenic; Likely pathogenic	rs515726148, rs121918399	RCV002336246 RCV004984646
Familial hypercholesterolemia	Pathogenic	rs515726148	RCV005621875
Familial type 3 hyperlipoproteinemia	Likely pathogenic; Pathogenic	rs2122137937, rs121918393, rs397514253, rs397514254, rs121918394, rs2122132718, rs121918396, rs121918397, rs387906567	RCV001837071 RCV000019430 RCV000019433 RCV000019434 RCV000019440 RCV000019444 RCV000019445 RCV000019449 RCV003227801
HYPERLIPOPROTEINEMIA, TYPE III, AND ATHEROSCLEROSIS ASSOCIATED WITH APOE5	Pathogenic	rs121918392	RCV000019429
HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE3(WASHINGTON)	Likely pathogenic	rs121918396	RCV000856605
Hyperlipoproteinemia, type III, due to APOE2	Pathogenic	rs121918394	RCV001804151
HYPERLIPOPROTEINEMIA, TYPE IV/V, DUE TO APOE2-DUNEDIN	Pathogenic	rs121918395	RCV004556717
Lipoprotein glomerulopathy	Likely pathogenic; Pathogenic	rs1332591068, rs121918397, rs121918399	RCV001391116 RCV002250463 RCV000019466 RCV000019468
Sea-blue histiocyte syndrome	Pathogenic	rs515726148	RCV000202536

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
-	no classification for the single variant	rs11083750, rs28931577, rs267606663, rs267606662, rs429358	-
Alzheimer disease	Conflicting classifications of pathogenicity; other; risk factor	rs429358	RCV000991302
Alzheimer disease 2	Conflicting classifications of pathogenicity; other; risk factor; Uncertain significance	rs563571689, rs769455, rs140808909, rs429358, rs190853081, rs267606661	RCV002302437 RCV005357151 RCV005357623 RCV000019448 RCV005367404 RCV005367405
Alzheimer disease 4	Conflicting classifications of pathogenicity; other; risk factor	rs429358, rs769452	RCV001195807 RCV001195944
APOE3(-)-FREIBURG	Likely benign	rs28931576	RCV000019457
APOE4(+)	Likely benign	rs28931579	RCV000019462
APOE5 VARIANT	Conflicting classifications of pathogenicity	rs201672011	RCV000019453
atorvastatin response - Efficacy	drug response	rs7412	RCV000211178
Coronary artery disease, severe, susceptibility to	risk factor	rs405509	RCV001804152
Hypercholesterolemia	drug response; Uncertain significance	rs7412, rs267606664	RCV001262472 RCV001262660
Hyperlipoproteinemia	Uncertain significance	rs1969863273	RCV001175125
Major depressive disorder	not provided	rs587778876, rs587778877	RCV000074336 RCV000074337
Primary degenerative dementia of the Alzheimer type, presenile onset	Conflicting classifications of pathogenicity; other; risk factor	rs429358	RCV000826089
Warfarin response	drug response; Conflicting classifications of pathogenicity; other; risk factor	rs7412, rs429358, rs405509, rs769450, rs439401	RCV000845582 RCV000845581 RCV000845578 RCV000845579 RCV000845580

Show/Hide Text Mining Associations (674)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
AA amyloidosis	Associate	15965197, 17916554, 20153809, 20373342, 20598287, 21061402, 21502596, 22155582, 22693110, 22972644, 23624169, 23965289, 24385135, 24577457, 24596678 View all (39 more)
AA amyloidosis	Stimulate	23762308, 35995824, 7534068
AA amyloidosis	Inhibit	31947546, 34586832, 39394110
Abetalipoproteinemia	Associate	7852858
Abnormalities Drug Induced	Associate	12507914, 30528368, 39670385
Abortion Spontaneous	Associate	22266326, 26952784, 30338758, 34867826
Acquired Immunodeficiency Syndrome	Associate	19808960, 29558961
Acute cholinergic dysautonomia	Associate	8618881
Acute Coronary Syndrome	Associate	10487142, 17174184, 19545491, 19851649, 40257950
Acute Disease	Associate	37304007
Acute Kidney Injury	Associate	24059882
Adenocarcinoma	Stimulate	19823059
Adenocarcinoma	Associate	33371142
Adenolymphoma	Associate	24205396
Adenoma Pleomorphic	Associate	24205396
Adrenal Cortex Diseases	Associate	21971450, 9728943
Adrenocortical Carcinoma	Inhibit	40109215
Adrenoleukodystrophy	Associate	31133696
Aging Premature	Associate	21803164, 37612284
Agnosia	Associate	19210035
AIDS Associated Nephropathy	Associate	21803164, 22972599, 23018443
AIDS Dementia Complex	Associate	21184197
Alcohol Amnestic Disorder	Associate	21346518, 23954887
Alcoholism	Associate	37350760
Alzheimer Disease	Associate	10027417, 10051007, 10064733, 10079962, 10087061, 10322238, 10329743, 10354518, 10404018, 10492731, 10530514, 10588960, 10599054, 10601411, 10631151 View all (1321 more)
Alzheimer Disease	Stimulate	11106581, 11369806, 12015813, 15060098, 15718039, 17175070, 17350142, 17822919, 18280754, 19091059, 19368858, 19828088, 19952867, 20412390, 21552550 View all (43 more)
Alzheimer Disease	Inhibit	15830056, 17540481, 19255410, 19720974, 24319058, 29861287, 30462377, 32282020, 32648923, 33287896, 33837271, 35041991, 35887259, 36276649, 36982820, 37400888, 39394110 View all (2 more)
Alzheimer's disease without Neurofibrillary tangles	Associate	26481403, 35691989, 36383681
Amyloid angiopathy	Associate	10648765, 26341746, 36383681, 37221560
Amyloid angiopathy	Stimulate	23762308
Amyloidosis	Associate	10920030, 23411427, 23686534, 27793990, 31648569, 34450034, 35066432, 37072097, 7672107
Amyloidosis Familial	Associate	7672107
Amyotrophic Lateral Sclerosis	Associate	28239025, 30240096, 30872628, 39278909
Angina Pectoris	Associate	1747611, 7175379
Angina Stable	Associate	10487142, 17174184
Anodontia	Associate	19455140
Anosmia	Associate	22305338
Anxiety	Associate	25499536, 31159873, 35205209, 35373862, 37510309, 40495575
Anxiety Disorders	Associate	31159873
Aortic Aneurysm Abdominal	Associate	11436088, 19818961
Aphasia	Associate	14991811, 20139337, 25054282, 36999481
Aphasia Primary Progressive	Associate	33441454
Apolipoprotein E Deficiency or Defect of	Associate	1361196, 28945989, 8571954
Apraxias	Associate	37958671
Arterial Occlusive Diseases	Associate	26710338
Arteriolosclerosis	Associate	30321502, 32925200
Arthritis Gouty	Associate	7794039
Arthritis Rheumatoid	Associate	23613766, 32253242, 36929812
Asthma	Associate	27447179
Astrocytoma	Associate	23411427, 29579087, 8922411
Ataxia Telangiectasia	Associate	24439168
Atherosclerosis	Associate	10412789, 10504484, 10583930, 10821138, 11060347, 11509287, 12118856, 12190886, 12754278, 15224026, 15475580, 1557388, 16943616, 17763167, 17991878 View all (44 more)
Atherosclerosis	Inhibit	24244577, 26068461, 7797534, 8617716
Atrial Fibrillation	Associate	17094271, 34587962, 35607269, 35850541
Atrial Fibrillation	Inhibit	38030292
Atrioventricular Block	Associate	40451134
Atrophy	Associate	18760504, 18786162, 19349226, 20833446, 20980669, 21098974, 21399729, 21892657, 22506016, 23152815, 24385135, 24453132, 24475827, 24878738, 25687593 View all (17 more)
Atrophy	Stimulate	21163916, 22512241, 24670887, 35122970
Attention Deficit and Disruptive Behavior Disorders	Associate	30605058
Attention Deficit Disorder with Hyperactivity	Associate	26306786, 26314833, 27547505
Auditory Perceptual Disorders	Associate	33731765
Autism Spectrum Disorder	Associate	34030059
Autistic Disorder	Associate	31808517
Autoimmune Diseases of the Nervous System	Associate	36929812
Azoospermia Nonobstructive	Associate	38403804
Basal Ganglia Diseases	Associate	29793545
Basal Laminar Drusen	Associate	22933840
beta Thalassemia	Associate	10920030, 9236226, 9787187
Bilateral temporal lobe disorder	Stimulate	18691658
Bile Duct Neoplasms	Associate	18296645
Binge Eating Disorder	Associate	37550530
Bipolar Disorder	Associate	20406267, 20964956
Blister	Associate	35874788
Blood Coagulation Disorders	Associate	31315437
Blood Platelet Disorders	Associate	10508213
Body Odor	Associate	31760549, 33422806
Bone Diseases	Associate	10404018
Bone Diseases	Stimulate	10703933
Brain Concussion	Associate	28948085, 32097865
Brain Diseases	Associate	10864599, 12507910, 22502767, 23022416, 23028511, 23240599, 24382617, 26822146, 30139626, 32913026, 32962736, 33522999, 33933117, 35471691, 36906845, 38353984, 7619525 View all (2 more)
Brain Diseases	Stimulate	25738563
Brain Edema	Associate	19251191, 19923550
Brain Injuries	Associate	12507910, 12656452, 16202217, 23384326, 24322171, 25282659, 26542262, 31133696, 39392607
Brain Injuries Diffuse	Associate	24786335
Brain Injuries Traumatic	Associate	15654038, 16614010, 16793859, 17287237, 19017669, 19158597, 24260563, 24670469, 25282659, 25703783, 27245878, 27480909, 28557010, 28752509, 28948085 View all (6 more)
Brain Ischemia	Associate	16202217, 25282659
Brain Neoplasms	Associate	24944262, 31123752, 33342004
Breast Neoplasms	Associate	21871081, 23828408, 24789331, 25355028, 32985495, 33731765, 37304007, 39198096, 40571309
Breast Neoplasms Male	Associate	30850364
Bronchitis	Associate	27447179
Brugada Syndrome	Stimulate	23276942
CADASIL	Associate	16484411, 37982214
Camptodactyly 1	Associate	32925200
Capillary Malformation Arteriovenous Malformation	Associate	15286151
Carcinogenesis	Associate	36057714
Carcinoma Endometrioid	Associate	19823059
Carcinoma Hepatocellular	Associate	15485881, 22726459, 24751902, 31173207, 40180213, 9468288
Carcinoma Lewis Lung	Associate	32912321
Carcinoma Ovarian Epithelial	Associate	30917846, 31718609
Carcinoma Renal Cell	Associate	19808960, 26191297, 34019793, 40303328
Carcinoma Squamous Cell	Associate	25427637
Carcinosarcoma	Associate	37304007
Cardiomyopathies	Associate	30095041
Cardiomyopathy Dilated	Associate	16714771, 28574812
Cardiomyopathy Restrictive	Associate	19564306
Cardiovascular Diseases	Associate	10487142, 12190886, 15237001, 15276651, 15543563, 16106048, 16282567, 16714771, 17763167, 18562290, 18843526, 18855268, 19252179, 19545491, 19691831 View all (47 more)
Cardiovascular Diseases	Stimulate	33734100, 34586066, 37699966
Carotid Artery Diseases	Associate	12190886, 15258198, 18056683, 19951432, 29103864, 36357490, 7762561
Carotid Stenosis	Associate	18219091, 36357490, 40079311
Cataract	Associate	18498549, 37988105
Cataract Age Related Nuclear	Associate	25883527
Cataract posterior polar 1	Associate	25883527
Central Nervous System Diseases	Associate	10027417, 14688681, 16484411
Cerebral Amyloid Angiopathy	Associate	15654038, 15814793, 17192928, 20153809, 20598287, 23771217, 24448547, 24797962, 25320098, 25920955, 25960448, 26341746, 27179972, 27318141, 27380243 View all (15 more)
Cerebral Amyloid Angiopathy	Stimulate	29860944
Cerebral Arterial Diseases	Stimulate	31133696
Cerebral Arterial Diseases	Associate	35535404
Cerebral Cortical Thinning	Associate	20686185, 28507298, 36116165
Cerebral Hemorrhage	Associate	10648765, 19251191, 21061402, 21741316, 22535266, 22621984, 23175721, 23559261, 24008570, 24448547, 25150286, 25716356, 26115730, 29959260, 30084487 View all (7 more)
Cerebral Infarction	Associate	15000890, 16519597, 18055294, 19017669, 23152815, 23290018, 25730003, 26710338, 27629735, 29074556, 29390290, 31823830, 32891149, 33490286, 34087973, 35305470, 36116165 View all (2 more)
Cerebral Infarction	Inhibit	29479056
Cerebral Intraventricular Hemorrhage	Associate	30084487
Cerebral Palsy	Associate	20002130, 22961963, 23384326, 24786335, 25703783, 30859759, 32517581, 32791423, 34660786, 39528057, 40079311, 9647302
Cerebral Palsy	Stimulate	34949230
Cerebral Small Vessel Diseases	Associate	28574812, 29074556, 36123141, 39528057
Cerebrovascular Disorders	Associate	21325652, 27629735, 30321502, 31315437, 33734100, 34088020, 35806110, 37385335, 38579393, 8648331, 8669492
Cerebrovascular Disorders	Stimulate	34949230
Chemical and Drug Induced Liver Injury	Associate	31636475, 33347879, 33776373
Child Development Disorders Pervasive	Associate	19564306
Child Nutrition Disorders	Associate	35734486
Cholangiocarcinoma	Inhibit	38274331
Cholelithiasis	Associate	10075965
Cholelithiasis	Stimulate	26019038
Cholestasis	Associate	35196362
Cholesterol pneumonia	Associate	26687702, 30369316
Chorea remitting with nystagmus and cataracts	Associate	24856546
Choriocarcinoma	Associate	1666673
Choroidal Neovascularization	Associate	22678500
Chromosome Aberrations	Associate	31744003
Chronic Kidney Disease Mineral and Bone Disorder	Associate	22874105
Chronic Traumatic Encephalopathy	Associate	35759276
Chronobiology Disorders	Associate	23050006, 31493534
Cleft Palate	Associate	21857382
Cognition Disorders	Associate	10811879, 12205106, 12405545, 14609807, 15165699, 15477624, 16207841, 16595618, 16634464, 16764677, 17698712, 17711604, 17979899, 18448849, 18620605 View all (255 more)
Cognition Disorders	Stimulate	28495939, 29405230, 29518107, 34780525
Cognitive Dysfunction	Associate	12876259, 14609807, 15660776, 16204712, 16207841, 18617739, 18691658, 19266700, 19587325, 19605830, 19788866, 19901172, 19907191, 20142627, 20306566 View all (97 more)
Cognitive Dysfunction	Stimulate	21889115, 23424640, 25497326, 27033407, 35387811
Cognitive Dysfunction	Inhibit	29518107
Colitis Ulcerative	Associate	33911469
Colorectal Neoplasms	Inhibit	19377787
Colorectal Neoplasms	Associate	19455140, 25428203, 36057714, 37024866, 37310025
Communicable Diseases	Associate	39774485
Congenital contractural arachnodactyly	Associate	12190886
Congenital Hypothyroidism	Associate	15739386
Conjunctivitis Acute Hemorrhagic	Associate	26732024
Constriction Pathologic	Associate	20552590
Constriction Pathologic	Stimulate	25883965
Conversion Disorder	Associate	20640544, 31919381, 32618758
Coronary Aneurysm	Associate	18219091
Coronary Artery Disease	Associate	10487142, 10583930, 10588960, 11079660, 12964943, 14563588, 15531693, 15543563, 16118069, 16682673, 16888319, 17174184, 17175070, 17273655, 17332893 View all (38 more)
Coronary Artery Disease	Stimulate	34814316
Coronary Disease	Associate	10484616, 11230170, 11483625, 11501342, 11714860, 12799433, 12923233, 14694215, 15121769, 15573849, 16251607, 16714771, 17092867, 1747611, 18163216 View all (31 more)
Coronary Disease	Stimulate	29654261
Coronary Disease	Inhibit	32648923
Coronary Restenosis	Associate	10583930, 15466371
Coronary Stenosis	Associate	21254242
Coronary Stenosis	Stimulate	25883965
Coronavirus Infections	Associate	33429394, 34118974
Corticobasal Degeneration	Associate	21455839
COVID 19	Associate	33422806, 33429394, 34118974, 34322810, 34419671, 35508522, 35915083, 35931737, 36371754, 37510324
COVID 19	Stimulate	33667465, 34949230
Coxa Magna	Associate	38102657
Craniocerebral Trauma	Associate	12379839, 16484645, 16684399, 19158597, 20129626
Creutzfeldt Jakob Syndrome	Associate	21799773, 8669492
Critical Illness	Associate	24382617
Crohn Disease	Associate	33911469
Cushing's symphalangism	Associate	20552590, 22837136
Cystic Fibrosis	Associate	32633402
Cytochrome c Oxidase Deficiency	Associate	35667615
Cytokine Release Syndrome	Inhibit	24244577
Death	Associate	12016588, 18464295, 18562290, 23954042, 24497847, 24992891, 26302353, 26836416, 31236578, 31356640, 34969069, 40382659
Delirium	Associate	24382617, 27122004, 32417770, 40514232
Delusional Parasitosis	Associate	40495575
Dementia	Associate	10746597, 10860300, 11081958, 11971052, 12023428, 12205106, 12558712, 12876259, 15304383, 15477624, 15932949, 16684399, 16758323, 17158432, 17350142 View all (173 more)
Dementia	Stimulate	21676498, 22076544, 24450926, 28399184, 36435340
Dementia Multi Infarct	Associate	9436725
Dementia Vascular	Associate	10687744, 10860300, 12845379, 12876259, 20375505, 23216585, 24696712, 24965284, 26981880, 30181149, 33682710, 34218115, 35172255, 39909351, 9436725
Dementia Vascular	Inhibit	29518107
Dental Plaque	Associate	8648331
Depressive Disorder	Associate	10322238, 14609807, 16980336, 18058831, 18641859, 19010425, 19155747, 19181718, 19244396, 19368858, 19812466, 21218563, 23171142, 24434953, 24856546 View all (18 more)
Depressive Disorder Major	Associate	29703883
Dermatitis Atopic	Inhibit	19116453
Diabetes Mellitus	Associate	10090925, 10412780, 15258198, 17006673, 18195144, 21325652, 22394699, 23110422, 23601373, 24381137, 25090243, 26006791, 26318958, 26998902, 27168072 View all (14 more)
Diabetes Mellitus Type 1	Associate	16740268, 22394699, 36929812
Diabetes Mellitus Type 2	Associate	1747611, 21283811, 21500980, 22028770, 22236693, 22520940, 23627755, 24875283, 26800892, 27077117, 27078154, 27189021, 27208321, 31153375, 31521122 View all (9 more)
Diabetic Nephropathies	Associate	21500980, 26662731, 28326331
Diabetic Neuropathies	Associate	21926103
Diarrhea	Associate	20401432
Diffuse Cerebral Sclerosis of Schilder	Associate	21163916, 21324265
Diffuse Neurofibrillary Tangles with Calcification	Associate	11447277, 12169205, 15475580, 20037210, 22968369, 23715207, 24145819, 24696712, 27979356, 28984587, 31657834, 32812023, 33693619, 35466940, 7972031, 8089103, 8648331 View all (2 more)
Diffuse Neurofibrillary Tangles with Calcification	Stimulate	9728943
Disease	Associate	21907175
Disorders of Excessive Somnolence	Associate	28752509, 36577409
Disruptive Impulse Control and Conduct Disorders	Associate	39334114
Dissociative Identity Disorder	Associate	26046356
Dizziness	Associate	34807243
Down Syndrome	Associate	10880397, 18464295, 21116050, 23601808, 29770843, 30909239, 32986108, 34302786, 40667715, 7724603, 9173910
Down Syndrome	Stimulate	40387921
Drug Related Side Effects and Adverse Reactions	Stimulate	10087061, 22637583
Drug Related Side Effects and Adverse Reactions	Associate	15814793, 31861093, 31947546, 34071762
Drug Related Side Effects and Adverse Reactions	Inhibit	37155564
Dysentery	Associate	20401432
Dysgeusia	Associate	22383234
Dyslipidemias	Associate	10803441, 1352296, 16106048, 16176168, 16317171, 17224996, 17535270, 19851649, 21325775, 21595502, 23613766, 24191141, 24239320, 24454848, 25026367 View all (19 more)
Dyslipidemias	Stimulate	36980195
Dystonic Disorders	Associate	9350853
Ectrodactyly	Associate	29558961
Edema	Associate	24450891, 34807243
Emergence Delirium	Associate	31761478
Emphysema	Associate	33285739
Encephalitis	Associate	32417770
Encephalitis Herpes Simplex	Associate	11118260
Endocrine System Diseases	Associate	35205269
Endometrial Hyperplasia	Associate	25741405
Endometrial Neoplasms	Associate	19823059, 25741405, 36123916
Endometriosis	Stimulate	34867826
Enhanced S Cone Syndrome	Associate	27294343
Epilepsy	Associate	17264404, 20002130, 22502727, 24252240, 24786335, 25703783, 34795746
Epilepsy Absence	Associate	20093050
Epilepsy Familial Mesial Temporal Lobe	Associate	26945380, 34795746
Epilepsy Idiopathic Generalized	Associate	35734486
Epilepsy Temporal Lobe	Associate	15660776, 17264404, 20093050, 20479234, 23992618, 26945380, 28086184, 36929812, 39337715, 9447442, 9785148
Epilepsy Tonic Clonic	Associate	30095041
Epileptic Syndromes	Associate	16401842, 1864973, 22859420, 2563166
Episodic Ataxia	Associate	26366714, 29396739
Esophageal Squamous Cell Carcinoma	Associate	36709495
Esophageal Squamous Cell Carcinoma	Stimulate	37187751
Essential Hypertension	Associate	18855268, 24634178
Extranodal Extension	Associate	11318963
Fabry Disease	Associate	25619383
Facial Asymmetry	Associate	10601411
Facial Nerve Diseases	Associate	3038959
Familial Mediterranean Fever	Associate	7672107
Fatigue	Associate	23916682, 34949230
Fatigue	Stimulate	33786555
Fatty Liver	Associate	24388885, 33347879, 33856023, 34899591
Fatty Liver	Inhibit	40451134
Feeding and Eating Disorders	Associate	16980336
Femur Head Necrosis	Associate	29750162
Fetal Growth Retardation	Associate	28480219
Fever	Associate	26732024
Fibromyalgia	Associate	21402364
Fibrosis	Associate	24388885, 33776373, 33856023, 33924242
Fractures Bone	Stimulate	15312249
Fractures Bone	Associate	18469278
Fractures Spontaneous	Associate	30240575, 32164763, 33485373
Fragile X Tremor Ataxia Syndrome	Stimulate	23492875
Frontotemporal Dementia	Associate	17224685, 19164761, 24359501, 25239657, 27899424, 30240096, 30292090, 35752680, 36474176
Frontotemporal Dementia	Stimulate	23887281
Frontotemporal Lobar Degeneration	Associate	16421115, 16421130, 16930470, 19746990, 22512241
Frontotemporal Lobar Degeneration	Stimulate	19091059
Gait Ataxia	Associate	28482102
Gait Disorders Neurologic	Associate	22245009
Gallbladder Neoplasms	Associate	18296645, 34185421
Gallstones	Associate	10075965
Gastroenteritis	Associate	3771764
Genetic Diseases Inborn	Associate	17467455, 24454848
Geographic Atrophy	Associate	30060980
Gerstmann Straussler Scheinker Disease	Associate	28658400
Glaucoma	Associate	11992263, 12379839, 19421411, 36479943, 37988105
Glaucoma 3 Primary Congenital A	Associate	19421411
Glaucoma Open Angle	Associate	11992263, 16110302, 16148883, 19145250, 19421411, 19578553, 23687437, 25893192, 32614373
Glaucoma Open Angle	Inhibit	37988105
Glioblastoma	Associate	33788386, 35802478
Glioma	Associate	19544381, 29168082, 35862252
Globus Sensation	Associate	26547561
Glomerulonephritis	Associate	10412731, 33633132
Glomerulonephritis Membranous	Associate	12631135, 30701487
Glomerulosclerosis Focal Segmental	Associate	12631135
Glucose Galactose Malabsorption	Stimulate	28495939
Glucose Intolerance	Stimulate	33814450
Glucose Intolerance	Associate	39774485
Glucose Metabolism Disorders	Associate	11903399, 26006791
Glut1 Deficiency Syndrome	Associate	37569528
Glutamate Monosodium Sensitivity	Associate	29520099
Glycogen Storage Disease Type II	Associate	21245410, 32979492
Gout	Associate	7794039
Gray Platelet Syndrome	Associate	37270543
Growth Disorders	Associate	20381076
Guillain Barre Syndrome	Inhibit	18343991, 20801190
Guillain Barre Syndrome	Stimulate	38143756
Hallucinations	Associate	24582705, 28219318, 40495575
Head and Neck Neoplasms	Associate	15654038
Headache	Associate	19184578, 34807243
Headache Disorders	Associate	18179501
Hearing Disorders	Associate	18976833
Hearing Loss	Associate	24906966, 36474172, 39271694
Hearing Loss Sensorineural	Associate	36349665
Heart Defects Congenital	Associate	19564306, 23049896, 25282659
Heart Diseases	Associate	24595593, 25482294, 27447179, 27622438, 28399184, 30528368, 31870643, 35499926, 36508411
Heart Diseases	Stimulate	32737755
Heart Diseases	Inhibit	38030292
Heart Failure	Associate	31455442, 32703621
Heart Murmurs	Associate	39572875
Hematoma	Associate	22535266
Hematuria	Associate	24676620
Hemolysis	Inhibit	32253242
Hemorrhage	Associate	21741316, 37414536
Hepatitis B	Associate	26823800, 31393946
Hepatitis C	Associate	26306786, 31393946, 31636475
Hepatitis C	Stimulate	27193023
Hepatitis C Chronic	Associate	31636475
Hepatitis E	Associate	30496280
Heredodegenerative Disorders Nervous System	Associate	10051007, 10406990, 12526018, 19017669, 23023945, 29456185, 33824317, 35347084, 38101486, 40106490
Hernia	Associate	23631828
Herpes Genitalis	Associate	20410080
Herpes Labialis	Associate	11118260
Herpes Zoster	Associate	34322810
Hip Fractures	Associate	10404018
Hippocampal Sclerosis	Associate	19251758, 21596774, 21889115, 25124854, 28189700, 28229235, 34526147, 37982214
HIV Infections	Associate	18562290, 20442634, 21184197, 21803164, 23018443, 23240599, 24191141, 25420659, 27021072, 27228100, 28321820, 29558961, 30478798, 33587445, 37134097
HIV Infections	Stimulate	35526056
HIV Seropositivity	Associate	22972599
Hodgkin Disease	Associate	293748, 36077307
Huntington Disease	Associate	10051007, 27447179
Hydrocephalus Normal Pressure	Associate	33720890
Hypercholesterolemia	Associate	10090925, 10484616, 11043917, 11483625, 12118856, 12631135, 18022922, 18052682, 22074026, 23098561, 26802169, 27622438, 31636475, 32971464, 34828374 View all (6 more)
Hyperglycemia	Associate	38563295
Hyperglycemic Hyperosmolar Nonketotic Coma	Associate	26318958
Hyperhomocysteinemia	Inhibit	17158432
Hyperinsulinism	Associate	11834531
Hyperkeratosis lenticularis perstans	Associate	17727701, 21463987, 7175379
Hyperkinesis	Associate	31038453
Hyperlipidemia Familial Combined	Associate	17127808, 22949395, 35628605
Hyperlipidemias	Associate	10821138, 11834531, 12631135, 12923233, 15769938, 15809899, 17727701, 18367629, 19034316, 21463987, 2341812, 25155022, 26662731, 3038959, 30571344 View all (7 more)
Hyperlipoproteinemia Type I	Stimulate	10946020
Hyperlipoproteinemia Type I	Associate	21597005, 31538826, 8077845
Hyperlipoproteinemia Type II	Associate	10428988, 22074026, 22949395, 24953047, 25414277, 26361156, 26802169, 28965616, 29374275, 29386597, 29561990, 30235358, 30269829, 32727492, 32759540 View all (8 more)
Hyperlipoproteinemia Type II	Inhibit	3745440
Hyperlipoproteinemia Type III	Associate	11318963, 11834531, 1352296, 1361196, 1430218, 14535841, 1730728, 19034316, 1973700, 21467726, 22069485, 22949395, 2313204, 2341812, 24239320 View all (21 more)
Hyperlipoproteinemia Type IV	Associate	2341812, 9548597
Hyperlipoproteinemia Type V	Associate	3379342, 3745440, 7096573, 8797053
Hyperlipoproteinemias	Associate	11834531, 1352296, 19034316, 2101409, 22069485, 3376106, 3705062, 7985674, 8198763, 8571954
Hypertension	Associate	10090925, 11675946, 16714771, 18297189, 18367629, 19432791, 21325652, 23601373, 25413697, 25688603, 26790728, 27168072, 27388789, 30205523, 31021357 View all (12 more)
Hypertension	Inhibit	26739741
Hypertriglyceridemia	Associate	11483625, 11714860, 1361196, 15809899, 18959431, 20160192, 20368524, 20429872, 21570960, 27108409, 2738044, 2816943, 30701487, 32115487, 33407432, 35568684, 36689289, 38346769, 8488843 View all (4 more)
Hypertriglyceridemic Waist	Associate	6323533, 8797053, 9548597
Hyperuricemia	Associate	21059196, 25356596, 25890021
Hypoalphalipoproteinemias	Associate	27724906, 37778510
Hypobetalipoproteinemia Familial Apolipoprotein B	Inhibit	3771793
Hypobetalipoproteinemias	Associate	11688825
Hypoglycemia	Associate	33931404
Hypoxia	Associate	21864519
Idiopathic Pulmonary Fibrosis	Associate	36674438
Immune System Diseases	Associate	26823800
Immunodeficiency due to Defect in MAPBP Interacting Protein	Associate	19564306
Immunoglobulin Light chain Amyloidosis	Associate	7615568
Immunologic Deficiency Syndromes	Stimulate	34987110
Inclusion Body Myopathy With Early Onset Paget Disease And Frontotemporal Dementia	Associate	17224685
Infarction	Associate	23076436, 26547561
Infections	Associate	22249475, 24751902, 25878259, 34586066, 37966014, 39774485
Inflammation	Associate	15224026, 16951484, 17493190, 19251191, 19818961, 20479360, 22632920, 22689192, 23098561, 23393188, 24388885, 25155022, 26130946, 27358062, 27585646 View all (29 more)
Inflammation	Inhibit	26720342, 30519244, 34586066
Inflammation	Stimulate	34071762, 35931030, 36217192, 36587392
Inflammatory Bowel Diseases	Associate	25624723, 33911469
Insulin Resistance	Associate	16251607, 20308781, 20467002, 20975297, 28550261, 28740125, 34872092
Intellectual Disability	Associate	24790992
Internal Hernia	Associate	19564306
Intracranial Aneurysm	Associate	26830841, 29213291
Intracranial Arterial Diseases	Associate	31199015
Intracranial Arteriosclerosis	Associate	26875519, 29074556
Intracranial Arteriovenous Malformations	Associate	17986934
Intracranial Hemorrhages	Associate	12656452, 16639317, 17986934
Intrauterine Growth Retardation Metaphyseal Dysplasia Adrenal Hypoplasia Congenita And Genital Anomalies	Associate	29221491, 34807243, 35542993, 36151869, 37295957, 37357276, 38165296, 40671162, 40696469
Ischemia	Associate	12507910, 31791659
Ischemic Attack Transient	Associate	32070224
Ischemic Stroke	Associate	36640294
Isolated Growth Hormone Deficiency Type II	Associate	39368996
Joint Diseases	Associate	23613766
Juvenile gout	Associate	25356596
Keratoconjunctivitis	Associate	26732024
Keratoconus	Associate	38136930
Ketosis	Associate	21992747
Kidney Diseases	Associate	10412731, 23411427, 30701487, 34327815
Kidney Failure Chronic	Associate	10412731, 19565203, 25155022, 37456207
Kidney Neoplasms	Associate	29520099
Language Disorders	Associate	23601373, 24126216, 39801136, 40220152
Late Onset Disorders	Associate	15248153, 20368805
Learning Disabilities	Associate	15660776, 38101486
Lecithin Cholesterol Acyltransferase Deficiency	Associate	7706948
Legg Calve Perthes Disease	Inhibit	26438379
Leprosy	Associate	38273053
Leukemia	Associate	23849470
Leukemia Myeloid Acute	Associate	28407176
Leukoencephalopathies	Associate	15090562, 19349226, 20558387, 21163916, 21889590, 24577457, 25672924, 27208321, 28235680, 28324763, 28574812, 30903549, 32572010, 37270543, 37982214 View all (5 more)
Lewy Body Disease	Associate	15699383, 18653200, 20389122, 21552550, 21907175, 24639435, 24973356, 26527105, 26627638, 26836416, 27036121, 27312774, 28219318, 29263008, 29544979 View all (16 more)
Lewy Body Variant of Alzheimer Disease	Associate	35471463
limbic predominant age related TDP 43 encephalopathy	Associate	24252240, 31039256, 34597386
Lipid Metabolism Disorders	Associate	11043917, 15641930, 35717858, 39363901, 39684364
Lipoprotein Glomerulopathy	Associate	10412734, 10432380, 10504484, 11318963, 18046082, 19197098, 21325775, 21467726, 23110818, 23448537, 24025644, 24487366, 24676620, 25300642, 29398675 View all (9 more)
Lipoprotein Glomerulopathy	Stimulate	21325775
Liver Cirrhosis	Inhibit	23091810
Liver Cirrhosis	Associate	33776373, 33856023, 33924242, 35168183
Liver Diseases	Associate	23091810, 26306786, 26823800, 33347879
Liver Diseases	Inhibit	40451134
Liver Failure	Associate	26306786
Liver Neoplasms	Associate	20129626
Locked In Syndrome	Associate	25403724
Low Tension Glaucoma	Associate	12379839, 32614373, 37988105
Lp(A) Deficiency Congenital	Associate	16276010, 22069485, 24487366, 24676620
Lung Neoplasms	Stimulate	24175756
Lung Neoplasms	Associate	37738239
Lupus Erythematosus Systemic	Stimulate	24144108
Lupus Erythematosus Systemic	Associate	36929812
Lupus Nephritis	Associate	37026377
Lymphatic Metastasis	Stimulate	36123916
Lymphatic Metastasis	Associate	37310025
Lymphoma Large B Cell Diffuse	Associate	34873574
Lysosomal Storage Diseases	Associate	40106490, 40149441
Machado Joseph Disease	Associate	22023810, 25369462, 34871736
Macrophage Activation Syndrome	Associate	40149441
Macular Degeneration	Associate	11141572, 14594998, 16288198, 18461138, 18498549, 19845562, 21541275, 21882290, 22933840, 24346170, 25945528, 26176866, 26427386, 26854823, 27447179 View all (10 more)
Macular Degeneration	Inhibit	31654486, 37988105
Malaria	Associate	37134097, 38007518
Malaria Cerebral	Associate	38007518
Malformations of Cortical Development	Associate	23050006
Malformations of Cortical Development Group I	Inhibit	33631652
Malnutrition	Associate	18052682, 20640544
Megalencephaly	Associate	20002130
Melanoma	Associate	10706736
Memory Disorders	Associate	16595618, 16930470, 18235080, 18617739, 18722591, 19433661, 19571734, 19788866, 20619505, 23100439, 23152815, 24914687, 24944262, 25187219, 25687593 View all (22 more)
Meningioma	Associate	23111736, 25413266
Mental Disorders	Associate	12438469, 15314125, 16980336, 19564306, 20964956, 23270420, 24582705, 26306786, 26538817, 32925200, 33208795, 33587445, 33715647, 36474176, 37350760, 37510309, 38279143, 9790747 View all (3 more)
Mental Disorders	Stimulate	31744003
Mental Fatigue	Stimulate	34949230
Mental Retardation X Linked Syndromic Christianson Type	Associate	32737755
Metabolic Diseases	Associate	29229897
Metabolic Syndrome	Associate	19056482, 19851649, 21324458, 21767357, 25413697, 26365620, 26739741, 27388789, 28740125, 29229897, 33163038, 34016094, 34503513, 36011277
Metabolic Syndrome	Stimulate	21488185
Metrorrhagia	Associate	39528057
Microcephaly	Associate	20002130
Microphthalmia Syndromic 10	Associate	19164761, 19584447, 21324265, 21803164, 23587689, 24260406, 26843007, 27173368, 29911873, 30530186, 31199015, 35122970, 35491776, 40514232
Microphthalmia Syndromic 10	Stimulate	22512241
Microvascular Angina	Associate	37385335
Migraine Disorders	Associate	19184578, 29357368
Migraine with Aura	Associate	29357368
MINOCA	Associate	19851649
Mitochondrial Diseases	Associate	38236019
Mitral Valve Insufficiency	Associate	39528057
Mixed Dementias	Associate	9583189
Mobility Limitation	Associate	16282567, 23741513, 26503029
Mood Disorders	Associate	19244396
Motor Disorders	Associate	33646158
Motor Neuron Disease	Associate	25239657
Motor Neuron Disease with Dementia and Ophthalmoplegia	Associate	27036121
Motor Skills Disorders	Associate	19564306
Mouth Diseases	Associate	19851649, 20410080
Movement Disorders	Associate	18179501, 32361736
Multi centric Castleman's Disease	Associate	34438448
Multiple Pterygium Syndrome Autosomal Dominant	Associate	31686034
Multiple Sclerosis	Associate	10406990, 10864599, 11836653, 12526018, 19244396, 19473356, 20479360, 21324265, 23762311, 26046356, 34088020
Multiple Sclerosis Chronic Progressive	Associate	21110240
Muscular Diseases	Associate	25224634, 7992832
Muscular Disorders Atrophic	Associate	20620666
Muscular Dystrophy Emery Dreifuss	Associate	35011591
Myasthenia Gravis	Associate	20644276
Myocardial Infarction	Associate	10090925, 10487142, 12799433, 12923233, 15531693, 16276010, 16519597, 16714771, 1747611, 19439088, 19545491, 21593560, 25482294, 27622438, 32727492 View all (6 more)
Myocardial Ischemia	Associate	10758960, 12798568, 17006673, 17436307, 17535270, 18219091, 20160192, 20697334, 25111166, 33927215, 34203181, 6480826, 9825196
Myopathies Structural Congenital	Stimulate	37187751
Myositis Inclusion Body	Associate	25670332, 8577761
Nausea	Associate	34807243
Necrosis	Inhibit	26720342
Neointima	Inhibit	7846048
Neoplasm Metastasis	Associate	32766727, 37310025
Neoplasms	Stimulate	17822919, 34019793, 35090515
Neoplasms	Associate	18296645, 19544381, 19823059, 21332925, 24205396, 24497847, 25482294, 31236578, 33403740, 33748669, 34520129, 34873574, 35094057, 35799671, 35892323 View all (9 more)
Neoplasms	Inhibit	37434484, 37699966, 38274331
Neoplasms Adipose Tissue	Associate	22069463, 2373952, 33892328, 34872092, 36088317
Neoplasms Squamous Cell	Associate	26783151
Nephrosis congenital	Associate	12631135
Nephrosis Lipoid	Associate	12379839, 20930274
Nephrotic Syndrome	Associate	10412731, 10412734, 19341173, 24025644, 24676620, 34311745
Nephrotic Syndrome	Stimulate	12631135
Nerve Degeneration	Associate	10027417, 10406990, 11992263, 15201366, 20373342, 22502767, 24385135, 27593520, 29632371, 34890142, 35058547, 36430645, 7498406, 9218507
Nervous System Diseases	Associate	12526018, 29172001
Neuralgia Postherpetic	Associate	37966014
Neurobehavioral Manifestations	Associate	22512241, 27061069, 33485373, 8971103
Neuroblastoma	Associate	37290814
Neurocognitive Disorders	Associate	16207841, 20442634, 27925140, 28321820, 29558961, 32417770
Neurodegenerative Diseases	Associate	15031162, 15548484, 15718039, 17606532, 18562290, 19164761, 20640544, 21110240, 21283692, 21360299, 21907175, 23216585, 23240599, 23492875, 23593485 View all (48 more)
Neurodegenerative Diseases	Stimulate	21889115, 32097865
Neurodevelopmental Disorders	Associate	18179924, 25282659
Neuroinflammatory Diseases	Associate	24252240, 34071762, 35041991, 35977506, 37087107, 37155564, 37305557
Neuroinflammatory Diseases	Inhibit	30139626
Neuroinflammatory Diseases	Stimulate	32417770, 33337362
Neurologic Manifestations	Associate	16484411, 19164761, 23887281, 24118648, 24411483, 25482294, 25744138, 27979356, 34088020
Neuronal intestinal pseudoobstruction	Associate	11770901, 27036121
Neurotoxicity Syndromes	Associate	22512241, 34071762, 35471463, 35768831, 37336366
Niemann Pick Disease Type A	Associate	1565614
Niemann Pick Disease Type C	Associate	23023945, 40301465
Night blindness congenital stationary	Associate	35058547
Non alcoholic Fatty Liver Disease	Associate	24388885, 31386691, 33856023, 34664321
Non ST Elevated Myocardial Infarction	Associate	33667626
Noncommunicable Diseases	Associate	30205523
Obesity	Associate	14569045, 14694215, 19368122, 19545491, 20373846, 20682755, 20975297, 21059196, 21244662, 21570960, 21595502, 22520940, 22628237, 22844488, 2341812 View all (15 more)
Obesity	Stimulate	21488185
Obesity	Inhibit	26739741
Obesity Abdominal	Associate	20467002, 21767357, 25413697, 38563295
Obesity Morbid	Associate	32646381, 35205269
Obsessive Compulsive Disorder	Associate	31808517
Ocular Albinism type 1	Associate	37945700
Oculocerebrorenal Syndrome	Associate	25073959, 28359293
Oculocutaneous albinism type 1	Associate	37569528
Olfaction Disorders	Associate	22305338, 28444135, 31724031, 33422806
Optic Nerve Injuries	Associate	11992263
Optic Neuritis	Associate	35885971
Osteoarthritis	Associate	37188537
Osteoarthritis Knee	Associate	39471788
Osteogenesis imperfecta type 3	Associate	3038959, 6289314, 6300187, 6313758
Osteogenesis Imperfecta Type IV	Associate	3705062
Osteogenesis Imperfecta Type V	Associate	3745440
Osteoporosis	Associate	10404018, 20640544, 38098042, 39271694
Ovarian Neoplasms	Associate	37304007
Overweight	Associate	20032478, 22628237, 26188224
Pain	Associate	33337380
Pancreatic Neoplasms	Associate	16215274, 25347153
Pancreatic Neoplasms	Stimulate	24349355
Pancreatitis	Associate	16106048, 24009459, 38346769
Pantothenate Kinase Associated Neurodegeneration	Associate	26547561
Parkinson Disease	Associate	10746597, 11015454, 15548484, 15985314, 17113231, 17177184, 20037210, 20389122, 21360299, 21741729, 21907175, 22023810, 22344634, 24175296, 24582705 View all (26 more)
Pediatric acute onset neuropsychiatric syndrome	Associate	18641859, 33403740
Perceptual Disorders	Associate	34602479
Perinatal Death	Associate	16183800
Peripheral Vascular Diseases	Associate	28249002
Persian Gulf Syndrome	Associate	37415220
Persistent Infection	Associate	33369208
Personality Disorders	Associate	15314125, 16980336, 23934233
Personality Disorders	Stimulate	24821476
Pick Disease of the Brain	Associate	15548484, 24312462, 7498406, 8669492
Plaque Amyloid	Associate	11447277, 12169205, 15475580, 17916554, 18474516, 22232206, 22390463, 23419831, 23965289, 24385135, 24582705, 26302353, 26413742, 29172001, 30134963 View all (26 more)
Plaque Amyloid	Stimulate	23424640, 39913635
Plaque Amyloid	Inhibit	31831047, 34586832, 36071110
Plaque Atherosclerotic	Associate	10487142, 1557388, 7635986
Pneumonia	Associate	27447179
Pneumonia Lipid	Associate	15809899, 29233125, 3705062, 38507115, 8724110
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy	Associate	26374897
Polycystic Ovary Syndrome	Associate	19057990, 38256230
Polycystic Ovary Syndrome	Stimulate	36980195
Popliteal Artery Aneurysm	Associate	37509110
Porencephaly	Associate	7635986
Post Acute COVID 19 Syndrome	Associate	37924708
Post Concussion Syndrome	Associate	30521018
Postoperative Cognitive Complications	Associate	30922389, 32417770
Postural Orthostatic Tachycardia Syndrome	Associate	20884673
Pre Eclampsia	Associate	16106048, 28396342, 9659248
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	23849470, 38507115
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	29180721
Primary Progressive Nonfluent Aphasia	Associate	14991811
Prion Diseases	Associate	18757886, 21799773
Progressive supranuclear palsy atypical	Associate	17675576
Prostatic Neoplasms	Associate	23934233, 35799671, 36124532, 36681849, 37270661, 38179769
Prostatitis	Associate	23934233
Protein Deficiency	Associate	23715207
Proteinuria	Associate	10412731, 11318963, 12631135, 24025644, 25300642, 32441489, 34327815, 35119017
Proteostasis Deficiencies	Associate	36458951, 37280636
Pseudoxanthoma Elasticum	Inhibit	25064003
Psoriasis	Associate	24782577, 38273053
Psychological Distress	Associate	21283811
Psychological Trauma	Associate	24132908, 25090243, 36901420
Psychomotor Agitation	Associate	16980336, 40495575
Psychotic Disorders	Associate	10322238, 21820212, 23270420, 28219318, 28847281
Pulmonary Arterial Hypertension	Associate	19851649
Pulmonary Atresia	Associate	18179924
Pulmonary Disease Chronic Obstructive	Associate	26503029, 31920121, 33285739
Pulmonary Embolism	Associate	36371754
Pyruvate Carboxylase Deficiency Disease	Associate	27248362
Radiation Injuries	Associate	35802478
Renal Artery Obstruction	Associate	35259553
Renal Insufficiency	Associate	24676620, 29032015
Renal Insufficiency	Stimulate	9787187
Renal Insufficiency Chronic	Associate	19056482, 19406964, 19852818, 30851738, 34814699, 36261295
Renal Insufficiency Chronic	Stimulate	32046176
Respiratory Distress Syndrome	Associate	29463164
Respiratory System Abnormalities	Associate	37336366
Reticular dysgenesis	Associate	35136347
Retinal Artery Occlusion	Associate	40451134
Retinal Drusen	Associate	14594998, 28632844, 9634502
Retinal Vein Occlusion	Associate	26851238
Retinitis	Associate	14594998, 26851238
Retrograde Degeneration	Associate	27321472, 36430645, 37657448
Schistosomiasis	Associate	25051269
Schistosomiasis mansoni	Associate	25051269
Schizophrenia	Associate	11748362, 20964956, 27078154, 28077398, 29233125, 33178131, 34135129, 34285334
Sciatic Neuropathy	Associate	8922411
Sea Blue Histiocyte Syndrome	Associate	22949395
Seizures	Associate	16202217, 20093050
SeSAME syndrome	Associate	37532513
Severe Acute Respiratory Syndrome	Associate	38007518
Sexual Infantilism	Associate	22357643
Siderosis	Associate	25716356, 29070669, 29070715, 32517581, 34807243, 38165296
Signs and Symptoms	Associate	11971084, 36123648
Skin Neoplasms	Associate	24497847
Sleep Apnea Obstructive	Associate	21864519, 24232699, 24733985, 36577409
Sleep Apnea Syndromes	Associate	23609427, 23729930, 24439479, 24733985, 26314507, 28482100
Sleep Deprivation	Associate	21864519
Sleep Initiation and Maintenance Disorders	Associate	31907066, 34310026
Sleep Wake Disorders	Associate	26314507, 27020605, 27777343, 28747136, 30359892, 30605058, 31553501, 35180114, 35491776
Sleepiness	Associate	28752509
Smith Lemli Opitz Syndrome	Associate	15286151
Smith McCort Dysplasia	Associate	25253756
Smoke Inhalation Injury	Associate	10090925, 16288198, 25847292, 39261765, 7703749
Snoring	Associate	26314507
Spinal Cord Injuries	Associate	18581664
Spinal Dysraphism	Associate	37657448
Spinocerebellar Degenerations	Associate	19455140
Splenic Infarction	Associate	40149441
Splenomegaly	Associate	40149441
Spondylocostal dysostosis autosomal recessive	Associate	15312249
Squamous Cell Carcinoma of Head and Neck	Associate	28751006, 35892323, 37686462
ST Elevation Myocardial Infarction	Associate	40076958
Status Asthmaticus	Associate	32338995
Stomach Neoplasms	Associate	23098561, 26817942, 33015179, 38054821
Stress Disorders Post Traumatic	Associate	19766540, 24132908, 29463164
Stroke	Stimulate	11553004
Stroke	Associate	12656452, 12715012, 16401842, 16519597, 17672902, 21593560, 22221491, 24090469, 26710338, 27168072, 27447179, 27849638, 31315437, 31455442, 34933635, 35332187, 40514232 View all (2 more)
Stroke Lacunar	Associate	18653200
Subarachnoid Hemorrhage	Associate	17672902, 25735919, 29213291, 29769126, 39647920
Supranuclear Palsy Progressive	Associate	29076559, 35842134, 38301647
Sveinsson Chorioretinal Atrophy	Associate	7672107
Syndrome	Associate	26141491
Synucleinopathies	Associate	23407718
Tachycardia Sinoatrial Nodal Reentry	Stimulate	34737220
Takotsubo Cardiomyopathy	Associate	32695227
Tangier Disease	Associate	14754908, 15066991
Tauopathies	Associate	28160067, 30040735, 30465754, 34927275, 36383681, 37433038
Temporal epilepsy familial	Stimulate	23965289
Tension Type Headache	Associate	19184578
Testicular Germ Cell Tumor	Associate	37304007
Tetralogy of Fallot	Associate	18179924
Thalassemia	Associate	17296580
Thoracic Outlet Syndrome	Associate	35058547
Thrombophilia	Associate	27729560
Thrombosis	Associate	19818961, 23652625, 25073959
Thrombotic Microangiopathies	Associate	23448537
Thyroid Cancer Papillary	Associate	32766727, 33521130, 35090515
Thyroid Neoplasms	Associate	40157360
Tooth Loss	Associate	19349226, 28578156, 31862015, 39900278
Tooth Loss	Stimulate	21889115, 22637583, 23424640, 33139712
Tooth Mobility	Associate	16282567
Transposition of Great Vessels	Associate	27547505
Trauma Nervous System	Associate	19017669, 30840313
Triglyceride Storage Disease Type I	Associate	16317171
Uremia	Associate	23448537, 26790728
Urinary Bladder Neoplasms	Associate	23631828, 25387487
Urinary Bladder Neurogenic	Associate	33804213
Urolithiasis	Associate	34782536
Uterine Cervical Neoplasms	Associate	25427637
Vascular Diseases	Associate	10412789, 11118404, 12715012, 16519597, 17158432, 22245009, 26790728, 28727855, 31315437
Vascular System Injuries	Associate	22245009, 26720342, 31364446
Vasospasm Intracranial	Associate	29996665
Venous Thrombosis	Associate	19825914, 24456740
Ventricular Dysfunction	Associate	18222096
Ventricular Dysfunction Left	Associate	17296580, 30095041
Ventricular Fibrillation	Associate	17916554, 7639323
Ventricular Remodeling	Associate	10406990
Venular Insufficiency Systemic	Associate	28775055
Virus Diseases	Associate	30496280
Vision Disorders	Associate	23715207, 30060980, 30451020, 36474172
Voice Disorders	Associate	16614010
Vulvar Neoplasms	Associate	40451134
Weight Loss	Associate	10404018, 20359781, 23152815, 27897403
Wounds and Injuries	Associate	29996665, 30478798, 8890772
Wrist Fractures	Associate	10404018, 15312249
Xanthomatosis	Associate	10984082, 7468588

APOE (apolipoprotein E)