Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	347730
Gene name Gene Name - the full gene name approved by the HGNC.	Leucine rich repeat transmembrane neuronal 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LRRTM1
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p12

Show/Hide all(10)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021433	hsa-miR-9-5p	Microarray	17612493
MIRT1121062	hsa-miR-1263	CLIP-seq
MIRT1121063	hsa-miR-3613-3p	CLIP-seq
MIRT1121064	hsa-miR-509-3p	CLIP-seq
MIRT1121065	hsa-miR-520d-5p	CLIP-seq
MIRT1121066	hsa-miR-524-5p	CLIP-seq
MIRT1121067	hsa-miR-548c-3p	CLIP-seq
MIRT2430854	hsa-miR-1247	CLIP-seq
MIRT2430855	hsa-miR-4449	CLIP-seq
MIRT2430856	hsa-miR-4707-3p	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002091	Process	Negative regulation of receptor internalization	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	17667961
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0009986	Component	Cell surface	IDA	17667961
GO:0016020	Component	Membrane	IEA
GO:0030424	Component	Axon	IDA	17667961
GO:0030426	Component	Growth cone	IDA	17667961
GO:0031623	Process	Receptor internalization	IEA
GO:0035418	Process	Protein localization to synapse	IEA
GO:0035640	Process	Exploration behavior	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050808	Process	Synapse organization	IEA
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IBA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0060291	Process	Long-term synaptic potentiation	IEA
GO:0098982	Component	GABA-ergic synapse	IDA	27565350
GO:0098982	Component	GABA-ergic synapse	IMP	27565350
GO:0099634	Component	Postsynaptic specialization membrane	IDA	27565350
GO:0099634	Component	Postsynaptic specialization membrane	IMP	27565350

MIM	HGNC	e!Ensembl
610867	19408	ENSG00000162951

Protein

UniProt ID

Q86UE6

Protein name

Leucine-rich repeat transmembrane neuronal protein 1

Protein function

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	113 → 173	Leucine rich repeat	Repeat
PF13855	LRR_8	161 → 221	Leucine rich repeat	Repeat
PF13855	LRR_8	256 → 315	Leucine rich repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in forebrain regions including thalamus and cerebral cortex. {ECO:0000269|PubMed:12676565, ECO:0000269|PubMed:17667961}.

Sequence

MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEA
PHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTL
SSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRI
FQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCL
RRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRIL
NSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAF
HLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAE
NAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQM
AAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV

Sequence length

522

Interactions

View interactions

	Reactome
			Neurexins and neuroligins

LRRTM1 (leucine rich repeat transmembrane neuronal 1)