Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3476
Gene name	Immunoglobulin binding protein 1
Gene symbol	IGBP1
Synonyms (NCBI Gene)	ALPHA-4IBP1MRXS28alpha4
Chromosome	X
Chromosome location	Xq13.1
Summary	The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signa

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Show/Hide all (146)

miRTarBase ID	miRNA	Experiments	Reference
MIRT529584	hsa-miR-34b-3p	PAR-CLIP	20371350
MIRT529583	hsa-miR-8485	PAR-CLIP	20371350
MIRT529582	hsa-miR-329-3p	PAR-CLIP	20371350
MIRT529581	hsa-miR-362-3p	PAR-CLIP	20371350
MIRT529580	hsa-miR-603	PAR-CLIP	20371350
MIRT529578	hsa-miR-216b-3p	PAR-CLIP	20371350
MIRT529577	hsa-miR-3614-5p	PAR-CLIP	20371350
MIRT529576	hsa-miR-6500-3p	PAR-CLIP	20371350
MIRT529575	hsa-miR-3117-5p	PAR-CLIP	20371350
MIRT529574	hsa-miR-3941	PAR-CLIP	20371350
MIRT529573	hsa-miR-514a-3p	PAR-CLIP	20371350
MIRT529572	hsa-miR-514b-3p	PAR-CLIP	20371350
MIRT529584	hsa-miR-34b-3p	PAR-CLIP	22012620
MIRT529583	hsa-miR-8485	PAR-CLIP	22012620
MIRT529582	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT529581	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT529580	hsa-miR-603	PAR-CLIP	22012620
MIRT529579	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT529578	hsa-miR-216b-3p	PAR-CLIP	22012620
MIRT529577	hsa-miR-3614-5p	PAR-CLIP	22012620
MIRT529576	hsa-miR-6500-3p	PAR-CLIP	22012620
MIRT529575	hsa-miR-3117-5p	PAR-CLIP	22012620
MIRT529574	hsa-miR-3941	PAR-CLIP	22012620
MIRT529573	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT529572	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT529574	hsa-miR-3941	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529574	hsa-miR-3941	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529574	hsa-miR-3941	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529574	hsa-miR-3941	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529584	hsa-miR-34b-3p	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529584	hsa-miR-34b-3p	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529584	hsa-miR-34b-3p	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529574	hsa-miR-3941	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529574	hsa-miR-3941	Luciferase reporter assayqRT-PCRWestern blot	28012229
MIRT529584	hsa-miR-34b-3p	PAR-CLIP	20371350
MIRT529583	hsa-miR-8485	PAR-CLIP	20371350
MIRT529582	hsa-miR-329-3p	PAR-CLIP	20371350
MIRT529581	hsa-miR-362-3p	PAR-CLIP	20371350
MIRT529580	hsa-miR-603	PAR-CLIP	20371350
MIRT529578	hsa-miR-216b-3p	PAR-CLIP	20371350
MIRT529577	hsa-miR-3614-5p	PAR-CLIP	20371350
MIRT529576	hsa-miR-6500-3p	PAR-CLIP	20371350
MIRT529575	hsa-miR-3117-5p	PAR-CLIP	20371350
MIRT529574	hsa-miR-3941	PAR-CLIP	20371350
MIRT529573	hsa-miR-514a-3p	PAR-CLIP	20371350
MIRT529572	hsa-miR-514b-3p	PAR-CLIP	20371350
MIRT529584	hsa-miR-34b-3p	PAR-CLIP	22012620
MIRT529583	hsa-miR-8485	PAR-CLIP	22012620
MIRT529582	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT529581	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT529580	hsa-miR-603	PAR-CLIP	22012620
MIRT529579	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT529578	hsa-miR-216b-3p	PAR-CLIP	22012620
MIRT529577	hsa-miR-3614-5p	PAR-CLIP	22012620
MIRT529576	hsa-miR-6500-3p	PAR-CLIP	22012620
MIRT529575	hsa-miR-3117-5p	PAR-CLIP	22012620
MIRT529574	hsa-miR-3941	PAR-CLIP	22012620
MIRT529573	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT529572	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT1061164	hsa-miR-4789-5p	CLIP-seq
MIRT1061165	hsa-miR-4797-5p	CLIP-seq
MIRT2246489	hsa-miR-1914	CLIP-seq
MIRT2246490	hsa-miR-4265	CLIP-seq
MIRT2246491	hsa-miR-4296	CLIP-seq
MIRT2246492	hsa-miR-4322	CLIP-seq
MIRT2246493	hsa-miR-4648	CLIP-seq
MIRT2246494	hsa-miR-4654	CLIP-seq
MIRT2246495	hsa-miR-4694-5p	CLIP-seq
MIRT2246496	hsa-miR-4747-5p	CLIP-seq
MIRT2246497	hsa-miR-4769-5p	CLIP-seq
MIRT2550047	hsa-miR-1207-5p	CLIP-seq
MIRT2550048	hsa-miR-1288	CLIP-seq
MIRT2550049	hsa-miR-1321	CLIP-seq
MIRT2550050	hsa-miR-1909	CLIP-seq
MIRT2550051	hsa-miR-1910	CLIP-seq
MIRT2246489	hsa-miR-1914	CLIP-seq
MIRT2550052	hsa-miR-217	CLIP-seq
MIRT2550053	hsa-miR-3157-3p	CLIP-seq
MIRT2550054	hsa-miR-3160-3p	CLIP-seq
MIRT2550055	hsa-miR-3169	CLIP-seq
MIRT2550056	hsa-miR-3189-3p	CLIP-seq
MIRT2550057	hsa-miR-330-3p	CLIP-seq
MIRT2550058	hsa-miR-3613-5p	CLIP-seq
MIRT2550059	hsa-miR-3620	CLIP-seq
MIRT2246490	hsa-miR-4265	CLIP-seq
MIRT2550060	hsa-miR-4270	CLIP-seq
MIRT2550061	hsa-miR-4290	CLIP-seq
MIRT2246491	hsa-miR-4296	CLIP-seq
MIRT2246492	hsa-miR-4322	CLIP-seq
MIRT2550062	hsa-miR-4441	CLIP-seq
MIRT2550063	hsa-miR-451b	CLIP-seq
MIRT2246493	hsa-miR-4648	CLIP-seq
MIRT2246494	hsa-miR-4654	CLIP-seq
MIRT2550064	hsa-miR-4655-3p	CLIP-seq
MIRT2246495	hsa-miR-4694-5p	CLIP-seq
MIRT2550065	hsa-miR-4722-5p	CLIP-seq
MIRT2550066	hsa-miR-4728-5p	CLIP-seq
MIRT2550067	hsa-miR-4736	CLIP-seq
MIRT2550068	hsa-miR-4739	CLIP-seq
MIRT2246496	hsa-miR-4747-5p	CLIP-seq
MIRT2550069	hsa-miR-4756-5p	CLIP-seq
MIRT2550070	hsa-miR-4763-3p	CLIP-seq
MIRT2550071	hsa-miR-4768-3p	CLIP-seq
MIRT2246497	hsa-miR-4769-5p	CLIP-seq
MIRT2550072	hsa-miR-4786-5p	CLIP-seq
MIRT1061165	hsa-miR-4797-5p	CLIP-seq
MIRT2550073	hsa-miR-502-5p	CLIP-seq
MIRT2550074	hsa-miR-518a-5p	CLIP-seq
MIRT2550075	hsa-miR-527	CLIP-seq
MIRT2550076	hsa-miR-874	CLIP-seq
MIRT2550047	hsa-miR-1207-5p	CLIP-seq
MIRT2550048	hsa-miR-1288	CLIP-seq
MIRT2550049	hsa-miR-1321	CLIP-seq
MIRT2550050	hsa-miR-1909	CLIP-seq
MIRT2550051	hsa-miR-1910	CLIP-seq
MIRT2246489	hsa-miR-1914	CLIP-seq
MIRT2550052	hsa-miR-217	CLIP-seq
MIRT2550053	hsa-miR-3157-3p	CLIP-seq
MIRT2550054	hsa-miR-3160-3p	CLIP-seq
MIRT2550055	hsa-miR-3169	CLIP-seq
MIRT2550056	hsa-miR-3189-3p	CLIP-seq
MIRT2550057	hsa-miR-330-3p	CLIP-seq
MIRT2550058	hsa-miR-3613-5p	CLIP-seq
MIRT2550059	hsa-miR-3620	CLIP-seq
MIRT2246490	hsa-miR-4265	CLIP-seq
MIRT2550060	hsa-miR-4270	CLIP-seq
MIRT2550061	hsa-miR-4290	CLIP-seq
MIRT2246491	hsa-miR-4296	CLIP-seq
MIRT2246492	hsa-miR-4322	CLIP-seq
MIRT2550062	hsa-miR-4441	CLIP-seq
MIRT2550063	hsa-miR-451b	CLIP-seq
MIRT2550064	hsa-miR-4655-3p	CLIP-seq
MIRT2246495	hsa-miR-4694-5p	CLIP-seq
MIRT2550065	hsa-miR-4722-5p	CLIP-seq
MIRT2550066	hsa-miR-4728-5p	CLIP-seq
MIRT2550067	hsa-miR-4736	CLIP-seq
MIRT2550068	hsa-miR-4739	CLIP-seq
MIRT2550069	hsa-miR-4756-5p	CLIP-seq
MIRT2550070	hsa-miR-4763-3p	CLIP-seq
MIRT2550071	hsa-miR-4768-3p	CLIP-seq
MIRT2550072	hsa-miR-4786-5p	CLIP-seq
MIRT1061165	hsa-miR-4797-5p	CLIP-seq
MIRT2550073	hsa-miR-502-5p	CLIP-seq
MIRT2550074	hsa-miR-518a-5p	CLIP-seq
MIRT2550075	hsa-miR-527	CLIP-seq
MIRT2550076	hsa-miR-874	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	17438131
GO:0005515	Function	Protein binding	IPI	9647778, 16085932, 16769727, 18186651, 18614045, 18715871, 18782753, 19156129, 21988832, 23892082, 24255178, 25277244, 26496610, 27880917, 28330616, 32296183, 32814053, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	9647778
GO:0005829	Component	Cytosol	IBA
GO:0007165	Process	Signal transduction	NAS	9647778
GO:0009966	Process	Regulation of signal transduction	IEA
GO:0019888	Function	Protein phosphatase regulator activity	IDA	9647778
GO:0032873	Process	Negative regulation of stress-activated MAPK cascade	IMP	17438131
GO:0034612	Process	Response to tumor necrosis factor	IMP	17438131
GO:0035303	Process	Regulation of dephosphorylation	IBA
GO:0035556	Process	Intracellular signal transduction	IMP	17438131
GO:0042113	Process	B cell activation	IEA
GO:0051721	Function	Protein phosphatase 2A binding	IBA
GO:0060632	Process	Regulation of microtubule-based movement	IMP	18949047
GO:0070555	Process	Response to interleukin-1	IMP	17438131

MIM	HGNC	e!Ensembl
300139	5461	ENSG00000089289

P78318

Protein name

Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16)

Protein function

Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiqu

PDB

4IYP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04177	TAP42	12 → 329	TAP42-like family	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas.

Sequence

MAAEDELQLPRLPELFETGRQLLDEVEVATEPAGSRIVQEKVFKGLDLLEKAAEMLSQLD
LFSRNEDLEEIASTDLKYLLVPAFQGALTMKQVNPSKRLDHLQRAREHFINYLTQCHCYH
VAEFELPKTMNNSAENHTANSSMAYPSLVAMASQRQAKIQRYKQKKELEHRLSAMKSAVE
SGQADDERVREYYLLHLQRWIDISLEEIESIDQEIKILRERDSSREASTSNSSRQERPPV
KPFILTRNMAQAKVFGAGYPSLPTMTVSDWYEQHRKYGALPDQGIAKAAPEEFRKAAQQQ
EEQEEKEEEDDEQTLHRAREWDDWKDTHPRGYGNRQNMG

Sequence length

339

Interactions

View interactions

	KEGG
	Autophagy - other Autophagy - animal

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome	Pathogenic	rs2147562704	RCV000012329

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
IGBP1-related disorder	Uncertain significance; Benign	rs368773089, rs2520551794, rs376859259, rs11551789	RCV003405726 RCV003406036 RCV003421117 RCV003932906

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	28012229
Adenocarcinoma of Lung	Associate	28012229
Esophageal Squamous Cell Carcinoma	Associate	31875416
Intellectual Disability	Associate	23871722
Lupus Nephritis	Stimulate	31137925
Lymphoma Follicular	Associate	24357726
Neoplasms	Associate	31875416
Opitz GBBB Syndrome X Linked	Associate	11806752
Opitz Kaveggia syndrome	Associate	11806752
Status Asthmaticus	Associate	7525343

IGBP1 (immunoglobulin binding protein 1)