IFRD1 (interferon related developmental regulator 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3475
Gene name Gene Name - the full gene name approved by the HGNC.
Interferon related developmental regulator 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IFRD1
Synonyms (NCBI Gene) Gene synonyms aliases
PC4, TIS7
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(709)
miRTarBase ID miRNA Experiments Reference
MIRT005143 hsa-miR-30a-5p pSILAC 18668040
MIRT001623 hsa-let-7b-5p pSILAC 18668040
MIRT001454 hsa-miR-16-5p pSILAC 18668040
MIRT026426 hsa-miR-192-5p Microarray 19074876
MIRT005143 hsa-miR-30a-5p Proteomics;Other 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IEA
GO:0006357 Process Regulation of transcription by RNA polymerase II IEA
GO:0007518 Process Myoblast fate determination TAS 7756174
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
603502 5456 ENSG00000006652
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID O00458
Protein name Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4)
Protein function Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05004 IFRD 42 → 347 Interferon-related developmental regulator (IFRD) Family
PF04836 IFRD_C 392 → 445 Interferon-related protein conserved region Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a variety of tissues.
Sequence
Sequence length 451
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Charcot-Marie-Tooth Disease Charcot-Marie-Tooth Disease N/A N/A ClinVar
Spinocerebellar Ataxia spinocerebellar ataxia type 18 N/A N/A GenCC
Show/Hide Text Mining Associations (13)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 31118040
Asthma Associate 33150670
Ataxia Associate 19409521
Colorectal Neoplasms Associate 29094309
Disease Models Animal Associate 25939412
Heredodegenerative Disorders Nervous System Associate 19409521
Muscle Neoplasms Associate 25531450
Myelodysplastic Syndromes Associate 26010722
Neoplasms Associate 29094309
Osteoarthritis Hip Associate 25939412