STRA8 (stimulated by retinoic acid 8)

Gene

• Entrez ID: 346673
• Gene name: Stimulated by retinoic acid 8
• Gene symbol: STRA8
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q33
• Summary: This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human protein

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	22899867
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006260	Process	DNA replication	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	ISS
GO:0007283	Process	Spermatogenesis	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0030154	Process	Cell differentiation	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048477	Process	Oogenesis	IBA
GO:0048477	Process	Oogenesis	IEA
GO:0048477	Process	Oogenesis	ISS
GO:0051321	Process	Meiotic cell cycle	IBA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051321	Process	Meiotic cell cycle	ISS
GO:0071300	Process	Cellular response to retinoic acid	IEA
GO:0071300	Process	Cellular response to retinoic acid	ISS
GO:0090427	Process	Activation of meiosis	IBA
GO:0090427	Process	Activation of meiosis	ISS

Other IDs

• MIM: 609987
• HGNC: 30653
• e!Ensembl: ENSG00000146857

Protein

• UniProt ID: Q7Z7C7
• Protein name: Stimulated by retinoic acid gene 8 protein homolog
• Protein function: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events
• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically in testis and fetal ovaries. {ECO:0000269|PubMed:12489526, ECO:0000269|PubMed:26742488}.
• Sequence:

  MGKIDVDKILFFNQEIRLWQLIMATPEENSNPHDRATPQLPAQLQELEHRVARRRLSQAR
  HRATLAALFNNLRKTVYSQSDLIASKWQVLNKAKSHIPELEQTLDNLLKLKASFNLEDGH
  ASSLEEVKKEYASMYSGNDSFPQNGSSPWYLNFYKQTMDLLTGSGIITPQEAALPIVSAA
  ISHLWQNLSEERKASLRQAWAQKHRGPATLAEACREPACAEGSVKDSGVDSQGASCSLVS
  TPEEILFEDAFDVASFLDKSEVPSTSSSSSVLASCNPENPEEKFQLYMQIINFFKGLSCA
  NTQVKQEASFPVDEEMIMLQCTETFDDEDL

• Sequence length: 330

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Arrest of spermatogenesis	Associate	37867192	★☆☆☆☆ Found in Text Mining only
Azoospermia	Associate	23320086	★☆☆☆☆ Found in Text Mining only
Infertility	Associate	37867192	★☆☆☆☆ Found in Text Mining only
Male Infertility with Large Headed Multiflagellar Polyploid Spermatozoa	Associate	24803180	★☆☆☆☆ Found in Text Mining only
Oligospermia	Associate	23320086	★☆☆☆☆ Found in Text Mining only
Primary Ovarian Insufficiency	Associate	36732629	★☆☆☆☆ Found in Text Mining only
Spermatogenic Failure Nonobstructive Y Linked	Associate	23320086	★☆☆☆☆ Found in Text Mining only