ECT2L (epithelial cell transforming 2 like)

Gene

• Entrez ID: 345930
• Gene name: Epithelial cell transforming 2 like
• Gene symbol: ECT2L
• Synonyms (NCBI Gene): ARHGEF32, C6orf91, FBXO49, LFDH, dJ509I19.2, dJ509I19.3, dJ509I19.5
• Chromosome: 6
• Chromosome location: 6q24.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT951858	hsa-miR-1297	CLIP-seq
MIRT951859	hsa-miR-1305	CLIP-seq
MIRT951860	hsa-miR-26a	CLIP-seq
MIRT951861	hsa-miR-26b	CLIP-seq
MIRT951862	hsa-miR-4465	CLIP-seq
MIRT951863	hsa-miR-4670-3p	CLIP-seq
MIRT951864	hsa-miR-498	CLIP-seq
MIRT951865	hsa-miR-1227	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951867	hsa-miR-136	CLIP-seq
MIRT951868	hsa-miR-2467-5p	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951871	hsa-miR-3188	CLIP-seq
MIRT951872	hsa-miR-3663-5p	CLIP-seq
MIRT951873	hsa-miR-3975	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951875	hsa-miR-4316	CLIP-seq
MIRT951876	hsa-miR-4438	CLIP-seq
MIRT951877	hsa-miR-4690-5p	CLIP-seq
MIRT951878	hsa-miR-4710	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951880	hsa-miR-4716-5p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951883	hsa-miR-4781-3p	CLIP-seq
MIRT951884	hsa-miR-4792	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951887	hsa-miR-485-5p	CLIP-seq
MIRT951888	hsa-miR-5095	CLIP-seq
MIRT951889	hsa-miR-515-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq
MIRT1981878	hsa-miR-130a	CLIP-seq
MIRT1981879	hsa-miR-130b	CLIP-seq
MIRT1981880	hsa-miR-301a	CLIP-seq
MIRT1981881	hsa-miR-301b	CLIP-seq
MIRT1981882	hsa-miR-3616-5p	CLIP-seq
MIRT1981883	hsa-miR-3647-5p	CLIP-seq
MIRT1981884	hsa-miR-3666	CLIP-seq
MIRT1981885	hsa-miR-3929	CLIP-seq
MIRT1981886	hsa-miR-4295	CLIP-seq
MIRT1981887	hsa-miR-4419b	CLIP-seq
MIRT1981888	hsa-miR-4478	CLIP-seq
MIRT1981889	hsa-miR-454	CLIP-seq
MIRT1981890	hsa-miR-4795-5p	CLIP-seq
MIRT1981891	hsa-miR-494	CLIP-seq
MIRT1981892	hsa-miR-519a	CLIP-seq
MIRT1981893	hsa-miR-519b-3p	CLIP-seq
MIRT1981894	hsa-miR-519c-3p	CLIP-seq
MIRT1981895	hsa-miR-573	CLIP-seq
MIRT2216776	hsa-miR-106a	CLIP-seq
MIRT2216777	hsa-miR-106b	CLIP-seq
MIRT1981878	hsa-miR-130a	CLIP-seq
MIRT1981879	hsa-miR-130b	CLIP-seq
MIRT2216778	hsa-miR-150	CLIP-seq
MIRT2216779	hsa-miR-17	CLIP-seq
MIRT2216780	hsa-miR-20a	CLIP-seq
MIRT2216781	hsa-miR-20b	CLIP-seq
MIRT951868	hsa-miR-2467-5p	CLIP-seq
MIRT1981880	hsa-miR-301a	CLIP-seq
MIRT1981881	hsa-miR-301b	CLIP-seq
MIRT951871	hsa-miR-3188	CLIP-seq
MIRT1981882	hsa-miR-3616-5p	CLIP-seq
MIRT1981883	hsa-miR-3647-5p	CLIP-seq
MIRT951872	hsa-miR-3663-5p	CLIP-seq
MIRT1981884	hsa-miR-3666	CLIP-seq
MIRT2216782	hsa-miR-371-5p	CLIP-seq
MIRT2216783	hsa-miR-371b-5p	CLIP-seq
MIRT1981885	hsa-miR-3929	CLIP-seq
MIRT951873	hsa-miR-3975	CLIP-seq
MIRT1981886	hsa-miR-4295	CLIP-seq
MIRT951875	hsa-miR-4316	CLIP-seq
MIRT1981887	hsa-miR-4419b	CLIP-seq
MIRT2216784	hsa-miR-4464	CLIP-seq
MIRT1981888	hsa-miR-4478	CLIP-seq
MIRT1981889	hsa-miR-454	CLIP-seq
MIRT951878	hsa-miR-4710	CLIP-seq
MIRT951880	hsa-miR-4716-5p	CLIP-seq
MIRT2216785	hsa-miR-4748	CLIP-seq
MIRT951883	hsa-miR-4781-3p	CLIP-seq
MIRT951884	hsa-miR-4792	CLIP-seq
MIRT1981890	hsa-miR-4795-5p	CLIP-seq
MIRT951887	hsa-miR-485-5p	CLIP-seq
MIRT1981892	hsa-miR-519a	CLIP-seq
MIRT1981893	hsa-miR-519b-3p	CLIP-seq
MIRT1981894	hsa-miR-519c-3p	CLIP-seq
MIRT2216786	hsa-miR-519d	CLIP-seq
MIRT2216787	hsa-miR-520g	CLIP-seq
MIRT2216788	hsa-miR-520h	CLIP-seq
MIRT1981895	hsa-miR-573	CLIP-seq
MIRT2216789	hsa-miR-93	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq
MIRT951865	hsa-miR-1227	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951867	hsa-miR-136	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951876	hsa-miR-4438	CLIP-seq
MIRT951878	hsa-miR-4710	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951880	hsa-miR-4716-5p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951883	hsa-miR-4781-3p	CLIP-seq
MIRT951884	hsa-miR-4792	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951888	hsa-miR-5095	CLIP-seq
MIRT951889	hsa-miR-515-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq
MIRT951865	hsa-miR-1227	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951867	hsa-miR-136	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951875	hsa-miR-4316	CLIP-seq
MIRT951876	hsa-miR-4438	CLIP-seq
MIRT951878	hsa-miR-4710	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951880	hsa-miR-4716-5p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951883	hsa-miR-4781-3p	CLIP-seq
MIRT951884	hsa-miR-4792	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951888	hsa-miR-5095	CLIP-seq
MIRT951889	hsa-miR-515-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q008S8
• Protein name: Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH)
• Protein function: May act as a guanine nucleotide exchange factor (GEF).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12937	F-box-like	79 → 124	F-box-like	Domain
  PF14252	DUF4347	290 → 460	Domain of unknown function (DUF4347)	Family
  PF00621	RhoGEF	570 → 752	RhoGEF domain	Domain

• Sequence:

  MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLR
  FVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMP
  KCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREAAATYGTLNEPKTEDEELLER
  QREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVLKPRCQPRLSQTVRERVGLHEAL
  EKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVHKNDDRSSYALRPHFMLISSRIPAY
  EMVMESVKAGVVSVVYEHSVTLESLLYLIEKALDGQKAQSIGIFSDGDSREINLLQGYKI
  GVKNLLRPEVRDFWEKLGSYVATEEEGGHVDFFVPLGASEAGIEVLSQLSQLTGTFFTAP
  TGIATGSYQHILSDWLGSQWGKAPSSIYFCESKLQTWSSFTDFLEETLKTVRKQLYPFFK
  ELQKSISGRMIGQFMFDTMGMTNILNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKS
  RLSKNDLNFEALINLERILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAAL
  SSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTY
  TNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLL
  YAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEV
  NRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKT
  TYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKS
  SMEK

• Sequence length: 904

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cholangiocarcinoma	not provided	rs554645676	RCV005867910
Colon adenocarcinoma	not provided	rs554645676	RCV005867907
Hepatocellular carcinoma	not provided	rs554645676	RCV005867908
Malignant tumor of esophagus	not provided	rs554645676	RCV005867909
Sarcoma	not provided	rs79069095	RCV005890492
Thymoma	not provided	rs144150484	RCV005889467

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	36344993
Neoplasms	Associate	30865299
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	22237106
Spastic Paraplegia Hereditary	Associate	36344993