Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3456
Gene name Gene Name - the full gene name approved by the HGNC.	Interferon beta 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IFNB1
Synonyms (NCBI Gene) Gene synonyms aliases	IFB, IFF, IFN-beta, IFNB
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p21.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are importa

Show/Hide all(24)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004614	hsa-let-7b-5p	ELISA, Luciferase reporter assay, qRT-PCR	20130213
MIRT004615	hsa-miR-26a-5p	ELISA, Luciferase reporter assay, qRT-PCR	20130213
MIRT004616	hsa-miR-145-5p	ELISA, Luciferase reporter assay, qRT-PCR	20130213
MIRT004617	hsa-miR-34a-5p	ELISA, Luciferase reporter assay, qRT-PCR	20130213
MIRT644955	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT644954	hsa-miR-4282	HITS-CLIP	23824327
MIRT644953	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT644952	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT644951	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT644950	hsa-miR-8063	HITS-CLIP	23824327
MIRT644949	hsa-miR-4698	HITS-CLIP	23824327
MIRT644948	hsa-miR-6080	HITS-CLIP	23824327
MIRT644947	hsa-miR-607	HITS-CLIP	23824327
MIRT736422	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT004616	hsa-miR-145-5p	Western blotting, qRT-PCR, ELISA	32808389
MIRT644955	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT644954	hsa-miR-4282	HITS-CLIP	23824327
MIRT644953	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT644952	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT644951	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT644950	hsa-miR-8063	HITS-CLIP	23824327
MIRT644949	hsa-miR-4698	HITS-CLIP	23824327
MIRT644948	hsa-miR-6080	HITS-CLIP	23824327
MIRT644947	hsa-miR-607	HITS-CLIP	23824327

Transcription factors

Show/Hide all(21)

Transcription factor	Regulation	Reference
ATF2	Activation	17496231
ATF2	Unknown	10848607
IRF1	Activation	8021262
IRF1	Unknown	17073600;18575764;22547704
IRF2	Activation	8021262
IRF2	Unknown	17073600
IRF3	Activation	12077266;17496231;23096996
IRF3	Unknown	10848607;15955070;16125763;17079305;19541850;20048166;20453844;20483755
IRF7	Activation	17236232
IRF7	Repression	22698399
IRF7	Unknown	22547704;23906644
JUN	Unknown	10848607
NFKB1	Activation	10074115;12077266;17496231
NFKB1	Unknown	15955070;16125763;17079305
NFKBIA	Repression	10074115
NFKBIB	Repression	10074115
PML	Activation	11042692
RELA	Activation	10074115;12077266;17496231
RELA	Unknown	15955070;16125763;17079305;22547704
STAT1	Repression	19096445
YY1	Unknown	22065573

Show/Hide all(68)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IBA
GO:0002286	Process	T cell activation involved in immune response	IBA
GO:0002312	Process	B cell activation involved in immune response	IBA
GO:0002312	Process	B cell activation involved in immune response	IMP	12932356
GO:0002323	Process	Natural killer cell activation involved in immune response	IBA
GO:0002683	Process	Negative regulation of immune system process	IEA
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IDA	6157094, 7813427, 8027027, 8969169, 10556041, 19008854, 33581076
GO:0005125	Function	Cytokine activity	IEA
GO:0005126	Function	Cytokine receptor binding	IDA	10556041
GO:0005126	Function	Cytokine receptor binding	IEA
GO:0005126	Function	Cytokine receptor binding	IPI	7813427, 8798579, 8969169
GO:0005132	Function	Type I interferon receptor binding	IBA
GO:0005132	Function	Type I interferon receptor binding	NAS	2414376
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	6157094, 21873635
GO:0005615	Component	Extracellular space	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	9020188, 28753426
GO:0006950	Process	Response to stress	IEA
GO:0006952	Process	Defense response	IEA
GO:0006955	Process	Immune response	IEA
GO:0006959	Process	Humoral immune response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10640778
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IDA	7813427, 8027027, 8798579, 8969169
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IDA	7526154, 7657660, 7759950, 8605876, 23139419, 28753426
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IDA	10556041
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	TAS	8232552
GO:0008811	Function	Chloramphenicol O-acetyltransferase activity	IMP	19176627
GO:0009615	Process	Response to virus	NAS	12120696
GO:0009893	Process	Positive regulation of metabolic process	IEA
GO:0010508	Process	Positive regulation of autophagy	ISS
GO:0019221	Process	Cytokine-mediated signaling pathway	IDA	6157094, 7813427
GO:0030101	Process	Natural killer cell activation	NAS	11987821
GO:0035458	Process	Cellular response to interferon-beta	IDA	7759950
GO:0035458	Process	Cellular response to interferon-beta	IDA	7813427, 8027027, 8969169, 18035482
GO:0042100	Process	B cell proliferation	NAS	3135963
GO:0043330	Process	Response to exogenous dsRNA	IBA
GO:0043330	Process	Response to exogenous dsRNA	IDA	21266579
GO:0045071	Process	Negative regulation of viral genome replication	IDA	19008854
GO:0045087	Process	Innate immune response	IDA	7813427
GO:0045089	Process	Positive regulation of innate immune response	NAS	11987821
GO:0045321	Process	Leukocyte activation	IEA
GO:0045343	Process	Regulation of MHC class I biosynthetic process	NAS	8805651
GO:0045581	Process	Negative regulation of T cell differentiation	IDA	20554961
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	18035482
GO:0051241	Process	Negative regulation of multicellular organismal process	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	ISS
GO:0051607	Process	Defense response to virus	TAS	19416887
GO:0060337	Process	Type I interferon-mediated signaling pathway	IBA
GO:0060337	Process	Type I interferon-mediated signaling pathway	IDA	18035482, 33581076
GO:0060337	Process	Type I interferon-mediated signaling pathway	NAS	30936491
GO:0070050	Process	Neuron cellular homeostasis	ISS
GO:0071359	Process	Cellular response to dsRNA	IEA
GO:0071360	Process	Cellular response to exogenous dsRNA	TAS	21266579
GO:0097696	Process	Cell surface receptor signaling pathway via STAT	IDA	18035482
GO:0098586	Process	Cellular response to virus	IEA
GO:0098586	Process	Cellular response to virus	IEP	28146100
GO:0098586	Process	Cellular response to virus	NAS	30936491
GO:0140123	Process	Negative regulation of Lewy body formation	ISS
GO:0140374	Process	Antiviral innate immune response	IDA	19008854, 19416887, 21642987
GO:1900182	Process	Positive regulation of protein localization to nucleus	IDA	8605876, 26479788
GO:2000552	Process	Negative regulation of T-helper 2 cell cytokine production	IDA	20554961
GO:2001235	Process	Positive regulation of apoptotic signaling pathway	IDA	10918594, 11337497

MIM	HGNC	e!Ensembl
147640	5434	ENSG00000171855

Protein

UniProt ID

P01574

Protein name

Interferon beta (IFN-beta) (Fibroblast interferon)

Protein function

Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10049744, PubMed:10556041, PubMed:6157094, PubMed:6171735, PubMed:7665574, PubMed:8027027, PubM

PDB

1AU1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00143	Interferon	27 → 185	Interferon alpha/beta domain	Domain

Sequence

MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD
IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK
TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR
LTGYLRN

Sequence length

187

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity TNF signaling pathway Alcoholic liver disease Shigellosis Yersinia infection Chagas disease Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Lipid and atherosclerosis		Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production

IFNB1 (interferon beta 1)