Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3440
Gene name Gene Name - the full gene name approved by the HGNC.	Interferon alpha 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IFNA2
Synonyms (NCBI Gene) Gene synonyms aliases	IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p21.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral,

Show/Hide all(23)

miRTarBase ID	miRNA	Experiments	Reference
MIRT736417	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT1060630	hsa-miR-103b	CLIP-seq
MIRT1060631	hsa-miR-19a	CLIP-seq
MIRT1060632	hsa-miR-19b	CLIP-seq
MIRT1060633	hsa-miR-203	CLIP-seq
MIRT1060634	hsa-miR-323-3p	CLIP-seq
MIRT1060635	hsa-miR-494	CLIP-seq
MIRT1060636	hsa-miR-518a-5p	CLIP-seq
MIRT1060637	hsa-miR-527	CLIP-seq
MIRT1549737	hsa-miR-3607-3p	CLIP-seq
MIRT1549738	hsa-miR-3686	CLIP-seq
MIRT1549739	hsa-miR-3909	CLIP-seq
MIRT1549740	hsa-miR-4310	CLIP-seq
MIRT1549741	hsa-miR-4704-3p	CLIP-seq
MIRT1549739	hsa-miR-3909	CLIP-seq
MIRT1549740	hsa-miR-4310	CLIP-seq
MIRT1549741	hsa-miR-4704-3p	CLIP-seq
MIRT1060633	hsa-miR-203	CLIP-seq
MIRT2451618	hsa-miR-627	CLIP-seq
MIRT2451619	hsa-miR-924	CLIP-seq
MIRT2549837	hsa-miR-3121-3p	CLIP-seq
MIRT2549838	hsa-miR-548c-3p	CLIP-seq
MIRT2549838	hsa-miR-548c-3p	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
IRF7	Activation	17236232

Show/Hide all(40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IBA
GO:0002286	Process	T cell activation involved in immune response	IBA
GO:0002312	Process	B cell activation involved in immune response	IBA
GO:0002323	Process	Natural killer cell activation involved in immune response	IBA
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IDA	8082511
GO:0005125	Function	Cytokine activity	IEA
GO:0005126	Function	Cytokine receptor binding	IEA
GO:0005132	Function	Type I interferon receptor binding	IBA
GO:0005132	Function	Type I interferon receptor binding	TAS	6158094
GO:0005515	Function	Protein binding	IPI	7759950, 21854986, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	8082511
GO:0005615	Component	Extracellular space	IEA
GO:0006915	Process	Apoptotic process	TAS	10477584
GO:0006952	Process	Defense response	IEA
GO:0006954	Process	Inflammatory response	TAS	10477584
GO:0006959	Process	Humoral immune response	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	6158094
GO:0007267	Process	Cell-cell signaling	TAS	10477584
GO:0010629	Process	Negative regulation of gene expression	IDA	20554961
GO:0031012	Component	Extracellular matrix	HDA	28327460
GO:0031012	Component	Extracellular matrix	HDA	28675934
GO:0032696	Process	Negative regulation of interleukin-13 production	IDA	20554961
GO:0032714	Process	Negative regulation of interleukin-5 production	IDA	20554961
GO:0043330	Process	Response to exogenous dsRNA	IBA
GO:0045581	Process	Negative regulation of T cell differentiation	IDA	20554961
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	20554961
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IDA	22783022
GO:0051607	Process	Defense response to virus	IDA	22783022
GO:0051607	Process	Defense response to virus	IEA
GO:0060337	Process	Type I interferon-mediated signaling pathway	IBA
GO:0060337	Process	Type I interferon-mediated signaling pathway	IDA	21854986
GO:0060337	Process	Type I interferon-mediated signaling pathway	IDA	8082511, 22783022
GO:0060337	Process	Type I interferon-mediated signaling pathway	NAS	30936491
GO:0097696	Process	Cell surface receptor signaling pathway via STAT	IDA	22783022
GO:0098586	Process	Cellular response to virus	NAS	30936491
GO:2000552	Process	Negative regulation of T-helper 2 cell cytokine production	IDA	20554961

MIM	HGNC	e!Ensembl
147562	5423	ENSG00000188379

Protein

UniProt ID

P01563

Protein name

Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)

Protein function

Produced by macrophages, IFN-alpha have antiviral activities.

PDB

1ITF , 1RH2 , 2HYM , 2KZ1 , 2LAG , 2LMS , 3S9D , 3SE3 , 4YPG , 4Z5R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00143	Interferon	26 → 184	Interferon alpha/beta domain	Domain

Sequence

MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFG
FPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEA
CVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNL
QESLRSKE

Sequence length

188

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Necroptosis Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity Alcoholic liver disease Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Autoimmune thyroid disease Lipid and atherosclerosis		Interferon alpha/beta signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production

IFNA2 (interferon alpha 2)