IFI35 (interferon induced protein 35)

Gene

• Entrez ID: 3430
• Gene name: Interferon induced protein 35
• Gene symbol: IFI35
• Synonyms (NCBI Gene): IFP35
• Chromosome: 17
• Chromosome location: 17q21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2549311	hsa-miR-1208	CLIP-seq
MIRT2549312	hsa-miR-1255a	CLIP-seq
MIRT2549313	hsa-miR-1255b	CLIP-seq
MIRT2549314	hsa-miR-146a	CLIP-seq
MIRT2549315	hsa-miR-146b-5p	CLIP-seq
MIRT2549316	hsa-miR-1470	CLIP-seq
MIRT2549317	hsa-miR-1908	CLIP-seq
MIRT2549318	hsa-miR-1972	CLIP-seq
MIRT2549319	hsa-miR-199a-5p	CLIP-seq
MIRT2549320	hsa-miR-199b-5p	CLIP-seq
MIRT2549321	hsa-miR-3150a-3p	CLIP-seq
MIRT2549322	hsa-miR-3175	CLIP-seq
MIRT2549323	hsa-miR-337-3p	CLIP-seq
MIRT2549324	hsa-miR-3605-5p	CLIP-seq
MIRT2549325	hsa-miR-4302	CLIP-seq
MIRT2549326	hsa-miR-4651	CLIP-seq
MIRT2549327	hsa-miR-4730	CLIP-seq
MIRT2549328	hsa-miR-491-5p	CLIP-seq
MIRT2549329	hsa-miR-589	CLIP-seq
MIRT2549330	hsa-miR-608	CLIP-seq
MIRT2549331	hsa-miR-663	CLIP-seq
MIRT2549332	hsa-miR-939	CLIP-seq
MIRT2549311	hsa-miR-1208	CLIP-seq
MIRT2549314	hsa-miR-146a	CLIP-seq
MIRT2549315	hsa-miR-146b-5p	CLIP-seq
MIRT2549316	hsa-miR-1470	CLIP-seq
MIRT2549317	hsa-miR-1908	CLIP-seq
MIRT2549318	hsa-miR-1972	CLIP-seq
MIRT2549319	hsa-miR-199a-5p	CLIP-seq
MIRT2549320	hsa-miR-199b-5p	CLIP-seq
MIRT2549321	hsa-miR-3150a-3p	CLIP-seq
MIRT2549322	hsa-miR-3175	CLIP-seq
MIRT2549323	hsa-miR-337-3p	CLIP-seq
MIRT2549325	hsa-miR-4302	CLIP-seq
MIRT2549326	hsa-miR-4651	CLIP-seq
MIRT2549327	hsa-miR-4730	CLIP-seq
MIRT2549328	hsa-miR-491-5p	CLIP-seq
MIRT2549329	hsa-miR-589	CLIP-seq
MIRT2549330	hsa-miR-608	CLIP-seq
MIRT2549331	hsa-miR-663	CLIP-seq
MIRT2549332	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002281	Process	Macrophage activation involved in immune response	IDA	29038465
GO:0002281	Process	Macrophage activation involved in immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	8954125, 10779520, 10950963, 18624398, 26342464, 28514442, 32296183, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IDA	29038465
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	8288566, 10950963
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	10950963
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	10779520, 10950963
GO:0005829	Component	Cytosol	TAS
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	29350881
GO:0016020	Component	Membrane	IDA	10950963
GO:0034145	Process	Positive regulation of toll-like receptor 4 signaling pathway	IDA	29038465
GO:0042802	Function	Identical protein binding	IDA	10950963
GO:0045087	Process	Innate immune response	IEA
GO:0045088	Process	Regulation of innate immune response	IEA
GO:0045089	Process	Positive regulation of innate immune response	IDA	29038465
GO:0045089	Process	Positive regulation of innate immune response	IEA
GO:0050729	Process	Positive regulation of inflammatory response	IDA	29038465
GO:0050729	Process	Positive regulation of inflammatory response	IEA
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IEA
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IMP	29350881
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IEA
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	ISS

Other IDs

• MIM: 600735
• HGNC: 5399
• e!Ensembl: ENSG00000068079

Protein

• UniProt ID: P80217
• Protein name: Interferon-induced 35 kDa protein (IFP 35) (Ifi-35)
• Protein function: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate im
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07334	IFP_35_N	8 → 80	Interferon-induced 35 kDa protein (IFP 35) N-terminus	Family
  PF07292	NID	81 → 170	Nmi/IFP 35 domain (NID)	Domain
  PF07292	NID	179 → 266	Nmi/IFP 35 domain (NID)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in a wide range of cell types, including fibroblasts, macrophages, and epithelial cells. {ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:8288566}.
• Sequence:

  MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP
  EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM
  VTTIQMSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVM
  LGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNIPD
  ILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG

• Sequence length: 286

Pathways

Reactome:

Interferon alpha/beta signaling