Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3416
Gene name	Insulin degrading enzyme
Gene symbol	IDE
Synonyms (NCBI Gene)	INSULYSIN
Chromosome	10
Chromosome location	10q23.33
Summary	This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and k

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025720	hsa-miR-7-5p	Microarray	17612493
MIRT025720	hsa-miR-7-5p	Microarray	19073608
MIRT675952	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT623645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT623644	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT623643	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT623642	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT623641	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT623640	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT623639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT623638	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT657240	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT623637	hsa-miR-572	HITS-CLIP	23824327
MIRT623645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT623644	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT623642	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT623641	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT623640	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT623639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT623638	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT657240	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT623637	hsa-miR-572	HITS-CLIP	23824327
MIRT639708	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT639707	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT639706	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT639705	hsa-miR-3176	HITS-CLIP	23824327
MIRT639704	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT639703	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT639702	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT639701	hsa-miR-1254	HITS-CLIP	23824327
MIRT639700	hsa-miR-3116	HITS-CLIP	23824327
MIRT639699	hsa-miR-661	HITS-CLIP	23824327
MIRT639698	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT639697	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT639696	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639695	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT630447	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT630446	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT630445	hsa-miR-4635	HITS-CLIP	23824327
MIRT630444	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT630443	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT630442	hsa-miR-6131	HITS-CLIP	23824327
MIRT630441	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT630440	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT630439	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT623645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT623644	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT623643	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT623642	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT623641	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT623640	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT623639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT623638	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT623637	hsa-miR-572	HITS-CLIP	23824327
MIRT623645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT623644	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT623643	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT623642	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT623641	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT623640	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT623639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT623638	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT623637	hsa-miR-572	HITS-CLIP	23824327
MIRT639696	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT675952	hsa-miR-3529-3p	HITS-CLIP	27418678
MIRT675952	hsa-miR-3529-3p	HITS-CLIP	27418678
MIRT675952	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT623645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT623644	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT623643	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT623642	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT623641	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT623640	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT623639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT623638	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT657240	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT623637	hsa-miR-572	HITS-CLIP	23824327
MIRT623645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT623644	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT623642	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT623641	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT623640	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT623639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT623638	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT657240	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT623637	hsa-miR-572	HITS-CLIP	23824327
MIRT639708	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT639707	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT639706	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT639705	hsa-miR-3176	HITS-CLIP	23824327
MIRT639704	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT639703	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT639702	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT639701	hsa-miR-1254	HITS-CLIP	23824327
MIRT639700	hsa-miR-3116	HITS-CLIP	23824327
MIRT639699	hsa-miR-661	HITS-CLIP	23824327
MIRT639698	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT639697	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT639696	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639695	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT630447	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT630446	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT630445	hsa-miR-4635	HITS-CLIP	23824327
MIRT630444	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT630443	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT630442	hsa-miR-6131	HITS-CLIP	23824327
MIRT630441	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT630440	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT630439	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT623645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT623644	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT623643	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT623642	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT623641	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT623640	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT623639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT623638	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT623637	hsa-miR-572	HITS-CLIP	23824327
MIRT623645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT623644	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT623643	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT623642	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT623641	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT623640	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT623639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT623638	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT623637	hsa-miR-572	HITS-CLIP	23824327
MIRT1059063	hsa-miR-106a	CLIP-seq
MIRT1059064	hsa-miR-106b	CLIP-seq
MIRT1059065	hsa-miR-1185	CLIP-seq
MIRT1059066	hsa-miR-1224-5p	CLIP-seq
MIRT1059067	hsa-miR-127-5p	CLIP-seq
MIRT1059068	hsa-miR-1289	CLIP-seq
MIRT1059069	hsa-miR-129-5p	CLIP-seq
MIRT1059070	hsa-miR-1304	CLIP-seq
MIRT1059071	hsa-miR-132	CLIP-seq
MIRT1059072	hsa-miR-17	CLIP-seq
MIRT1059073	hsa-miR-20a	CLIP-seq
MIRT1059074	hsa-miR-20b	CLIP-seq
MIRT1059075	hsa-miR-212	CLIP-seq
MIRT1059076	hsa-miR-3148	CLIP-seq
MIRT1059077	hsa-miR-3152-5p	CLIP-seq
MIRT1059078	hsa-miR-3198	CLIP-seq
MIRT1059079	hsa-miR-3605-5p	CLIP-seq
MIRT1059080	hsa-miR-3606	CLIP-seq
MIRT1059081	hsa-miR-3609	CLIP-seq
MIRT1059082	hsa-miR-362-5p	CLIP-seq
MIRT1059083	hsa-miR-3677-5p	CLIP-seq
MIRT1059084	hsa-miR-3679-5p	CLIP-seq
MIRT1059085	hsa-miR-369-3p	CLIP-seq
MIRT1059086	hsa-miR-374c	CLIP-seq
MIRT1059087	hsa-miR-3915	CLIP-seq
MIRT1059088	hsa-miR-3926	CLIP-seq
MIRT1059089	hsa-miR-4276	CLIP-seq
MIRT1059090	hsa-miR-4294	CLIP-seq
MIRT1059091	hsa-miR-4309	CLIP-seq
MIRT1059092	hsa-miR-4504	CLIP-seq
MIRT1059093	hsa-miR-4642	CLIP-seq
MIRT1059094	hsa-miR-4684-5p	CLIP-seq
MIRT1059095	hsa-miR-4689	CLIP-seq
MIRT1059096	hsa-miR-4697-3p	CLIP-seq
MIRT1059097	hsa-miR-4715-5p	CLIP-seq
MIRT1059098	hsa-miR-4768-5p	CLIP-seq
MIRT1059099	hsa-miR-4774-3p	CLIP-seq
MIRT1059100	hsa-miR-4796-3p	CLIP-seq
MIRT1059101	hsa-miR-500b	CLIP-seq
MIRT1059102	hsa-miR-501-5p	CLIP-seq
MIRT1059103	hsa-miR-514	CLIP-seq
MIRT1059104	hsa-miR-514b-3p	CLIP-seq
MIRT1059105	hsa-miR-519d	CLIP-seq
MIRT1059106	hsa-miR-539	CLIP-seq
MIRT1059107	hsa-miR-548a-3p	CLIP-seq
MIRT1059108	hsa-miR-548ah	CLIP-seq
MIRT1059109	hsa-miR-548e	CLIP-seq
MIRT1059110	hsa-miR-548f	CLIP-seq
MIRT1059111	hsa-miR-548s	CLIP-seq
MIRT1059112	hsa-miR-571	CLIP-seq
MIRT1059113	hsa-miR-629	CLIP-seq
MIRT1059114	hsa-miR-633	CLIP-seq
MIRT1059115	hsa-miR-655	CLIP-seq
MIRT1059116	hsa-miR-875-3p	CLIP-seq
MIRT1059117	hsa-miR-93	CLIP-seq
MIRT1059118	hsa-miR-1245	CLIP-seq
MIRT1059068	hsa-miR-1289	CLIP-seq
MIRT1059119	hsa-miR-199a-3p	CLIP-seq
MIRT1059120	hsa-miR-199b-3p	CLIP-seq
MIRT1059121	hsa-miR-30a	CLIP-seq
MIRT1059122	hsa-miR-30b	CLIP-seq
MIRT1059123	hsa-miR-30c	CLIP-seq
MIRT1059124	hsa-miR-30d	CLIP-seq
MIRT1059125	hsa-miR-30e	CLIP-seq
MIRT1059126	hsa-miR-3120-3p	CLIP-seq
MIRT1059127	hsa-miR-3129-3p	CLIP-seq
MIRT1059128	hsa-miR-3129-5p	CLIP-seq
MIRT1059076	hsa-miR-3148	CLIP-seq
MIRT1059078	hsa-miR-3198	CLIP-seq
MIRT1059129	hsa-miR-320a	CLIP-seq
MIRT1059130	hsa-miR-320b	CLIP-seq
MIRT1059131	hsa-miR-320c	CLIP-seq
MIRT1059132	hsa-miR-320d	CLIP-seq
MIRT1059081	hsa-miR-3609	CLIP-seq
MIRT1059133	hsa-miR-3613-3p	CLIP-seq
MIRT1059134	hsa-miR-3653	CLIP-seq
MIRT1059135	hsa-miR-3658	CLIP-seq
MIRT1059136	hsa-miR-3680	CLIP-seq
MIRT1059137	hsa-miR-377	CLIP-seq
MIRT1059138	hsa-miR-3978	CLIP-seq
MIRT1059139	hsa-miR-409-5p	CLIP-seq
MIRT1059089	hsa-miR-4276	CLIP-seq
MIRT1059090	hsa-miR-4294	CLIP-seq
MIRT1059091	hsa-miR-4309	CLIP-seq
MIRT1059140	hsa-miR-4422	CLIP-seq
MIRT1059141	hsa-miR-4429	CLIP-seq
MIRT1059092	hsa-miR-4504	CLIP-seq
MIRT1059142	hsa-miR-4661-3p	CLIP-seq
MIRT1059143	hsa-miR-4670-3p	CLIP-seq
MIRT1059096	hsa-miR-4697-3p	CLIP-seq
MIRT1059144	hsa-miR-4781-3p	CLIP-seq
MIRT1059145	hsa-miR-4797-3p	CLIP-seq
MIRT1059146	hsa-miR-4798-3p	CLIP-seq
MIRT1059147	hsa-miR-520d-5p	CLIP-seq
MIRT1059148	hsa-miR-524-5p	CLIP-seq
MIRT1059108	hsa-miR-548ah	CLIP-seq
MIRT1059149	hsa-miR-548t	CLIP-seq
MIRT1059150	hsa-miR-578	CLIP-seq
MIRT1059151	hsa-miR-603	CLIP-seq
MIRT1059113	hsa-miR-629	CLIP-seq
MIRT1059152	hsa-miR-876-3p	CLIP-seq
MIRT1059153	hsa-miR-936	CLIP-seq
MIRT2013785	hsa-miR-1179	CLIP-seq
MIRT2013786	hsa-miR-1200	CLIP-seq
MIRT2013787	hsa-miR-1264	CLIP-seq
MIRT2013788	hsa-miR-140-3p	CLIP-seq
MIRT2013789	hsa-miR-3117-3p	CLIP-seq
MIRT2013790	hsa-miR-3120-5p	CLIP-seq
MIRT2013791	hsa-miR-4251	CLIP-seq
MIRT2013792	hsa-miR-431	CLIP-seq
MIRT2013793	hsa-miR-4324	CLIP-seq
MIRT2013794	hsa-miR-4418	CLIP-seq
MIRT1059094	hsa-miR-4684-5p	CLIP-seq
MIRT2013795	hsa-miR-4742-3p	CLIP-seq
MIRT2013796	hsa-miR-4760-3p	CLIP-seq
MIRT1059098	hsa-miR-4768-5p	CLIP-seq
MIRT2013797	hsa-miR-500a	CLIP-seq
MIRT2013798	hsa-miR-509-3-5p	CLIP-seq
MIRT2013799	hsa-miR-509-5p	CLIP-seq
MIRT2013800	hsa-miR-513a-3p	CLIP-seq
MIRT1059106	hsa-miR-539	CLIP-seq
MIRT2013801	hsa-miR-544b	CLIP-seq
MIRT2013802	hsa-miR-548ag	CLIP-seq
MIRT2013803	hsa-miR-548ai	CLIP-seq
MIRT2013804	hsa-miR-548g	CLIP-seq
MIRT2013805	hsa-miR-568	CLIP-seq
MIRT2013806	hsa-miR-592	CLIP-seq
MIRT2013807	hsa-miR-597	CLIP-seq
MIRT2013808	hsa-miR-604	CLIP-seq
MIRT1059114	hsa-miR-633	CLIP-seq
MIRT2013809	hsa-miR-643	CLIP-seq
MIRT2013810	hsa-miR-647	CLIP-seq
MIRT2013811	hsa-miR-651	CLIP-seq
MIRT2245940	hsa-let-7a	CLIP-seq
MIRT2245941	hsa-let-7b	CLIP-seq
MIRT2245942	hsa-let-7c	CLIP-seq
MIRT2245943	hsa-let-7d	CLIP-seq
MIRT2245944	hsa-let-7e	CLIP-seq
MIRT2245945	hsa-let-7f	CLIP-seq
MIRT2245946	hsa-let-7g	CLIP-seq
MIRT2245947	hsa-let-7i	CLIP-seq
MIRT2013785	hsa-miR-1179	CLIP-seq
MIRT1059066	hsa-miR-1224-5p	CLIP-seq
MIRT2245948	hsa-miR-1269	CLIP-seq
MIRT2245949	hsa-miR-1269b	CLIP-seq
MIRT2245950	hsa-miR-1288	CLIP-seq
MIRT2245951	hsa-miR-1299	CLIP-seq
MIRT2245952	hsa-miR-193a-3p	CLIP-seq
MIRT2245953	hsa-miR-193b	CLIP-seq
MIRT2245954	hsa-miR-3169	CLIP-seq
MIRT2245955	hsa-miR-3664-3p	CLIP-seq
MIRT2245956	hsa-miR-3929	CLIP-seq
MIRT2245957	hsa-miR-4252	CLIP-seq
MIRT2245958	hsa-miR-4419b	CLIP-seq
MIRT2245959	hsa-miR-4432	CLIP-seq
MIRT2245960	hsa-miR-4436b-5p	CLIP-seq
MIRT2245961	hsa-miR-4458	CLIP-seq
MIRT2245962	hsa-miR-4478	CLIP-seq
MIRT2245963	hsa-miR-4500	CLIP-seq
MIRT2245964	hsa-miR-4515	CLIP-seq
MIRT2245965	hsa-miR-4701-5p	CLIP-seq
MIRT2245966	hsa-miR-4740-5p	CLIP-seq
MIRT2013795	hsa-miR-4742-3p	CLIP-seq
MIRT2245967	hsa-miR-4751	CLIP-seq
MIRT2245968	hsa-miR-510	CLIP-seq
MIRT2013800	hsa-miR-513a-3p	CLIP-seq
MIRT2245969	hsa-miR-588	CLIP-seq
MIRT2013806	hsa-miR-592	CLIP-seq
MIRT2013807	hsa-miR-597	CLIP-seq
MIRT2245970	hsa-miR-7	CLIP-seq
MIRT2245971	hsa-miR-760	CLIP-seq
MIRT2245972	hsa-miR-873	CLIP-seq
MIRT1059116	hsa-miR-875-3p	CLIP-seq
MIRT2245973	hsa-miR-892b	CLIP-seq
MIRT2245974	hsa-miR-98	CLIP-seq
MIRT1059065	hsa-miR-1185	CLIP-seq
MIRT1059066	hsa-miR-1224-5p	CLIP-seq
MIRT1059070	hsa-miR-1304	CLIP-seq
MIRT1059079	hsa-miR-3605-5p	CLIP-seq
MIRT1059084	hsa-miR-3679-5p	CLIP-seq
MIRT1059087	hsa-miR-3915	CLIP-seq
MIRT1059095	hsa-miR-4689	CLIP-seq
MIRT2013786	hsa-miR-1200	CLIP-seq
MIRT2013788	hsa-miR-140-3p	CLIP-seq
MIRT2013791	hsa-miR-4251	CLIP-seq
MIRT2013793	hsa-miR-4324	CLIP-seq
MIRT2013797	hsa-miR-500a	CLIP-seq
MIRT1059106	hsa-miR-539	CLIP-seq
MIRT2013801	hsa-miR-544b	CLIP-seq
MIRT1059065	hsa-miR-1185	CLIP-seq
MIRT1059066	hsa-miR-1224-5p	CLIP-seq
MIRT2549002	hsa-miR-1225-3p	CLIP-seq
MIRT1059067	hsa-miR-127-5p	CLIP-seq
MIRT2549003	hsa-miR-1297	CLIP-seq
MIRT1059070	hsa-miR-1304	CLIP-seq
MIRT1059071	hsa-miR-132	CLIP-seq
MIRT2549004	hsa-miR-1323	CLIP-seq
MIRT2549005	hsa-miR-134	CLIP-seq
MIRT1059075	hsa-miR-212	CLIP-seq
MIRT2549006	hsa-miR-26a	CLIP-seq
MIRT2549007	hsa-miR-26b	CLIP-seq
MIRT2549008	hsa-miR-3118	CLIP-seq
MIRT2549009	hsa-miR-3140-3p	CLIP-seq
MIRT1059076	hsa-miR-3148	CLIP-seq
MIRT2549010	hsa-miR-3164	CLIP-seq
MIRT2549011	hsa-miR-3189-5p	CLIP-seq
MIRT1059079	hsa-miR-3605-5p	CLIP-seq
MIRT2549012	hsa-miR-3611	CLIP-seq
MIRT2549013	hsa-miR-3614-3p	CLIP-seq
MIRT1059084	hsa-miR-3679-5p	CLIP-seq
MIRT2549014	hsa-miR-3688-3p	CLIP-seq
MIRT1059087	hsa-miR-3915	CLIP-seq
MIRT2549015	hsa-miR-3918	CLIP-seq
MIRT2549016	hsa-miR-3923	CLIP-seq
MIRT1059138	hsa-miR-3978	CLIP-seq
MIRT2549017	hsa-miR-409-3p	CLIP-seq
MIRT2549018	hsa-miR-4263	CLIP-seq
MIRT2549019	hsa-miR-4266	CLIP-seq
MIRT2549020	hsa-miR-4323	CLIP-seq
MIRT2549021	hsa-miR-4426	CLIP-seq
MIRT2549022	hsa-miR-4461	CLIP-seq
MIRT2549023	hsa-miR-4465	CLIP-seq
MIRT2549024	hsa-miR-4470	CLIP-seq
MIRT2549025	hsa-miR-4473	CLIP-seq
MIRT2549026	hsa-miR-4495	CLIP-seq
MIRT2549027	hsa-miR-452	CLIP-seq
MIRT2549028	hsa-miR-4645-3p	CLIP-seq
MIRT2549029	hsa-miR-4647	CLIP-seq
MIRT2549030	hsa-miR-4662b	CLIP-seq
MIRT2549031	hsa-miR-4676-3p	CLIP-seq
MIRT1059095	hsa-miR-4689	CLIP-seq
MIRT2549032	hsa-miR-4693-5p	CLIP-seq
MIRT2549033	hsa-miR-4694-3p	CLIP-seq
MIRT2549034	hsa-miR-4695-5p	CLIP-seq
MIRT2549035	hsa-miR-4724-3p	CLIP-seq
MIRT2549036	hsa-miR-4753-3p	CLIP-seq
MIRT1059098	hsa-miR-4768-5p	CLIP-seq
MIRT2549037	hsa-miR-4779	CLIP-seq
MIRT2549038	hsa-miR-4786-3p	CLIP-seq
MIRT2549039	hsa-miR-4799-5p	CLIP-seq
MIRT2549040	hsa-miR-488	CLIP-seq
MIRT2549041	hsa-miR-512-3p	CLIP-seq
MIRT2549042	hsa-miR-513b	CLIP-seq
MIRT2549043	hsa-miR-520f	CLIP-seq
MIRT2549044	hsa-miR-548ac	CLIP-seq
MIRT2549045	hsa-miR-548ae	CLIP-seq
MIRT2549046	hsa-miR-548aj	CLIP-seq
MIRT2549047	hsa-miR-548am	CLIP-seq
MIRT2549048	hsa-miR-548d-3p	CLIP-seq
MIRT2549049	hsa-miR-548o	CLIP-seq
MIRT2549050	hsa-miR-548x	CLIP-seq
MIRT2549051	hsa-miR-548z	CLIP-seq
MIRT2549052	hsa-miR-556-3p	CLIP-seq
MIRT2013805	hsa-miR-568	CLIP-seq
MIRT2549053	hsa-miR-576-3p	CLIP-seq
MIRT2549054	hsa-miR-576-5p	CLIP-seq
MIRT2549055	hsa-miR-607	CLIP-seq
MIRT2549056	hsa-miR-636	CLIP-seq
MIRT2013809	hsa-miR-643	CLIP-seq
MIRT2549057	hsa-miR-758	CLIP-seq
MIRT1059153	hsa-miR-936	CLIP-seq
MIRT1059065	hsa-miR-1185	CLIP-seq
MIRT1059066	hsa-miR-1224-5p	CLIP-seq
MIRT2549002	hsa-miR-1225-3p	CLIP-seq
MIRT1059067	hsa-miR-127-5p	CLIP-seq
MIRT2549003	hsa-miR-1297	CLIP-seq
MIRT1059070	hsa-miR-1304	CLIP-seq
MIRT2549005	hsa-miR-134	CLIP-seq
MIRT2549006	hsa-miR-26a	CLIP-seq
MIRT2549007	hsa-miR-26b	CLIP-seq
MIRT2549008	hsa-miR-3118	CLIP-seq
MIRT2682568	hsa-miR-3119	CLIP-seq
MIRT2549009	hsa-miR-3140-3p	CLIP-seq
MIRT1059076	hsa-miR-3148	CLIP-seq
MIRT2549010	hsa-miR-3164	CLIP-seq
MIRT2682569	hsa-miR-3188	CLIP-seq
MIRT2549011	hsa-miR-3189-5p	CLIP-seq
MIRT1059079	hsa-miR-3605-5p	CLIP-seq
MIRT2549012	hsa-miR-3611	CLIP-seq
MIRT2549013	hsa-miR-3614-3p	CLIP-seq
MIRT1059084	hsa-miR-3679-5p	CLIP-seq
MIRT2549014	hsa-miR-3688-3p	CLIP-seq
MIRT1059087	hsa-miR-3915	CLIP-seq
MIRT2549015	hsa-miR-3918	CLIP-seq
MIRT2549016	hsa-miR-3923	CLIP-seq
MIRT1059138	hsa-miR-3978	CLIP-seq
MIRT2549017	hsa-miR-409-3p	CLIP-seq
MIRT2549018	hsa-miR-4263	CLIP-seq
MIRT2549019	hsa-miR-4266	CLIP-seq
MIRT2549020	hsa-miR-4323	CLIP-seq
MIRT2549022	hsa-miR-4461	CLIP-seq
MIRT2549023	hsa-miR-4465	CLIP-seq
MIRT2549024	hsa-miR-4470	CLIP-seq
MIRT2549025	hsa-miR-4473	CLIP-seq
MIRT2549026	hsa-miR-4495	CLIP-seq
MIRT2549027	hsa-miR-452	CLIP-seq
MIRT2549028	hsa-miR-4645-3p	CLIP-seq
MIRT2549031	hsa-miR-4676-3p	CLIP-seq
MIRT1059095	hsa-miR-4689	CLIP-seq
MIRT2549032	hsa-miR-4693-5p	CLIP-seq
MIRT2549033	hsa-miR-4694-3p	CLIP-seq
MIRT2549034	hsa-miR-4695-5p	CLIP-seq
MIRT2549035	hsa-miR-4724-3p	CLIP-seq
MIRT2549036	hsa-miR-4753-3p	CLIP-seq
MIRT1059098	hsa-miR-4768-5p	CLIP-seq
MIRT2549037	hsa-miR-4779	CLIP-seq
MIRT2549038	hsa-miR-4786-3p	CLIP-seq
MIRT2549039	hsa-miR-4799-5p	CLIP-seq
MIRT2549040	hsa-miR-488	CLIP-seq
MIRT2549041	hsa-miR-512-3p	CLIP-seq
MIRT2549042	hsa-miR-513b	CLIP-seq
MIRT2549043	hsa-miR-520f	CLIP-seq
MIRT2549052	hsa-miR-556-3p	CLIP-seq
MIRT2013805	hsa-miR-568	CLIP-seq
MIRT2549054	hsa-miR-576-5p	CLIP-seq
MIRT2549056	hsa-miR-636	CLIP-seq
MIRT2013809	hsa-miR-643	CLIP-seq
MIRT2549057	hsa-miR-758	CLIP-seq
MIRT1059153	hsa-miR-936	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
NRF1	Activation	22870279

Show/Hide all (94)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001540	Function	Amyloid-beta binding	IEA
GO:0001618	Function	Virus receptor activity	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004175	Function	Endopeptidase activity	IDA	20364150
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IDA	17051221, 17613531
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS	10684867
GO:0005515	Function	Protein binding	IPI	17051221, 17055432, 17715127, 19966293, 20959807, 28514442, 32814053, 33961781
GO:0005524	Function	ATP binding	IDA	17613531
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IDA	9830016
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	ISS
GO:0005615	Component	Extracellular space	TAS	10684867
GO:0005634	Component	Nucleus	IDA	18226493
GO:0005634	Component	Nucleus	IDA	9231799, 15285718
GO:0005737	Component	Cytoplasm	IDA	9231799, 18226493, 23525105
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	15285718, 23525105
GO:0005739	Component	Mitochondrion	IEA
GO:0005777	Component	Peroxisome	IDA	9231799
GO:0005777	Component	Peroxisome	TAS	10684867
GO:0005782	Component	Peroxisomal matrix	IBA
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	9830016, 15285718, 20364150
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	10684867
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IDA	18602473, 20082125, 21185309
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IDA	17613531, 19321446
GO:0008270	Function	Zinc ion binding	IEA
GO:0008286	Process	Insulin receptor signaling pathway	NAS	3059494
GO:0009897	Component	External side of plasma membrane	IDA	16511862
GO:0009986	Component	Cell surface	IDA	16511862, 17055432
GO:0009986	Component	Cell surface	IEA
GO:0009986	Component	Cell surface	ISS
GO:0010815	Process	Bradykinin catabolic process	IDA	17613531, 21185309
GO:0010992	Process	Ubiquitin recycling	IDA	21185309
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IMP	16511862
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017046	Function	Peptide hormone binding	IEA
GO:0019885	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I	IMP	20364150
GO:0030163	Process	Protein catabolic process	IEA
GO:0030163	Process	Protein catabolic process	IMP	20364150
GO:0030163	Process	Protein catabolic process	ISS
GO:0031597	Component	Cytosolic proteasome complex	IEA
GO:0031626	Function	Beta-endorphin binding	IEA
GO:0032092	Process	Positive regulation of protein binding	IDA	9830016
GO:0042277	Function	Peptide binding	IPI	20082125
GO:0042447	Process	Hormone catabolic process	IBA
GO:0042447	Process	Hormone catabolic process	IDA	19321446
GO:0042447	Process	Hormone catabolic process	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	17051221, 24847884
GO:0042803	Function	Protein homodimerization activity	IDA	17613531, 19321446
GO:0043171	Process	Peptide catabolic process	IBA
GO:0043171	Process	Peptide catabolic process	IDA	20364150
GO:0043559	Function	Insulin binding	IDA	17051221
GO:0043559	Function	Insulin binding	IEA
GO:0043559	Function	Insulin binding	IPI	20082125
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045732	Process	Positive regulation of protein catabolic process	TAS	22383525
GO:0045861	Process	Negative regulation of proteolysis	IEA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050435	Process	Amyloid-beta metabolic process	IBA
GO:0050435	Process	Amyloid-beta metabolic process	IDA	9830016, 17613531, 26968463
GO:0050435	Process	Amyloid-beta metabolic process	IEA
GO:0051603	Process	Proteolysis involved in protein catabolic process	IBA
GO:0051603	Process	Proteolysis involved in protein catabolic process	IDA	9830016
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0070062	Component	Extracellular exosome	ISS
GO:0097242	Process	Amyloid-beta clearance	IEA
GO:0097242	Process	Amyloid-beta clearance	IMP	10684867, 16511862
GO:0097242	Process	Amyloid-beta clearance	ISS
GO:0150094	Process	Amyloid-beta clearance by cellular catabolic process	IEA
GO:0150094	Process	Amyloid-beta clearance by cellular catabolic process	IMP	23525105
GO:0150094	Process	Amyloid-beta clearance by cellular catabolic process	ISS
GO:1901142	Process	Insulin metabolic process	IDA	18448515
GO:1901143	Process	Insulin catabolic process	IDA	9231799, 9830016, 19321446
GO:1903715	Process	Regulation of aerobic respiration	IGI	23525105

MIM	HGNC	e!Ensembl
146680	5381	ENSG00000119912

P14735

Protein name

Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)

Protein function

Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:10684867, PubMed:170512

PDB

2G47 , 2G48 , 2G49 , 2G54 , 2G56 , 2JBU , 2JG4 , 2WBY , 2WC0 , 2WK3 , 2YPU , 3CWW , 3E4A , 3E4Z , 3E50 , 3H44 , 3HGZ , 3N56 , 3N57 , 3OFI , 3QZ2 , 4DTT , 4DWK , 4GS8 , 4GSC , 4GSF , 4IFH , 4IOF , 4LTE , 4M1C , 4NXO , 4PES , 4PF7 , 4PF9 , 4PFC , 4QIA , 4RAL , 4RE9 , 5CJO , 5UOE , 5WOB , 6B3Q , 6B70 , 6B7Y , 6B7Z , 6BF6 , 6BF7 , 6BF8 , 6BF9 , 6BFC , 6BYZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00675	Peptidase_M16	74 → 212	Insulinase (Peptidase family M16)	Family
PF05193	Peptidase_M16_C	237 → 417	Peptidase M16 inactive domain	Domain
PF16187	Peptidase_M16_M	422 → 703	Middle or third domain of peptidase_M16	Family
PF05193	Peptidase_M16_C	706 → 889	Peptidase M16 inactive domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in brain and in cerebrospinal fluid (at protein level). {ECO:0000269|PubMed:9830016}.

Sequence

MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL

Sequence length

1019

Interactions

View interactions

	KEGG		Reactome
	Virion - Herpesvirus Alzheimer disease		Ub-specific processing proteases Peroxisomal protein import

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs201349668	RCV005928964
Sarcoma	Likely benign	rs201349668	RCV005928965

Show/Hide Text Mining Associations (36)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
AA amyloidosis	Associate	17653279, 18317569, 33865867
Alzheimer Disease	Inhibit	12507914
Alzheimer Disease	Associate	17244626, 17496198, 17613531, 18813847, 19019493, 19896952, 20098734, 20142614, 20663017, 20724036, 21185309, 21731745, 21992747, 22107728, 23036584 View all (12 more)
Amyloid angiopathy	Associate	19019493
Amyotrophic Lateral Sclerosis	Associate	27244217
Brain Infarction	Associate	23076436
Breast Neoplasms	Associate	18813847
Carcinogenesis	Associate	25945652
Central Nervous System Neoplasms	Stimulate	23188819
Cognition Disorders	Associate	24660790, 28050343
COVID 19	Associate	36232381
Death	Inhibit	32191993
Diabetes Mellitus	Associate	17463249, 17613531, 18719881, 18813847, 19896952, 21185309, 23826334, 26173052
Diabetes Mellitus Type 1	Associate	19455305
Diabetes Mellitus Type 2	Associate	17463249, 18426861, 18633108, 19228808, 19592620, 19862325, 20490451, 20548773, 22107728, 22506066, 22998375, 23512735, 23527042, 23597493, 26173052 View all (4 more)
Diabetic Retinopathy	Associate	28821857
Down Syndrome	Associate	26166206
Drug Related Side Effects and Adverse Reactions	Associate	35204815
Glioma	Associate	32857715
Hereditary Breast and Ovarian Cancer Syndrome	Associate	18813847
Hyperinsulinism	Associate	36010613
Hypoglycemia	Associate	18633108
Hypoxia	Inhibit	32857715
Infarction	Associate	23076436
Infections	Associate	36232381
Insulin Resistance	Associate	17953957, 22998375, 35806251, 36010613
Ketosis	Associate	21992747
Late Onset Disorders	Associate	19019493
Metabolic Diseases	Associate	36010613
Neoplasms	Associate	18783335, 23188819
Neuroblastoma	Associate	21731745
Neuroblastoma	Stimulate	23188819
Plaque Amyloid	Associate	17244626
Polycystic Ovary Syndrome	Associate	17953957, 29734187
Schizophrenia	Associate	37515308
Varicella Zoster Virus Infection	Associate	23188819

IDE (insulin degrading enzyme)