SYT10 (synaptotagmin 10)

Gene

• Entrez ID: 341359
• Gene name: Synaptotagmin 10
• Gene symbol: SYT10
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12p11.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1407129	hsa-miR-1273d	CLIP-seq
MIRT1407130	hsa-miR-155	CLIP-seq
MIRT1407131	hsa-miR-24	CLIP-seq
MIRT1407132	hsa-miR-2681	CLIP-seq
MIRT1407133	hsa-miR-4284	CLIP-seq
MIRT1407134	hsa-miR-4720-3p	CLIP-seq
MIRT1407135	hsa-miR-4804-3p	CLIP-seq
MIRT1407136	hsa-miR-889	CLIP-seq
MIRT2121989	hsa-miR-101	CLIP-seq
MIRT2121990	hsa-miR-144	CLIP-seq
MIRT2121991	hsa-miR-146a	CLIP-seq
MIRT2121992	hsa-miR-146b-5p	CLIP-seq
MIRT1407131	hsa-miR-24	CLIP-seq
MIRT2121993	hsa-miR-3663-3p	CLIP-seq
MIRT2121994	hsa-miR-3920	CLIP-seq
MIRT2121995	hsa-miR-409-3p	CLIP-seq
MIRT1407133	hsa-miR-4284	CLIP-seq
MIRT2121996	hsa-miR-4698	CLIP-seq
MIRT2121997	hsa-miR-4762-3p	CLIP-seq
MIRT2121998	hsa-miR-520d-5p	CLIP-seq
MIRT2121999	hsa-miR-524-5p	CLIP-seq
MIRT2122000	hsa-miR-548c-3p	CLIP-seq
MIRT2122001	hsa-miR-582-5p	CLIP-seq
MIRT2122002	hsa-miR-589	CLIP-seq
MIRT2121990	hsa-miR-144	CLIP-seq
MIRT2344311	hsa-miR-3545-3p	CLIP-seq
MIRT2344312	hsa-miR-3658	CLIP-seq
MIRT2344313	hsa-miR-452	CLIP-seq
MIRT2344314	hsa-miR-4676-3p	CLIP-seq
MIRT2344315	hsa-miR-885-5p	CLIP-seq
MIRT2395469	hsa-miR-532-5p	CLIP-seq
MIRT2121996	hsa-miR-4698	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IEA
GO:0001786	Function	Phosphatidylserine binding	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006887	Process	Exocytosis	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007268	Process	Chemical synaptic transmission	ISS
GO:0007608	Process	Sensory perception of smell	IEA
GO:0007608	Process	Sensory perception of smell	ISS
GO:0016020	Component	Membrane	IEA
GO:0016079	Process	Synaptic vesicle exocytosis	ISS
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IBA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0045956	Process	Positive regulation of calcium ion-dependent exocytosis	IEA
GO:0045956	Process	Positive regulation of calcium ion-dependent exocytosis	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0061891	Function	Calcium ion sensor activity	IBA
GO:0070382	Component	Exocytic vesicle	IBA
GO:0070382	Component	Exocytic vesicle	IEA
GO:0070382	Component	Exocytic vesicle	ISS
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6XYQ8
• Protein name: Synaptotagmin-10 (Synaptotagmin X) (SytX)
• Protein function: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent syna
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	246 → 354	C2 domain	Domain
  PF00168	C2	378 → 498	C2 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed only in pancreas, lung and kidney. {ECO:0000269|PubMed:14756426}.
• Sequence:

  MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGSQGGSSTDISVSLLAVV
  VSFCGLALLVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISSAPTEVFETEEKKEIKENE
  KPAVKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPR
  QMQVSSVDFSMGTEPVLQRGETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQ
  YDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETF
  QFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTE
  SIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTT
  TKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDH
  WNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP

• Sequence length: 523

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANXIETY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations